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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Headache: The Journal of Head and Face Pain

Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations

Sonja Potrebic, Sarah Tanveer, Werner J. Becker, Rebecca Burch, Lara J. Cooke, Todd Fenton, Jeff J. Fletcher, Gillian L. Gordon Perue, Andrew D. Hershey, Jeffrey L. Jackson, Shirley Kessel, Elizabeth W. Loder, Mia T. Minen, Maryam Oskoui, Vijay K. Ramanan, Michelle Murren, Todd J. Schwedt, Stephen D. Silberstein, Don B. Smith, Kylie A. Botchway‐Doe, Heather M. Silsbee, Tamara Pringsheim

Abstract This practice guideline provides updated evidence‐based recommendations regarding the use of pharmacologic migraine prevention in adults. A multidisciplinary panel conducted a systematic review and developed practice recommendations following the process outlined in the 2017 edition of the American Academy of Neurology Clinical Practice Guideline Process Manual. The systematic review includes studies published through June 6, 2024, and is available in a companion publication. Recommendations are supported …

31.08.2026journal-article

International Journal of Urology

Comparative Prognostic Impact of Two‐Dimensional and Three‐Dimensional Computed Tomography‐Based Sarcopenia Indices in Metastatic Castration‐Sensitive Prostate Cancer

Tomohiro Hori, Hiroaki Iwamoto, Takahiro Inaba, Ryunosuke Nakagawa, Taiki Kamijima, Hiroshi Kano, Tomoyuki Makino, Renato Naito, Suguru Kadomoto, Hiroshi Yaegashi, Kazuyoshi Shigehara, Takahiro Nohara, Kouji Izumi, Atsushi Mizokami

ABSTRACT Objectives This study evaluated and compared the prognostic significance of three different computed tomography (CT)‐based radiological indices of sarcopenia—skeletal muscle index (SMI), psoas muscle index (PMI), and three‐dimensional (3D) psoas muscle volume index (PVI)—in patients with metastatic castration‐sensitive prostate cancer (mCSPC). Methods We retrospectively reviewed 120 patients diagnosed with mCSPC (2003–2022). Baseline muscle parameters were calculated from diagnostic CT scans. Sarcopenia wa …

31.08.2026journal-article

Medical Journal of Western Black Sea

Impact of HER2-low status on survival outcomes in patients with metastatic breast cancer treated with cdk4/6 inhibitors: A single-center experience

Esra Aydın, Çiğdem Öztürk, Oğuzhan Okcu, Ahmet Emin Öztürk, Anıl Yıldız, Bayram Şen, Oğuzhan Kesen, Muhammed Aydın, Eyyüp Ayas, Neşe Alyıldız, Recep Ak, Sema Rakici

Aim: Cyclin-dependent kinase (CDK) 4/6 inhibitors combined with endocrine therapy are recommended as the first-line treatment for hormone receptor-positive, HER2-negative metastatic breast cancer without visceral crisis. However, CDK4/6 inhibitor efficacy has been reported to differ between HER2-low and HER2-zero tumors; emerging data suggest that the therapeutic efficacy of CDK4/6 inhibitors may be reduced in HER2-low breast cancer. Therefore, we aimed to evaluate this association in a cohort of patients treated w …

31.08.2026journal-article

Acta Neurochirurgica

Intraoperative monitoring of inhibitory control

S. L. Hartung, P. Beele, T. M. Kos, C. Ruis, M. H. M. Mantione, I. M. C. Huenges Wajer, E. van Kessel, H. C. Dijkerman, P. A. Robe, M. J. E. van Zandvoort

Abstract Purpose Impairments in executive functioning (EF) and inhibitory control (IC) negatively affect patients’ health-related quality of life. We introduced an intraoperative Stroop task (iST) as means of monitoring IC. This study summarizes lessons learned over the past decade since implementation of iST. We focus on its feasibility, potential in preserving EF and anatomical correlates of intraoperative errors. Methods We retrospectively examined 119 treatment-naïve WHO grade II-IV glioma patients, undergoing …

31.08.2026journal-article

Cancers

Circulating Tumor DNA in Bladder Cancer: Current Clinical Evidence and Emerging Multi-Omics Perspectives—A Narrative Review

Mariam Grazia Polito, Luisana Sisca, Davide Caruso, Antonella Cosimati, Carla Adriana Ramirez Reinaga, Etien Leka, Daniele Santini, Gian Paolo Spinelli

Background: Circulating tumor DNA (ctDNA) analysis has emerged as a promising tool for real-time disease monitoring in muscle-invasive bladder cancer (MIBC). This narrative review summarizes current clinical evidence regarding ctDNA across disease stages. Methods: We examine recent translational and clinical findings, incorporating key prospective data from practice-changing trials, as well as insights into minimal residual disease (MRD) detection, treatment escalation and de-escalation strategies, and systemic bar …

31.08.2026journal-article

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz

Das Landeskrebsregister Nordrhein-Westfalen – ein historischer Rückblick 1974–2025

Andreas Stang, Heike Bertram, Andres Schützendübel

Zusammenfassung Die Krebsregistrierung in Nordrhein-Westfalen (NRW) begann 1974 und hatte 2024 ihr 50-jähriges Jubiläum. Das Ziel dieses Beitrags ist es, die Aufbauphasen der Krebsregistrierung in NRW der Jahre 1974 bis 2025 darzustellen. Nach einem internationalen Symposium in Düsseldorf 1973 und mit Unterstützung der Gesellschaft zur Bekämpfung der Krebskrankheiten (später: Krebsgesellschaft NRW) wurde 1974 in Münster unter Federführung von Prof. Ekkehard Grundmann ein Krebsregister zunächst mit dem Fokus auf die …

31.08.2026journal-article

Current Issues in Molecular Biology

Comparison of a Novel MRNA-Based Breast Cancer Subtyping Assay with PAM50 and Oncotype DX in Estrogen Receptor-Positive/HER2-Negative Breast Cancer: An Exploratory Age-Stratified Retrospective Cohort Study

Till Wallrabenstein, Elena Diana Chiru, Martina Sonderegger, Simone Muenst, Christian Kurzeder, Marcus Vetter

Immunohistochemistry (IHC) of ER, PR, HER2, and Ki67 are established prognostic and predictive markers in breast cancer. Gene expression assays such as PAM50 and Oncotype DX are increasingly used for molecular subtyping and recurrence risk calculation. The APIS Breast Cancer Subtyping Kit (BCSK) quantitatively measures the mRNA expression of these markers (ER, PR, HER2, and Ki67) and includes a novel four-gene BCSK Proliferation Signature (PS) designed for subtype classification and risk stratification. This explor …

31.08.2026journal-article

Journal of Clinical Medicine

Axillary Web Syndrome Beyond Breast Cancer: Expanding the Clinical Spectrum Through Illustrative Cases and Contemporary Evidence

Nathalia Cardoso Oliveira, José Marcelo Corassa, Fanilda Souto Barros, Brenno Augusto Seabra de Mello Netto, Anke Bergmann, Joana Storino

Background/Objectives: This study aimed to expand the recognized clinical spectrum of Axillary Web Syndrome (AWS) by integrating illustrative oncologic and non-oncologic cases with a contemporary review of the evidence regarding its epidemiology, diagnosis, pathophysiology, and management. Methods: This study combines a retrospective case series of three patients diagnosed with AWS with a contemporary narrative review of the literature. The series included one patient following breast cancer surgery and two patient …

31.08.2026journal-article

Journal of Inherited Metabolic Disease

Phase 3 Randomized Trial Results of DTX401 AAV Gene Therapy for the Treatment of GSDIa

John J. Mitchell, Jose E. Abdenur, Foekje de Boer, Monica Boyer, Margo Sheck Breilyn, María‐Luz Couce, Diva D. De Leon, Terry G. Derks, Areeg El‐Gharbawy, Andrea B. Haijer‐Schreuder, Karen Loechner, Nicola Longo, Allan M. Lund, Miguel Angel Martinez Olmos, Shawn E. McCandless, Bibiana Mello de Oliveira, Malaya Mount, Nicole Muschol, Kristina Pytlak, Kadakkal Radhakrishnan, Rebecca Riba‐Wolman, David F. Rodriguez‐Buritica, Alessandro La Rosa, Alessandro Rossi, Heather Saavedra, René Santer, Brian Shayota, G. Peter A. Smit, Carolina F. Moura De Souza, Melanie M. van der Klauw, David A. Weinstein, Joseph I. Wolfsdorf, Anne Blake, Andrew A. Grimm, Deepali Mitragotri, Syeda Rahman, Diane M. Turner‐Bowker, Richard Collis

ABSTRACT Glycogen storage disease type Ia (GSDIa) is a rare, life‐threatening inherited carbohydrate metabolism disorder caused by biallelic pathogenic G6PC gene variants resulting in deficiency of glucose‐6‐phosphatase. DTX401 is an investigational AAV8 vector containing the human G6PC gene. DTX401‐CL301 is a pivotal, phase 3, double‐blind, randomized, placebo‐controlled trial of DTX401 in patients ≥ 8 years with GSDIa. The primary endpoint was percent change from Baseline to Week 48 in daily cornstarch intake for …

31.08.2026journal-article

Nano Letters

An Oral Biomimetic Hydrogel for Colon-Localized and Tumor-Targeted Sonodynamic Therapy of Colorectal Cancer

Zeyang Tian, Jie Yang, Ya-Xuan Zhu, Han Lin, Jianlin Shi

Abstract Oral drug delivery systems show great promise for colorectal cancer (CRC) therapy but are limited by poor gastrointestinal stability, insufficient colon localization, and low tumor targeting. Here, we report an oral biomimetic hydrogel platform, SAM/Au-TiO2@Gel, for colon-localized and tumor-targeted sonodynamic therapy of CRC. Au deposition enhances the sonodynamic reactive oxygen species (ROS) generation capability of TiO2, while Staphylococcus aureus membrane (SAM) coating improves tumor targeting and u …

31.08.2026journal-article

Recent Patents on Anti-Cancer Drug Discovery

Glypican-1 in Rhabdomyosarcoma: A Multi-omics Exploration of a Targetable Biomarker

Belal Al-zu'bi, Fatemah OFO Alshammari, Randa AlQaisi, Jaber H. Jaradat, A. A. Al-abadleh, Rashed J. Gousous, Abulmaaty M. Elsayed, Yousef M. Al-saraireh, Mohammad Salem Hareedy

Introduction: Glypican-1 (GPC1), a heparan sulfate proteoglycan found on the cell surface, has been associated with carcinogenesis and chemoresistance in several malignancies. However, its function in rhabdomyosarcoma remains poorly understood. Methods: GPC1 protein expression was evaluated in rhabdomyosarcoma tissue microarrays using immunohistochemistry and quantified using the Allred scoring system. Transcriptomic analysis was performed using the GSE108022 dataset, and protein–protein interaction networks were a …

31.08.2026journal-article

Clinical and Experimental Otorhinolaryngology

Impact of Margin-to-Depth of Invasion Ratio on Oncologic Outcomes in Locally Advanced Oral Cancer Treated With Surgery and Chemoradiotherapy

Ming-Hsien Tsai, Yu-Tsai Lin, Hui-Ching Chuang, Chao-Hui Yang, Tai-Lin Huang, Hui Lu, Wen-Ling Tsai, Chih-Yen Chien, Fu-Min Fang

Objectives. This study aimed to evaluate the prognostic value of the margin-to-depth of invasion ratio (MDR) in patients with locally advanced oral squamous cell carcinoma (LAOSCC) who underwent curative surgery followed by adjuvant concurrent chemoradiotherapy (CCRT).Methods. We analyzed 422 consecutive patients with LAOSCC treated at a single institution between 2007 and 2017. MDR was defined as the ratio of the closest surgical margin (mm) to the tumor depth of invasion (mm). Survival outcomes, including overall …

31.08.2026journal-article

World Journal of Advanced Research and Reviews

When the Skin Becomes Armor: Carcinoma En Cuirasse revealing breast cancer progression

Yosra Ben Kraiem, Hyba Taounza, Mariame Meziane, Karima Senouci, Laila Benzekri

Carcinoma en cuirasse is a rare form of cutaneous metastasis associated with advanced breast cancer, characterized by diffuse sclerodermoid induration of the skin. We report the case of a 50-year-old woman treated for invasive ductal carcinoma of the left breast, who presented seven years later with pulmonary metastases and a progressively evolving erythematous, indurated plaque of the anterior chest wall, associated with infiltrated papules and a peau d'orange appearance. Skin biopsy showed infiltration of the der …

31.08.2026journal-article

European Journal of Anaesthesiology

Hospital exposome and physiological resilience are associated with postoperative delirium, major complications, and long-term cognitive decline in older adults undergoing cancer surgery

Shengjie Pan, Gang Wang

BACKGROUND Postoperative delirium (POD) and long-term cognitive decline remain frequent and incompletely explained complications in older adults undergoing cancer surgery. Hospital environmental exposures (exposomes) may be associated with age-related physiological vulnerability, yet prospective evidence integrating ward-level exposome data with multidomain physiological resilience is limited. OBJECTIVE To examine the associations of hospital environmental burden and physiological resilience with POD, major complic …

31.08.2026journal-article

Frontiers in Oncology

Patterns, causes, and clinical impact of treatment interruption on early outcomes in patients receiving radiotherapy for lung cancer: a retrospective study

Lifa Su, Longbin Zhang, Qiang Liu, Xin He, Xiaoqing Luo

Background Radiation therapy is key for lung cancer, but data on unplanned interruptions remains limited. Objectives This study investigated patterns, risk factors, and clinical impacts of radiotherapy interruptions in lung cancer patients. Methods A retrospective study enrolled 230 lung cancer patients undergoing radiotherapy (Jan 2020‐Dec 2022). After exclusion, 226 patients were analyzed and stratified into interrupted and non-interrupted groups by unplanned radiotherapy interruptions (≥1-day pause, excluding sc …

31.08.2026journal-article

Frontiers in Oncology

Risk of osteoporosis and fracture among patients with breast cancer: a systematic review and meta-analysis of cohort studies

Ke Li, Yanan Qian, Yujing Cao

Background Breast cancer survivors may be at increased risk of osteoporosis and fractures because of disease-related factors and treatment-induced bone loss. However, the available evidence remains inconsistent. This study aimed to evaluate the associations between breast cancer and the risks of osteoporosis and fracture through a systematic review and meta-analysis. Methods PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched from database inception to May 1, 2026. Cohort studies i …

31.08.2026journal-article

Acta Veterinaria Scandinavica

Treatment, monitoring, and euthanasia in canine diabetes mellitus - a questionnaire-based survey among veterinarians in Norway

Sivert Nerhagen, Esben Østergaard Eriksen, Jo Amundstad, Kristin Paaske Anfinsen

Abstract Background Canine diabetes mellitus (DM) is a relatively common endocrinopathy, and it requires dedication and commitment from an owner to care for a diabetic pet. This study aimed to describe treatment and monitoring habits, perceived owner and veterinary concerns when treating and monitoring a diabetic dog, as well as triggers for and risk of euthanasia in diabetic dogs among Norwegian veterinarians. A questionnaire was designed and made available online. Results A total of 125 veterinarians completed th …

31.08.2026journal-article

BMJ Supportive & Palliative Care

Prevalence of cachexia in advanced cancer and its impact on death: a retrospective analysis

Michael S Yule, Flora Flinn, Elizabeth Mitchell, Jonathan Grey, Ratish Balagangatharan, Christian Montgomery, Leo R Brown, Duncan J F Brown, Barry J A Laird, Richard J E Skipworth

Objectives Cancer cachexia (CC) reduces treatment efficacy, quality of life and survival. However, few contemporary data quantify its prevalence or impact on death. This study assessed cachexia prevalence in advanced cancer using multiple diagnostic frameworks and explored its role in cancer-related mortality. Methods A retrospective analysis was conducted of all deaths over 3 years (August 2020 to August 2023) at a specialist palliative care unit. Using clinical, biochemical and CT body composition data, four defi …

31.08.2026journal-article

GSC Biological and Pharmaceutical Sciences

SQUAMOUS PAPILLOMA OF THE EXTERNAL AUDITORY CANAL: A RARE BENIGN NEOPLASM WITH BILATERAL PRESENTATION FROM NORTHEASTERN PART OF INDIA—A CASE REPORT AND COMPREHENSIVE REVIEW OF LITERATURE

Dhivya N, Shashi Shekhar Prasad, Vijay Ganesh B

Background: Squamous papilloma is a benign epithelial tumor which is most commonly seen in the oral cavity, larynx, and skin. Its occurrence in the external auditory canal (EAC) is extremely rare, with bilateral presentation in rarest case. Case Presentation: This is a case report of a 34-year-old male from the north eastern part of India who presented with foreign body sensation and aural fullness in both ears for 4-5 months. He was examined and found to have multiple small papillomatous growth in both external au …

31.08.2026journal-article

European Scientific Journal, ESJ

Clinical Significance of DPYD Gene Polymorphism Testing in Colorectal Cancer Patients Receiving Fluoropyrimidine-Based Chemotherapy: A Single-Center Study in Latvia

Sofija Vilisova, Aija Gerina

Background: Fluoropyrimidine-based chemotherapy, including 5-fluorouracil (5-FU) and capecitabine, is a cornerstone of colorectal cancer (CRC) treatment. However, treatment-related toxicity varies substantially among patients and is influenced by pharmacogenetic factors. Variants in the DPYD gene, which encodes the enzyme dihydropyrimidine dehydrogenase (DPD), are associated with reduced enzyme activity and an increased risk of severe toxicity. Aim: To evaluate the prevalence of clinically relevant DPYD polymorphis …

31.08.2026journal-article

International Journal for Research in Applied Science and Engineering Technology

VGG16 and ResNet50 for Brain Tumor Classification: Comparative Performance and Grad-CAM++ Analysis

Ganeshula Sai Raghava

Reliable categorization of brain tumors from magnetic resonance imaging (MRI) is a prerequisite for timely clinical intervention, yet the great majority of transfer-learning studies in this space report a single backbone in isolation, leaving open the question of how much of the reported performance is attributable to the chosen architecture rather than to dataset or training choices. This paper presents a controlled comparative evaluation of two ImageNet-pretrained convolutional backbones, VGG16 and ResNet50, for …

31.08.2026journal-article

Neuro-Oncology

A CAR-T Tonic Signaling Code Predicts Anti-Tumor Efficacy in Diffuse Midline Glioma

Bing Deng, Xiaowen Zhong, Dazhuan Xin, Xiao Huang, Upendra K Soni, Wenkun Ma, Mingjun Cai, Po-Yu Liang, Jun Bai, Qian Qin, Shreya Mishra, Ming Hu, Arman E Bayat, Zaili Luo, Jiajie Diao, Mei Xin, Natasha Pillay-Smiley, Trent R Hummel, Charles B Stevenson, Jessica B Foster, Peter de Blank, Scott Raskin, Carl Koschmann, Jose A Cancelas, Yi Zheng, Q Richard Lu

Abstract Background Diffuse middle glioma (DMG or DIPG) is a fatal pediatric brain tumor. Although chimeric antigen receptor (CAR) T-cell therapy shows promise, clinical outcomes remain inconsistent due to premature exhaustion, underscoring a critical need to improve CAR-T persistence. A major barrier to CAR-T efficacy is antigen-independent tonic signaling, yet the extent to which tonic signaling shapes CAR-T durability and clinical outcomes, particularly in DMG, remains incompletely defined. Methods Using a clini …

31.08.2026journal-article

Korean Journal of Clinical Oncology

The expression of stemness markers in organoids according to histological subtypes of gastric cancer

Yie-Ri Yoo, Kyoungyun Jeong, Jaeun Yoo, Hyun Myong Kim, Ji-Yeon Shin, Min Kyu Kang, Kyoyoung Park, Sa-Hong Kim, Chungyoon Kim, Jeesun Kim, Young Suk Park, Seong-Ho Kong, Hyuk-Joon Lee, Han-Kwang Yang, Do Joong Park

Purpose: Gastric cancer is a heterogeneous disease in which cancer stem cell-associated properties may contribute to tumor heterogeneity and progression. This study aimed to establish paired normal and tumor gastric organoids, characterize stemness-related gene expression, and explore its association with organoid formation.Methods: Normal and tumor tissues were obtained from 12 patients with advanced gastric cancer. A total of 28 independent organoid cultures were established from 24 tissue specimens (12 normal an …

31.08.2026journal-article

Biomedicines

FTO-Driven m6A Demethylation of TNC Promotes Epithelial–Mesenchymal Transition and Gastric Cancer Metastasis

Jiao Deng, Shuang Liu, Feng Xia, Haokun Zhang, Zhen Sun

Background/Objectives: Gastric cancer (GC) remains a leading cause of cancer-related mortality, with metastasis being the primary driver of poor prognosis. The extracellular matrix glycoprotein tenascin-C (TNC) is implicated in tumor progression and metastasis, yet its regulatory mechanisms in GC remain poorly understood. Here, we identify RNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated protein (FTO) as a key modulator of TNC expression, promoting epithelial–mesenchymal transition (EMT) and …