Medizin: neue Gesundheitspublikationen – Seite 67

02.09.2026journal-article

Konya Journal of Engineering Sciences

STATISTICAL FEATURES ANALYSIS OF EEG DATA FOR ALS DIAGNOSIS USING MACHINE LEARNING ALGORITHMS

Kenan Yaramış, Hanife Göker, Mustafa Tosun

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurological disease resulting from the dysfunction of motor neurons, making early diagnosis difficult due to the slow progression of clinical symptoms. Early diagnosis is crucial to improving the patient's lifespan and quality of life. Electroencephalography (EEG) signals can be recorded non-invasively and at low cost, making them promising biomarkers for ALS diagnosis. Despite the promising results reported in previous EEG-based ALS diagnosis studies, many exis …

02.09.2026journal-article

Intensive Care Medicine Experimental

Early mechanical changes of limb muscle in septic shock assessed by dual-plane shear-wave elastography

Ivo Neto Silva, Rui Azevedo, Joana Duarte, Stanislas Abrard, José Alberto Duarte, Karim Bendjelid

Abstract Background Septic shock induces skeletal muscle wasting and neuromuscular dysfunction, contributing to ICU-acquired weakness (ICUAW) and poor recovery after critical illness. Conventional ultrasound primarily captures structural changes but provides limited insight into early muscle mechanical alterations or their relationships with clinical factors. Shear-wave elastography (SWE) enables non-invasive assessment of muscle stiffness, but its performance in critically ill patients remains poorly understood. M …

02.09.2026journal-article

Attahadi Medical Journal

Clinical, Epidemiological, and Laboratory Profiles of Mediterranean Spotted Fever among Pediatric and Adult Patients in Eastern Libya: A Retrospective Cohort Study

Arij Abdelgader

Mediterranean spotted fever (MSF) is a tick-borne rickettsiosis and continues to be endemic in the Mediterranean basin, but relatively little contemporary clinical data exist from Libya. This study characterized the epidemiological, clinical, laboratory, and seasonal profile of clinically diagnosed MSF and identified factors associated with severe disease. A hospital-based retrospective observational study was conducted among consecutive paediatric and adult patients managed at Al-Bayda Medical Center, Libya, from …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Prospective Assessment of the Performance of a Combi-Rapid Diagnostic Test to Accurately Diagnose Malaria and Detect C-Reactive Protein in Selected Settings in India

Bina Srivastava, Anup Anvikar, Deepali Anvikar, Supriya Sharma, Naseem Ahmed, Deendayal Swarnkar, Manoj K. Das, Khageshwar Pradhan, Kuldeep Singh, Alex Eapen, Sanal Kumar, Thomas Keller, Stephan Weber, Aurélien Mace, Stefano Ongarello, Sabine Dittrich, Sandra Incardona

ABSTRACT. Management of malaria-negative febrile patients is hampered by a lack of rapid diagnostic tests (RDTs) that guide treatment decisions, increasing the risks of antibiotic overuse and antimicrobial resistance. The simultaneous detection of malaria and C-reactive protein (CRP), a potentially useful host biomarker for distinguishing between bacterial and nonbacterial infections, using RDTs could help address this challenge. A prospective study was conducted at seven sites in India from April to December 2019 …

02.09.2026journal-article

International Journal of Stroke

Remote Ischemic Conditioning in the Acute Treatment of Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kaden Lam, Bogna Anna Drozdowska, Ryan Rosentreter, William Betzner, Jianhai Zhang, Mahesh Kate, Carlos Camara-Lemarroy, Zahinoor Ismail, Eric Edward Smith, Aravind Ganesh

Background Remote ischemic conditioning (RIC), a low-cost, non-invasive therapy involving brief cycles of limb ischemia and reperfusion, may be a neuroprotective adjuvant or alternative to reperfusion therapies in acute ischemic stroke (AIS) and may also have therapeutic effects in hemorrhagic stroke (HS). This systematic review and meta-analysis evaluated the efficacy of RIC in AIS and HS. Methods This review was conducted in accordance with PRISMA guidelines and was registered in PROSPERO (CRD42024549594). Litera …

02.09.2026journal-article

Journal of Medical Humanities

William Carlos Williams Poetry Competition Celebrates Medical Student and Physician Poets

Rachel Conrad Bracken

Northeast Ohio Medical University (NEOMED)’s annual poetry competition was named for and envisioned in the spirit of the iconic American poet and pioneering patient-centered physician William Carlos Williams. It honors his legacy by celebrating contemporary clinician writers—both medical students and established practitioners—whose work illustrates the art of medicine and the dynamic interplay of health care and the humanities. An influential poet in the imagist movement in modernist art and literature, Williams’ p …

02.09.2026journal-article

Journal of Cancer Research and Clinical Oncology

Time to subsequent therapy (TTST) as an endpoint in clinical studies: development of standardized documentation of subsequent therapy through systematic literature review, expert interviews, and Delphi survey

Bianca Biedenweg, Thorsten Ruppert, Thomas Kohlmann, Martin Danner, Anja Mehnert-Theuerkauf, Diana Lüftner, Ulrike Filippig, Janine Ziemann, Ulrike Osowski, Peter Kaskel

Abstract Background The endpoint Time to Subsequent Therapy (TTST) is an intermediate endpoint used in research and regulatory assessments. TTST denotes initiation of subsequent therapy and is a clearly definable, clinically relevant event for healthcare professionals. However, it has not been systematically established to which extent TTST is subjectively meaningful to patients. The objective of this study was to define TTST as a patient-relevant intermediate endpoint. Methods The study examined five oncological i …

02.09.2026journal-article

NeuroSci

Simultaneous Percutaneous Spinal Cord Stimulation Lead Placement During Spine Surgery

Hiroshi Inagaki

Spinal cord stimulation (SCS) is an established neuromodulatory therapy for refractory chronic pain; however, the timing of SCS initiation has received relatively little attention. In some patients requiring spine surgery, the indication for SCS is already present at the time of surgery. Percutaneous leads combine reversibility with low invasiveness, allowing the timing of SCS introduction to be matched to clinical need. We describe a technical approach for simultaneous percutaneous SCS lead placement during spine …

02.09.2026journal-article

Frontiers in Surgery

Developing expertise in laparoscopic management of total colonic aganglionosis cases: Duhamel vs. Swenson procedures

Ahmed Arafa, Mohamed Hamed Abouelfadl, Belal Eldomiaty, Aboubakr Ahmed, Ahmed Azzam, Mohamad Qinawy, Seham Anwar, Ahmed S. Ragab

Aim To describe technical evolution of minimally invasive surgery (MIS) for total colonic aganglionosis (TCA) either Duhamel or Swenson procedures conducted by a single pediatric surgical team. Methods 18 children with histologically proven TCA were managed between March 2018 and March 2022. All underwent laparoscopic definitive pull-through: Group A ( n = 8) received laparoscopic-assisted transanal Swenson-type ileoanal pull-through, and Group B ( n = 10) underwent laparoscopic Duhamel procedure. Thirteen patients …

02.09.2026journal-article

Physics in Medicine & Biology

Parameterizable salivary gland model for small-scale Monte Carlo radiopharmaceutical therapy dosimetry: evaluation of mouse and human models

David P Adam, Tahir Yusufaly, Ian Marsh, Remco Bastiaannet, Ana Kiess, Wesley E Bolch, Nouran Zaid, Anupriya Chhabra, Rebecca Krimins, Kathy Gabrielson, Cory Brayton, George Sgouros, Robert F Hobbs

Abstract Standard of care radiopharmaceutical therapy (RPT) may result in dose-limiting side effects of the salivary glands including sialadenitis and xerostomia that are inconsistent with outcomes from external beam for equivalent absorbed doses (ADs). This work develops a parameterizable ‘Macro-to-Micro’ (M2 μ ) model that demonstrates the consideration of small-scale dosimetry in comparison to conventional methods that typically assume uniform voxel or organ-level uptake. Anatomical features of the salivary glan …

02.09.2026journal-article

Clinical Spine Surgery

Prevalence and Clinical Implications of Vitamin D Deficiency in Spine Surgery Patients

Guoping Xu, Huanting Hu, Lihong Lai, Jiajiang Jiang, Li Li, Ying Ren, Zhan Wang

Study Design: Retrospective study. Objective: To determine the prevalence of vitamin D deficiency in patients undergoing spine surgery and to evaluate its distribution across demographic characteristics, bone mineral density (BMD), and spine disease categories. A secondary objective was to examine the associations between serum 25-hydroxyvitamin D (25(OH)D) levels and bone turnover markers (BTMs). Summary of Background Data: Vitamin D is essential for musculoskeletal health. Although previous studies have reported …

02.09.2026journal-article

Microbiology Spectrum

Persistence of Plasmodium falciparum DNA detection after antimalarial treatment and the implication of gametocytes: a prospective cohort study in a non-endemic setting

Azza Bouzayene, Valentin Joste, Tristan Candau, Rizwana Zaffaroullah, Véronique Sarrasin, Nicolas Argy, Sandrine Cojean, Sandrine Houzé

ABSTRACT Highly sensitive molecular assays are increasingly used for malaria diagnosis but are not recommended for follow-up, as Plasmodium falciparum DNA detection may persist after effective antimalarial treatment, complicating these tests’ clinical interpretation. The biological basis of this persistence remains poorly defined. We investigated the potential role of gametocytes in the context of treated infections. In a prospective cohort of 100 successfully treated patients, we analyzed 379 blood samples collect …

02.09.2026journal-article

European Journal of Heart Failure

Type 2 diabetes and chronic kidney disease combinations in heart failure across the ejection fraction spectrum: clinical associations, medication use, and cause-specific outcomes: a contemporary, real-world analysis of the Swedish Heart Failure Registry

Giulia Ferrannini, Tymon Pol, Charlotta Ljungman, Ulf Dahlström, Aurora Merolla, Lars H Lund

Abstract Aims The interactions between heart failure (HF), chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), and relative drug use remain poorly studied. Methods Patients enrolled in the Swedish HF registry 2017–2023 were divided according to CKD and T2DM. HF medication use and all-cause death, cardiovascular death, first HF hospitalization (HHF), their composite, and end-stage renal disease (ESRD) were assessed. Results Among 54 341 patients (34% females, mean age 73 years), 51% had no CKD/no T2DM, 24 …

02.09.2026journal-article

JEADV Clinical Practice

Prevalence of Mycoplasma genitalium in Asymptomatic Patients Attending a Department of Genitourinary Medicine: A Consecutive Series

Dabashis Mandal, Priya Pulickal, Gaynor Roberts, Chris Helm, Sarena Bhargava, Cyreline Tan, Hugo C. van Woerden

ABSTRACT Background Mycoplasma genitalium is a sexually transmitted infection (STI) linked to urogenital symptoms, pelvic inflammatory disease, and infertility in females. However, in accordance with British Association for Sexual Health and HIV (BASHH) guidelines, it is not routinely included in STI screening panels for asymptomatic individuals attending the genitourinary clinic due to limited evidence on the utility. Objectives The aim of the study is to calculate the prevalence and risk factors for M. genitalium …

02.09.2026journal-article

Sage Sphere International Journal

Ureteroscopia flexible versus litotricia extracorpórea en el tratamiento de litiasis renal

Adriana Micaela Aguayo Peralta, Joel Sebastian Chango Yosa, Anthony Bryan Cevallos Falcones, María Daniela Paladines García, Nathaly Pamela Mora Pinos

Introducción: La litiasis renal constituye una enfermedad frecuente cuya elección terapéutica depende del tamaño, localización y características del cálculo, así como de las condiciones individuales del paciente. La ureteroscopia flexible (UF) y la litotricia extracorpórea (LEC) representan alternativas mínimamente invasivas ampliamente utilizadas. Objetivo: Sintetizar la evidencia científica sobre la eficacia y los resultados clínicos de la UF frente a la LEC en el tratamiento de la litiasis renal. Metodología: Se …

02.09.2026journal-article

Journal of Clinical Medicine

Risk of Abnormal Uterine Bleeding in Women with Chronic Spontaneous Urticaria: Korean Nationwide Population-Based Cohort

Su Yeon Park, Jee Yeon Kim, Ji-Eun Song

Background: Chronic spontaneous urticaria (CSU) is an immune-mediated disorder driven by mast cell activation, whereas abnormal uterine bleeding (AUB) is a heterogeneous condition with diverse etiologies. Although immune and inflammatory dysregulation has been independently implicated in CSU and certain forms of AUB, the association between CSU and AUB remains unclear. We therefore examined whether CSU was associated with AUB. Methods: We performed a retrospective population-based cohort analysis using data from th …

02.09.2026journal-article

Asian Cardiovascular and Thoracic Annals

Hemocompatible polymer coating for extracorporeal circulation circuit affects lactate levels during cardiopulmonary bypass surgery

Masashi Tagaya, Shinya Okano, Takuo Murataka, Hiroki Handa, Shunsuke Ichikawa, Shunsuke Takahashi

Introduction Blood lactate level (LL) is a useful predictor of physiological issues during extracorporeal circulation (ECC) treatment. To determine variations in LL depending on the hemocompatible coatings used for ECC, in vitro experiments were performed using whole human blood samples. Methods Three types of experimental circuits were used, consisting of polymer-coated (PC), heparin-coated (HC), or noncoated (NC) membrane oxygenators ( n = 5), in which blood was circulated while heparin diluted with a glucose sol …

02.09.2026journal-article

International Journal of Nanoscience

Green Ferrite-Based Nanocomposites: Emerging Multifunctional Materials for Sustainable Wastewater Treatment and Environmental Remediation

Ruchika Sharma, Pooja Sharma, Ajay Kumar Sharma, Dhirendra Kumar, Thakur Sudesh Kumar Raunija, Vipin Kumar Jain

In the era of scarcity of potable water, there is need of immediate attention for sustainable treatment of wastewater. Water has such a strong tendency to dissolve other substances and that's why sometimes referred to as the universal solvent. Significant impact of water pollution is summarized such as human health, water pollution can lead to the spread of waterborne diseases, such as cholera, typhoid, and dysentery. Exposure to contaminated water can also cause cancer, neurological damage, and reproductive proble …

02.09.2026journal-article

Journal of Bursa Faculty of Medicine

Management of Oral and Dental Health in Paediatric Practice: A Comprehensive Review from Diagnosis to Referral

Emre Çelik

Oral and dental health is an intrinsic component of children’s overall health and well-being. Dental caries remains the most common chronic disease affecting children globally and, despite being preventable, continues to significantly impact pediatric health and psychosocial development.This review aims to define the fundamental preventive approaches pediatricians are expected to follow in light of global guidelines, the critical links between oral health and systemic diseases, and the clinical practice gaps in Tür …

02.09.2026journal-article

Magnetic Resonance in Medicine

Venous Oxygenation Measurements in the Upper Arm: Reproducibility and Sensitivity to a Physical Challenge

J. Diogo Fernandes, Koen P. A. Baas, Matthan W. A. Caan, Bart J. Biemond, John C. Wood, Aart J. Nederveen

ABSTRACT Purpose The feasibility and reproducibility of adapting the T2‐Relaxation‐Under‐Spin‐Tagging (TRUST) MRI sequence for noninvasive measurement of venous oxygenation in the upper arm were investigated, aiming to enable future in vivo validation of T 2 b ‐oxygenation calibration curves in sickle cell disease (SCD). Methods The TRUST sequence, originally developed for the brain, was optimized for the upper arm by comparing control, label and difference signal. Accuracy was assessed using a phantom experiment. …

02.09.2026journal-article

Sensors

Waveform-Prediction Augmentation and Deep Manifold Learning Enable Imbalanced Fault Diagnosis in Rotating Machinery

Yu Tian, Shunsheng Guo, Yibing Li, Xin Zhang, Li Jiang

Fault diagnosis of rotating machinery is essential for ensuring the reliable and safe operation of industrial equipment. However, imbalanced training data often bias intelligent diagnostic models toward majority classes, resulting in insufficient representation of minority faults. In addition, the high dimensionality and redundancy of vibration signals make it difficult to extract discriminative features and preserve meaningful neighborhood structures, thereby degrading diagnostic performance. To address these chal …

02.09.2026journal-article

Journal of Experimental Medicine

Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine

Luciana Conde, Valter Monteiro, Joao C.R. Freitas, Jameson Crandell, Lauren Lawres, Fernanda Tana, Mallery I. Breban, Fahima Akther, Jordan Polster, Abigail Porzucek, Tauyne M. Ramiro, Ana B. de Oliveira, Mauricio L. Nogueira, David R. Martinez, Nathan D. Grubaugh, Pedro R.J. Almeida, Daniela Weiskopf, Mauro M. Teixeira, Carolina Lucas

Dengue causes over 390 million annual infections globally. Qdenga (TAK-003), the only widely available dengue vaccine, has an incompletely defined immunological profile. We performed longitudinal immunological profiling of 110 adults from a dengue-endemic region, including older adults (≥65 years), to assess the effects of immune imprinting and vaccine design on humoral and cellular immunity. Qdenga elicited B and T cell activation across groups but generated serostatus-dependent, serotype-skewed antibody responses …

02.09.2026journal-article

Archives of Osteoporosis

Teriparatide treatment of osteoporosis in solid organ transplant recipients—a single-center experience

Talia Diker Cohen, Ilana Shraga-Slutzky, Keren Kaminer, Alexander Gorshtein, Idit Dotan, Gloria Tsvetov

Abstract Summary Solid organ transplant recipients face high fracture risk with limited evidence guiding anabolic therapy. In this real-world cohort, teriparatide was associated with significant improvements in bone mineral density and acceptable safety without adverse graft effects. These findings support selective anabolic treatment in high-risk transplant recipients and highlight the need for prospective studies. Purpose Solid organ transplant (SOT) recipients are at high risk for osteoporosis and fragility frac …

02.09.2026journal-article

European Spine Journal

Osteoporotic thoracolumbar fractures: age-modified Osteoporotic Fracture–based treatment decisions and length of hospital stay in elderly patients – a prospective single-centre cohort study

Dina Wilma Wiersbicki, Juliane Neumann, Tim Stelzner, Erik Schreiber, Thomas Neumuth, Christoph-Eckhard Heyde, Anna Voelker

Abstract Purpose Treatment decisions for osteoporotic thoracolumbar vertebral fractures (OVF) in elderly patients are challenging. The AO Spine–DGOU Osteoporotic Fracture (OF) classification and OF-score support treatment allocation but do not explicitly account for chronological age, despite its known prognostic relevance. In addition, determinants of length of hospital stay (LOS) in older and very old patients with OVF remain incompletely defined. Methods In this prospective single-centre cohort study, patients a …

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Aktuelle Forschung nach Fachgebiet

STATISTICAL FEATURES ANALYSIS OF EEG DATA FOR ALS DIAGNOSIS USING MACHINE LEARNING ALGORITHMS

Early mechanical changes of limb muscle in septic shock assessed by dual-plane shear-wave elastography

Clinical, Epidemiological, and Laboratory Profiles of Mediterranean Spotted Fever among Pediatric and Adult Patients in Eastern Libya: A Retrospective Cohort Study

Prospective Assessment of the Performance of a Combi-Rapid Diagnostic Test to Accurately Diagnose Malaria and Detect C-Reactive Protein in Selected Settings in India

Remote Ischemic Conditioning in the Acute Treatment of Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

William Carlos Williams Poetry Competition Celebrates Medical Student and Physician Poets

Time to subsequent therapy (TTST) as an endpoint in clinical studies: development of standardized documentation of subsequent therapy through systematic literature review, expert interviews, and Delphi survey

Simultaneous Percutaneous Spinal Cord Stimulation Lead Placement During Spine Surgery

Developing expertise in laparoscopic management of total colonic aganglionosis cases: Duhamel vs. Swenson procedures

Parameterizable salivary gland model for small-scale Monte Carlo radiopharmaceutical therapy dosimetry: evaluation of mouse and human models

Prevalence and Clinical Implications of Vitamin D Deficiency in Spine Surgery Patients

Persistence of Plasmodium falciparum DNA detection after antimalarial treatment and the implication of gametocytes: a prospective cohort study in a non-endemic setting

Type 2 diabetes and chronic kidney disease combinations in heart failure across the ejection fraction spectrum: clinical associations, medication use, and cause-specific outcomes: a contemporary, real-world analysis of the Swedish Heart Failure Registry

Prevalence of Mycoplasma genitalium in Asymptomatic Patients Attending a Department of Genitourinary Medicine: A Consecutive Series

Ureteroscopia flexible versus litotricia extracorpórea en el tratamiento de litiasis renal

Risk of Abnormal Uterine Bleeding in Women with Chronic Spontaneous Urticaria: Korean Nationwide Population-Based Cohort

Hemocompatible polymer coating for extracorporeal circulation circuit affects lactate levels during cardiopulmonary bypass surgery

Green Ferrite-Based Nanocomposites: Emerging Multifunctional Materials for Sustainable Wastewater Treatment and Environmental Remediation

Management of Oral and Dental Health in Paediatric Practice: A Comprehensive Review from Diagnosis to Referral

Venous Oxygenation Measurements in the Upper Arm: Reproducibility and Sensitivity to a Physical Challenge

Waveform-Prediction Augmentation and Deep Manifold Learning Enable Imbalanced Fault Diagnosis in Rotating Machinery

Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine

Teriparatide treatment of osteoporosis in solid organ transplant recipients—a single-center experience

Osteoporotic thoracolumbar fractures: age-modified Osteoporotic Fracture–based treatment decisions and length of hospital stay in elderly patients – a prospective single-centre cohort study