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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Vessel Plus

Case Report: Sequential transcatheter treatment of coronary artery fistula, aneurysmal atrial septal artery and mitral regurgitation

Yiyuan Huang, Zewei Chen, Zhaowei Zhu, Jianjun Tang, Zhenfei Fang

Coronary artery fistulas are rare vascular anomalies that may cause chronic left-to-right shunting, cardiac chamber remodeling, and heart failure. We report a 72-year-old woman with a left main coronary artery-to-right atrium fistula draining through a giant aneurysmal atrial septal artery and accompanied by severe secondary mitral regurgitation. Echocardiography and cardiac computed tomography showed a 19 mm fistulous tract, a 31 × 30 mm aneurysmal vascular structure with a 5 mm outlet to the right atrium, and sev …

31.08.2026journal-article

Läkartidningen

Handläggningen av urotelial cancer i övre urinvägarna varierar i Sverige

Johannes Bobjer, Firas Aljabery, Victor Falini, Truls Gårdmark, Tomas Jerlström, Henrik Kjölhede, Karin Söderkvist, Anders Ullén, Fredrik Liedberg

Urotelial cancer i övre urinvägarna är en ovanlig och diversifierad sjukdomsentitet där det föreligger regionala skillnader för de flesta kvalitetsindikatorer för handläggning och behandling. Målnivåer för de uppsatta kvalitetsindikatorerna nås bara i ett fåtal regioner, och oftare vid sjukhus med större behandlingsvolymer (>10 patienter per år). Förbättringsmöjligheter föreligger, och regionaliserade multidisciplinära tumörkonferenser skulle kunna vara en katalysator i ett sådant förändringsarbete. Ökad täckningsg …

31.08.2026journal-article

Frontiers in Oncology

An interpretable MRI radiomics approach for preoperative prediction of lymphovascular space invasion in cervical cancer using optimal peritumoral region

Xianyan Wu, Chuanfang Xu, Shan Shi, Chengbin Ye, Qun Zhong, Wenjie Yan

Background Lymphovascular space invasion (LVSI) is an important pathological feature associated with tumor aggressiveness and adverse prognosis in cervical cancer. However, reliable preoperative prediction of LVSI remains a challenge. This study aimed to develop and validate an MRI-based radiomics model incorporating intratumoral and peritumoral features for LVSI prediction and systematically evaluate the optimal peritumoral extent. Materials and methods In this single-center study comprising both retrospective and …

31.08.2026journal-article

Advanced Science

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang

ABSTRACT Doxorubicin remains an important component of chemotherapy for triple‐negative breast cancer (TNBC), yet chemoresistance severely limits its clinical efficacy. Here, we identify Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) as an epigenetically silenced gene that critically regulates doxorubicin response. Integrative analyses of The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and clinical cohorts reveal that high TNFRSF19 expression predicts superior pathological complete r …

31.08.2026journal-article

The Prostate

Black Race Predicts Poor Compliance and Higher Prostate Cancer Risk in a Multinational Repeat Biopsy Cohort: Secondary Analysis From the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Clinical Trial

Alexis R. Freedland, Daniel M. Moriera, Jun Gong, Stephen J. Freedland

ABSTRACT Background On a population level, black patients have more prostate cancer (PC), particularly aggressive PC. Similarly, on initial biopsy, black race has been linked with higher PC and high‐grade PC risk. Whether this extends to first repeat biopsy is unknown. We tested if black race predicts PC risk, grade, and biopsy compliance within a phase 3 PC prevention trial with study‐mandated biopsies among patients with an initial negative prestudy biopsy. Methods Analysis of 7445 patients (2.4% black, 97.6% whi …

31.08.2026journal-article

Bioinformation

Oral health and treatment needs across tribal and non-tribal groups: A tertiary care cross-sectional study

Sonal Saigal

Comparative oral health data for tribal and non-tribal populations in India remain limited, particularly regarding whether disparities reflect disease burden or healthcare access. This cross-sectional study assessed 343 participants (169 non-tribal, 174 tribal) at a tertiary care institution using WHO Basic Oral Health Survey (2013) criteria across three age strata. Overall caries experience differed statistically between the groups, although the absolute difference in mean affected surfaces was small (3.54 versus …

31.08.2026journal-article

ChemistrySelect

Sustainable Plant‐Derived Polymeric Materials‐Based Nanocarriers for Targeted Drug Delivery of Breast Cancer Therapeutics: State‐of‐the‐Art Review

Selvaraj Kunjiappan, Parasuraman Pavadai, Devika Muraleedharan, Basavana Gowda Hosur Dinesh, Murugesan Sankaranarayanan

ABSTRACT Globally, breast cancer is the most common cause of cancer‐related deaths in women. Despite considerable scientific advancements in drug design and discovery, the mortality rate has increased. However, finding precision breast cancer therapy and high‐efficiency anticancer drug delivery is still a considerable difficulty. A major challenge in cancer therapy is the lack of a highly selective drug‐delivery system that targets malignant cells without damaging healthy cells, thereby minimizing off‐target effect …

31.08.2026journal-article

Organ Medicine

A Prognostic Stratification Model for Ovarian Cancer Integrating the Tumor‐Associated Macrophages/Programmed Death‐Ligand 1 Axis

Li Liu, Chenya Zhuo, Tingting Zhao, Qiongshan Liu, Yun Liu, Jingran Du, Dandan Yan, Qiuxiao Tan, Hui Fei, Xiaohui Tian, Mengxiong Li

ABSTRACT Background Tumor‐associated macrophages (TAMs) drive ovarian cancer (OC) progression and immune escape mainly via programmed death‐ligand 1 (PD‐L1) upregulation. Elevated TAM infiltration correlates with poor OC prognosis, yet the combined prognostic stratification value of TAMs and PD‐L1 for ovarian malignancy remains poorly characterized. This study aimed to profile TAM infiltration and PD‐L1 expression, and construct a risk stratification model integrating these two immune biomarkers for OC precision pr …

31.08.2026journal-article

Endodontics Today

Comparative evaluation of diode laser with 2% sodium fluoride and 5% potassium nitrate in the treatment of dentin hypersensitivity

S. A. Shammal, A.A.A. Sofan, M. Alsabri, S.A.M. Aldumaini, A. A. Badri, M.A.M. Taher, A.A.Y. Al-Motairi

INTRODUCTION. Dentin hypersensitivity is a common clinical condition that may negatively affect oral function and quality of life. Several desensitizing approaches are available, but no universally accepted treatment protocol has been established. AIM. This study aimed to compare the clinical effectiveness of 5% potassium nitrate toothpaste and diode laser combined with 2% sodium fluoride gel in reducing dentin hypersensitivity. MATERIALS AND METHODS. This assessor-blinded randomized clinical trial included 170 hyp …

31.08.2026journal-article

Bulletin of the Tomsk Polytechnic University Geo Assets Engineering

Modern technologies for acid treatment of carbonate reservoirs in the Middle East

Mohammad Almohammad Alnayef, Elena V. Bezverkhaya, Elena V. Gnidan

Relevance. Acid treatment of the bottomhole zone of wells in carbonate reservoirs of the Middle East, characterized by significant layer-by-layer heterogeneity and low filtration-capacity properties, is associated with a number of complications. This negatively affects the stimulation of oil inflow, restoration of productivity of producing wells and injectivity of injection wells. Consideration of technological solutions and approaches to acidizing in carbonate reservoir conditions is of research and practical inte …

31.08.2026journal-article

Medicina

Personalized Anticoagulation in Cancer Patients: Current Evidence and Future Perspectives

Ștefan Chiorescu, Mihaela Mocan, Bianca Patricia Dinică, Ovidiu Nicolae Grad, Vlad-Ionuț Nechita, Roxana Mihaela Chiorescu

Background and Objectives: Cancer-associated thrombosis (CAT) is still a leading cause of morbidity and mortality in patients with malignancy and represents a major challenge in cardio-oncology. Although low-molecular-weight heparins (LMWH) have long been the standard of care, direct oral anticoagulants (DOACs) have broadened treatment options. However, balancing thrombotic and bleeding risks, accounting for tumor- and individual-specific characteristics, requires an individualized therapeutic approach. This review …

31.08.2026journal-article

The Prostate

Long‐Term Oncologic Outcomes of Neoadjuvant Tumor‐Directed Immunotherapy (PROSTVAC) Before Radical Prostatectomy for Localized Prostate Cancer: A Secondary Analysis of a Neoadjuvant Trial

Braden Millan, Alexander P. Kenigsberg, Charles Hesswani, Christopher R. Koller, Sahil H. Parikh, Zoe Blake, Hangcheng Fu, Ruben Blachman‐Braun, Patrick Michael, Sandeep Gurram, Baris Turkbey, Howard Parnes, Fatima Karzai, Renee N. Donahue, Jeffrey Schlom, James Gulley, Peter A. Pinto

ABSTRACT Background Biochemical recurrence (BCR) following radical prostatectomy (RP) occurs in 20%–40% of patients with localized prostate cancer. Neoadjuvant PROSTVAC has been shown to enhance T‐cell infiltration into the tumor immune microenvironment, but whether these immunologic changes translate into improved long‐term oncologic outcomes remains unknown. Patients and Methods This secondary analysis evaluated 26 patients from a Phase II neoadjuvant PROSTVAC trial who underwent RP. Patients received recombinant …

31.08.2026journal-article

TUMI Oral Health

Chemotherapy and salivary pH in adults with cancer: an analytical cross-sectional study at a hospital in Cajamarca, Peru

Frida Hoyos-Sagastegui

Introduction: Chemotherapy may disrupt salivary gland function and alter oral acid–base balance, increasing susceptibility to dental caries, infections, and mucosal complications. Objetive: This study aimed to determine the association between chemotherapy duration and salivary pH in adults with cancer treated at a hospital in Cajamarca, Peru. Methods: An observational, analytical, cross-sectional study with prospective data collection was conducted in 68 adults selected through convenience sampling. Chemotherapy d …

31.08.2026journal-article

Cancer Drug Resistance

ST6GAL1 promotes cancer stem-like cell-associated paclitaxel resistance through the EGFR-mTOR-SOX2/BMI1 axis in non-small cell lung cancer

Yuxi Yang, Binghui Liang, Weijie Hong, Sau Har Lee, Dongfang Tang, Shuxian Xie, Changtai Qin, Liu Shen, Zhumei Sun, Xiaofeng Yan, Hua Li, Xiaoling Wang, Xudong Hu, Tingjie Ye, Wei Zhang, Wei Xu

Aim: Despite the contribution of cancer stem-like cells (CSLCs) to acquired paclitaxel resistance in non-small cell lung cancer (NSCLC), the biomarkers and regulatory mechanisms sustaining their stemness under chemotherapy pressure remain poorly understood. This study aimed to identify the stemness-maintaining programs underlying CSLC-associated paclitaxel resistance. Methods: Paclitaxel-resistant NSCLC cell models were established. RNA-seq data from resistant spheres and adherent resistant cells were integrated wi …

31.08.2026journal-article

Chulalongkorn Medical Journal

Integrative Analysis of Bioinformatics Databases to Identify Thyroid Cancer Drug Target Candidates

Desti Rahmawati, putri permata suka admanegara, Rista Yulianti, Siska Widiastuti, Wirawan Adikusuma, Brilliant Citra Wirashada, Rahmat Dani Satria, Darmawi Darmawi, Baik Heni Rispawati, Rockie Chong, Ilker ATES, Lalu Muhammad Irham, Petrina Theda Philothra

Background: Thyroid cancer is an endocrine malignancy whose incidence continues to rise globally. Although thyroid cancer generally has a favourable prognosis, aggressive subtypes such as anaplastic thyroid cancer remain a therapeutic challenge. Drug repurposing strategies offer the opportunity to accelerate the development of therapies by utilising drugs already available and with an established safety profile. Objective: This study aims to identify candidate thyroid cancer risk genes by analyzing data extracted f …

31.08.2026journal-article

HCA Healthcare Journal of Medicine

Beyond Drainage: Can Pleural Effusion Naturally Tamponade Tumor Hemorrhage? Literature Review of Hypotheses for Possible Mechanisms

Pratyush Kumar, Kumar Abhishek, Pankti Shah, Amelia Goslin, Archana Machavarapu, Catherine Joyce, Michael J Waxman, Kari Nilsen

Background Malignant pleural effusion (MPE) is a common complication of advanced lung cancer and is typically treated with therapeutic drainage to relieve symptoms. Although this is a well-established palliative approach, removing pleural fluid—especially in cases of necrotic or post-radiation tumors—may disturb the fragile pressure balance within the thoracic cavity. The question of whether pleural effusion can act as a natural tamponade against tumor-related vascular fragility has not been thoroughly investigated …

31.08.2026journal-article

Bioinformation

Role of 3D facial scanning in esthetic analysis and treatment planning for maxillofacial prosthetics

Sreya Chowdhury

Maxillofacial prosthetic rehabilitation demands high precision for esthetic and functional success, yet conventional methods often lack accuracy and patient comfort. Therefore, it is of interest to compare the traditional techniques with advanced 3D facial scanning in 48 patients requiring facial prostheses. 3D scanning showed greater dimensional accuracy (0.31 ą 0.12 mm versus 1.24 ą 0.45 mm, p

31.08.2026journal-article

Advances in Communication and Swallowing

Speech and Language Therapy Interventions Throughout the Oral Cavity Cancer Pathway: A Scoping Review

Kate Baker, Sinead Rothrie, Grainne Brady, Susanne Cruickshank, Justin Roe

Objective The anatomical location of oral cavity cancer (OCC), plus its usual treatment options of surgery with or without (chemo-)radiotherapy, may impact profoundly on speech and swallowing outcomes. The aim of this scoping review was to identify and summarise speech and language therapy (SLT) intervention types and service delivery models employed in OCC over the last 25 years, in order to summarise current practice. Method Systematic searches were conducted in three databases and via Google Scholar for papers p …

31.08.2026journal-article

Journal of Chemical Information and Modeling

Leveraging a Deep Learning Model and Computational Screening for the Discovery of ABCG2 Inhibitors against Drug-Resistant Breast Cancer

Haonan Li, Zichu Wang, Jia Wang, Yongliang Yang

Abstract Multidrug resistance (MDR) mediated by ATP-binding cassette transporter G2 (ABCG2) remains a major clinical challenge in breast cancer chemotherapy, primarily due to its role in reducing intracellular adriamycin (ADR) concentrations. To address this challenge, we developed an integrated computational strategy for the rapid identification of potent ABCG2 inhibitors capable of reversing ADR resistance. We first established the Prediction of Protein–Ligand’s pKd (PPLK), a specialized deep learning model that …

31.08.2026journal-article

World Journal of Surgery

Lesion Diameter Versus Inflammatory Biomarkers and Clinical Severity in Predicting Treatment Selection in Idiopathic Granulomatous Mastitis

Muhammet Fatih Keyif, Sabahattin Destek

ABSTRACT Background Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease with no established predictor to guide medical versus surgical treatment. Neutrophil‐to‐lymphocyte ratio (NLR) and C‐reactive protein (CRP) have been proposed, but prior reports rarely adjusted for lesion morphology or other markers of disease severity. We evaluated whether NLR, CRP, lesion diameter and clinical severity variables independently predict treatment selection in IGM. Methods Single‐center retrospec …

31.08.2026journal-article

Open Forum Infectious Diseases

A Retrospective Analysis Examining the Impact of Educational Attainment and Social Determinants of Health on Rifampicin-Resistant Tuberculosis Treatment Outcomes

Titilade Kehinde Ayandeyi Teibo, Rubeshan Perumal, Lateef Babatunde Amusa, Letitia Shunmugam, Nonkululeko Mzinyane, Darshan Chetty, Resha Boodhram, Radhamoney Narasimmulu, Takondwa Kachoka, Claudia Shozi, Max R O’Donnell, Allison Wolf, Sunitha Chotoo, Nalini Singh, Ricardo Alexandre Arcêncio, Nesri Padayatchi, Kogieleum Naidoo

Abstract Background Rifampicin-resistant tuberculosis (RR-TB) remains a major public health challenge in TB-endemic regions. While social determinants of health, including socioeconomic status, affect infectious disease outcomes, their impact on RR-TB remains poorly understood. This study evaluated the relationship between educational attainment, social disadvantage, and RR-TB outcomes. Methods We conducted a retrospective cohort study using data from four CAPRISA RR-TB clinical trials. Social vulnerability was mea …

31.08.2026journal-article

Frontiers in Medicine

Performance trade-offs between dense prediction and sparse query mechanisms for brain tumor MRI detection: a comparative study of YOLOv8 and RT-DETR

Lianxin Xie, Jinghui Chen, Zhipeng Sun, Yuhan Huang, Shan Ye, Chengbin Ye

Objective This study investigates optimal training strategies for YOLOv8s in brain tumor MRI detection, systematically evaluates the effects of key hyperparameters on model performance, and compares the adaptability and trade-offs between convolution-based dense prediction and Transformer-based sparse query mechanisms in medical image detection. Methods Experiments were conducted on publicly available Kaggle MRI datasets of meningioma and glioma. YOLOv8s was adopted as the baseline model, and a systematic hyperpara …

31.08.2026journal-article

Molecular Nutrition & Food Research

Combined Docosahexaenoic Acid and Captopril Treatment Attenuates Indole Acetic Acid Induced Cardiovascular Injury in Chronic Kidney Disease

Santosh Pushpa Ramya Ranjan Nayak, Raghul Murugan, Mariadhas Valan Arasu, Ilavenil Soundharrajan, Bader O. Almutairi, Selvaraj Arokiyaraj, Jesu Arockiaraj

ABSTRACT Chronic kidney disease (CKD) is associated with the accumulation of protein‐bound uremic toxins (PBUTs), which cause cardiovascular dysfunction via oxidative stress, inflammation, and fibrosis. Indole‐3‐acetic acid (IAA), a uremic toxin generated from the gut microbiota, has been identified as a key modulator of cardiovascular injury in CKD. This study looked at the therapeutic efficacy of a 10% docosahexaenoic acid (DHA) supplemented diet paired with captopril (100 mg/kg) in CKD rats exposed to IAA (50 mg …

31.08.2026journal-article

B-ENT

Diagnosis and Surgical Treatment of a Rare Giant Osteoma of the Mastoid: A Case Report

Rocco Pio Ortore, Michele Cassano, Stefano Patruno, Christian Fiorentino, Lazzaro Cassano, Aurelio D’Ecclesia

A 43-year-old man presented with a giant retro-auricular osteoma of the right mastoid. The osteoma was removed through a retroauricular incision and removed by drilling the mastoid under continuous irrigation and using a hammer and chisel. The results from an aesthetic point of view were reported by the patient as very satisfactory. No recurrence was found in the subsequent 6-month follow-up. The experience shows that the management and surgical approach described in scientific literature can be considered effectiv …