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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal of Clinical Medicine

Risk of Abnormal Uterine Bleeding in Women with Chronic Spontaneous Urticaria: Korean Nationwide Population-Based Cohort

Su Yeon Park, Jee Yeon Kim, Ji-Eun Song

Background: Chronic spontaneous urticaria (CSU) is an immune-mediated disorder driven by mast cell activation, whereas abnormal uterine bleeding (AUB) is a heterogeneous condition with diverse etiologies. Although immune and inflammatory dysregulation has been independently implicated in CSU and certain forms of AUB, the association between CSU and AUB remains unclear. We therefore examined whether CSU was associated with AUB. Methods: We performed a retrospective population-based cohort analysis using data from th …

02.09.2026journal-article

Sensors

Waveform-Prediction Augmentation and Deep Manifold Learning Enable Imbalanced Fault Diagnosis in Rotating Machinery

Yu Tian, Shunsheng Guo, Yibing Li, Xin Zhang, Li Jiang

Fault diagnosis of rotating machinery is essential for ensuring the reliable and safe operation of industrial equipment. However, imbalanced training data often bias intelligent diagnostic models toward majority classes, resulting in insufficient representation of minority faults. In addition, the high dimensionality and redundancy of vibration signals make it difficult to extract discriminative features and preserve meaningful neighborhood structures, thereby degrading diagnostic performance. To address these chal …

02.09.2026journal-article

Magnetic Resonance in Medicine

Venous Oxygenation Measurements in the Upper Arm: Reproducibility and Sensitivity to a Physical Challenge

J. Diogo Fernandes, Koen P. A. Baas, Matthan W. A. Caan, Bart J. Biemond, John C. Wood, Aart J. Nederveen

ABSTRACT Purpose The feasibility and reproducibility of adapting the T2‐Relaxation‐Under‐Spin‐Tagging (TRUST) MRI sequence for noninvasive measurement of venous oxygenation in the upper arm were investigated, aiming to enable future in vivo validation of T 2 b ‐oxygenation calibration curves in sickle cell disease (SCD). Methods The TRUST sequence, originally developed for the brain, was optimized for the upper arm by comparing control, label and difference signal. Accuracy was assessed using a phantom experiment. …

02.09.2026journal-article

Journal of Experimental Medicine

Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine

Luciana Conde, Valter Monteiro, Joao C.R. Freitas, Jameson Crandell, Lauren Lawres, Fernanda Tana, Mallery I. Breban, Fahima Akther, Jordan Polster, Abigail Porzucek, Tauyne M. Ramiro, Ana B. de Oliveira, Mauricio L. Nogueira, David R. Martinez, Nathan D. Grubaugh, Pedro R.J. Almeida, Daniela Weiskopf, Mauro M. Teixeira, Carolina Lucas

Dengue causes over 390 million annual infections globally. Qdenga (TAK-003), the only widely available dengue vaccine, has an incompletely defined immunological profile. We performed longitudinal immunological profiling of 110 adults from a dengue-endemic region, including older adults (≥65 years), to assess the effects of immune imprinting and vaccine design on humoral and cellular immunity. Qdenga elicited B and T cell activation across groups but generated serostatus-dependent, serotype-skewed antibody responses …

02.09.2026journal-article

European Spine Journal

Osteoporotic thoracolumbar fractures: age-modified Osteoporotic Fracture–based treatment decisions and length of hospital stay in elderly patients – a prospective single-centre cohort study

Dina Wilma Wiersbicki, Juliane Neumann, Tim Stelzner, Erik Schreiber, Thomas Neumuth, Christoph-Eckhard Heyde, Anna Voelker

Abstract Purpose Treatment decisions for osteoporotic thoracolumbar vertebral fractures (OVF) in elderly patients are challenging. The AO Spine–DGOU Osteoporotic Fracture (OF) classification and OF-score support treatment allocation but do not explicitly account for chronological age, despite its known prognostic relevance. In addition, determinants of length of hospital stay (LOS) in older and very old patients with OVF remain incompletely defined. Methods In this prospective single-centre cohort study, patients a …

02.09.2026journal-article

Archives of Osteoporosis

Teriparatide treatment of osteoporosis in solid organ transplant recipients—a single-center experience

Talia Diker Cohen, Ilana Shraga-Slutzky, Keren Kaminer, Alexander Gorshtein, Idit Dotan, Gloria Tsvetov

Abstract Summary Solid organ transplant recipients face high fracture risk with limited evidence guiding anabolic therapy. In this real-world cohort, teriparatide was associated with significant improvements in bone mineral density and acceptable safety without adverse graft effects. These findings support selective anabolic treatment in high-risk transplant recipients and highlight the need for prospective studies. Purpose Solid organ transplant (SOT) recipients are at high risk for osteoporosis and fragility frac …

02.09.2026journal-article

World Advances in Renal Medicine

Identifying key prognostic indicators for extended hemodialysis survival: A comprehensive analysis of clinical, laboratory, and demographic factors

Ahmed Atris, Issa Al Salmi, Munira JM Alamrani, Ghada AI Al Balushi, Nahid H Alyahmadi, Michael Mamdouh Soliaman, Hamed Ali Said Ahmad AlShahri

Objectives: Although maintenance dialysis prevents death from uremia, mortality among patients with end-stage kidney disease-ESKD remains high. Hence, this study aims to detect the demographic, clinical, and laboratory parameters that contribute to long-term survival on hemodialysis-HD. Material and Methods: We conducted a retrospective case-control comparative study based on a single-center experience involving patients on regular HD aged 18 years and older at ASSEEB RDC, the second-largest dialysis center in Oman …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

USE OF BIRD FEATHERS AS OIL SORBENTS TO REMOVE HYDROCARBONS FROM WATER SURFACE

I.G. Shaikhiev, A.A. Fazullina

Hydrocarbon spills are one of the urgent environmental problems of our time. To eliminate accidental oil and petroleum product spills from water surfaces there are used various methods: mechanical, chemical, physicochemical, thermal, and biological. The most common method for hydrocarbon removing from natural water body surface is sorption, based on the use of various materials as oil sorbents. Agricultural waste of plant and animal origin has been found to be promising oil sorbents. This article summarizes literat …

02.09.2026journal-article

Journal of Bursa Faculty of Medicine

Management of Oral and Dental Health in Paediatric Practice: A Comprehensive Review from Diagnosis to Referral

Emre Çelik

Oral and dental health is an intrinsic component of children’s overall health and well-being. Dental caries remains the most common chronic disease affecting children globally and, despite being preventable, continues to significantly impact pediatric health and psychosocial development.This review aims to define the fundamental preventive approaches pediatricians are expected to follow in light of global guidelines, the critical links between oral health and systemic diseases, and the clinical practice gaps in Tür …

02.09.2026journal-article

International Journal of Nanoscience

Green Ferrite-Based Nanocomposites: Emerging Multifunctional Materials for Sustainable Wastewater Treatment and Environmental Remediation

Ruchika Sharma, Pooja Sharma, Ajay Kumar Sharma, Dhirendra Kumar, Thakur Sudesh Kumar Raunija, Vipin Kumar Jain

In the era of scarcity of potable water, there is need of immediate attention for sustainable treatment of wastewater. Water has such a strong tendency to dissolve other substances and that's why sometimes referred to as the universal solvent. Significant impact of water pollution is summarized such as human health, water pollution can lead to the spread of waterborne diseases, such as cholera, typhoid, and dysentery. Exposure to contaminated water can also cause cancer, neurological damage, and reproductive proble …

02.09.2026journal-article

International Journal of Dermatology

Factors Influencing Stages of Mohs Micrographic Surgery: A Comprehensive Analysis

Elissa J. Goorman, Mehdi Boostani, Michael J. Bax, Cerrene N. Giordano, Li Yan, Joshua Kent, Lovely Pierre, Avery Williams, Wendy J. Huss, Kimberly L. Brady, Gyorgy Paragh

ABSTRACT Background Mohs micrographic surgery (MMS) achieves high cure rates for basal cell carcinoma (BCC) but may require multiple stages when tumors extend beyond clinically visible margins. Preoperative biopsy subtype information may help identify cases most likely to require additional stages and therefore benefit from adjunctive presurgical imaging. Methods In this retrospective single‐center cohort of 1541 BCCs treated with MMS, we evaluated clinicopathologic features in relation to first‐stage positivity (d …

02.09.2026journal-article

Clinical Cancer Research

Clinical, Genomic, and Spatial Transcriptomic Features of Pancreatic Adenosquamous Carcinoma Support Subtype-Specific Therapeutic Strategies

S. Daniel Haldar, Meredith Wetzel, Jiayun Lu, Jae W. Lee, Hassan Sinan, Christopher D. Jakubowski, Fen Saj, Dean Pavlick, Ryon P. Graf, Julia Quintanilha, Gerald Li, Jerry Mitchell, Jeffrey S. Ross, Anirban Maitra, Milind Javle, Shubham Pant, Hao Wang, Richard Burkhart, Daniel A. Laheru, Elizabeth M. Jaffee, Elana J. Fertig, Elizabeth D. Thompson, Dimitrios N. Sidiropoulos, Luciane T. Kagohara, Nilofer S. Azad

Abstract Purpose: Pancreatic adenosquamous carcinoma (ASQ) is a rare variant with poorly defined clinical and molecular features compared with conventional pancreatic ductal adenocarcinoma (PDAC). This study aimed to characterize the clinical outcomes, genomic landscape, and spatial transcriptomic architecture of ASQ. Experimental Design: We retrospectively evaluated the clinicopathologic features, treatment patterns, and survival of patients with ASQ treated at Johns Hopkins from 2013 to 2023 (n = 178). Genomic la …

02.09.2026journal-article

Montenegrin Journal of Sports Science and Medicine

Myotonometric Assessment of Achilles Tendon and Gastrocnemius Stiffness in Recreationally Active Young Adults: Reliability, Impact of Sex, and Links to Linear Sprint

Matic Sašek, Petra Brnelić, Žiga Kozinc

This study examined the relationship between passive Achilles tendon (AT) and gastrocnemius (GAS) stiffness, measured by myotonometry, and 40-m sprint performance across acceleration and maximal velocity phases, while accounting for sex differences. Twenty-one student athletes (10 males, 11 females) underwent bilateral passive stiffness assessments of the AT and GAS using MyotonPRO, followed by 40-m sprint testing with 10, 20, 30, and 40 m splits. Reliability was assessed using the intraclass correlation coefficien …

02.09.2026journal-article

International Journal of Sports Physical Therapy

Calcific Patellar Tendinopathy. A Case Report Integrating Diagnostic Ultrasound Throughout a Multi-Modal Treatment Approach

Ian Young, Adam Salzman, James Dunning, Joshua Prall, Sam Fischer, Brittany Forbes, James Escaloni

Background Calcific tendinopathy can be difficult to diagnose and manage from a traditional, non-invasive physical therapy perspective. However, there is preliminary evidence supporting the use of diagnostic ultrasound and dry needling interventions to evaluate and treat the pain and disability associated with this chronic condition. The purpose of this case report was to describe the integration of diagnostic ultrasound in the successful evaluation and multi-modal treatment of a patient with calcific patellar tend …

02.09.2026journal-article

Canadian Geriatrics Journal

Fall Risk Identification with Innovative Technologies for Aging in Place: A Clinical Needs Assessment Study

Titilola Yakubu, Nooshin Jafari, Michael Lim, Jamie Lam, Michelle Lin, Di Jiang, Kendall Ho

Background Falls are a leading cause of injury and loss of independence among older adults. While gait-monitoring technologies offer promise for early fall risk detection, adoption is hindered by usability, cost, and integration challenges. Few studies incorporate perspectives from both patients and providers to inform user-centred design. Objective To identify barriers, facilitators, and design considerations for implementing gait-monitoring and fall-assessment technologies among older adults, caregivers, and heal …

02.09.2026journal-article

Journal of Clinical Medicine

Preoperative SGLT2 Inhibitor Use and Outcomes After Major Cardiac Procedures: A Propensity Score-Matched Analysis of the TriNetX Network

Mirza Muhammad Hadeed Khawar, Faizan Ahmed, Mohab Elnashar, Cheryl Vanessa Lewis, Minahil Shahid, Ali Asgher Shuja, Fatima Afzal, Naheed Sajjad, Muhammad Amir Khan, Meeran Atta, Umair Arshad, Muneeb Khawar, Nazila Dalir, Haris Bin Tahir

Background/Objectives: Sodium–glucose cotransporter-2 (SGLT2) inhibitors improve cardiorenal outcomes in patients with diabetes, heart failure, and chronic kidney disease. Their association with perioperative outcomes after major cardiac procedures remains uncertain. Methods: In this retrospective cohort study using the TriNetX U.S. Collaborative Network, adults (≥18 years) undergoing cardiac procedures were identified. Patients with documented SGLT2 inhibitor use within 1 year before the index procedure were compa …

02.09.2026journal-article

Clinical Oral Investigations

Evaluation of the physicochemical properties and adhesive interface quality of BioRoot Flow and BioRoot RCS endodontic sealers: An in vitro study

Dione Tavares Reis, Gustavo Alexandre de Castro-Vasconcelos, Gustavo Creazzo, Helena Cristina de Assis, Igor Bassi Ferreira Petean, Manoel Damiao de Sousa-Neto, Jardel Francisco Mazzi-Chaves, Fabiane Carneiro Lopes-Olhê

Abstract Objective Bioceramic sealers have been increasingly used in endodontics due to their favorable physicochemical and biological properties. However, evidence regarding the physicochemical properties, push-out bond strength, and adhesive interface characteristics of BioRoot Flow compared with other root canal sealers remains limited. Therefore, this study evaluated the physicochemical properties, push-out bond strength, failure pattern, and adhesive interface quality of BioRoot Flow (BRF), BioRoot RCS (BRR), …

02.09.2026journal-article

Uludağ Üniversitesi Tıp Fakültesi Dergisi

Clinical Characteristics, Antifungal Susceptibility, and Prognosis of Candidozyma auris Infections: A Single-Center Retrospective Study

Esra Kazak, Emel Yilmaz, Zilan Konak, Büşra Çalışır, Uğur Önal, Melek Öztürk Demir, Esma Souleiman, Hafize Aysun Yılmaz, Habibe İmer, Hatice Aydın Tüfekçi, Gül Çalışkan, Laman Aliyeva, Yasemin Heper, Cüneyt Özakın, Beyza Ener, Halis Akalın

Candidozyma auris (formerly Candida auris) is an emerging multidrug-resistant fungal pathogen associated with healthcare-associated infections and high mortality. This study evaluated the clinical characteristics, antifungal susceptibility profiles, and risk factors for candidemia and mortality in patients with C. auris isolation. This retrospective cohort study included patients with at least one clinical specimen positive for C. auris between May 2023 and June 2025. Patients were classified as having colonization …

02.09.2026journal-article

Perspectives of the ASHA Special Interest Groups

Reconsidering the Clinical Fellowship: Lessons From the 2025 Centers for Medicare & Medicaid Services Clarification for Speech-Language Pathology Services to Older Adults

Amber Heape

The 2025 Centers for Medicare & Medicaid Services (CMS) clarification, which initially excluded clinical fellows (CFs) from the definition of a qualified speech-language pathologist, revealed broader issues in how the clinical fellowship aligns with contemporary licensure and health care systems. Although CMS later clarified that provisionally licensed CFs could bill under state law, the rapid shift in guidance resulted in uncertainty, hiring delays, and care disruptions for older adults in Medicare-funded settings …

02.09.2026journal-article

Indian Journal of Community Medicine

Implementation of WHO Package of Essential Noncommunicable-Based Brief Behavior-Change Interventions in Primary Care: A Quasi-Experimental Study from Himachal Pradesh, India

Anupam Parashar, Anmol Kumar Gupta, Rajeev Marwaha, Prem Lal

Abstract Background: Over 86% of premature deaths from noncommunicable diseases (NCDs) occur in low- and middle-income countries. This study aimed to assess the impact of integrating components of the WHO’s Package of Essential Noncommunicable Disease (PEN) protocols on blood pressure control. Secondary objectives included evaluating changes in biological and behavioral NCD risk factors, 10-year cardiovascular disease (CVD) risk, and treatment adherence. Material and Methods: A quasi-experimental study was conducte …

02.09.2026journal-article

Physics in Medicine & Biology

Unified-distribution residual diffusion model for cross-scanner generalizable low-dose CT denoising

Siman Huang, Siyuan Ma, Mingqiang Meng, Yujian Zhang, Haotao Jiang, Jing Huang, Yongbo Wang, Zhaoying Bian, Jianhua Ma

Abstract Objective. The growing adoption of multi-center diagnostic and treatment protocols has heightened the demand for consistent image quality across Computed tomography (CT) devices, yet scanner-specific variations in image characteristics pose a significant challenge. Recently, deep learning-based low-dose CT (LDCT) reconstruction algorithms have been widely developed and successfully deployed in commercial clinical systems. However, existing methods for cross-scanner LDCT imaging suffer from inadequate align …

02.09.2026journal-article

Journal of Wound Care

Simulation-based pressure ulcer/injury education in undergraduate nursing: perceived effectiveness versus demonstrated clinical competence

Beáta Grešš Halász

Objective: To evaluate the effectiveness of a simulation-based educational programme designed to support evidence-based pressure ulcer/injury (PU/I) prevention and management among undergraduate nursing students (P.J. Šafárik University in Košice, Slovakia) and to examine the relationship between perceived educational effectiveness and objectively demonstrated clinical competence. Method: A single-group post-intervention observational study was conducted among second-year undergraduate nursing students. The educati …

02.09.2026journal-article

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

Machine learning for the identification of mild to moderate EDTA contamination of serum samples

Christopher-John Lancaster Farrell, Julie Sherfan, Tony Badrick

Background K2EDTA contamination of serum samples is a preanalytical error that poses a risk to patient safety. Contamination is most frequently mild to moderate, which standard detection procedures often miss. We examined whether machine learning models could improve the detection of K2EDTA contamination. Methods Artificial neural network, decision tree (both simple and complex), extreme gradient boosting, k-nearest neighbours, logistic regression, naïve Bayes, random forest, and support vector machine models were …

02.09.2026journal-article

Experimental & Molecular Medicine

Histone deacetylases in cancer metabolic reprogramming

Yu Hyun Jeon, Hyeyeong Seo, Ji Woo Youn, Jung Yoo, Sang Wu Lee, Soo Yeon Oh, So Hee Kwon

Abstract Cancer cells undergo extensive metabolic reprogramming to sustain rapid proliferation and adapt to heterogeneous tumour microenvironments. These metabolic alterations are tightly linked to epigenetic regulation, which reshapes gene expression and cellular signalling mechanisms. Among epigenetic regulators, histone deacetylases (HDACs) have emerged as key modulators of cancer metabolic reprogramming. Along with their canonical roles in histone deacetylation, HDACs regulate non-histone substrates, including …