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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Translating analytical performance into clinical misclassification risk: a probabilistic framework for HbA 1c interpretation

Lorenza Fagnani, Rita Tennina, Pierangelo Bellio, Patrizia Frascaria, Marco Rossi, Sabrina Viggioni, Moira Tucceri Cimini, Consuelo Scimia, Alessandra Piccirilli, Mariagrazia Perilli, Fabio Antonelli, Giuseppe Celenza

Abstract Objectives Using HbA 1c for diabetes diagnosis directly links analytical uncertainty to patient classification. Since traditional performance metrics provide limited insight into these clinical implications, we developed a probabilistic framework to translate HbA 1c concentrations and components of analytical uncertainty into clinically interpretable diagnostic risk. Methods The framework was applied to 100,472 HbA 1c results obtained from a real-world Laboratory Information System. Analytical bias, analyt …

03.09.2026journal-article

Competitio

A logisztikai szektor dolgozóinak digitalizáció iránti motivációja a személyiségjegyek függvényében

Patrik Urbán

Digitalization has become a key driver of economic and organizational development, fundamentally transforming the operation of the logistics sector. In this process, it is especially important to understand what motivates employees working in logistics to adopt digitalization, and how their personality traits - primarily extraversion - affect their openness to technology. Based on a questionnaire measuring Eysenck’s personality dimensions, the findings show that employees have strong internal motivation to use digi …

03.09.2026journal-article

International Journal of Computer Science and Mathematical Theory

Mathematical Modelling of Epidemiological Infectious Disease Transmission Dynamics: Public Health Intervention Strategies

Christiana Nkuturum

This study explores the epidemiological infectious disease transmission dynamics with public health intervention strategies using nonlinear ordinary differential equations with four compartments in a mathematical modeling approach. The study identified two major public intervention strategies as preventive and treatment measures. The findings of this study are that the region D of the subset is a positively-invariant set mathematically and epidemiologically from the model equation (1) as a result of the two interve …

03.09.2026journal-article

Frontiers in Health Services

Patient misidentification and data integrity risks in ultrasound imaging: a case report using multi-framework incident analysis

Benedicta Osei-Donkor, Abdallah Hassoun, Md Shafiqur Rahman Jabin

Background Digital imaging workflows depend on accurate scheduling, patient identity reconciliation, and reliable metadata continuity to ensure safe image storage and retrieval. Disruptions in these processes may not directly affect image acquisition but can delay access to imaging information and pose significant patient safety risks. Objective To examine a recurrent ultrasound workflow failure that compromised downstream image availability and to identify practical strategies for preventing recurrence. Methods A …

03.09.2026journal-article

Sage Sphere International Journal

Cirugía laparoscópica versus cirugía robótica en la resección de tumores hepáticos: resultados y beneficios clínicos

Joel Sebastian Chango Yosa, Kelvin Alejandro Torres Quezada, Mario Gabriel Salas Martínez, Dana Isabel Morales Figueroa, Alonso Patricio Espinoza Ayala

Introducción: La resección hepática constituye el tratamiento principal de diversos tumores hepáticos. Los abordajes laparoscópico y robótico han ampliado las posibilidades de cirugía mínimamente invasiva, especialmente en procedimientos técnicamente complejos. Objetivo: Sintetizar la evidencia científica sobre los resultados y beneficios clínicos de la cirugía laparoscópica versus robótica en la resección de tumores hepáticos. Metodología: Se realizó una revisión bibliográfica narrativa mediante búsquedas en PubMe …

03.09.2026journal-article

Frontiers in Dental Medicine

Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives

Ana Carolina Aparecida Rivas, Mario Taba, Paola Gomes Souza

Curcumin, the active polyphenol in turmeric (Curcuma longa), is well-known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising therapeutic agent for a range of diseases, including neuroinflammatory conditions and periodontal disease. Periodontitis, a prevalent oral disease, is associated with chronic inflammation and bacterial infection. Curcumin has demonstrated antibacterial effects against periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas g …

03.09.2026journal-article

Frontiers in Oncology

Analysis of clinical features and outcomes in a Chinese cohort with ALK fusion across pan-cancer: a retrospective study

Meng Zhang, Yi Feng, Xue Du, Changda Qu, Meizhu Meng, Meiying Ye, Min Liang, Ziran Yang, Wenjuan Gong, Xingyu Ma, Jialiang Guo, Wenmei Li, Shuqin Jia

Background ALK fusions are validated oncogenic drivers, yet their molecular heterogeneity and therapeutic implications remain poorly characterized. This study defined the landscape of ALK fusion partners, EML4-ALK variants, and co-mutations and their impact on treatment responses in a large Chinese pan-cancer cohort. Methods We retrospectively analyzed 16,335 consecutive pan-cancer patients via next-generation sequencing to identify ALK fusions. Clinical characteristics, fusion partners, co-mutations, and treatment …

03.09.2026journal-article

Reslaj: Religion Education Social Laa Roiba Journal

Aktivitas Belajar Mandiri Santri Berbasis Teknologi Digital untuk Mengasah Kreativitas di Pesantren

Nadia Safira Firdaus, Estu Miyarso

The development of digital technology has brought significant transformations to education, including Islamic boarding school (pesantren) environments. This study aims to describe the self-directed learning (SDL) activities of santri in utilizing digital technology to enhance creativity at Pondok Pesantren An Nawawi Berjan, Purworejo. A qualitative descriptive approach with a case study design was employed. Data were collected through three-week direct observation, in-depth interviews, and documentation involving s …

03.09.2026journal-article

Sustainability

Lean Practices, Process Innovativeness, Digital Transformation, and Value Impact in New Energy Vehicle Manufacturing: An Integrated Resource-Optimization Framework

Zhenyu Tang, Tachakorn Wongkumchai, Uswin Chaiwiwat

New energy vehicle (NEV) manufacturers must reduce operational waste while adapting to technological change and preserving long-term value. This study tests an integrated model linking Lean Practices, Process Innovativeness, Digital Transformation, and Value Impact. Of 500 survey invitations distributed across China’s NEV supply chain, 400 complete responses passed a broad screen; 49 cases reporting less than one year of lean or digital implementation were subsequently excluded, yielding a duration-consistent prima …

03.09.2026journal-article

Journal of Clinical Medicine

The Impact of Glucagon-like Peptide-1 (GLP-1) Receptor Agonists on Body Composition in Individuals with Overweight and Obesity: A Systematic Review and Meta-Analysis

Miłosz Woźniak, Zofia Tarcz, Gabriela Pyczek, Julia Bogacka, Andrzej Diniejko, Alina Kuryłowicz, Artur Mamcarz, Daniel Śliż

Background/Objectives: Excess adipose tissue is associated with adverse changes in muscle metabolism and body composition. GLP-1 receptor agonists (GLP-1 RA) have transformed the treatment of obesity; however, concerns remain regarding the potential impact of treatment-associated weight loss on lean mass. This study aimed to evaluate the effects of GLP-1 RA on body composition in adults with obesity without type II diabetes mellitus (T2DM), with a particular focus on changes in lean mass. Methods: A database search …

03.09.2026journal-article

Scientific Reports

Genomic and epidemiological comparative analysis of clinical Campylobacter isolates from public and private healthcare centers in Santiago, Chile

Dona Benadof, Mirta I. Acuña-Ávila, Mireya Ahumada, Lorena Porte, Thomas Weitzel, Alfonso Fernández, Gabriel Cavada, Christopher Grim, Narjol González-Escalona, Carlos J Blondel, Assaf Katz, Verónica Bravo

Abstract Campylobacteriosis remains underestimated in Latin America due to limited surveillance and diagnostic capacity. In this context, a comparison was made of clinical Campylobacter strains from two distinct healthcare settings in Santiago, Chile: a public pediatric hospital and a private tertiary clinic. Through genomic analysis, host-source attribution was observed to vary across socioeconomic profiles: poultry-associated lineages (such as ST-353 and ST-443 complexes) were, as expected, frequently identified …

03.09.2026journal-article

Mental Health and Social Inclusion

Patriarchal career constraints and mental well-being among rural young women: a scoping review of gendered barriers and psychological distress

Shreya Rana, Sunita Dhenwal

Purpose This paper aims to examine the relationship between patriarchal career constraints and mental well-being among rural young women. It explores how gendered barriers related to family authority, restricted mobility, educational discontinuity, marriage expectations and limited employment exposure contribute to psychological distress and social exclusion. Design/methodology/approach This paper adopts a scoping review approach to map and synthesise literature on patriarchy, rural young women, career barriers, ps …

03.09.2026journal-article

BMC Cancer

Towards a universal ovarian cancer biomarker model: clinical validation of Trx1 and CA125 dual strategy

Mi A Park, Songhak Kim, Xiaoguang Yang, Jong Am Song, Geon Woo Lee, Heon Jong Yoo, Soyoung Kim, Kyoung Hoon Suh, Young Bok Ko

Abstract Background Ovarian cancer is the fifth leading cause of cancer-related mortality in women, with early detection being critical for improving patient outcomes. Current diagnostic biomarkers, including Cancer antigen 125 (CA125), human epididymis protein 4 (HE4), and their combined Risk of Ovarian Malignancy Algorithm (ROMA), exhibit limited sensitivity and specificity, particularly in early-stage disease and premenopausal women. Thioredoxin-1 (Trx1) has emerged as a potential complementary biomarker. This e …

03.09.2026journal-article

Frontiers in Political Science

Fear goes viral: the digital securitization of immigration in the 2024 elections

Anastasios Stavropoulos

Introduction Immigration was among the defining issues of the 2024 electoral cycle on both sides of the Atlantic. This study examines how the securitization framing of immigration in campaign discourse — its construction as an existential threat — relates to electoral mobilization, and whether the affordances of social-media platforms amplify that frame. It compares two dissimilar democratic contexts: the 2024 U.S. presidential election and the 2024 European Parliament elections. Methods Combining framing theory an …

03.09.2026journal-article

Current Opinion in Otolaryngology & Head & Neck Surgery

A translational framework for early-phase inner-ear gene therapy: clinical trial design, regulatory strategy, and ethical considerations

Emma C. Dunn, Spencer H. Short, Ravi N. Samy

Purpose of review Hereditary hearing loss has historically been approached as a diagnostic category rather than a therapeutically modifiable disease. Recent advances in molecular genetics, cochlear gene delivery, and first-in-human clinical trials are changing that. This review summarizes contemporary progress in the genetics of hearing loss, with emphasis on emerging gene-based therapies, clinical trial design, regulatory and ethical considerations, and practical implications for otolaryngologists as biologic trea …

03.09.2026journal-article

Frontiers in Public Health

Psychosocial determinants of exercise behavior in Parkinson’s disease: a mini-review

Guanyu Zhang

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by progressive motor and non-motor symptoms that profoundly impact quality of life. Physical exercise has emerged as a promising non-pharmacological intervention with neuroprotective potential, yet adherence rates remain suboptimal. This mini-review synthesizes current evidence on psychosocial determinants influencing exercise behavior in PD patients. Accumulating evidence suggests that psychosocial factors play an importan …

03.09.2026journal-article

Frontiers in Neuroscience

Multimodal neuroimaging fusion in presurgical evaluation of drug-resistant epilepsy: current evidence, clinical integration, and future directions

Yuying Zhao, Mingli Wang, Bo Shen, Wei Luo

Approximately 30% of patients with epilepsy are drug-resistant, and for many of them surgical resection of the epileptogenic zone (EZ) offers the best chance of seizure freedom. Because the EZ cannot be measured directly by any single test, it must be inferred from the convergence of complementary imaging markers, and multimodal neuroimaging fusion has therefore become central to modern presurgical evaluation. This critical narrative review examines what each modality—structural MRI, [18F]FDG-PET, ictal SPECT/SISCO …

03.09.2026journal-article

Frontiers in Public Health

Latent class analysis of sleep-related worry and its influencing factors among shift work nurses: a cross-sectional study

Shuangli Zhang, Zhilin Cheng, Jianhong Qiao

Objective To identify the distinct profiles of sleep-related worry among shift-work nurses and explore their influencing factors, thereby providing a basis for developing targeted interventions for nursing management. Methods A convenience sampling method was used to select 653 shift nurses from three tertiary grade A hospitals in Shandong Province from March to July 2025 as the study participants. Data were collected using a general information questionnaire, the Anxiety and Preoccupation about Sleep Questionnaire …

03.09.2026journal-article

Frontiers in Endocrinology

Artificial intelligence in obesity management: clinical evidence, translational gaps, and implementation priorities—a structured narrative review

Wenneng Liu, Jian Zhao, Dan Zhang, Chun Dang, Yaoheng Lu, Xiao Du

Obesity is a chronic, relapsing disease that requires long-term lifestyle treatment, pharmacotherapy, and metabolic and bariatric surgery. Artificial intelligence (AI) is increasingly being studied across these pathways, but its clinical readiness varies substantially. This Scale for the Assessment of Narrative Review Articles (SANRA)-informed structured narrative review searched PubMed/MEDLINE, Embase, Scopus, ScienceDirect, and Google Scholar through 1 June 2026, primarily for literature published since 2015, wit …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Diagnostic accuracy of recombinase polymerase amplification-based assays for mosquito-borne virus detection in clinical samples: a systematic review and meta-analysis

Yonghui Gao, Jihong Chen

Background Mosquito-borne viral diseases pose an important public health threat due to their frequent outbreaks, similar early clinical manifestations, and potential for rapid transmission. Conventional diagnostic methods, such as virus isolation, serological assays and RT-qPCR, are reliable but may be limited by long turnaround time, cross-reactivity, laboratory equipment requirements and trained operators. Recombinase polymerase amplification (RPA)-based methods have emerged as promising tools for rapid detection …

03.09.2026journal-article

Frontiers in Dental Medicine

Making periodontal risk visible: the role of artificial intelligence in recall adherence

Prajakta Karkare

Supportive periodontal care is essential for maintaining periodontal stability after active therapy, yet adherence to periodontal maintenance remains difficult. Once bleeding, halitosis or other presenting concerns improve, some patients may interpret the disease as resolved and the maintenance visit as “just a clean.” This Perspective uses the intention–behaviour gap to examine behavioural, financial and health-literacy barriers to continued supportive care. It then considers a narrower, testable hypothesis: artif …

03.09.2026journal-article

Frontiers in Public Health

The role of universities in enhancing interprofessional collaboration during COVID-19 in Lebanon: academia as neutral convener in a public-private twinning initiative—a qualitative case study

Kawthar Jaber Fadlallah, Michèle Kosremelli Asmar, Joumana Stephan Yeretzian

Background The Coronavirus Disease 2019 (COVID-19) pandemic underscored the importance of interprofessional collaboration, including partnerships between academic institutions and healthcare organizations. Such collaborations, however, are challenging to initiate and sustain during public health emergencies. This study examines the role and perceived effectiveness of academic involvement within a public–private twinning initiative designed to strengthen COVID-19 response capacities in Lebanon. Methods Using a quali …

03.09.2026journal-article

Discover Artificial Intelligence

A survey of world models for physical AI with uncertainty representation and control

Sven Kirchner, Nils Purschke, Alois Knoll

Abstract Physical AI systems must reason about real-world dynamics in order to perceive, predict, and act safely under partial observability and uncertainty. World models–learned predictive representations of environment dynamics and action consequences–have emerged as a unifying framework for integrating perception, prediction, planning, and control in embodied agents. This survey provides a comprehensive and technically grounded review of learning-based world models for Physical AI, with particular emphasis on cl …