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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Buildings

Age-Friendly Regeneration of Historic Urban Districts: Psychological Pathways Linking Spatial Resources to Older Adults’ Walking

Jingrong Yang, Bart Julien Dewancker, Yi Yang, Chao Nai, Peng Chen

Age-friendly regeneration of historic urban districts that focuses primarily on functional conditions such as streets, facilities, and accessibility may overlook place-based resources and experiences relevant to older adults’ everyday walking. Taking the Cuihu Historic and Cultural District in Kunming, China, as a case study, this study developed a Spatial Resource Index (SRI) comprising historical spatial resources, walking support resources, public cultural resources, and restorative environmental resources. GIS- …

03.09.2026journal-article

AVANCA | CINEMA

Entre o Controle e a Ruptura: Representações acerca do Envelhecimento na Distopia do filme O Último Azul

Liliane Maria Macedo Machado, Marcus Vinicius Azevedo de Mesquita

This article analyzes Gabriel Mascaro’s film The Blue Trail (O Último Azul, 2025) through the lens of the social representations of female aging, employing an intersectional approach that articulates gender, social class, and age. The authors investigate how the film constructs its narrative within a dystopian world and challenges stereotypes traditionally associated with older women, who are often portrayed as fragile, unproductive, and socially invisible. Drawing on feminist and gender studies scholars such as Na …

03.09.2026journal-article

Dementia

“Like a Prisoner”: Stories From Evergreen Manor

Erica MacTavish, K. Aly Bailey, Kimberly J. Lopez, Sherry Dupuis

Stigmatizing accounts of dementia emphasize tragedy, constructing people living with dementia as ‘unagentic’ and ‘failed’ aging subjects, and cognitive changes as a loss of self. This stigma has significant consequences for people living with dementia in all aspects of their lives. For example, coupled with the biomedical culture in many long-term care settings, recreation and leisure is often focused on targeting therapeutic goals or managing “difficult behaviours,” rather than on life enrichment. A social citizen …

03.09.2026journal-article

Frontiers in Nutrition

Combined effects of resistant dextrin and inulin on the reduction of harmful metabolites during in vitro fecal fermentation in older adults

Kazuma Yoshida, Takeshi Matsubara, Shunsuke Morita, Yasuyuki Sakata, Hirofumi Sonoki, Kazuhiro Miyaji

Background/objectives Aging-related dysbiosis is associated with increased production of harmful gut-derived metabolites. Reducing these metabolites by modulating the gut microbiota is important for maintaining health in older adults. This study aimed to investigate whether a combination of resistant dextrin and inulin suppresses the production of harmful metabolites in the gut microbiota of older adults using in vitro fecal fermentation and a metabolomics approach. Methods Fecal samples from eight older adults wer …

03.09.2026journal-article

Frontiers in Public Health

Factors associated with social support among older inpatients with schizophrenia: a cross-sectional study from a tertiary psychiatric hospital in Guangzhou, China

Jinrong Li, Junrong Ye, Jiao Chen, Dingjie Liu, Xueyu Zheng, Yulin Li, Na Ma, Yuhan Zhang, Yanheng Wei, Tian Zhou, Jianxiong Guo, Aixiang Xiao

Background Older inpatients with schizophrenia have lower social support levels that may affect clinical outcomes, yet the associated factors in this population remain underexplored. Objective To explore the factors associated with social support in older inpatients with schizophrenia. Methods A cross-sectional study was conducted among 204 inpatients with schizophrenia recruited from a tertiary psychiatric hospital in Guangzhou, China, between February 2023 and December 2024. Social support and its three dimension …

03.09.2026journal-article

Frontiers in Oncology

Lattice SFRT in a geriatric patient with an initially inoperable leg bulky sarcoma: case report and literature review

Francesco Di Siervi, Bruno Curcio, Renato Cuocolo, Silvio Maffei, Carolina Mainardi, Immacolata A.M. Pilotti, Davide Di Gennaro

Background Management of inoperable bulky soft tissue sarcomas mostly in geriatric patients presents a significant clinical challenge due to high and hypoxia-induced radioresistance, proximity to dose-limiting Organs at Risk (OARs), and the need to minimize systemic toxicity. Spatially Fractionated Radiation Therapy (SFRT), specifically 3D Lattice Radiation Therapy (LRT), offers a novel approach to safely escalate dose within the tumor volume. Case presentation 85-year-old female presenting a massive (20.7 x 9.8 cm …

03.09.2026journal-article

Frontiers in Health Services

Development of targeted strategies to enhance linkage and retention in HIV care among people living with HIV/AIDS in Mpumalanga province

Thuso Charity Mafhungo, Mygirl Lowane, Linda Skaal

Background Despite significant progress in HIV services, significant patient loss occurs at every stage of the HIV care continuum. While efforts made by the NDoH aim to combat the HIV epidemic and achieve the 95-95-95 targets, these targets cannot be reached unless PLHIV are effectively linked to and retained in care. This study aims to develop targeted strategies to improve linkage to and retention in HIV care among PLHIV in the Msukaligwa Sub-district, Mpumalanga Province. Methods A convergent parallel mixed-meth …

03.09.2026journal-article

Frontiers in Public Health

Activity-function transitions and interpretable machine learning for predicting incident depressive symptoms among ACE-exposed middle-aged and older adults: a multi-cohort study

Zhenhao Lin, Yuwen Shangguan, Young-Je Sim, Dahua Chen, Xiang Wang

Background Ad--verse childhood experiences (ACEs) are associated with increased risk of depressive symptoms in later life. This study aimed to develop and externally validate an interpretable machine-learning model for predicting incident depressive symptoms among ACE-exposed middle-aged and older adults. Methods Data were obtained from the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS). Participants with baseline depressive symptoms were excluded. ELSA was used for model devel …

03.09.2026journal-article

Clinical Rehabilitation

Responsiveness of the Timed ‘Up and Go’ test in people with Parkinson's disease

John K Brincks, Jens Bansi, Martin Langeskov-Christensen, Ulrik Dalgas, Caroline S Nielsen, Line V Neergaard, Isa Slotboom, Franziska Riegel, Jacob Callesen

Objectives This study evaluates the responsiveness of the Timed ‘Up and Go’ test in people with Parkinson’s disease to determine its sensitivity in detecting changes in functional mobility. Design Retrospective cohort study. Setting Inpatient rehabilitation. Participants One hundred ninety-six people with Parkinson's disease. Main measures Data on the Timed ‘Up and Go’ test, the 10 m walk test, and the 6 min walk test, collected before and after an assigned multidisciplinary inpatient rehabilitation stay, were retr …

03.09.2026journal-article

Geriatrics

Behavioral Interventions to Increase Physical Activity Among Dementia Caregivers: A Narrative Review of Behavior Theory, Behavior Change Techniques, and Mechanisms of Behavior Change

Ashley M. Goodwin, Alex Makhnevich, Karina W. Davidson, Liron Sinvani, Mark J. Butler

Background: Due to the rise in Alzheimer disease (AD) and AD-related dementias (AD/ADRD) in an aging population, millions of caregivers will be at risk for physical and mental health decline. As those they care for already have physical and cognitive impairment, it is crucial that caregivers maintain health-promoting behaviors. Because regular physical activity (PA) prevents functional loss and improves physical health and well-being, understanding how to help caregivers adopt and sustain PA despite unique time, ca …

03.09.2026journal-article

Indoor and Built Environment

Exploring environmental attributes shaping older adults’ preferences in care homes using electroencephalography, questionnaires, and interviews

Chendi Wang, Fangyi Chen, Yuheng Chen, Fanyu Yang, Yuxuan Zhang

With the aging population, the design of care homes has gained increasing attention. However, the older adults’ preferences for various environmental attributes were often overlooked and still need to be further explored. This study aims to explore these environmental preferences to support their emotional well-being. A fractional factorial design was adopted to identify significant factors. Totally, 32 scenes were developed, incorporating eight environmental attributes: illuminance, colour temperature, view out, f …

03.09.2026journal-article

Frontiers in Neurology

Pharmacological management in frontotemporal dementia and patient outcomes: a retrospective cohort study using the TriNetX platform

Lorenza Pabst Botton, Fernando Jacob Lazzaretti, Carlos Lokschin, Tharick A. Pascoal, Jaderson Costa da Costa, Bruce L. Miller, Lucas P. Schilling, Cristiano S. Aguzzoli

Symptomatic treatment remains the cornerstone of therapeutic management in frontotemporal dementia (FTD), as disease-modifying therapies are currently unavailable. However, several medications originally developed for other neuropsychiatric conditions may represent potentially harmful medications (PHMs) in FTD. This study aimed to describe prescribing patterns following an FTD diagnosis and to evaluate the association between PHM exposure and hospital-based acute care (HBAC) utilization. We conducted a retrospectiv …

03.09.2026journal-article

Frontiers in Rehabilitation Sciences

Functional recovery and mortality after intensive inpatient rehabilitation for severe acquired brain injury in older adults: a retrospective cohort study

Valeria Pingue, Chiara Pavese, Jasmine Invernizzi Descalzi, Loretta Fiorina, Vittorio Gabba, Gianluca Bellaviti, Antonio Nardone

Background Severe acquired brain injury (sABI) is a major cause of mortality and long-term disability. Although its prevalence is increasing among older adults (≥65 years), evidence on independent determinant of rehabilitation outcomes in this population remains limited. This study aimed to identify early factors associated with poor functional outcomes and mortality in younger and older patients undergoing intensive inpatient rehabilitation following severe acquired brain injury (sABI). Methods In this single-cent …

03.09.2026journal-article

Frontiers in Surgery

Distal radius fractures reduction and immobilization using a novel device in older adults in emergency department

Dongdong Jiang, Junwei Yan, Xiao Wang, Bin Liang, Zhaowei Yin

Background The purpose of this study was to introduce a new device for the reduction and immobilization of distal radius fractures. Methods We retrospectively reviewed 40 patients aged 65 years or older who had been treated for displaced distal radius fractures between January 1 and December 31, 2023. Patients were grouped according to the treatment documented in their medical records: conventional manual closed reduction and cast immobilization ( n = 20) or device-assisted reduction and cast immobilization ( n = 2 …

03.09.2026journal-article

Frontiers in Medicine

Clinical Frailty Scale and 12-month adverse health outcomes among community-dwelling older adults in Vietnam: a prospective cohort study

Ha Bich Thi Trinh, Kien Gia To, Tan Van Nguyen

Background Frailty is an important predictor of adverse health outcomes in older adults, but evidence from community settings in Vietnam remains limited. This study examined the association between frailty and adverse health outcomes among community-dwelling older adults. Methods In this prospective cohort study, 1,208 community-dwelling older adults were assessed using the Clinical Frailty Scale (CFS) and followed for 12 months. The primary outcome was a composite of all-cause mortality, falls, and hospitalization …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons

Qingyu Bai, Yan Yan, Chao Zeng, Xue Li, Guihua Zeng, Aleena Saidova, Hui Li, Hong Qing

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) share progressive memory impairment, yet their upstream pathologies differ. This review synthesizes evidence across these disorders to frame memory decline through engram ensembles and proposes an excitability-vulnerability tradeoff, in which the physiological requirements for engram function, including elevated excitability, synaptic plasticity, and coordinated network activity, also increase sensit …

03.09.2026journal-article

Diabetes Technology & Therapeutics

Optimizing Continuous Glucose Monitoring for Older Adults with Diabetes: From Clinical Evidence to a Practical Implementation Pathway

Tong Yang, Jinghao Cai, Jiaying Ni, Jingyi Lu, Jian Zhou

Older adults represent a growing proportion of people with diabetes and often experience hypoglycemia, glycemic variability (GV), multimorbidity, frailty, and treatment-related vulnerabilities that are not fully captured by glycated hemoglobin A1c (HbA1c) alone. Continuous glucose monitoring (CGM) provides time-resolved glucose profiles, trend information, alerts, and remote data sharing, making it well suited to safety-focused geriatric diabetes care. In this narrative review, we synthesize evidence on CGM feature …

03.09.2026journal-article

Medical Journal of Indonesia

Length of stay and readmission risks among geriatric patients with delirium: a retrospective secondary hospital study in Jakarta

Nicholas Hardi, Ignatius Danny Pattirajawane, Ivany Lestari Goutama, Christina Jeanny Soekiono

BACKGROUND Delirium is common in geriatric inpatients and may increase hospital burden. This study aimed to analyze the association of length of stay (LOS), in-hospital mortality, and 30-day readmission among geriatric inpatients at a secondary hospital in Jakarta. METHODS A retrospective study was conducted using secondary data from geriatric inpatients assessed with the comprehensive geriatric assessment (CGA) at Atma Jaya Hospital (March 2024–February 2025). Demographic, functional, nutritional, frailty, and com …

03.09.2026journal-article

Monaldi Archives for Chest Disease

Sociodemographic, behavioral, and life-course risk factors for tuberculosis in older Indian adults: evidence from a nationally representative survey

Saurav Basu, Shubhanjali Roy, Puja Samanta, Suneela Garg

While tuberculosis (TB) propagation is multifactorial, the intersection of biological vulnerability (undernutrition) and cumulative life-course adversities is increasingly recognized as a crucial modifiable determinant. This study aimed to identify the independent biological, socioeconomic, behavioral, and life-course determinants of self-reported TB prevalence among middle-aged and older adults in India. We conducted a cross-sectional analysis using Wave 1 of the Longitudinal Ageing Study in India (LASI, 2017-18). …

03.09.2026journal-article

JMIR Research Protocols

Cocreation, Implementation, and Evaluation of Two Digital Innovations to Improve Home Adaptation for Older Adults: Protocol for an Action Research Pilot Study

Lucien Coulibaly, Maude Laberge, Manon Guay, Noémie Séguin-Tremblay, Paule Langlois, Isabel Paradis, Jean Philippe Nadeau, Mireille Jobidon, René Chamard, Karine Latulippe

Abstract Background Aging in place is a priority for many older adults but often requires home adaptations when temporary or permanent physical disabilities arise. It reduces the risk of falls, improves health-related quality of life, and enhances social participation. Two new digital innovations aim to support home adaptation: Hygiene 2.0, which facilitates the adaptation of baths and showers, and MapIt, which provides 3D mapping of the environment. Objective This action study aims to cocreate and evaluate the imp …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Ferroptosis–neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders

Khuzin Dinislam, Valeriy A. Kataev, Mohammad Rehan Ajmal, Ayman S. Amer, Pratibha Prasad, Azna Zuberi

Oxidative stress, iron dyshomeostasis, and chronic neuroinflammation are the principal mechanisms involved in the progression of central nervous system (CNS) disorders, which are a significant source of death and chronic disability worldwide. This review focuses on understanding the mechanistic relationship between ferroptosis and neuroinflammation in central nervous system (CNS) disorders, which involves the molecular mechanisms, their role in the pathogenesis of the disease, and therapeutic opportunities availabl …

02.09.2026journal-article

Journal of Alzheimer’s Disease

Memory, social cognition, and beyond: Neuropsychological markers differentiating Alzheimer's disease and frontotemporal dementia

Jana Marie Freitag, Franz Felix Konen, Johannes Heck, Kirsten Jahn, Stefanie Groba, Martin Klietz, Thomas Skripuletz, Florian Wegner, Martin Schulze Westhoff, Sebastian Schröder

Background Distinguishing Alzheimer's disease (AD) from frontotemporal dementia (FTD) remains a major clinical challenge, particularly in early disease stages due to overlapping symptoms. Although neuropsychological assessment is central to diagnosis, brief cognitive screening instruments often emphasize episodic memory, whereas comprehensive neuropsychological assessment encompasses multiple cognitive domains. Nevertheless, social cognition and other relevant functions may remain underrepresented in routine clinic …

02.09.2026journal-article

Journal of Applied Polymer Science

Evaluation of Varnishes to Slow Down the Aging of Plasticized PVC

Mathilde Larrieu, Nathalie Balcar, Gilles Barabant, Maroussia Duranton, Odile Fichet, Sophie Cantin

ABSTRACT This study investigates the preventive and curative potential of surface varnishes to mitigate the aging of plasticized PVC (p‐PVC), with particular emphasis on the influence of the PVC formulation on coating efficiency. Two industrial p‐PVC formulations were studied: PVC‐nP plasticized with Diisodecyl Phthalate and Epoxidized Soybean Oil, and PVC‐wP containing an additional phosphate plasticizer, each in pigmented and unpigmented versions. Three aqueous polyurethane‐based varnishes, vPU, vVA, and vFC were …

02.09.2026journal-article

npj Dementia

Motivational drive influences motor and cerebellar alterations in the triple transgenic Alzheimer’s disease model

Adrienn Szabó, Szidónia Farkas, Alexandra Edit Milu, Anna Tóth, Bibiána Török, Csilla Lea Fazekas, Eszter Sipos, Kinga Lénárt, Krisztina Bánrévi, Pedro Correia, Tiago Chaves, Tamás Juhász, Tamás Kovács, Dóra Zelena

Abstract Alzheimer’s disease (AD) is accompanied by early motor alterations, yet the contribution of motivational state and testing history to these changes remains poorly understood. We examined locomotor, fine-motor, and molecular profiles in 6–8-month-old male 3xTg-AD mice across separate cohorts. 3xTg-AD mice displayed reduced locomotion in the open field test, but this hypolocomotion was less evident in reward-driven contexts (such as single pellet reaching test, radial arm maze test, staircase test), where an …