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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Creating outdoor air pollution exposome metrics for assessing breast and lung cancer risks in the United States

Joseph Boyle, Rena R. Jones, Alexandra J. White, Junfeng (Jim) Zhang, Verónica M. Vieira, Bernard F. Fuemmeler

Abstract Background. Air pollution (AP) is a known cause of lung cancer (LC); growing evidence links AP with breast cancer (BC) risk. Many epidemiological studies analyze PM2.5, though AP is a complex mixture of many pollutants. New metrics are necessary to fully represent the carcinogenic constituents of AP. Therefore, we aimed to develop cancer-specific metrics to determine where and what types of AP drive incident cancers. Methods. We combined databases of AP across the continental US in 2005-2020, including the …

01.09.2026journal-article

Journal of Medical Topics and Updates

Clinical Predictors of Early Treatment Failure After Tube Thoracostomy in First-Episode Primary Spontaneous Pneumothorax

Tuba Şahinoğlu, Dursun Öz, Kübra Altıntaş, Atilla Can, Hüseyin Yıldıran

Objective: Early treatment failure following initial tube thoracostomy remains a major clinical challenge in patients with first-episode primary spontaneous pneumothorax (PSP). This study aimed to identify clinical predictors of early treatment failure and evaluate its association with short-term clinical outcomes.Materials and Methods: This retrospective single-center study included 80 consecutive patients with first-episode PSP treated with initial tube thoracostomy between January 2014 and January 2026. Early tr …

01.09.2026journal-article

BMC Neurology

Real-world treatment patterns and disease burden in generalized myasthenia gravis patients receiving non-steroidal immunosuppressants within the Brazilian public health system: a claims database study

Acary Souza Bulle Oliveira, Marcondes Cavalcante França, Paulo Victor Sgobbi Souza, Ligia Coelho, Gabriela Kanevsky, Julio Cesar Barbour Oliveira, Caroline Tianeze de Castro, Renato Watanabe de Oliveira

Abstract Background Generalized myasthenia gravis (gMG) is a chronic autoimmune disorder affecting patients and healthcare systems. Limited real-world data exist on clinical journey and outcomes of patients with gMG within the Brazilian public health system (SUS). This study aimed to describe clinical profiles, treatment patterns, and healthcare resource use of patients with gMG receiving non-steroidal immunosuppressive therapy (NSIST) in SUS. Methods This retrospective cohort study used DATASUS database claims dat …

01.09.2026journal-article

Frontiers in Cell and Developmental Biology

Multidimensional roles and clinical significance of GATA3 in breast cancer

Junjuan Tan, Weihan Chen, Kaiyan Song, Xiaoqian Zhu, Liwei Hong, Juju Zhou, Kai Chen, Haitong Lv

Background GATA-binding protein 3 (GATA3) is a pivotal transcriptional regulator during mammary gland development and serves as a core biomarker in breast cancer. Although traditionally recognized for maintaining luminal differentiation, its high mutation frequency reveals a complex, dual role in tumorigenesis. Methods This review summarizes the multidimensional roles of GATA3, with an emphasis on molecular regulatory networks, clinical diagnostic applications, and significance in therapeutic response in the field …

01.09.2026journal-article

Cellular Physiology and Biochemistry

Tumor Destructive Mechanical Impulse (TMI) Treatment of Solid Tumors. Part IV: Palliative Management of Painful Bone Metastases, Pain Relief – and Beyond

Axel Erich Theuer, Stella Exner, Ioannis Thomas, Florian Lang, John Warlick, John David Mullins, Thomas K. Eigentler, Gerhard Franz Walter

Background/Aims: Bone metastases are a frequent and highly debilitating complication of advanced malignancies and are associated with severe pain, structural instability and loss of functional capacity. Radiotherapy, systemic antineoplastic therapy, bone-targeted agents and interventional techniques remain the clinical standard, yet a relevant proportion of patients experience only incomplete or transient pain relief. Non-invasive focal approaches are therefore being explored. Tumor-destructive mechanical impulses …

02.09.2026journal-article

The Oncologist

4 Baseline and Early On-Treatment Plasma Kidney Injury Molecule-1 (KIM-1) Levels are Associated with Outcomes in Advanced Renal Cell Carcinoma (aRCC)

Wenxin Xu, Habib Hamidi, Robert J Motzer, Thomas Powles, Laurence Albiges, Marc Machaalani, Svetlana Andrianova, Saurabh Gupta, Venu Valmeekam, Toni K Choueiri, Bradley A McGregor, Andrew Simmons

Abstract Background KIM‑1 is a circulating biomarker expressed by injured renal tubular epithelium and renal tumor cells. Prior studies suggest prognostic relevance in aRCC; however, validation in large prospective trials and contemporary immunotherapy‑based regimens is limited. We evaluated baseline and early on-treatment plasma KIM‑1 levels and their associations with baseline characteristics and clinical outcomes in COSMIC‑313 (NCT03937219), a randomized phase III trial comparing cabozantinib plus nivolumab and …

02.09.2026journal-article

The Oncologist

30 Myeloid- Versus Effector-Driven Circulating Immune States Define Treatment-Specific Benefit in Metastatic Clear Cell Renal Cell Carcinoma

Mariangela Calabrese, Nathalie Chaput, Marine Aglave, Macarena Rey-Cardenas, Lydie Cassard, Jean Jouniaux, Marie Naigeon, Javier Gavira-Diaz, Luigi Roca, Mohamed-Amine Bani, Escudier Bernard, Laurence Albiges, Ronan Flippot

Abstract Background Metastatic clear cell renal cell carcinoma (ccRCC) first-line treatment relies on immune checkpoint inhibitor (ICI)-based regimens, including either dual ICI or ICI plus antiangiogenic tyrosine kinase inhibitor (TKI). Despite substantial clinical progress, predictive biomarkers guiding regimen selection are lacking. Circulating biomarkers may provide a broader and more accessible overview of the tumor immune landscape compared with tissue-based biomarkers. Methods To assess whether circulating i …

02.09.2026journal-article

Journal of Antimicrobial Chemotherapy

Acute kidney injury in Staphylococcus aureus bacteraemia: a multicentre cohort study of incidence, timing, recovery and associations with antibiotic treatment

F S Sinkeler, I J E Kouijzer, N G L Jager, J ten Oever, E Leegwater, J Gisolf, D Reuling, Z M Spoel, M P M Hensgens, R J Brüggemann

Abstract Background and objectives Staphylococcus aureus bacteraemia (SAB) is associated with high mortality and frequent complications, including acute kidney injury (AKI). Although flucloxacillin has been associated with higher AKI rates than cefazolin, the clinical characteristics of AKI, including severity, timing, recovery and the potential influence of dosing, remain unclear. Methods We conducted a retrospective multicentre cohort study across three hospitals in the Netherlands, including adults with SAB trea …

01.09.2026journal-article

Blood Advances

The complexity of "provoked" venous thromboembolism: one treatment plan does not fit all Commentary on the HI-PRO Trial.

Andrew Peseski, Sargam Kapoor, Thomas L. Ortel

The decision whether to continue patients diagnosed with venous thromboembolism (VTE) on anticoagulation after the initial treatment period is often a nuanced decision. Many patients will have one or more transient risk factors associated with a time-limited increased risk for VTE. Transient risk factors are further divided into major, such as joint replacement, or minor, such as prolonged travel, which defines the magnitude of risk for an initial VTE. In addition, major transient risk factors generally carry a low …

01.09.2026journal-article

Veterinary and Comparative Oncology

Combination of Hypofractionated Radiation Therapy and Gilvetmab for the Treatment of Cutaneous or Subcutaneous Mast Cell Tumours in Dogs

Tiffany W. Martin, Douglas H. Thamm, Kristen M. Weishaar

ABSTRACT Gilvetmab is a caninised monoclonal antibody against canine PD‐1. Concurrent or sequential administration of anti‐PD‐1 antibodies and radiation therapy (RT) improves survival time in various species. Eighteen dogs with mast cell tumours (MCTs) were prospectively treated with 24 Gy of RT over Days 0, 7 and 21 and gilvetmab every 2 weeks beginning on the second fraction of RT (Day 7) for up to 10 doses. Best tumour response was complete in one (6%), partial in eight (44%) and stable disease in nine dogs (50% …

01.09.2026journal-article

Cancers

Cardiovascular Morbidity Following Definitive Chemoradiotherapy for Lung Cancer in an Appalachian Population

Vivian Salama, Joseph A. Schmidlen, John Christopher Knoth, Troy Nguyen, Aaron Naveen Joseph, Matthew Trotta, Ramon Alfredo Siochi, Raymond R. Raylman, Jeffrey Ryckman, Mohammed Almubarak, Christopher M. Bianco, David A. Clump, Mina F. Hanna, Phillip M. Pifer

Background/Objectives: Cardiovascular morbidity following definitive chemoradiotherapy (CRT) for lung cancer is a major concern in Appalachia due to high rates of smoking and pre-existing cardiovascular disease. This study characterized the cardiovascular burden following CRT in a real-world Appalachian population. Methods: A retrospective study was conducted among Appalachian patients with lung cancer treated with definitive CRT from 2013 to 2025. Cardiovascular adverse event (CVAE) incidence, spectrum, and tempor …

02.09.2026journal-article

Health Science Reports

Knowledge, Attitudes, and Uptake of Cervical Cancer Screening Among Female Students and Staff at a Tertiary Institution in Northern Uganda: A Cross‐Sectional Study

Milton Anguyo, Morrish Obol Okello, David Komakec, Emmanuel Alyoomu, Habert Aziku, Ruth Catherine Ouma, Pebalo Francis Pebolo

ABSTRACT Background and Aims Cervical cancer remains a leading cause of cancer‐related deaths among women in low‐resource settings like Uganda. Screening is essential for early detection and prevention, yet knowledge, attitudes, and uptake among university females are poorly understood. This study aimed to investigate knowledge, attitudes, and uptake of cervical cancer screening among females at a tertiary institution in Northern Uganda. Methods A cross‐sectional quantitative study was conducted at a tertiary insti …

03.09.2026journal-article

Pathology International

Current and Future Perspectives on Adipo‐Oncology: Roles of Adipocytes in Local and Systemic Tumor Regulation

Shinya Sato

ABSTRACT Adipose tissue has traditionally been regarded as an energy‐storage organ; however, accumulating evidence indicates that adipocytes actively regulate cancer biology through local and systemic mechanisms. These findings have contributed to the emergence of adipo‐oncology, an interdisciplinary field focused on interactions between adipose tissue and cancer. This review summarizes current evidence on the local and systemic roles of adipocytes in tumor progression and discusses how tissue heterogeneity and pla …

04.09.2026journal-article

The Journal of Sexual Medicine

Unmet needs in the treatment of erectile dysfunction and a place for topical treatments in the therapeutic landscape

Gerald B Brock, Faysal A Yafi, Wayne J G Hellstrom, Christian Nelson, David Ralph, Stanton Honig, Geoff Hackett, Rachel Rubin, Amy Pearlman, Sam Ward, Eric Chung, Hossein Sadeghi-Nejad, Noah Stern

Abstract Background Systemic therapy with phosphodiesterase type 5 inhibitors (PDE5is) is the standard of care for erectile dysfunction (ED), but these treatments are not effective in all men, and others may prefer non-systemic treatment options. Aim The goal of this Delphi consensus initiative was to address unmet needs in the treatment of men with ED and the best use of a US Food and Drug Administration (FDA) cleared topical therapy, MED3000 (Eroxon®), that is available without a prescription. Methods The iterati …

01.09.2026journal-article

Nano Research

A multi-enzyme mimetic nanozyme sensitizes esophageal cancer to CDK4/6 inhibition via oxidative stress

Ling Lan, Jiwen Fan, Yang Li, Zihan Li, Zhu Yuan, Imran Shakir, Binwu Ying, Limei Luo, Yi Li, Xuping Sun, Jin Zhou

Abstract Esophageal squamous cell carcinoma (ESCC) exhibits frequent cell cycle pathway alterations, particularly hyperactivation of the Cyclin D1/Cyclin-dependent kinase 4 and 6 (CDK4/6) axis, but clinical trials of CDK4/6 inhibitor Palbociclib in ESCC have not shown evidence of curative effect. In this work, we rationally engineered a Pt nanoparticle-decorated monolayer CoAl layered double hydroxide nanosheet to sensitize Palbociclib and achieve synergistic antitumor efficacy in ESCC model. The nanosheet exhibits …

01.09.2026journal-article

Current Organic Chemistry

Design and Synthesis of Pyrimidine-Based Heteroaryl Compounds and their Applications for the Treatment of Cancer

Koustav Singha, Imran Habib, Manirul Mandal, Kaberi Sikdar, Mossaraf Hossain

Pyrimidines are nitrogen-containing singular heterocycles renowned for having a broad spectrum of therapeutic applications in anticancer and antiviral drug development. Many anticancer drugs that are sold commercially contain pyrimidine moieties. Based on these findings, the synthesis of several possible pyrimidine derivatives with anticancer activity, reported between 2018 and 2023, is thoroughly explained in this review. Further, this review highlights the in vitro and molecular docking studies of several maligna …

01.09.2026journal-article

Foods

Traditional and Non-Conventional Methods of Pre-Treatment of Biological Raw Materials for Drying Food

Dorota Nowak, Ewa Jakubczyk

Pre-treatment before drying is a crucial phase in food processing. This review highlights key traditional and innovative pre-treatment methods, focusing on their mechanisms of action at the cellular and tissue levels. This discourse examines innovative technologies with significant promise across various applications, as well as widely recognised methodologies. These include cold plasma, ultrasonication, pulsed electric fields, high-pressure processing, UV-C light, pulsed light, and coating techniques. It addresses …

01.09.2026journal-article

Journal of Comparative Effectiveness Research

Treatment gaps in osteoporosis care following recurrent fractures: a nationwide cohort study

Hyun Jin Han, Miryoung Kim, Eyoung Wang, Min Ji Kim, Hae Sun Suh

Aim: This nationwide cohort study primarily aimed to descriptively characterize real-world treatment patterns, including treatment initiation, adherence, treatment duration and discontinuation of the first treatment drug, among patients who experienced a recurrent osteoporotic fracture. Materials & methods: This population-based, retrospective cohort study used data from the Health Insurance Review and Assessment Database of South Korea. It included male and female patients aged 55 years and older who experienced a …

01.09.2026journal-article

Frontiers in Oncology

BCG after trimodality therapy: managing non-muscle-invasive recurrence in the irradiated bladder

Nicola Fazaa, Etan Eigner, Melissa Atallah, Yuval Shafran, Gilad Amiel, Azik Hoffman

Trimodality therapy (TMT) is an established bladder-preserving option for selected patients with muscle-invasive bladder cancer, but non-muscle-invasive recurrence remains a clinically relevant challenge. The role of intravesical bacillus Calmette–Guérin (BCG) after prior bladder-directed chemoradiation is uncertain because the available evidence is limited to small retrospective cohorts and indirect studies in previously irradiated bladders. This mini-review examines the efficacy and tolerability of BCG after TMT, …

01.09.2026journal-article

Journal of Engineering Research and Reports

Evaluation of Vernonia amygdalina and Senna alata as Low-cost Plant-based Coagulants and Antibacterial Materials for Water Treatment

Abidat Olayemi Fasasi-Aleshinloye, Suleiman Makka Aliyu, Adedeji Yusuff Fasasi, Oluwatunmise Peter Abolarin, Victor Ojo Thomas, Tolulope Adelola Akintunde

Access to safe drinking water remains a critical challenge in many Nigerian communities, where reliance on untreated surface, well and borehole water increases exposure to microbiological and physicochemical contaminants. This study evaluated the phytochemical composition, antibacterial activity and coagulation potential of Vernonia amygdalina (Ewuro-ijebu) and Senna alata (Asunwon) as low-cost plant-based materials for raw-water pre-treatment. Healthy leaves of both plants were collected, shade-dried, milled and e …

01.09.2026journal-article

Chemical Biology & Drug Design

Integrative Multi‐Omics Analysis Identifies Thrombosis‐Associated Molecular Features Linked to Germline Susceptibility and Immune Cell Communication in Gastric Cancer

Xiaogang Lu, Lin Sun, Fujun Jin, Biao Cheng, Ying Huang, Yuzhu Tang, Xiaolong Nie, Feng Gao

ABSTRACT Emerging evidence indicates that coagulation‐related molecular programs are associated with thrombosis, tumor progression, and molecular dysregulation in gastric cancer (GC). However, thrombosis‐associated molecular features in GC and their potential links to inherited susceptibility remain insufficiently understood. Integrated analyses of transcriptomic data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were performed to identify thrombosis‐associated genes and establish a …

02.09.2026journal-article

The Oncologist

81 Tumor-Informed Circulating Tumor DNA Monitoring in Fumarate Hydratase–Deficient Renal Cell Carcinoma

Antonio Ocejo, Andrea Knezevic, Ayaa Essafi, Sahil D Doshi, Andrew Cornish, Neil J Shah, David H Aggen, Robert J Motzer, A Ari Hakimi, Darren R Feldman, Ritesh R Kotecha, Martin H Voss, Maria I Carlo

Abstract Background Fumarate hydratase (FH)–deficient renal cell carcinoma (RCC) is a rare and aggressive subtype associated with hereditary leiomyomatosis and RCC (HLRCC) syndrome. These tumors are characterized by early onset, frequent de novo metastatic presentation, and poor prognosis. Treatment standards are poorly defined, and no validated molecular biomarkers exist for real-time disease monitoring. Circulating tumor DNA (ctDNA) is showing promise as a liquid biomarker in clear cell RCC, but its feasibility a …

01.09.2026journal-article

Journal of the Egyptian Women's Dermatologic Society

Evaluation of the efficacy and safety of photodynamic therapy using liquid crystal-loaded methylene blue and intense pulsed light in treatment of vitiligo

Manal M. Abdel-Monem, Amany M. Abdel-Latif, Gamal M. El Maghraby, Esraa E. Elhawary

Background Depigmented macules and patches characterize vitiligo, an acquired autoimmune skin condition that has several lines of treatment. A new treatment for vitiligo, photodynamic therapy (PDT), has mixed results. Objective To evaluate the efficacy and safety of PDT using liquid crystal-loaded methylene blue and intense pulsed light in the treatment of vitiligo. Patients and methods This prospective, randomized study was conducted in 40 patients with multiple vitiligo lesions. For each patient, three vitiligo l …