Vollständiger Abstract
Worum geht es in dieser Arbeit?
Pyrimidines are nitrogen-containing singular heterocycles renowned for having a broad spectrum of therapeutic applications in anticancer and antiviral drug development. Many anticancer drugs that are sold commercially contain pyrimidine moieties. Based on these findings, the synthesis of several possible pyrimidine derivatives with anticancer activity, reported between 2018 and 2023, is thoroughly explained in this review. Further, this review highlights the in vitro and molecular docking studies of several malignancies. Recent advances in the synthesis of pyrimidine analogs, along with their anticancer activity reported in this review, make this heterocyclic moiety an attractive scaffold for discovering newer anticancer drugs.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Koustav Singha, Imran Habib, Manirul Mandal, Kaberi Sikdar, Mossaraf Hossain
- Quelle
- Current Organic Chemistry
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1385-2728
- Zitationen
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Zitierfähiger Nachweis
Koustav Singha, Imran Habib, Manirul Mandal, Kaberi Sikdar, Mossaraf Hossain (2026). Design and Synthesis of Pyrimidine-Based Heteroaryl Compounds and their Applications for the Treatment of Cancer. Current Organic Chemistry. https://doi.org/10.2174/0113852728456999260406102859