JAMA Psychiatry
Bridget King, Kirsten Borup Bojesen, Charlotte Crisp, Andrea de Bartolomeis, Lieuwe de Haan, Camilo de la Fuente-Sandoval, Kara Dempster, Richard J. Drake, Paola Dazzan, Bjørn H. Ebdrup, Lejia Fan, Ariel Graff-Guerrero, Birte Yding Glenthøj, Shiori Honda, Oliver Howes, Li-Chung Huang, Rene Kahn, James MacCabe, Marta Matrone, Kate Merritt, Meghan McIlwain, Philip McGuire, Shinichiro Nakajima, Stephen M. Lawrie, Lena Palaniyappan, Francisco Reyes-Madrigal, Bruce Russell, Akira Sawa, Sukhi Shergill, Krish D. Singh, Iris E. Sommer, James M. Stone, Junyu Sun, Sakiko Tsugawa, Fumihiko Ueno, Marieke van der Pluijm, Elsmarieke van de Giessen, James T. R. Walters, Kun Yang, Yen Kuang Yang
Importance Revealing neurobiological markers of antipsychotic nonresponse in psychosis may aid outcome prediction and inform novel treatment targets. Objective To examine differences in neurometabolites in antipsychotic nonresponsive compared to antipsychotic-responsive psychosis using individual participant data and meta-analysis. Data Sources Web of Science was searched for studies published between January 1, 1980, and November 1, 2025. Authors of 21 eligible studies identified before August 2024 were invited to …
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