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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

BMC Musculoskeletal Disorders

Effectiveness of dynamic neuromuscular stabilization exercises on clinical variables in postoperative rehabilitation of patients with lumbar disc herniation: a randomized controlled trial

Burak Buğday, Büşra Arısüt, Elif Esma Bayraktar, Ömer Şevgi̇n

Abstract Purpose This study evaluates the effects of an 8-week Dynamic Neuromuscular Stabilization (DNS) program on disability, physical activity, and fear-avoidance behaviors in postoperative lumbar disc herniation (LDH) patients. Method The study was designed as a randomized controlled trial. Participants of both sexes, aged 35–50 years, were recruited from a single-center postoperative outpatient physiotherapy setting and randomized into DNS (intervention) and standard care (control) groups. The DNS program emph …

02.09.2026journal-article

Perioperative Medicine

Peri-operative non-surgical determinants of prolonged length of stay following anterior cervical decompression and fusion surgery: a public healthcare perspective

Ella Snowdon, Gokul Raj Krishna, Sayan Biswas, Clementine Wood, Hana Dorey, Hannah Cheng, Rhianne Devlin, Sidharth Suresh, Sayed Farhan Sayed Yaqub Mehdi, Ved Sarkar, K. Joshi George

Abstract Background Prolonged length of stay (PLOS) following anterior cervical discectomy and fusion (ACDF) is associated with increased hospital burden. While surgical and comorbidity-related factors have been widely studied, routinely documented non-surgical and social variables are less consistently reported. This study evaluated univariable associations between these factors and PLOS after ACDF. Methods A retrospective analysis of 1,719 ACDF procedures performed between 2012 and 2022 at a single tertiary centr …

02.09.2026journal-article

Journal of Clinical Medicine

Can Ultrasound Texture Analysis Differentiate Liver Metastases According to the Histopathological Origin of the Primary Tumor?

Seda Nida Karakucuk, Murat Baykara, Mehmet Demir, Ali İsler

Objective: We aimed to investigate whether ultrasound-based texture analysis can differentiate liver metastases according to the histopathological origin of the primary tumor and to evaluate the quantitative texture characteristics of metastases originating from colorectal, pancreatic, and breast cancer. Materials and Methods: This prospective study included 75 patients with biopsy-proven liver metastases, comprising 25 colorectal adenocarcinoma, 25 pancreatic ductal adenocarcinoma, and 25 invasive ductal breast ca …

02.09.2026journal-article

Clinical Rheumatology

Effectiveness and safety of Janus Kinase inhibitors in patients with rheumatoid arthritis, results from a multicenter observational “real-life” GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

Daniela Iacono, Maura Raimondi, Valentina Marino, Flavia Riccio, Maria Laura Marchesano, Alessandra Milone, Addolorata Corrado, Cinzia Rotondo, Ilaria Firenze, Lidia La Barbera, Chiara Rizzo, Simona Montalbano, Luca Navarini, Alberto Lo Gullo, Marianna Oliva, Elvira Favoino, Ida Orlando, Francesco Paolo Cantatore, Paola Cipriani, Enrico Tirri, Roberto Giacomelli, Federico Perosa, Giuliana Guggino, Piero Ruscitti, Francesco Ciccia

Abstract Objectives To evaluate the “real-life” effectiveness and safety of Janus kinase inhibitors (JAKis) in patients with rheumatoid arthritis (RA) and to analyze the impact of cardiometabolic comorbidities on these outcomes. Methods Patients with RA treated with JAKis were evaluated for disease activity scores, patient-reported outcomes (PROs), and safety in a 12‑month multicenter observational study conducted within the GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale). Patients were g …

02.09.2026journal-article

Life

Voice-Based Screening of Depression and Anxiety Using Machine Learning and Deep Learning: A Scoping Review of Methods and Clinical Readiness

Mădălina Muntean-Codrea, Bogdan Nemeș, Horia George Coman, Ciprian Ionuț Băcilă, Raluca Nicoleta Trifu, Radu Flaviu Oroian, Marinela Minodora Manea, Dana Cristina Herța, Sergiu Șușman

Despite the high global prevalence of depressive and anxiety disorders, access to early clinical assessment remains limited for many. Although this field has grown rapidly, existing reviews have focused primarily on technical performance, with limited systematic attention to whether current models meet the prerequisites for clinical implementation. This scoping review mapped methodological approaches across this domain and evaluated clinical readiness using five predefined indicators: sample size adequacy, external …

02.09.2026journal-article

Journal of Medical Internet Research

A Secure, Scalable Large Language Model–Based System (CIDER) for High-Throughput Clinical Data Extraction From Medical Reports: Retrospective Validation Study

Máté Posta, Aida Figler, Zsófia Dobolyi, Balázs Győrffy

Background A substantial proportion of clinically relevant information remains locked in unstructured narrative documents, creating a bottleneck for clinical research, biobank annotation, registry development, and real-world evidence generation. While large language models (LLMs) enable advanced clinical text mining, adoption is constrained by concerns regarding data security, multilingual performance, and reproducibility. Manual data abstraction remains predominant for registry curation and retrospective research, …

02.09.2026journal-article

The Journal of Knee Surgery

Objective Quantification of Soft-Tissue Balance in Total Knee Arthroplasty: Expanded Validation of the Pendulum Knee Drop Test Across Multiple Surgeons

Kevin Abbruzzese, Michael A. Mont, Michael Dunbar, Jared Weir, Chase W. Smitterberg, Sally LiArno

Abstract Despite increasing evidence showing major diversity in subjective balancing approaches, soft-tissue balance during total knee arthroplasty (TKA) remains primarily based upon empirical surgeon assessment. A quantitative technique for describing knee stiffness and laxity after TKA was previously introduced: the modified pendulum knee drop (PKD) test. This study expands upon prior validation work by evaluating the reproducibility of surgeon-directed balancing assessments compared with the modified PKD test ac …

02.09.2026journal-article

Journal of Biological Studies

Effect of piperine on antifungal-resistant clinical isolates of Candida albicans and PLB1 expression

Abbas M. Ammari, Noor Abdulhafedh Jajees, Shahrazad Ahmed Khalaf

Candida albicans is the most common cause of oral, cutaneous and vaginal Candidiasis which the incidence ranging up to 50% among those patients. Phospholipase proteins, genes like PLB1 act as virulence genes that code for C. albicans colonization and biofilm formation. Piperine is alkaloids content located in the seed of black pepper (Piper nigrum), and it has antimicrobial effects. This study aimed to study the effectiveness of piperine on resistant isolates of yeast isolated from patients with candidiasis. One hu …

02.09.2026journal-article

British Journal of Clinical Pharmacology

Medicines, misinformation and machines: Navigating infodemics in the generative AI era

Natansh D. Modi, Lisa M. Kalisch Ellett, Michael D. Wiese, Ashley M. Hopkins

Health information is now widely accessed through smartphones, online searches and increasingly through generative artificial intelligence (AI). These systems create new opportunities for communication, and in some routine contexts, well‐governed AI assistants could reduce exposure to lower quality sources by providing cautious, evidence‐aligned answers. During health emergencies, however, evidence is incomplete, and demand for rapid guidance is high. Under these conditions, generative AI could produce or amplify i …

02.09.2026journal-article

Experimental & Molecular Medicine

The long non-coding RNA-encoded microprotein MKKS3 drives colorectal cancer chemoresistance

Hui-Fang Hu, Qi Zhou, Jia-Zhen Huang, Jia-Ying Fu, Zhi-Ting Zuo, Qing-Yu He

Abstract Although oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), CRC recurrence is commonly observed owing to oxaliplatin resistance. The roles of long non-coding RNAs-encoded microproteins in oxaliplatin chemoresistance remain inadequately explored. In this study, a CRISPR/Cas9 library was developed to target previously identified 314 microproteins translated from long non-coding RNAs, followed by functional screening. This strategy identified MKKS3, encoded by NR_072977, as a ke …

02.09.2026journal-article

The Laryngoscope

Treatment of Congenital Cytomegalovirus Beyond the Neonatal Period: A Single‐Arm Meta‐Analysis

Thamiris D. D. Cabral, Marcela Mafra, Jaime Plane, Matheus Sewastjanow‐Silva, Isadora Martins Nascimento, Asitha D. L. Jayawardena, Abby Meyer, Andrew Redmann, Luke Jakubowski

ABSTRACT Objective To evaluate hearing outcomes in postneonatal treatment of congenital cytomegalovirus (cCMV) infection and assess the effect of treatment initiated after the first month of life. Data Sources PubMed, Embase, Web of Science, and Cochrane Library were systematically searched. Review Methods Articles reporting antiviral treatment of cCMV, with Ganciclovir (GCV) or Valganciclovir (VGCV) in the postneonatal period were included. Outcomes of interest included viral load (urine and plasma), neutropenia, …

02.09.2026journal-article

World Advances in Renal Medicine

Antibiotic catheter lock: An adjunct therapy for recurrent tunneled hemodialysis catheter infections

Ahmed Atris, Issa Al Salmi, ThaMr.een Al Zadjali, Adham Ahmed, Muhammed Elneel, Michael Mamdouh Soliaman, Hamed Ali Said Al Shahri

The objective of the study is to evaluate the use of antibiotic catheter locks in reducing recurrent catheter-related bloodstream infections (CRBSIs) in hemodialysis (HD) patients. This prospective case series was conducted at ASeeb Renal Dialysis Center, from September 2022 to August 2023, including four hemodialysis outpatients with recurrent catheter-related infections. All patients were unfit for an arteriovenous fistula (AVF) or graft (AVG) and were maintained on dialysis via their last access option, which wa …

02.09.2026journal-article

Journal of Clinical Medicine

The Prognostic Value of the Advanced Lung Cancer Inflammation Index on Disease-Free Survival in Patients with Gastric Cancer Receiving Neoadjuvant Chemotherapy

Mahmut Kara, Muslih Ürün, Senar Ebinç, Yasin Sezgin, Yonca Yılmaz Ürün, Mehmet Naci Aldemir

Objectives: The present study investigated whether the pre-treatment Advanced Lung Cancer Inflammation Index (ALI) could serve as a prognostic indicator of disease-free survival (DFS) in patients with locally advanced gastric cancer treated with neoadjuvant chemotherapy followed by curative D2 gastrectomy. Methods: We retrospectively analyzed 157 patients with gastric adenocarcinoma who received treatment between 2016 and 2025. The pre-treatment ALI was derived from body mass index, serum albumin concentration, and …

02.09.2026journal-article

Cells

Three-Dimensional Bioprinting in Reconstructive Plastic Surgery: A Comprehensive Review

Rahim Hirani, Sarina Iraj, Mathew Trandafirescu, Carter J. Boyd, Mill Etienne

Three-dimensional (3D) bioprinting is an evolving biofabrication approach in regenerative medicine with the potential to overcome many limitations of conventional reconstructive techniques, including donor-site morbidity, limited tissue availability, and suboptimal restoration of form and function. Recent advances in biofabrication have accelerated the development of patient-specific living constructs for reconstructive applications. This narrative review synthesizes contemporary evidence on the use of 3D bioprinti …

02.09.2026journal-article

JAMA Dermatology

Delphi Consensus Statement on Treatment of Severe Alopecia Areata in US Adults

Samantha Gregoire, Eliza Dewey, Ursula Biba, Katherine Sanchez, Hanna Englander, Lana Salloum, Sherry Ershadi, Debby Cheng, Basil Alex McIntosh, Nikki Zangenah, Maria Vazquez-Machado, Aneri Parekh, Lisa Kam, Nora Bensellam, Crystal Aguh, Wilma Bergfeld, Valerie D. Callender, Leslie Castelo-Soccio, Brittany Craiglow, Dirk Elston, Ronda Farah, Jennifer Fu, Carolyn Goh, Emma Guttman-Yassky, Kathie P. Huang, Ali Jabbari, Chesahna Kindred, Justin Ko, Mark Lebwohl, Kristen I. Lo Sicco, Amy McMichael, Natasha A. Mesinkovska, Paradi Mirmirani, Melissa Piliang, Maryanne Senna, Jerry Shapiro, Jennifer Soung, Susan Taylor, Antonella Tosti, Benjamin Ungar

Importance Alopecia areata (AA) is an autoimmune hair loss disorder that affects more than 7 million people in the US. Before US Food and Drug Administration–approved trials of Janus kinase inhibitors, numerous treatments had been explored, with variable efficacy and quality of evidence. The absence of standardized treatment guidelines may lead to poor treatment outcomes and payer coverage. Objective To establish a consensus on treatment for adults with severe AA in the US. Evidence Review Systematic literature rev …

02.09.2026journal-article

Physics in Medicine & Biology

A physics-constrained Bayesian framework for QSM with uncertainty quantification and variational susceptibility source separation

K A Shahriar, Maruf Ahmed

Abstract Objective . Quantitative susceptibility mapping (QSM) requires inversion of a convolutional dipole operator whose null-space renders susceptibility reconstruction severely ill-posed, making the estimated susceptibility highly sensitive to measurement noise and modeling errors. Existing deep learning methods primarily produce deterministic reconstructions and typically perform susceptibility source separation as an independent post-processing step without explicitly modeling inversion uncertainty or incorpo …

02.09.2026journal-article

Materials and Structures

Impact of induced rapid surface carbonation (IRS-C) treatment on the steel corrosion in reinforced concrete: a counterintuitive effect

Raquel Ruiz, Julio Ramirez, Mirian Velay-Lizancos

Abstract Corrosion of steel reinforcement in concrete is one of the main issues plaguing aging infrastructure worldwide. While concrete’s carbonation is usually associated with an increased risk of corrosion, this study proposes a counterintuitive method that uses carbonation of hardened elements to reduce corrosion risk: the induced rapid surface carbonation (IRS-C) treatment. Besides, this study analyzes the impact of IRS-C on the corrosion resistance of precast reinforced concrete elements and explains the mecha …

02.09.2026journal-article

International Journal of Computer Assisted Radiology and Surgery

Design and development of an endoscopic robotic system and deep reinforcement learning path planning algorithm for fine-needle biopsy of liver lesions

Raghav Khanna, Nikola Fischer, Zhenting Du, Christos Bergeles

Abstract This paper presents the design, development and evaluation of a novel robotic platform for endoscopic ultrasound-guided fine-needle biopsy of liver lesions. The system combines a four degrees-of-freedom (DoF) two-segment tendon-driven continuum robot (TDCR) endoscope with a two DoF superelastic nickel–titanium bevel-tip steerable needle. Needle path planning is achieved using NeedleNav, a soft actor–critic (SAC) deep reinforcement learning (DRL) model that generates collision-free trajectories to deep-seat …

02.09.2026journal-article

Current Opinion in HIV and AIDS

Development of adjuvanted HIV vaccines tailored for early life: immunologic rationale, clinical experience, and future directions

Kinga K. Smolen, Kristina De Paris, Asimenia Angelidou, Troy M. Martin, Simon D. van Haren, Ofer Levy

Purpose of review This review highlights the rationale for and clinical experience in advancing age-specific adjuvantation systems to develop well tolerated and effective pediatric HIV vaccines. Recent findings Due to both cellular and soluble factors, infant immunity is distinct from that of older children and adults, featuring Th2 bias, tolerogenic APC programming, and reduced Tfh support. Due to distinct functional responses downstream of pattern recognition receptor signaling, adjuvant action is age-specific. D …

02.09.2026journal-article

Physics in Medicine & Biology

Biologically optimized 3D range modulators for fast conformal carbon ion therapy: in vitro validation, treatment planning, and robustness analysis

Sae Hyun Hailey Ahn, Domenico Ivan Filosa, Peter Lysakovski, Stephan Brons, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Thomas Tessonnier, Andrea Mairani

Abstract Objective. Patient-specific 3D range modulators (RMs) allow rapid and conformal particle therapy with monoenergetic beams and may support motion management and ultra-high dose rate (UHDR) studies. For carbon ions, however, relative biological effectiveness (RBE) varies strongly with depth, so RM geometry should be optimized for biological effect rather than physical dose alone. This work presents a translational pathway for biologically optimized 3D RMs (bio-RMs) for carbon ion therapy, evaluated through d …

02.09.2026journal-article

INTERNATIONAL JOURNAL OF APPLIED SCIENCE AND MATHEMATICAL THEORY

Survival Times of Triple-Negative Breast Cancer Patients Based on Treatment Type: A Comparative Nonparametric Survival Analysis

Hindatu Saidu

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with poor prognosis and limited treatment options. Survival outcomes among TNBC patients are known to vary depending on the type of treatment received, making comparative survival evaluation essential for clinical decision-making. This study aimed to assess and compare the survival times of TNBC patients based on different treatment types, including chemotherapy, radiotherapy, surgery, and combination therapy. Survival data fr …

02.09.2026journal-article

Pediatric Nephrology

Patient-reported ratings of transfer to adult care among young adults with chronic kidney disease

Kelsey L. Richardson, Brett Boyer, Kim Grzesek, Cozumel Pruette, Rebecca J. Johnson, Susan L. Furth, Bradley A. Warady, Matthew B. Matheson, Stephen R. Hooper, for the CKiD study investigators

Abstract Background Effective healthcare transitions and transfers of care are crucial for improving long-term health outcomes among adolescents and young adults (AYA) with chronic kidney disease (CKD). Patient-reported outcomes are an important tool to understand patient experience and are underused in CKD transfer evaluation. This study sought to preliminarily identify differences in the transfer experience among AYAs with CKD and identify contributing factors. Methods Participants enrolled in the Chronic Kidney …

02.09.2026journal-article

Behavioral Sciences

Beyond Invisible: Confronting the Policy and Practice Void in Eating Disorder Prevention and Treatment for Indigenous Peoples in Canada

Katherine Fredrickson, Amelia Austin, Maureen Plante, Kienan Williams, Gina Dimitropoulos, Carolyn Melro

Indigenous populations internationally experience eating disorders (EDs) at similar or higher rates than colonizing majority populations. In Canada, emerging evidence suggests that this is also true among First Nations, Métis, and Inuit (FNMI) populations. However, most existing recommendations and best practices for ED prevention, early intervention, and treatment do not consider unique contextual and cultural factors that are relevant to FNMI Peoples, such as the effects of historical and ongoing colonialism. Thi …

02.09.2026journal-article

Southern African Journal of HIV Medicine

Adherence thresholds of tenofovir diphosphate in dried blood spots for HIV treatment and pre-exposure prophylaxis: A scoping review

Mohammed K. Alghamdi, Mohammed W. Ali, Anel Schoonees, Tamara Kredo, Eric Decloedt, Roland van Rensburg

Background: Tenofovir (TFV) is a key antiretroviral used in HIV pre-exposure prophylaxis (PrEP) and treatment, with efficacy contingent on adherence. Quantifying TFV concentrations in dried blood spots (DBS) as tenofovir diphosphate (TFV-DP) is a robust method for determining long-term adherence. However, standardised TFV-DP adherence thresholds in DBS have not been established. Objectives: To map the existing literature on TFV-DP concentration thresholds in DBS for assessing adherence to TFV-based HIV prevention a …