EUVIMEDEuropean Health Evidence
Uhr 10/10Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Onkologie · Seite 57

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH

Treatment of Teeth with Apical Root Resorption Using MTA

Selin İsaoğlu Bulut, Emre Bodrumlu

ABSTRACTObjective: Apical stenosis may be impaired due to pulpal pathologies, iatrogenically, etc. Apical inflammatory root resorption usually occurs due to periapical pathology without any clinical symptoms. The aim of this case series is to utilize calcium silicate based materials to provide hermetic occlusion in the treatment of teeth with compromised apical integrity. Case Report: Case 1: A 21-year-old woman with no systemic disease. Tooth number 11 had swelling and fistula tract extending to the buccal mucosa. …

01.09.2026journal-article

Advanced Functional Materials

Mechanically Powered Piezoelectric Pulsed‐Field System for Tumor Ablation

Jingwen Hu, Linyu You, Huan Yu, Dongmei Cun, Rafael V. Davalos, Dengning Xia

ABSTRACT Pulsed electric‐field tumor ablation enables localized treatment but depends on bulky, costly high‐voltage equipment, limiting use to specialized settings. Here, we developed a portable, mechanically powered piezoelectric pulsed‐field (MPPF) system based on an ultra‐low‐cost commercial piezoelectric igniter. Through mechano‐electrical transduction, charge accumulation and pulse modulation, discrete thumb actuations were converted into kilovolts‐level, microsecond exponential‐decay pulses without batteries …

01.09.2026journal-article

Biomedicines

Frequencies of CYP2C19 Polymorphisms in Mexican Mestizo Patients with Coronary or Cerebral Atherosclerosis and Their Association with Residual Platelet Activity on Clopidogrel Treatment

Raúl Izaguirre-Ávila, Beatriz Villegas-Torres, Evelyn Cortina de La Rosa, Juan Carlos Fernández-López, Jesús Manuel Ayala-Guerrero, Elias Vinicio Merlín-González, Claudia Lerma

Background/Objectives: There is wide variability in the individual response to clopidogrel, which depends on CYP2C19 polymorphisms as well as on intrinsic and extrinsic platelet factors. Clopidogrel resistance has been related to an adverse evolution in patients with coronary artery disease. The aim of this study is to analyze the prevalence of CYP2C19 polymorphisms in Mexican mestizo patients and their relationship with clopidogrel platelet response by means of platelet aggregation. Methods: Patients who experienc …

01.09.2026journal-article

Journal of Applied Physics

Effect of discharge geometry on methylene blue degradation performance in electrohydrodynamic water treatment

Ji Hong Chung, Youngjin Kim, Dong Kee Sohn, Han Seo Ko

Plasma-based water purification has emerged as a promising technique for degrading persistent organic pollutants without chemical additives, but the influence of reactor geometry on its efficiency remains insufficiently understood. This study investigates how geometric parameters affect degradation performance in needle-to-water discharge current corona discharge system using methylene blue as a pollutant. The discharge gap and water height were varied to evaluate their effects on both electrohydrodynamic behavior …

01.09.2026journal-article

Medicina Fluminensis

Karcinom dojke

Valentina Viljevac Korotaj, Olivia Perković, Ulla Marton, Neda Smiljan Severinski

Dojka je najčešće sijelo zloćudnih tumora u žena u Republici Hrvatskoj (25 %), kao i u svijetu, a karcinom dojke najčešći je uzrok smrti u žena oboljelih od zloćudnih tumora. Liječenje karcinoma dojke povezano je sa smanjenom vjerojatnosti spontanog i pomognutog začeća te rizikom razvoja neplodnosti. Stoga se savjetovanje o prezervaciji fertiliteta smatra obaveznim korakom standardiziranog protokola liječenja. Postupci očuvanja fertiliteta podrazumijevaju zamrzavanje oocita i hormonsku zaštitu gonada. Prezervacija …

01.09.2026journal-article

Materials

Cancer Drug Delivery with Nanoparticles and Biomolecules: Stimuli-Responsive, Theranostic, and AI-Guided Approaches

Chiara Boncristiani, Francesca Baldassarre, Khadija Eddahaoui, Giuseppe Ciccarella, Viviana Vergaro

Cancer remains a major global health challenge, and the limitations of conventional therapies, including systemic toxicity, drug resistance, and poor tumor selectivity, continue to drive the development of advanced nanomedicine strategies. In this context, nanocarriers offer promising opportunities to improve pharmacokinetics, enhance tumor accumulation, and enable controlled or stimuli-responsive drug release. Among them, inorganic nanoparticles (NPs) have gained considerable attention because of their structural …

01.10.2026journal-article

Environmental Epidemiology

Exposure to outdoor ultrafine particle number concentrations and incidence of childhood cancer

Emmanuelle Batisse, Marshall Lloyd, Eric Lavigne, Seungmi Yang, Arman Ganji, Junshi Xu, Marianne Hatzopoulou, Jill Baumgartner, Scott Weichenthal

Background: In urban areas, transportation and industry-related combustion processes release large quantities of outdoor ultrafine particles (UFPs;

01.09.2026journal-article

Journal of Korean Medicine

Research Trends on the Acupuncture treatment for Delayed Onset Muscle Soreness

Min Geon Lee, Eun Ji Oh, Han Eung Jo, Hyang Gi Lim, Sang Ha Woo, Yun Kyu Lee, Hyun-Jong Lee, Jae Soo Kim, Jung Hee Lee

Objectives: This study aimed to analyze research trends in randomized controlled trials (RCTs) of acupuncture for delayed-onset muscle soreness (DOMS) published from January 2000 to December 2025.Methods: Seven electronic databases were searched for eligible RCTs. Data on publication characteristics, participants, DOMS induction methods, interventions, outcome measures, results, and adverse events were extracted and analyzed descriptively.Results: Nine RCTs involving 270 participants were included. Most participant …

02.09.2026journal-article

BMJ Open

Screening for obstructive sleep apnoea in the general population in Iceland and uptake of positive airway pressure treatment: a prospective cohort study

Elin Helga Thorarinsdottir, Bryndis Benediktsdottir, Thor Aspelund, Hjordis Sigrun Palsdottir, Sesselja Hreggvidsdottir, Tryggvi Leo Gudmundsson, Ali Reza Matin, Bjorg Eysteinsdottir, Christer Janson, Eva Lindberg, James Potts, Andre FS Amaral, Thorarinn Gislason

Objectives To estimate uptake of obstructive sleep apnoea (OSA) screening and initiation and long-term use of positive airway pressure (PAP) treatment in a middle-aged and older general population cohort. Design Prospective population-based cohort study. Setting Icelandic arm of the multinational Burden of Obstructive Lung Disease follow-up study II (2019–2021) Participants 378 non-institutionalised adults aged 54–91 years were invited from a general population cohort. 26 with prior OSA diagnosis were excluded. Of …

01.09.2026journal-article

Current Nanomedicine

Revolutionizing Conjunctivitis Treatment: Nanotechnology Advances and Innovative Drug Delivery Strategies

Prem Yadav, Sandhya Jaiswal, Shalu Shukla

This comprehensive review outlines the challenges and advancements in the treatment of conjunctivitis, emphasizing the limitations of conventional therapies and the promise of nanotechnology- based solutions. Conjunctivitis, one of the common external eye diseases, is a tissue inflammation that affects people of all ages. Redness, irritation, tearing, and increased secretions are the primary symptoms of conjunctivitis. This review highlights the eye's complex anatomy and physiological barriers, i.e., corneal, pre-c …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Prognostic Impact of Recurrence Location in Locally Recurrent Rectal Cancer: A Single-Center Retrospective Study

SHO NAMBARA, KOJI ANDO, TETSURO KAWAZOE, SHOTARO KOREHISA, YASUO TSUDA, TOMONORI NAKANOKO, EIJI OKI, TOMOHARU YOSHIZUMI

Background/Aim: Locally recurrent rectal cancer (LRRC) remains challenging, and optimal treatment strategies vary by recurrence location. We retrospectively evaluated treatment patterns and outcomes of LRRC without distant metastasis, focusing on the Memorial Sloan Kettering Cancer Center (MSKCC) pelvic compartment classification. Patients and Methods: We retrospectively analyzed 20 patients with LRRC without distant metastasis treated at our institution between 2005 and 2025. Recurrence sites were categorized as a …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Prognostic Significance of Number of Liver Metastases in Patients With Advanced Pancreatic Cancer Receiving Nab-paclitaxel Plus Gemcitabine

KIYOTSUGU IEDE, TERUMASA YAMADA, HIROTOSHI TAKAYAMA, MASARU SASAKI, TOMO ISHIDA, MASAFUMI YAMASHITA, YUKAKO MOKUTANI, TSUKASA TANIDA, JIN MATSUYAMA, KEN NAKATA, SHUSEI TOMINAGA

Background/Aim: The prognostic significance of the number of liver metastases in patients with advanced pancreatic cancer (APC) treated with nab-paclitaxel plus gemcitabine (AG) remains unclear. This study was performed to investigate the impact of the number of liver metastases on survival outcomes in this population. Patients and Methods: From January 2015 to July 2024, 103 patients with APC received AG as first-line chemotherapy at Higashiosaka City Medical Center. The patients were categorized into three groups …

01.09.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

Investigating mitochondrial stress signalling and the integrated stress response.

Natalie McIntosh

Mitochondria produce cellular energy, but because most mitochondrial proteins are stored in the nucleus, they also function as signalling centres that regulate homeostasis and stress responses. In response to stressors, including DNA damage and amino acid imbalance, mitochondria communicate with the nucleus through mito-nuclear signalling pathways. One such pathway is the mitochondrial integrated stress response (mtISR), although the mechanisms by which mitochondrial stressors activate this response remain unclear. …

01.09.2026journal-article

Journal of the Egyptian Women's Dermatologic Society

Comparative study between the efficacy of microneedling combined with topical insulin versus microneedling combined with topical ascorbic acid 20% in the treatment of striae alba

Rawda G. Qotb, Moshira M. Ali, Azza S. Amer

Introduction Striae alba (SA) are a prevalent cosmetic dermatologic condition characterized by dermal collagen and elastin disruption due to mechanical stretching. Clinically, they appear as atrophic, hypopigmented linear bands that commonly affect the abdomen and are therapeutically challenging due to their refractory nature. Objective: To compare the efficacy and safety of microneedling with topical insulin versus microneedling with 20% ascorbic acid in treating SA. Patients and methods This prospective comparati …

01.09.2026journal-article

Frontiers in Oncology

Metformin potentiates arsenic disulfide in diffuse large B-cell lymphoma: modulation of BAX/BCL-2 apoptotic pathway and hedgehog pathway

Jiahao Zhang, Huawei Li, Mingxin Zhao, Chen Chen, Shenghong Du, Ling Wang

Background Arsenic disulfide (As 2 S 2 ) inhibits proliferation and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells, its clinical application is constrained by toxicity. Metformin has also been reported to exert antitumor effects across various malignancies. This study investigated whether metformin potentiates the anti-lymphoma efficacy of As 2 S 2 in DLBCL cells and evaluated associated alterations in apoptosis-related markers and Hedgehog signaling molecules. Methods DLBCL cell lines (DB and SU- …

02.09.2026journal-article

The Oncologist

79 Renal Cell Carcinoma Among Native American Patients in Oklahoma: A Single-Institution Experience from an NCI-Designated Cancer Center

Jafer Raza, Anoushka Mullasseril, Abhirami Das, Kai Ding, Maribeth Mead, Saqib Balkhi, Dorothy Rhoades, Mark Doescher, Kelly Stratton, Brian Cross, Andrew McIntosh, Sanjay Patel, Michael Cookson, Adanma Ayanambakkam

Abstract Background Native American (NA) populations in Oklahoma experience disproportionately high incidence (43.7 vs 20.7 per 100,000) and mortality (8.6 vs 4.7 per 100,000) from renal cell carcinoma (RCC) compared with Non-Hispanic White (NHW) populations. However, population-based datasets lack patient-level clinical detail, limiting understanding of outcomes both overall and at academic cancer centers. We characterized disease presentation, treatment patterns, and overall survival (OS) among NA RCC patients tr …

01.09.2026journal-article

IECCMEXICO

Time to Oncological Surgery: Impact of Treatment Delays on Tumor Progression, Clinical Outcomes, and Healthcare Efficiency

Ivana Cárdenas Ayala, Heriberto Inclán Figueroa, Pedro Aníbal Bailón de la O, Jaime Héctor Cisneros Sandoval, Diego Clemente Moreno, Pablo Eduardo Navarro López, Aldo Bolivar Zavala Segovia, Andrea Delgado Cardona

Delays between cancer diagnosis and definitive oncological surgery have become an increasingly relevant concern due to their potential impact on tumor progression, clinical outcomes, and healthcare efficiency. This study analyzed available evidence regarding the relationship between surgical waiting times and oncological outcomes in adult patients with solid tumors, with particular emphasis on breast, colorectal, lung, pancreatic, bladder, and head and neck cancers. A structured integrative review was conducted usi …

01.09.2026journal-article

Advanced Therapeutics

Advancing Preclinical Oncology: Next‐Generation Mouse Models for Decoding Tumor Progression and Metastasis

Abhishek Sharma, Aman Kumar, Preeti Patel, Balak Das Kurmi

ABSTRACT Next‐generation mouse models have transformed preclinical oncology by enabling detailed study of tumor initiation, progression, immune interactions, and metastasis. Traditional systems lacked tumor heterogeneity and immune relevance. Advanced platforms such as genetically engineered mouse models (GEMMs), humanized mice, patient‐derived xenografts (PDXs), and organoid‐based models provide genetic accuracy, patient‐specific biology, and functional immune environments. Recent developments, such as intravital …

01.09.2026journal-article

Journal of Iranian Medical Council

The Role of ceRNA Networks in the Development and Progression of Gastric Cancer

Maryam Askari, Hassan Akrami, Mahdi Bagheri

MicroRNAs or miRNAs bind to miRNA Response Elements (MREs), a location on target transcripts, causing either transcript destruction or translational inhibition. NcRNAs with MREs can compete with mRNA as a miRNA sponge and are involved in a complex regulatory network that regulates the transcription of mRNAs through miRNAs competitive binding. According to the ceRNA hypothesis, ncRNAs, including lncRNAs, circRNAs, and pseudogenes, contend against mRNAs in binding to miRNAs via miRNAs’ MRE. MicroRNA is the most impor …

01.09.2026journal-article

Discover Oncology

Prognostic stratification and treatment patterns in pancreatic adenocarcinoma with mixed subtypes based on an exploratory retrospective cohort study

Xuefeng Hua, Hui Gong, Ziwei Yin

Abstract Background Pancreatic adenocarcinoma with mixed subtypes (p‑AMs) is a rare malignancy, and evidence to guide clinical management remains lacking. This study aimed to develop a prognostic model and explore treatment patterns across risk strata. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, we developed a treatment‑free baseline nomogram based on independent prognostic factors identified by multivariable Cox regression. Patients were stratified into low‑ and high‑risk groups …

01.09.2026journal-article

JNCI: Journal of the National Cancer Institute

Matched targeted therapy use after broad genomic profiling in advanced Non-Small cell lung cancer

Xiao Wang, Jessica B Long, John Rothen, Akintunde O Aremu, Sida Huang, Pamela R Soulos, Timothy J Robinson, Carolyn J Presley, Sarah B Goldberg, Ronac Mamtani, Shi-Yi Wang, Shuangge Ma, Michaela A Dinan, Cary P Gross

Abstract Introduction While broad genomic profiling is increasingly used in advanced NSCLC (aNSCLC), the impact of test results on subsequent guideline-concordant targeted therapy selection remains incompletely understood. Methods Using a merged dataset of two large, nationwide, patient-level databases, we identified patients who were diagnosed with aNSCLC 2017–2023, had potentially actionable genomic profiling findings, and initiated systemic therapy. Patients were categorized into actionability subgroups based on …

01.09.2026journal-article

Journal of Biomolecular Techniques

Cancer Center Shared Resources: A Nexus for Discovery, Innovation, and Impact

Sheenah Mische, Jay W. Fox, Nicholas P. Ambulos

Shared Research Resources (SRRs) are indispensable to modern cancer research, powering discovery through advanced technologies, specialized expertise, and strategic scientific partnership. At NCI-designated Cancer Centers, their role has expanded from core service platforms to drivers of innovation, rigor, and translational impact. In 2024, this evolution led to the creation of the National Alliance of Cancer Center Shared Resources (NACCSR), a national collaboratory uniting Shared Resource leaders to advance best …

01.09.2026journal-article

ASCE MAGAZINE

Tratamiento de Pseudoartrosis Congénita de Tibia mediante Terapia Génica In Situ y Colgajo Libre de Peroné Contralateral: Reporte de un Caso con Seguimiento a 5 Años

Darío Javier Velastegui Andrade, Marcelo Andrés Pinto Proaño, Maria Georgina Pazmiño Beltrán, Nicolas Augusto Vasquez Barreneche, Gustavo Fernando Guastay Guingla

La pseudoartrosis congénita de tibia (PCT) es una enfermedad rara y grave, asociada a neurofibromatosis tipo 1, con tasas de fracaso del 40-60% incluso con múltiples cirugías. Objetivo: Presentar un caso de PCT tratado con terapia génica in situ (transferencia del gen BMP-2 mediante vector adenoviral) y colgajo libre vascularizado de peroné contralateral, con seguimiento a 5 años. Métodos: Reporte de caso único de un paciente de 3 años con PCT tipo II de Crawford en tercio medio de tibia derecha, asociada a neurofi …