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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Environmental Engineering Science

Dynamic Multiobjective Optimization for Wastewater Treatment Using Bayesian Optimization and Model Predictive Control with Observer

Xianjun Du, Chunyi Zhou

In wastewater treatment processes, there exists a typical conflict between the objectives of energy consumption (EC) and effluent quality (EQ). Achieving energy savings while ensuring effluent compliance remains a critical challenge. This article proposes a dynamic optimal control method to reconcile this trade-off. The approach integrates intelligent modeling, multiobjective optimization, and advanced control techniques. First, a hybrid optimization strategy combining Bayesian optimization (BO) and the multiobject …

01.09.2026journal-article

Microbiology Spectrum

Vaginal microbe-binding antibody interactions with a Lactobacillus crispatus live biotherapeutic following treatment for bacterial vaginosis

Rachel Liu, Eric Armstrong, Anke Hemmerling, Steve Miller, Sanja Huibner, Laurel Lagenaur, Thomas P. Parks, Craig R. Cohen, Bryan Coburn, Rupert Kaul

ABSTRACT The vaginal application of LACTIN-V, a live biotherapeutic containing Lactobacillus crispatus CTV-05, reduces the recurrence of bacterial vaginosis (BV) and promotes L. crispatus colonization; however, colonization success is variable. In 65 women with BV randomized to LACTIN-V or placebo following metronidazole treatment, we evaluated whether pre-existing or treatment-induced vaginal L. crispatus CTV-05-binding antibodies shaped colonization outcomes. CTV-05-binding IgA and IgG were commonly detected prio …

02.09.2026journal-article

Briefings in Bioinformatics

DNAmBERT: a transformer-based model for non-invasive cancer diagnosis using DNA sequence and methylation data

Maryam Yassi, Mark Ezegbogu, Euan J Rodger, Peter Stockwell, Aniruddha Chatterjee, Matthew Parry

Abstract DNA methylation alterations are early and stable hallmarks of cancer and represent promising biomarkers for non-invasive detection using circulating cell-free DNA (cfDNA). However, current computational approaches often model DNA sequence and methylation features separately and struggle to capture complex read-level methylation architecture in heterogeneous, low-signal liquid biopsy data. Here, we present DNAmBERT, a Transformer-based deep learning framework designed to jointly model DNA sequence context a …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Casein Kinase 1 Alpha 1 Is Over-expressed in Pancreatic Adenocarcinoma Tissues and Correlates With Shorter Patient Survival

SHIN-NOSUKE YAMASHITA, YOSHIATSU TANAKA, SHAJEDUL ISLAM, TAKAO KITAGAWA, KAZUHIRO TOKUDA, DURGA PAUDEL, SARITA GIRI, TOHRU OHTA, FUMIYA HARADA, HIROKI NAGAYASU, YASUHIRO KURAMITSU

Background/Aim: A quarter of a century has passed since the start of the 21st century, and cancer, once considered an incurable disease, has become manageable thanks to the development of various treatments. However, pancreatic adenocarcinoma (PAAD) remains one of the deadliest cancers in the world, with over 95% of patients dying within five years. This is because the anatomical location of the pancreas makes it very difficult to detect with imaging, and symptoms often do not appear until the cancer invades the ne …

03.09.2026journal-article

Cancer Research Communications

Advancing Prostate Cancer Survivorship through Transatlantic Consortium Science: The iCCaRE Initiative

Folakemi T. Odedina, Roxana Dronca, Kimlin Tam Ashing, Ernest Kaninjing, Solomon Rotimi, Che Ngufor, Arnold Merriweather, Vinessa Gordon, Emelina Asto-Flores, for the iCCaRE Consortium Group, Kayode Adeniji, Emmanuel Agboola, Uju Aliche, Usman M. Aliyu, Gladys Asiedu, Paul Badejo, Kim Barbel Johnson, Patrick Beckford, Renaldo Blocker, Opeyemi Bolajoko, Timethia Bonner, Ivey Breland, Amanda Caballero, Rickey Carter, Alex Cattnell, Ewan Cobran, Gerardo Colon-Otero, John A. Copland, Getachew Dagne, Opeyemi C. De Campos, Melissa Doty, Ebenezer Erefah, Kaila Falzon, Damian Francis, Michelle Fudge, Dottington Fullwood, Jeffery Gainer, Dee Glaser-Boivin, Mahesh Gokara, Antony Hill

Abstract Black/African American populations, globally, bear the greatest prostate cancer burden compared with other racial/ethnic groups. Addressing prostate cancer disparities in Black men is complex, requiring a patient-centered, community-centric, and comprehensive approach. This study integrates Inclusive Cancer Care Research Equity (iCCaRE) Consortium findings and broader literature to address unmet needs in survivorship care. The iCCaRE Consortium implemented five complementary pilot studies using mixed-metho …

01.09.2026journal-article

Journal of Immunotherapy and Precision Oncology

Trastuzumab Deruxtecan-Associated Pneumonitis in Non-Breast Solid Tumors: A Retrospective Cohort Study

Abdelrahman M. Attia, Jose Carlos Tuesta Delgado, Alexia Dayan Lecaros Zavalla, Kevin Bernal Medina, Ivan Alexander Flores Hernandez, Emilio Jacques Villarreal, Saadia A. Faiz, Girish S. Shroff, Funda Meric-Bernstam, Bora Lim, Mehmet Altan, Ajay Sheshadri

Abstract Introduction Trastuzumab deruxtecan (T-DXd) has transformed treatment for HER2-expressing malignancies, yet pneumonitis remains a potentially fatal toxicity. Most pneumonitis data derive from breast cancer cohorts, but risk factors and outcomes in non-breast solid organ tumors are poorly characterized. Materials and Methods We conducted a retrospective, single-center cohort study of adults with advanced non-breast solid organ tumors receiving T-DXd in routine clinical practice at a comprehensive cancer cen …

01.09.2026journal-article

Biosensors

Nanocarbon as a Quantum Material for Biointerfaces and Magnetic Platforms in Theranostic Biomedicine in Oncology: A Critical Review

Priscila M. Galdino, Barbara R. Geraldino, Nilséia A. Barbosa, Fernando M. Araújo-Moreira

Nanostructured carbon materials are low-dimensional systems relevant to oncology biosensing, with their utility arising from an electronic structure coupled to defect and edge states, a charge-transfer behavior and optical response that report molecular binding, an interfacial chemistry governing contact with the analyte, and, in selected cases, magnetic properties enabling manipulation and readout. In functional terms, these behaviors trace to specific quantum-relevant features—quantum confinement, edge and defect …

01.09.2026journal-article

Journal of Neuro-Oncology

Long-term outcomes after a randomized phase II trial of nerve growth factor eye drops for optic pathway gliomas: four-year follow-up findings in children

Antonio Ruggiero, Giorgio Attinà, Giorgio Placidi, Elena D’Agostino, Alessia Amato, Tommaso Verdolotti, Stefano Mastrangelo, Benedetto Falsini

Abstract Purpose A previous double-blind, randomized, placebo-controlled, phase II clinical trial reported beneficial effects of a short-term treatment (10 days) with murine nerve growth factor (mNGF) eye drops on visual function in children with optic pathway gliomas (OPG). The present study aimed to evaluate long-term changes in clinical and neuroradiological parameters in the cohort of OPG patients who had previously participated in the phase II mNGF trial. Methods Fifteen of the 18 patients originally enrolled …

01.09.2026journal-article

Healthcare

Recurrent Unilateral Vulvar Syringoma Mimicking Treatment-Resistant Condyloma Acuminata: A Case Report and Review of the Literature

Saeed Baradwan, Mohammad Alyafi, Haneen Al-Maghrabi, Sumaih Shinawi

Background: Vulvar syringoma is a rare benign adnexal neoplasm originating from eccrine sweat ducts. Although syringomas most commonly occur in the periorbital region, vulvar involvement is uncommon and frequently underrecognized. Due to its nonspecific clinical appearance, vulvar syringoma may mimic more common vulvar conditions, resulting in delayed diagnosis and repeated ineffective treatments. Case Presentation: A 41-year-old multiparous woman presented with a several-year history of recurrent pruritic papular …

01.09.2026journal-article

Cancer Discovery

Long-Read Haplotype Phasing Resolves Allelic Configuration as a Missing Layer of Precision Oncology

Josh N. Vo, Yi-Mi Wu, Rui Wang, Tiffany Pham, Xuhong Cao, Sophie Yeung, Mingyu Park, Yelena Kleyman-Smith, Guo Ci Teo, Alyssa J. Wu, Anne Li, James C. Estill, Lakshmi P. Kunju, Chen Yang, Dan R. Robinson, Arul M. Chinnaiyan

Abstract Short-read sequencing cannot determine whether co-occurring variants within a cancer gene lie on the same allele (cis) or opposing alleles (trans), a distinction with direct therapeutic consequences: trans configurations confirm biallelic tumor suppressor inactivation, whereas cis configurations generate compound oncogenic alleles with enhanced activity. Among 768 patients with prostate, breast, or ovarian cancers, we used mutational signatures to nominate cryptic genomic instability cases lacking a causat …

01.09.2026journal-article

Radiology

Performance of Photon-counting CT for Assessing Pretreatment Breast Cancer: Comparison with Mammography, MRI, and 18 F-FDG PET/CT

Qiuyi Fu, Yufei Zeng, Rui Chang, Zhihan Xu, Ying Zhan, Ling Tan, Jiahao Zhou, Xiaosong Chen, Weimin Chai, Fuhua Yan

Photon-counting CT is comparable to MRI for clinical T categorization and has better diagnostic performance for nodal metastases; however, assessment of microcalcifications is limited compared with mammography.

02.09.2026journal-article

Psycho-Oncology

Effect of a Nurse‐Navigated Game‐Based Program on Transition Readiness and Psychosocial Outcomes in Adolescents With Osteosarcoma: A Cluster‐Nonrandomized Controlled Study

Jun Ma, Xia Zhang, Jing Li, Fei Liu

ABSTRACT Background Adolescents with osteosarcoma face clinical and psychosocial challenges during the transition from adolescence to adulthood. Aims This study examined the effects of a nurse‐navigated game‐based intervention (N 2 ‐GBI) on transition readiness in adolescents. Methods Participants in the control group received usual care, whereas the intervention group received the N 2 ‐GBI programme alongside usual care. Transition readiness was assessed using the Self‐Management and Transition to Adulthood with R …

01.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Cancer Screening in the Postpandemic Era: Lessons from Disruption and a Path Forward

Gloria D. Coronado, Anna M. Morenz, Josheili Llavona-Ortiz

Abstract The COVID-19 pandemic exposed critical vulnerabilities in cancer screening systems while revealing strategies that enabled resilience. Analysis of data from the National Cancer Institute’s Population-based Research to Optimize the Screening Process (PROSPR) consortium across 10 US health systems documented dramatic declines in cervical, colorectal, and lung cancer screening during April to May 2020, with some sites experiencing drops of up to 96%. Systems with established mailed fecal testing programs reco …

01.09.2026journal-article

Radiology: Imaging Cancer

Robotic Needle Insertion for CT-guided Percutaneous Biopsy of Thoracoabdominal Lesions: A Prospective Multicenter Randomized Trial

Haozhe Huang, Chao Chen, Ying Wang, Lichao Xu, Hua Jiang, Hui Zeng, Wentao Li

In a multicenter randomized trial, a novel robotic system for CT-guided percutaneous thoracoabdominal biopsy improved needle placement accuracy and technical success while reducing complications, compared with the conventional freehand approach.

01.09.2026journal-article

Journal of Clinical Oncology

International Myeloma Working Group Recommendations for the Diagnosis and Management of Solitary Plasmacytomas

Efstathios Kastritis, Shaji K. Kumar, Vincent S. Rajkumar, Wee Joo Chng, Luciano Costa, Monika Engelhardt, Wilson Gonsalves, Vania Hungria, Jens Hillengass, Dragan Jevremovic, Eirini Katodritou, Sigurður Yngvi Kristinsson, Sagar Lonial, Heinz Ludwig, Philip McCarthy, Elias Mai, Salomon Manier, Tom Martin, Maria-Victoria Mateos, Hira Mian, Joseph Mikhael, Philippe Moreau, Nikhil C. Munshi, Bruno Paiva, Charlotte Pawlyn, Leo Rasche, Joshua Richter, Jesús San Miguel, Douglas W. Sborov, Saad Z. Usmani, Meletios A. Dimopoulos, Elena Zamagni

Solitary plasmacytomas (SPs) are rare localized tumors of clonal plasma cells, either in the bone (solitary bone plasmacytoma) or in soft tissue/extraosseous (extramedullary) with either no or with minimal bone marrow (BM) infiltration (

01.09.2026journal-article

Journal of Clinical Oncology

Risk Prognostication After Hypomethylating Agents Combined With Venetoclax in AML: The PRISM Risk Model

Curtis A. Lachowiez, Joshua F. Zeidner, Jad Othman, Andy Kaempf, Seongseok Yun, Maël Heiblig, Michael Heuser, Rabia Shahswar, Rafael Madero Marroquin, Joseph M. Cannova, Andrius Žučenka, Jennifer Marvin-Peek, Jayastu Senapati, Yasmin Abaza, Alok Swaroop, Irene Zacheo, Federica Monaco, Amine Belhabri, Urbain Tauveron-Jalenques, Emmanuelle Tavernier, Martin Carré, Gaspar Aspas Requena, Rachel J. Cook, Elie Traer, Jennifer N. Saultz, Jenny O'Nions, Faisal Basheer, John Laurie, Shivani Handa, Eytan M. Stein, Maria R. Baer, Rebecca Olin, William Blum, Gary Schiller, Tara Lin, Emily Curran, Ashley Yocum, Ellen Madarang, Naval Daver, Tapan M. Kadia

PURPOSE As risk stratification for patients with AML treated with lower-intensity venetoclax-based therapy remains suboptimal, we developed and validated a prognostic model integrating clinical, cytogenetic, and molecular features. METHODS We assembled a multinational data set comprising 2,092 adults with newly diagnosed AML treated with hypomethylating agents plus venetoclax (HMA + VEN). One thousand nine hundred eighteen patients with complete data were randomly divided into training (70%) and internal validation …

01.09.2026journal-article

Radiation

Economic Evaluation of Lutetium-177 (177Lu)–PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer in Italy

Jacopo Giuliani, Emilia Durante, Giuseppe Napoli, Marina Tommasi, Giuseppe Aprile, Francesco Fiorica

Introduction: The increasing costs of cancer care have raised the need for economic evaluations that integrate treatment efficacy and resource utilization. This study aimed to assess the economic value of Lutetium-177 (177Lu)–prostate-specific membrane antigen (PSMA)-617 in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) from an Italian healthcare perspective. Patients and Methods: A cost-effectiveness analysis was performed using clinical efficacy data from randomized controlled …

01.09.2026journal-article

Frontiers in Oncology

Swyer syndrome complicated by rapidly progressive invasive ovarian dysgerminoma with bladder and rectal direct invasion: a rare case report

Yuan Feng, Xueqin Chen, Yaru Xu, Meng Xia, Tengda Xie, Rong Yang, Kang Du, Yiou Chen

A 16-year-old patient with a female social gender was admitted because of “a pelvic mass detected for one year”, accompanied by primary amenorrhea and poorly developed secondary sexual characteristics. Laboratory tests after admission showed elevated levels of follicle-stimulating hormone and luteinizing hormone, decreased estradiol level, and increased levels of β-human chorionic gonadotropin and carbohydrate antigen 125. Imaging examinations suggested multiple masses in the bilateral adnexal regions and abdominop …

01.09.2026journal-article

Kidney Research and Clinical Practice

Effectiveness and safety of denosumab on osteoporosis treatment in kidney transplant recipients

Jin Kyung Kwon, Yaerim Kim, Jin Hyuk Paek, Kyubok Jin, Seungyeup Han, Woo Yeong Park

Background: Denosumab has been reported to improve bone mineral density (BMD), but the clinical impact of denosumab on osteoporosis in kidney transplant recipients (KTRs) remains controversial.Methods: We analyzed 98 KTRs who used denosumab from 2018 to 2023. We investigated the change in BMD, laboratory findings, complications of denosumab, fracture risk assessment tool (FRAX) score, acute rejection within 1 year, and graft failure.Results: Mean T-scores at 1 year after denosumab were significantly increased compa …

2 Zitationen
01.09.2026journal-article

Clinical and Experimental Medicine

Exercise-induced systemic and tumor-microenvironment adaptations regulating chemokine-guided immune-cell trafficking

Amir Hossein Ahmadi Hekmatikar, Aliakbar Yousefi-Ahmadipour, Diego Fernández-Lázaro

Abstract Exercise is increasingly recognized as a biologically active intervention in cancer, yet its role in shaping the chemokine landscape of the tumor microenvironment remains incompletely defined. Importantly, immune-cell mobilization in the circulation does not necessarily translate into productive tumor infiltration, because effective homing depends on chemokine availability, endothelial permissiveness, stromal architecture, metabolic state, and spatial organization within the tumor microenvironment. In this …

01.09.2026journal-article

JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH

Treatment of Teeth with Apical Root Resorption Using MTA

Selin İsaoğlu Bulut, Emre Bodrumlu

ABSTRACTObjective: Apical stenosis may be impaired due to pulpal pathologies, iatrogenically, etc. Apical inflammatory root resorption usually occurs due to periapical pathology without any clinical symptoms. The aim of this case series is to utilize calcium silicate based materials to provide hermetic occlusion in the treatment of teeth with compromised apical integrity. Case Report: Case 1: A 21-year-old woman with no systemic disease. Tooth number 11 had swelling and fistula tract extending to the buccal mucosa. …

01.09.2026journal-article

Learning Health Systems

Evaluation of a Real‐Time Knowledge Exchange Network Supporting Syphilis Rapid Testing and Immediate Treatment in Seven Public Health Units in Ontario, Canada

Megan Ann Carter, Sara Tryon, Mary Southall, Kandace Belanger, Mary France Caron‐Bruneau, Anne Charron, Sandra Dereski, Michael Evans, Natasha Larkin, Kassandra Plante, Melanie St. John, Nicole Szumlanski, Lucy Mackrell, Sahar Saeed

ABSTRACT Introduction The Syphilis Point of care Rapid testing and Immediate Treatment Evaluation (SPRITE) is a collaborative, community‐based initiative that strengthens syphilis prevention and control in Ontario, Canada through flexible outreach nursing and point‐of‐care testing (POCT) and immediate treatment. Seven public health units (PHUs) partnered with 86 community‐based organizations (CBOs) to deliver syphilis/HIV POCTs in underserved settings. This study evaluated a real‐time knowledge exchange network tha …

01.09.2026journal-article

Journal of Clinical Medicine

Anti-Amyloid Antibodies in the Treatment of Alzheimer’s Disease: An Umbrella Review

Stefania Kalampokini, Iraklis Keramidiotis, Antonis Frontistis, Francesca Zuchi, Dimitrios Michmizos, Vasileios Papaliagkas, Effrosyni Koutsouraki

Background: Over the last decade, numerous studies have investigated the administration of monoclonal anti-amyloid antibodies (AAAs) as a therapeutic approach in Alzheimer’s disease (AD). The purpose of this umbrella review is to summarize current knowledge concerning the efficacy and safety of FDA- and EMA-approved AAAs for AD, namely, lecanemab and donanemab. Methods: We conducted a literature search in the PubMed, Scopus, and Web of Science databases in English, focusing on systematic reviews and/or meta-analyse …