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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Current Issues in Molecular Biology

A Versatile Anti-CXCR5 Monoclonal Antibody (Cx5Mab-6) for Basic Research and Diagnosis

Airi Nomura, Hiroyuki Suzuki, Saori Okuno, Haruto Yamamoto, Reina Ito, Yukari Ogura, Kai Shimizu, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Mika K. Kaneko, Yukinari Kato

The G protein-coupled receptor, CXC chemokine receptor 5 (CXCR5), is predominantly expressed on B cells located in the secondary lymphoid tissues, follicular helper T cells, and lymphoma cells. Binding to its ligand, CXCL13, mediates cell migration and regulates lymphocyte trafficking. Aberrant CXCL13/CXCR5 expression and signaling have been implicated in tumor progression, autoimmune diseases, and chronic inflammatory disorders. Therefore, specific mAbs against CXCR5 are expected to be useful for diagnosis and the …

03.09.2026journal-article

Experimental & Molecular Medicine

Bone marrow stromal cells promote chemoresistance in acute myeloid leukaemia through P2RX7-mediated antioxidant defence

Ruolan You, Xiaoting Wang, Xiaoming Zheng, Wenqi Fang, Cen Jiang, Jingru Liu, Xiaolin Xu, Maoqing Tan, Danni Cai, Diyu Hou, Jing Zheng, Xinjian Lin, Huifang Huang

Abstract Acute myeloid leukaemia (AML) remains a therapeutically challenging malignancy owing to its high relapse rates and chemoresistance, often linked to elevated antioxidant defences. Here, we demonstrate that bone marrow stromal cells (BMSCs) confer chemoresistance in AML by upregulating the purinergic receptor P2RX7. Blocking P2RX7 restored chemosensitivity of AML cells. Mechanistically, BMSC-mediated P2RX7 overexpression induces calcium influx and mitochondrial calcium overload, triggering mitochondrial stre …

03.09.2026journal-article

Communications Medicine

Comparison of surgical techniques for myopia correction: a systematic review and comprehensive network meta-analysis of refractive procedures

Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan

Abstract Background Myopia is increasingly prevalent worldwide, and several refractive surgical options are available, including photorefractive keratectomy (PRK), laser-assisted in situ keratomileusis (LASIK), femtosecond laser-assisted LASIK (FS-LASIK), small-incision lenticule extraction (SMILE), laser-assisted subepithelial keratectomy (LASEK), and phakic intraocular lens (PIOL) implantation. This network meta-analysis compared their visual, refractive, and corneal outcomes. Methods PubMed, Embase, Web of Scien …

03.09.2026journal-article

Journal of Functional Biomaterials

Enhancing Wear Resistance and Surface Hardness of Three-Dimensionally Printed Denture Teeth Through Post-Treatment Under Elevated Temperature and Pressure

Shanglin Wu, Yuriko Komagamine, Bohan Tang, Tamaki Hada, Aung Soe Myint, Pong Pongprueksa, Manabu Kanazawa

Three-dimensionally (3D)-printed denture teeth are increasingly used in clinical practice; however, their wear resistance and surface hardness may be insufficient for long-term clinical application. Moreover, the effect of post-treatment under elevated temperature and pressure on these properties remains unclear. This study aimed to evaluate the effect of such post-treatment on the wear resistance and Vickers hardness of 3D-printed denture teeth resin. One hundred disk-shaped specimens (10 × 2 mm) were 3D-printed u …

03.09.2026journal-article

Catalysts

An Artificial Rabbit Optimization-Enhanced Support Vector Regression Framework for Sustainable Solar Photocatalytic Water Treatment

Nayeemuddin Mohammed, Rakesh Prasad, Yun-Huoy Choo, Santosh Kumar Sahu, Mohan Kumar Siddalingaiah, Mohammed Aman, Hiren Mewada, Feroz Shaik

Due to industrialization, urbanization, and the need for sustainable water resources, the treatment of organic water has become a major environmental concern. Semiconductor photocatalysts degrade organic contaminants through a clean, energy-efficient process called photocatalysis. In this study, batch reactor experiments were performed under natural solar irradiation to examine the influence of zinc oxide (ZnO) dosage, pH, and reaction time (inputs) on photocatalytic performance, with total organic carbon (TOC) as …

03.09.2026journal-article

Journal of Craniofacial Surgery

Prominent Premaxilla in Bilateral Cleft Lip: A Blinded Expert-Panel Assessment of Orthopedic Response and Final Aesthetic Outcomes

Daniela Y. S. Tanikawa, David K. Chong, David M. Fisher, Roberto L. Flores, Maria Costanza Meazzini, Pradip R. Shetye, Álvaro A. Figueroa

Background: A prominent premaxilla in bilateral cleft lip presents significant orthopedic and surgical challenges. Although presurgical infant orthopedics (PSIO) is widely used, evidence linking orthopedic response to clinically meaningful outcomes remains limited. This study evaluated orthopedic response, need for lip adhesion, and final aesthetic outcomes using blinded expert-panel assessments. Methods: Fifty consecutive bilateral cleft patients treated with PSIO were reviewed, including 25 treated with nasal ele …

03.09.2026journal-article

Journal of Craniofacial Surgery

Anterior Cervical Lipectomy for Neck Contouring in Multiple Symmetric Lipomatosis Improved Obstructive Sleep Apnea Control With Sustained Airway Decompression

Koji Kanayama, Koichi Toyoshima, Jun Takami, Hiroki Mori, Mutsumi Okazaki

Multiple symmetric lipomatosis can cause extraluminal upper-airway compression and aggravate obstructive sleep apnea (OSA). The authors report a 60-year-old man with severe OSA and marked anterior cervical lipomatosis who had persistent residual respiratory events despite adherent use of continuous positive airway pressure (CPAP) therapy. Anterior cervical lipectomy for neck contouring was performed, removing 2552 g of lipomatous tissue. Postoperatively, snoring improved and the device-reported residual apnea-hypop …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

A case report of cardiogenic shock with transcranial color-coded ultrasound monitoring under ECMO

Yuyi Chen, Jingyi Wu, Huiying Chen, Jiefeng Xie, Yuping Liao, Qianwei Zheng, Yu Gan

Background Cardiogenic shock (CS) during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support carries high mortality, often due to neurological injury. Precise matching of ECMO flow to cerebral perfusion is critical. Transcranial color-coded sonography (TCCS) offers real-time, non-invasive hemodynamic assessment to guide flow titration, though its clinical integration remains limited. Case presentation This study reports a 58-year-old male firefighter who suffered out-of-hospital cardiac arrest due to …

03.09.2026journal-article

Frontiers in Neurology

The clinical features of anti-CNTN1 antibodies associated autoimmune nodopathies with nephropathy: a case series

Jinping Wan, Tiegen Xiong, Jianian Hu, Shaojun Liu, Jie Lin, Chongbo Zhao, Chong Sun, Hai Xiao

Objective The concurrence of anti-contactin-1 (CNTN1) antibody-associated autoimmune nodopathies (AN) and nephropathy has been sporadically reported, though the underlying relationship remains unclear. This case series study aimed to investigate the clinical characteristics and renal pathology of anti-CNTN1 antibody-associated AN with nephropathy. Methods A retrospective case series was conducted including 69 patients diagnosed with AN, among whom 11 patients tested positive for anti-CNTN1 antibodies. Clinical mani …

03.09.2026journal-article

Frontiers in Oncology

Lattice SFRT in a geriatric patient with an initially inoperable leg bulky sarcoma: case report and literature review

Francesco Di Siervi, Bruno Curcio, Renato Cuocolo, Silvio Maffei, Carolina Mainardi, Immacolata A.M. Pilotti, Davide Di Gennaro

Background Management of inoperable bulky soft tissue sarcomas mostly in geriatric patients presents a significant clinical challenge due to high and hypoxia-induced radioresistance, proximity to dose-limiting Organs at Risk (OARs), and the need to minimize systemic toxicity. Spatially Fractionated Radiation Therapy (SFRT), specifically 3D Lattice Radiation Therapy (LRT), offers a novel approach to safely escalate dose within the tumor volume. Case presentation 85-year-old female presenting a massive (20.7 x 9.8 cm …

03.09.2026journal-article

Allergies

Biologic Therapies for Severe Pediatric Asthma: Current Evidence, Clinical Indications, and Future Directions

Dafni Moriki, Michalis Kalogiannis, Maria Tsouprou, Vasilis Grammeniatis, Konstantinos Douros, Despoina Koumpagioti

Severe pediatric asthma remains a significant clinical challenge despite advances in conventional therapy. Some children continue to experience persistent symptoms, recurrent exacerbations, and substantial morbidity despite optimized treatment with inhaled corticosteroids and long-acting bronchodilators. Advances in the understanding of asthma immunopathology, particularly type 2 (T2) inflammation, have led to the development of targeted biologics that modulate key inflammatory pathways. Several monoclonal antibodi …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

Sentinel Lymph Node Imaging, Biopsy in Head/Neck and Breast Cancers: A Comprehensive Review

Palaniswamy Shanmuga Sundaram, Padma Subramanyam

Sentinel lymph node imaging and biopsy (SLNI and SLNB) have become key components in the management of many solid tumours, especially Head / Neck cancer (HNCa) and breast cancer (BC), offering an accurate and minimally invasive lymph nodal staging. The rationale being that the sentinel lymph node (SLN) is the first draining node from the primary tumour site and, therefore, is the most likely site for early lymphatic dissemination of metastatic tumour cells. SLN identification is conventionally performed using minut …

03.09.2026journal-article

Frontiers in Medicine

Identifying systemic vulnerability phenotypes associated with programmed regimens in frozen embryo transfer: a secondary analysis of a multicentre randomized clinical trial

Junfeng Chen, Hu Li, Mengfei Wang, Bailian Cai, Junjie Qu, Yiran Li

Background Programmed endometrial preparation is widely used for frozen embryo transfer (FET) because it allows flexible scheduling. Recent randomized evidence has shown that programmed regimens increase the risk of hypertensive disorders of pregnancy, particularly pre-eclampsia, compared with natural ovulation regimens. However, it remains unclear whether this risk is distributed uniformly across patients or concentrated in women with specific baseline characteristics. Objective This study aimed to evaluate the he …

03.09.2026journal-article

Frontiers in Medicine

The role of Advanced Practice Providers in improving primary care capacity: practice perspectives on challenges and opportunities

Marie Shoen, Ben Webel, Jacqueline Britz, Hailee Hoffman, Jennifer Gilbert, Alex H. Krist, E. Marshall Brooks

Background In Virginia and across the United States, primary care workforce shortages limit access to care and exacerbate adverse health outcomes. We conducted a statewide survey of primary care practices in 2022 and found that 42% of practices reported losing a physician or Advanced Practice Provider (APP), including Nurse Practitioners (NPs) and Physician Assistants (PAs), in the past year. Adding APPs to primary care teams is one strategy practices are using to mitigate the shrinking availability of primary care …

03.09.2026journal-article

Frontiers in Surgery

Case Report: Management of tibial fracture nonunion: a case study of treatment failure and lessons learned

Chaoshuai Wang, Chen Wang

Concept of “mechanical–biological balance” is fundamental to successful fracture healing; disruption of either component can lead to healing failure. Fractures of the middle and distal tibia are commonly encountered in clinical practice, particularly when associated with comminution. Managing fracture nonunion requires a comprehensive assessment of infection status, skeletal alignment, bone defect, implant stability, and host biological characteristics. This case report aims to explore the etiological factors of ti …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

Long-term patient-reported outcomes and quality of life after tibiofemoral knee dislocations in patients with open growth plates: a retrospective case series from a Level 1 trauma center

Pierre Hepp, Yasmin Youssef, Ralf Henkelmann

Abstract Background Tibiofemoral dislocations in children and adolescents are rare, and treatment guidelines are primarily based on adult data and algorithms. This case series of four pediatric and adolescent patients aims to add to the limited literature and highlights key aspects of diagnosis, treatment, and patient-reported outcomes. Methods We conducted a retrospective-prospective single-center case series of pediatric and adolescent patients (

03.09.2026journal-article

Frontiers in Medicine

EchoSAM2: enhancing anatomical consistency in few-shot cardiac ultrasound segmentation via sequence-wise memory and registration

Chunmin Li, Ziyu Zhou, Lijuan Guo, Qiulian Wang, Xiaoji Bai, Wenhao Wang

Introduction Few-shot segmentation in echocardiography is highly valuable for rapid clinical assessment, yet remains challenging because expert annotations are scarce, cardiac morphology varies across patients, and ultrasound videos exhibit complex temporal motion. Although the Segment Anything family provides strong generic priors, its direct deployment on echocardiographic videos often suffers from unstable frame-wise predictions and limited adaptation under low-label conditions. Methods We propose EchoSAM2, a fe …

03.09.2026journal-article

Frontiers in Medicine

Differential risk signals of cutaneous adverse drug reactions among β-lactam antibiotics: ceftriaxone shows increased signals for SJS/TEN in clinical and real-world cohorts

Leonard von Grundherr, Henrike Alexandra Faesser, Andreas Recke, Ralf J. Ludwig, Katharina Boch, Philip Curman

Background Cutaneous adverse drug reactions (CADRs) are triggered by numerous antibiotic drugs. Most drug reactions are in the spectrum of a maculopapular eruption (MPE) with a self-limiting disease course. In contrast, severe cutaneous adverse reactions (SCARs), including Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), are rare but may follow a life-threatening course. In this study, we investigated the key drug-related triggers of CADRs in a retrospective single-center cohort and, based on these fi …

03.09.2026journal-article

Frontiers in Medicine

Case Report: A case of cutaneous collagenous vasculopathy

Chenjian Tang, Liping Chen, Jiangxiu Yu, Mei Zhu

We report a case of a 62-year-old woman presenting with a 6-year history of purpuric patches and macules on the lower extremities, initially misdiagnosed as allergic purpura and treated with prednisone. Skin biopsy revealed dilated dermal vessels with perivascular collagen deposition, positive for collagen IV and diastase–periodic acid–Schiff (D-PAS) staining, consistent with cutaneous collagenous vasculopathy (CCV). Treatment included hydroxychloroquine, vitamin C, doxepin, and topical mucopolysaccharide polysulfa …

03.09.2026journal-article

Smart Molecules

AI‐enabled engineering of hesperidin/ursodeoxycholic acid nanomedicine for synergistic treatment of drug‐induced liver injury

Kai Xiao, Meng Fan, Haoyu Zheng, Boyuan Gu, Shaowen Wang, Ziping Wu, Shiming Zhang, Xin Zhao, Wensheng Zhang, Quanxin Ning, Sigen A, Chao Yang, Huayi Sun, Ren Mo, Dan Shao

Abstract Drug‐induced liver injury (DILI) is a complex and intractable disease because existing anti‐oxidate therapies in clinic fail to modulate multiple pathological pathways concurrently. Here, we present a direction‐aware framework that integrates disease‐network analysis, AI‐guided molecular screening, and self‐assembled nanomedicine design for precise protection of DILI. Time‐resolved transcriptomic profiling of DILI identifies two complementary repair axes: the suppression of cytokine‐cytokine receptor signa …

03.09.2026journal-article

Communications Medicine

KV7 channel activation inhibits human and murine myometrium contractility and delays delivery in a mouse model of preterm birth

Yosef T. Mansour, Hiten D. Mistry, Evonne C. Chin-Smith, Mariola K. Zaleska, Deanna C. Sekulich, Jennifer L. Herington, Jeff Reese, Rima Patel, Philip I. Aaronson, Donna M. Slater, Sarah K. England, Iain A. Greenwood, Mark R. Johnson, Paul D. Taylor, Rachel M. Tribe

Abstract Background Spontaneous preterm birth, defined as delivery before 37 weeks of gestation, remains a global cause of neonatal illness and death, yet treatments for preterm labor remain limited. We hypothesized that K V 7 channels in the uterus (myometrium), could be a therapeutic target for preventing or treating preterm labor. The aim was to characterize K V 7 channel subtypes in human myometrium present after labor onset, and to use a preterm birth mouse model to provide proof-of-principal evidence that act …

03.09.2026journal-article

JAMA Ophthalmology

Patient With Bilateral Corneal Opacities

John Placide, Daniel J. Lee, Afshan A. Nanji

A 31-year-old woman from Guam with no known medical history was referred by an ophthalmologist to a US cornea clinic for bilateral progressive blurred vision and corneal opacities. What would you do next?

03.09.2026journal-article

Clinical Rehabilitation

Responsiveness of the Timed ‘Up and Go’ test in people with Parkinson's disease

John K Brincks, Jens Bansi, Martin Langeskov-Christensen, Ulrik Dalgas, Caroline S Nielsen, Line V Neergaard, Isa Slotboom, Franziska Riegel, Jacob Callesen

Objectives This study evaluates the responsiveness of the Timed ‘Up and Go’ test in people with Parkinson’s disease to determine its sensitivity in detecting changes in functional mobility. Design Retrospective cohort study. Setting Inpatient rehabilitation. Participants One hundred ninety-six people with Parkinson's disease. Main measures Data on the Timed ‘Up and Go’ test, the 10 m walk test, and the 6 min walk test, collected before and after an assigned multidisciplinary inpatient rehabilitation stay, were retr …

03.09.2026journal-article

Culture, Medicine, and Psychiatry

…And Breathe! Wellness, the Nation, and Holistic Reproductive Practitioners in India

Adhvik Shetty

Abstract Garbh Sanskar (GS) is an Indian holistic reproductive programme that claims roots in ancient Ayurvedic and yogic traditions while drawing upon contemporary wellness practices and international health policy. GS centres offer breathwork, guided meditation, and counselling to expectant and hopeful couples. This article draws upon interviews with GS practitioners across nine Indian cities to examine how these practitioners use wellness discourses to articulate strategies of individual and national improvement …