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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Europe’s Journal of Psychology

Effectiveness of cognitive behavioural therapy on sleep outcome for patients with chronic fatigue syndrome in a routine clinical service

Chotiman Chinvararak, Olivia Sterry, Trudie Chalder

Objective We aimed to study the effectiveness of CBT for sleep difficulties in patients with chronic fatigue syndrome/myalgic encephalitis (CFS/ME). Method We conducted a retrospective cohort study at the Persistent Physical Symptoms Research and Treatment Unit, Maudsley Hospital, between 2014 and 2019. The primary outcome was sleep quality and other sleep parameters assessed by the Pittsburgh Sleep Quality Index (PSQI). The secondary assessments comprised the Chalder Fatigue Questionnaire (CFS), the Work and Socia …

28.08.2026journal-article

Journal of Primary Care Dentistry and Oral Health

Chairside Direct Fabrication of Cheek Plumpers on an Existing Complete Denture for Facial Esthetic Rehabilitation: A Clinical Case Report

Guddolla Venkata Prasanna, Karukayil Amrutha Mohanbabu, Vinnakota Dileep Nag

Abstract Esthetic rehabilitation in completely edentulous patients involves restoration of function and facial appearance. Loss of buccal fat, muscular tone, and alveolar bone support may result in sunken cheeks and compromised facial esthetics. Cheek plumpers support the facial musculature but are commonly incorporated during fabrication of new dentures; however, some patients may be unwilling to replace well-fitting existing prostheses. This clinical case report describes the conservative management of a patient …

28.08.2026journal-article

Current Signal Transduction Therapy

Molecular Insights into Signalling Pathways and Therapeutic Monitoring of Chronic Low-grade Inflammation-associated Obesity

Nidhi Singh, Avijit Mazumder, Priyanka Bansal

Introduction: Obesity has emerged as a major global public health concern. It is a multifactorial condition encompassing genetic, environmental, socioeconomic, and psychosocial factors. This narrative review aims to highlight the key pathophysiological processes associated with chronic low-grade inflammation (CLGI) in obesity. Methods: Data collection was performed using the PubMed, Scopus, Web of Science, and Google Scholar databases, using the search terms “chronic low-grade inflammation”, “pathophysiology of obe …

28.08.2026journal-article

Journal of Clinical Medicine

Comparison of Rehabilitation Outcomes Between Surgical and Conservative Treatments for Incomplete Intertrochanteric Proximal Femur Fractures—A Retrospective Cohort Study

Cheuk Kin Kwan, Yu Hei Choi, Rossetti Hiu Yin Lam, Richard Ku, Tsz Hang Ma, Wing Hong Liu, Wing Hoi Cheung, Chaoran Liu, Sheung Wai Law, Ronald Man Yeung Wong

Background/Objectives: Incomplete intertrochanteric proximal femur fractures pose a management dilemma regarding the choice between surgery and conservative care. This study compared radiographic and functional outcomes between surgical fixation and conservative treatment and evaluated whether immediate full weight-bearing (FWB) can be performed by conservatively managed patients. Methods: This is a retrospective cohort study of consecutive patients aged ≥60 who presented with MRI-confirmed incomplete intertrochant …

28.08.2026journal-article

Malignant tumours

The Geriatric-8 (G8) screening questionnaire as a predictor of anticancer therapy toxicity in elderly patients: a comprehensive analysis of current data

A. B. Elmurzaev, I. N. Danilov, I. V. Rykov, G. A. Chizh, T. P. Nikitina, S. O. Kuzin, O. S. Lokotosh, V. A. Mirgorodskaya

Introduction. Treatment of elderly cancer patients is challenging due to high risk of adverse events. Comprehensive Geriatric Assessment (CGA) is the gold standard but time-consuming. The G8 screening tool rapidly identifies patients requiring CGA. Aim. To summarize current evidence on the predictive value of the G8 for chemotherapy toxicity, assess its diagnostic accuracy, compare it with other geriatric scales, and evaluate its applicability in the Russian population. Materials and methods . A systematic search o …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Study on the Effect of Scaffold Carriers on Tissue Repair and Rehabilitation in Cellular Environment

Yuwei Jiang

Scaffold carriers are three dimensional porous biomaterial structures that provide structural support, metabolic signalling and an appropriate cellular environment for tissue regeneration. This article covers the effects of scaffold carrier mechanisms on tissue healing and rehabilitation in three key tissue systems: bone and cartilage, skin and soft tissue and neural tissue. This review integrates principles of extracellular matrix (ECM) biomimicry, scaffold material classification frameworks and cell-scaffold mech …

28.08.2026journal-article

International Journal of Molecular Sciences

Magnetic Mitohormesis as a Potential Non-Invasive Restorative Therapy for X-Linked Muscular Dystrophies

Jan Nikolas Iversen, Alfredo Franco-Obregón

Duchenne and Becker X-linked muscular dystrophies are no longer viewed as disorders arising solely from passive sarcolemmal fragility but as diseases that progress because of disruption of cellular mechanotransduction. Evidence is accumulating that the gating of TRPC1 and TRPC3 mechanosensitive channels is altered in the absence of dystrophin, resulting in a breakdown of sarcoplasmic calcium homeostasis and preferential loss of type II glycolytic muscle fibres, while type I oxidative fibres are spared. TRPC1-mediat …

28.08.2026journal-article

Journal of Endovascular Therapy

Endovascular Aspiration Thrombectomy of the Superior Mesenteric Artery for Treatment of Acute Mesenteric Ischemia: Results From the ENDO-SMA2MI Registry

Mario D’Oria, Sandro Lepidi, Paolo Spath, Mauro Gargiulo, Ciro Ferrer, Gioele Simonte, Stefano Gennai, Francesco Giurazza, Anna Maria Ierardi, Diego Visconti, Reinhold Perkmann, Raffaello Bellosta, Nicolò De Manzini, Cristiano Calvagna, Alan Biloslavo

Background/Objective. Acute mesenteric ischaemia (AMI) is a multidisciplinary emergency, requiring the involvement of different medical specialties for successful management. Endovascular aspiration thrombectomy (EAT) has entered the field leading to the possibility of treating acute arterial occlusions with a minimally invasive approach. The aim of the study was to provide contemporary data on results after use of EAT in AMI patients. Methods. The study was a retrospective, observational, multicentre study conduct …

28.08.2026journal-article

Frontiers in Immunology

Recognition and management of early complications in CAR-T cell therapy and virus-specific T-lymphocyte therapy: a practical clinical reference

Marek Ussowicz, Ewa Jakubczyk, Tomasz Wróbel, Anna Czyż

Background Cellular immunotherapies—including chimeric antigen receptor T-cell (CAR-T) therapies and adoptive transfer of virus-specific T lymphocytes (VSTs) — have transformed the treatment of refractory hematological malignancies and post-transplant infectious complications. Eight products are currently authorized by the European Medicines Agency, encompassing seven autologous CAR-T products targeting CD19 or BCMA and tabelecleucel (Ebvallo), the first approved allogeneic off-the-shelf EBV-specific T-cell product …

28.08.2026journal-article

International Journal of Molecular Sciences

Cell Membrane-Coated Biomimetic Nanocarriers for Plaque-Targeted Atherosclerosis Therapy: Molecular Mechanisms, Inflammatory Microenvironments, and Translational Challenges

Ruiyu Zhang, Xujing Yuan, Jinpeng Sun, Yumiao Wei

Atherosclerosis (AS) is a lipid-driven chronic inflammatory disease and the principal pathological basis of coronary artery disease, ischemic stroke, and peripheral artery disease. Despite advances in lipid-lowering, antiplatelet, anti-inflammatory, and revascularization strategies, current treatments do not selectively modulate the heterogeneous cellular and inflammatory microenvironments within individual plaques. Cell membrane-coated nanoparticles (CMNs) have therefore emerged as biomimetic delivery platforms th …

28.08.2026journal-article

Respirology Case Reports

Long‐Term Recurrence‐Free Outcome After Doxycycline Pleurodesis With Pulmonary Rehabilitation and Nutritional Support in an Underweight Patient With COPD : A Case Report

Kemas Rakhmat Notariza, Prasenohadi Pradono, Siti Chandra Widjanantie, Elfina Rachmi, Agus Dwi Susanto

ABSTRACT Secondary spontaneous pneumothorax (SSP), a complication of chronic obstructive pulmonary disease (COPD), recurs more frequently in underweight patients. This case report describes a 63‐year‐old malnourished man with COPD presenting with recurrent left‐sided SSP shortly after hospital discharge for a previous episode. Following chest tube reinsertion and complete lung re‐expansion, chemical pleurodesis was performed using 1000 mg doxycycline in saline. Transient pleuritic pain was controlled with intraveno …

28.08.2026journal-article

Recent Patents on Nanotechnology

Chitosan-functionalized PLGA Nanoparticles: Exploring Recent Patents, Advanced Strategies for Controlled and Targeted Anticancer Therapy

Madhusudan Maity, Niranjan Panda, Subas Chandra Dinda, Bikash Ranjan Jena, Parameswar Patra, Chinmaya Keshari Sahoo

Introduction: Recent advances in the field of nanotechnology have accelerated the development of polymeric nanocarriers for cancer therapy, enabling high precision and improved therapeutic efficiency. Among these, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) have gained significant attention, as PLGA is a U.S. FDA-approved polymer for various biomedical applications. Methods: PLGA has several important properties, including biodegradability, biocompatibility, sustained drug-release properties, and minim …

28.08.2026journal-article

Biomedicines

Mechanisms of Action of Herbal Preparations for the Rehabilitation of Dust-Related Diseases of the Bronchopulmonary System

Georgiy A. Demchenko, Alexandr E. Gulyayev, Sayagul A. Kairgeldina, Madina B. Baurzhan, Marat R. Khanturin, Kanat K. Tekebayev, Nazym S. Sagandykova, Laura U. Koibasova, Makpal A. Yessenova

The aim of this study was to summarize current evidence on dust-related diseases of the bronchopulmonary system, medicinal plants, herbal formulations, and their underlying mechanisms of action. A literature review was conducted based on publications indexed in ScienceDirect, Google Scholar, SciFinder, Scopus, and Medline (PubMed), focusing on the mechanisms underlying dust-related diseases of the bronchopulmonary system, pneumoconiosis, and the potential of phytotherapeutic approaches to modulate these processes. …

28.08.2026journal-article

Medicine

The application and effectiveness of acceptance and commitment therapy on psychological resilience in the primary caregivers of ostomy patients

Li Teng, Xin Wu, Huili Xu, Yun Wang, Tian Luo, Adan Fu

Background: This study aims to investigate the effects of acceptance and commitment therapy (ACT) on enhancing psychological resilience, psychological flexibility, caregiving capacity, and benefit-finding among caregivers of ostomy patients. Methods: A total of 106 primary caregivers of ostomy patients were recruited from a tertiary hospital in Wuhan. Participants were randomly assigned to the intervention or control group in a 1:1 ratio using a computer-generated random sequence. Allocation was concealed using seq …

28.08.2026journal-article

Clinical Cancer Research

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial

Xing Zhang, Bushu Xu, Qiuzhong Pan, Ruiqing Peng, Desheng Weng, Jingjing Zhao, Xizhi Wen, Qiyan Cai, Wei Li, Hongcheng Hu, Ruihua Xu

Abstract Purpose: Advanced sarcomas lack effective maintenance therapies after first-line chemotherapy. We present long-term phase I results evaluating multiantigen stimulated cell therapy I (MASCT-I), a novel immunotherapy integrating dendritic cell vaccination with adoptive T-cell transfer, as maintenance treatment (NCT03034304). Patients and Methods: Thirty-one patients with disease control after chemotherapy received MASCT-I alone (n = 17) or with ifosfamide (n = 14). The primary endpoint was safety. Secondary …

28.08.2026journal-article

Frontiers in Computing and Intelligent Systems

A Study on Reducing Latency and Handling Accent Variation in Real-time Speech Translation Systems

Wenxuan Hu

Real-time speech translation, or RST, sits at the heart of cross-language instant communication. It shows up in plenty of places now—cross-border video meetings, commercial translation gadgets, smart wearables, and so on. Still, two bottlenecks keep holding back practical deployment: latency control and accent robustness. Most existing reviews tend to zoom in on just one dimension, leaving the interplay between the two largely overlooked. This paper takes a systematic look at the core technologies and recent progre …

28.08.2026journal-article

Occupational Medicine

Contact dermatitis among marking nut workers in rural India

U Kawalkar, R Sangale, A Gaidhane, A Mankar, P Kogade, S Aggarwal

Abstract Background Informal processing of Semecarpus anacardium (marking nut) provides livelihood to many women in rural India. The nut contains potent phenolic compounds with strong irritant and allergenic properties, yet occupational contact dermatitis related to this exposure remains poorly documented in community settings. Aims To describe the prevalence, clinical severity and occupational determinants of contact dermatitis among female informal workers involved in marking nut processing in rural Vidarbha, Ind …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Personalization of therapy for infections caused by N. gonorrhoeae, C. trachomatis, M. genitalium and T. vaginalis. Part II. Evaluation of the clinical effectiveness of personalized therapy

E.S. Negasheva, N.V. Frigo, A.E. Guschin, A.Yu. Khachaturyan, I.R. Baskakova, O.V. Zhukova

Background. Currently used antimicrobial agents, their doses, and treatment durations are clearly defined by standards and clinical guidelines. Nevertheless, treating patients with sexually transmitted infections presents significant challenges despite the availability of highly effective drugs. In this connection, the transition to personalized treatment is relevant, which is consistent with the provisions of the Strategy for Research and Technological Development of the Russian Federation adopted in 2024. Objecti …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Drug-induced sarcoid-like reaction during BRAF/MEK inhibitor therapy for metastatic melanoma

A.N. Khlebnikova, V.E. Shikina, A.V. Semenkov, A.I. Zotov, G.R. Setdikova

In recent years, targeted therapy with BRAF/MEK inhibitors has been successfully used for treating metastatic melanoma. Although generally well tolerated, it may lead to the development of both systemic and cutaneous side effects. The most frequently reported adverse events include nausea, vomiting, diarrhea, pyrexia, chills, and hypertension. Cutaneous side effects manifest as alopecia, acneiform rash, maculopapular rash, dry skin, and photosensitivity reactions. Cases of squamous cell carcinoma and keratoacanthom …

28.08.2026journal-article

Opera in Linguistica Ukrainiana

NEOREALISTIC VIEWS ON FOREIGN LANGUAGE VOCABULA IN UKRAINIAN SPEECH

L. V. Reva-Lievshakova

The purpose of the study is to analyze the functioning of foreign vocabulary in Ukrainian speech, to determine the features of its use, adaptation and role in the modern language space from the standpoint of neorealist views and considerations. The object of the study is modern Ukrainian speech in the context of the active functioning of foreign vocabulary. The subject of the study is neorealist views on the semantic role of foreign vocabulary, the features of its use, adaptation and functioning in the Ukrainian la …

28.08.2026journal-article

American Journal of Occupational Therapy

GenAI in Occupational Therapy: A Survey of Adoption, Ethical Concerns, and Training Needs

Adam Lockwood, Ryan Farmer, Tara Mansour

Importance Occupational therapy practitioners are rapidly adopting generative artificial intelligence (GenAI) tools in clinical settings, yet little is known about current usage patterns, ethical concerns, or training needs specific to the profession. Objective To examine how occupational therapy practitioners are using GenAI in practice and explore their ethical concerns, and training needs. Design Cross-sectional survey study. Participants 277 occupational therapists; 77 occupational therapy assistants with a mea …

28.08.2026journal-article

Journal of Molecular Modeling

Molecular insights and ADMET profiling of iridoids as candidate leads for erectile dysfunction therapy

Marcos Aurélio Carpina de Oliveira Filho, Jacilene Silva, Victor Moreira de Oliveira, Damião Sampaio de Sousa, Matheus Nunes da Rocha, Márcia Machado Marinho, Emmanuel Silva Marinho

Abstract Context Erectile dysfunction (ED) significantly affects male psychosocial health and has an increasing incidence. Although phosphodiesterase 5 (PDEi-5) inhibitors are the first-line therapy, the occurrence of visual side effects resulting from cross-inhibition of the PDE-6 isoform limits their adoption. In this context, the plant Veronica anagallis-aquatica L. emerges as a promising source of bioactive therapeutic compounds. This work investigated the inhibitory potential and selectivity of eight iridoid g …

28.08.2026journal-article

Frontiers in Oncology

Combination therapy with Nifuroxazide and Lenvatinib exerts superior anti-hepatocellular carcinoma effect by enhancing the anti-tumor immune response

Jing Yang, Jiaxin Geng, Yue Yin, Kangle Wang, Leyao Tian, Jingyi Wang, Huijie Jia, Lei Wang, Yongxi Zhang, Tiesuo Zhao

Background Lenvatinib is a first-line multi-target tyrosine kinase inhibitor for hepatocellular carcinoma (HCC) that exerts anti-angiogenic effects by blocking VEGF signaling. However, its clinical efficacy is often compromised by adaptive resistance. Nifuroxazide, an anti-diarrheal agent, has been identified by our group as a potent inhibitor of PD-L1 expression in HCC. Objective This study aimed to evaluate the therapeutic potential and underlying molecular mechanisms of nifuroxazide combined with lenvatinib agai …

28.08.2026journal-article

ARACÊ

EFEITOS DA MUSICOTERAPIA COMO INTERVENÇÃO COMPLEMENTAR NO TRATAMENTO DE PACIENTES COM DEPRESSÃO: UMA ABORDAGEM CLÍNICA

Janete Maria de Oliveira Praxedes Lira Costa

Contexto: A depressão é um transtorno mental de alta prevalência associado a comprometimentos significativos na qualidade de vida. Perante as limitações dos tratamentos convencionais, a busca por abordagens complementares e não farmacológicas vem se tornado essencial. Objetivo: Analisar os efeitos da musicoterapia como intervenção complementar no tratamento de pacientes com depressão, a partir de uma perspectiva clínica. Metodologia: Trata-se de uma revisão de escopo (scoping review), de abordagem qualitativa e car …