EUVIMED Themenbrowser · Onkologie · Seite 52
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Radiology: Imaging Cancer
Hyperpolarized [1- 13 C]pyruvate MRI enabled noninvasive metabolic characterization of focal liver lesions, and alanine-indexed metrics emerged as biological markers of progression to hepatocellular carcinoma beyond CT/MRI–based Liver Imaging Reporting and Data System categorization.
Revista Mexicana de Investigación Médica
Childhood cancer has a negative impact on the lives of affected children, affecting them socially, emotionally, and in terms of their development. Social support (SS) influences a patient’s adaptation, adherence to treatment, and well-being; receiving SS from the time of diagnosis can prevent negative psychological consequences. Una Nueva Esperanza A.B.P. (UNE) is a nonprofit organization that supports low-income children with cancer by offering comprehensive treatment. The objective of this study was to determine …
Frontiers in Cardiovascular Medicine
Methods We conducted a retrospective observational cohort study in a cardiogeriatric unit to compare cardiological, geriatric, biological, and therapeutic profiles across LVEF phenotypes in very old adults hospitalised for heart failure (HF). All patients with HF and classifiable LVEF were included and categorised according to 2021 European Society of Cardiology (ESC) criteria as heart failure with reduced ejection fraction (HFrEF, ≤40%), heart failure with mildly reduced ejection fraction (HFmrEF, 41%–49%), and he …
Neuro-Oncology Advances
Abstract Background We evaluated the outcome of radiosurgically treated patients with ≥10 brain metastases (BM), compared to patients <10 BM. Methods Patients, who underwent at least one Gamma Knife radiosurgical (GKRS) treatment for at least one BM without previous CNS treatments, were retrospectively divided into two groups: 1) <10 or 2) ≥10 BM. Results At GKRS1, 1293 patients had <10 BM and 126 patients had ≥10 BM. The estimated median survival after GKRS1 was significantly longer in patients with <10 BM (9.9 mo …
Journal of the International AIDS Society
ABSTRACT Introduction In eastern, central and southern Africa, HIV is a leading cause of mortality, and both HIV and depression contribute substantially to morbidity. Depression can impede effective HIV treatment and prevention, yet access to depression treatment remains limited. We estimated the impact and cost‐effectiveness of scaling up depression screening and treatment to different population segments in western Kenya . Methods We adapted a previously validated HIV transmission model for western Kenya (EMOD‐HI …
Journal of Environmental Health
Approximately 14% of the U.S. population relies on private wells for drinking water. Little is known about well stewardship, well water contaminants and their health impacts, ideal water testing frequency, and preferred water treatment. Our mixed-methods study focused on identifying well stewardship practices and beliefs in Colorado. We contacted septic permit holders and enrolled them in this study if they met eligibility criteria. Although annual testing is recommended, only 8.2% of study participants had tested …
Journal of Arthroscopy and Joint Surgery
Abstract Tenosynovial giant cell tumors (TGCTs) are tumors of the tendon sheath and are usually seen proximal to the wrist joint or in fingers, contrary to this case, as seen in the hypothenar region. It is primarily caused by a mutation in the synovial membrane’s stromal cells, which results in an overexpression of colony-stimulating factor. A 34-year-old male presented with swelling over the right hand palmar aspect over the hypothenar eminence which was gradually progressive in nature. The site and local examina …
JAMA Psychiatry
This Viewpoint highlights the determinants of treatment thresholds that should be considered for psychiatric care and explores the implications of recent developments in clinimetrics in this field.
Water and Environment Journal
ABSTRACT This study develops a quadrilateral evolutionary game model to examine strategic interactions and system evolution among the central government, local governments, polluting enterprises and the public in industrial wastewater treatment (IWWT) under collaborative governance in China. Numerical simulations use official Chinese statistical data related to IWWT, supplemented by parameters from relevant literature. Results show that (1) Increasing central government punishment for incomplete local regulation, e …
Frontiers in Public Health
Objective Based on the journey map, this study identified the multidimensional real-world experiences and core pain points of time toxicity among young and middle-aged breast cancer patients throughout the entire disease course, to provide a reference for alleviating patients’ time burden, optimizing the medical experience, and improving their quality of life. Methods A descriptive qualitative study was conducted. From August 2025 to February 2026, purposive sampling was used to recruit 19 young and middle-aged pat …
BMJ Open
Introduction In 2024, 30.4% of the German population had a migration background. People with migration-related language barriers face numerous challenges within the healthcare system, which can negatively impact their health outcomes. While language barriers affect healthcare in general, oncology represents a complex field in which effective communication is crucial. For people with cancer in particular, difficulties in understanding information, treatment options, and the healthcare system itself may hinder access …
JAMA
This randomized clinical trial examines 1-year safety and efficacy outcomes in patients who underwent intra-arterial thrombectomy or medical management following an acute ischemic stroke with large-core infarcts.
BMC Medical Imaging
Abstract Background MRI exhibits inherent limitations for preoperative TNM staging of rectal cancer, partially limiting its clinical utility. This head-to-head study compared the performance of ⁶⁸Ga-FAPI-04 PET/CT and MRI for stratified preoperative TNM staging of rectal cancer. We further assessed the predictive efficacy of quantitative PET/CT parameters for differentiating T stages, and explored whether these quantitative indicators could act as an adjunct to MRI staging. Methods This single-center retrospective …
Cancers
Mitochondria are increasingly recognized as dynamic regulators of cancer-cell adaptation, immune function, and therapeutic response. Beyond their canonical role in energy production, mitochondrial metabolism, dynamics, quality control, and stress signaling influence tumor-cell survival and the capacity of immune effector cells to sustain antitumor activity within the tumor microenvironment. In this narrative review, we examine mitochondrial fitness as a multidimensional functional property encompassing bioenergetic …
Forests
The effects of thermal modification, lactic acid (LA) impregnation, and their combined application on the physical properties and biological durability of European beech (Fagus sylvatica L.) were investigated to identify potential synergistic interactions between these environmentally friendly wood-modification methods. Beech lamellae were subjected to thermal treatment at 180 °C, LA impregnation followed by polymerization at 120 or 160 °C, and two different treatment sequences combining both modifications. Density …
European Heart Journal
Abstract Despite significant advances in stent technology, long-term complications—such as restenosis and stent thrombosis—remain relatively common and clinically impactful due to their association with recurrent myocardial infarction and adverse outcomes. Among the causes of stent failure, neoatherosclerosis has gained recognition as a key pathological mechanism, driven by impaired vascular healing, chronic inflammation, platelet activation, and immune responses following coronary stenting. Advances in diagnostic …
Journal of the National Comprehensive Cancer Network
Castleman disease (CD) comprises a heterogeneous group of rare lymphoproliferative disorders unified by characteristic lymph node histopathology but with substantial clinical, biologic, and therapeutic diversity. Over the past decade, major advances in disease classification, pathophysiologic understanding, and targeted therapy have reshaped the management of CD, particularly idiopathic multicentric CD (iMCD). The introduction of IL-6–directed therapy has transformed the management of iMCD by shifting treatment fro …
Journal of Scientific Research and Reports
Oncogenic viruses contribute substantially to the global burden of malignancy and remain an important challenge for cancer prevention, early detection, and surveillance. This review examines the molecular signatures associated with major oncogenic viruses, including human papillomavirus, hepatitis B virus, hepatitis C virus, Epstein–Barr virus, Kaposi’s sarcoma-associated herpesvirus, and Merkel cell polyomavirus. The manuscript discusses key mechanisms through which viral infections promote carcinogenesis, includi …
Journal of the American Heart Association
Background Obstructive sleep apnea (OSA) and cancer are independently associated with increased cardiovascular disease (CVD) risk. However, it is unclear whether OSA confers additional CVD risk among individuals with cancer. Methods A retrospective cohort study was conducted using the TriNetX database, including adults ≥40 years diagnosed with cancer between 2012 and 2023. Individuals with and without OSA were propensity score matched on demographics and comorbidities. The primary outcome was a composite of heart f …
The Oncologist
Abstract Background Renal cell carcinoma (RCC) is characterized by an immunogenic tumor microenvironment and frequent activation of angiogenic pathways. Therefore, combining immune checkpoint blockade with VEGF pathway inhibition is a rational therapeutic approach. PF‑08634404 is an investigational anti–PD‑1 and anti‑VEGF bispecific antibody that effectively binds both targets. PF‑08634404 uses a tetravalent (2 + 2) structure that enables binding cooperativity between PD-1 and VEGF-A, increasing the avidity for and …
TERRA ORTHOPAEDICA
Summary. Gunshot injuries of the peripheral nerves of the extremities are a part of severe polystructural combat trauma and are characterized by specific features of the injury mechanism, diagnosis, and reconstructive treatment. The main types and characteristics of gunshot injuries to peripheral nerves, methods of clinical and instrumental diagnosis, optimal timing and principles of surgical repair, as well as approaches to reconstructive treatment of the consequences of trauma are presented.
Salud Medicina e Innovación Journal
Introduction: Urinary tract infections (UTIs) are among the most common bacterial infections in children and are one of the leading causes of medical consultations, as well as antibiotic use and hospitalization; Various studies in recent years have shown an increase in antimicrobial resistance, particularly in pathogens such as E. coli, which has created challenges in empirical treatment and led to higher rates of treatment failure, as well as recurrent infections and long-term renal complications. Objective of the …
Vasa
Summary: Peripheral Artery Disease (PAD) is a significant global health concern, leading to morbidity through progressive stenosis and eventually occlusion of the lower extremity arterial vasculature. Advanced imaging modalities play a major role in diagnosing PAD, in planning endovascular as well as surgical interventions, and in monitoring post-treatment outcomes. This review highlights the current major imaging techniques, including duplex ultrasound, computed tomography angiography (CTA) and magnetic resonance …
Journal for ImmunoTherapy of Cancer
Background A substantial amount of research has been dedicated to the mechanisms by which tumor cells evade immune system recognition and manipulate the immune microenvironment to facilitate immune escape. Recent studies have shown that viruses and tumors can protect themselves from immune cytotoxicity by remodeling the actin cytoskeleton. However, cytoskeleton-mediated immune resistance and the specific cytoskeleton-related proteins involved require further research. Methods Single-cell RNA sequencing was used to …
