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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Clinical and Experimental Dermatology

Uncommon benign tumour of the scalp

Peter Robinson, Sam Cook, Stephanie Ball, Fraser Charlton, Neil Rajan

A 37-year-old male (Fitzpatrick skin type III) presented with a 10-month history of an enlarging nodule on the right parietal scalp. There was a paternal history of melanoma, but no family history of similar skin lesions. Physical examination revealed an ill-defined, pink, round, non-tender, mobile nodule measuring 15 x 15 mm. A second similar papule measuring 6 x 5 mm was found at the right scalp apex.

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

Luisa Agnello, Andrea Pilotto, Lorenzo Gaetani, Giovanni Bellomo, Valentina Bessi, Marco Bozzali, Annachiara Cagnin, Angelo Labate, Federico Massa, Fabio Moda, Roberto Monastero, Giulia Musso, Tommaso Piccoli, Giulia Sancesario, Lucilla Parnetti, Alessandro Padovani, Marcello Ciaccio

Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, therapeutic decision-making, and longitudinal disease monitoring. To effectively support clinical decision-making, biomarker measurements must be communicated in a standardized, transparent, and clinically interpretable manner. Despite internati …

03.09.2026journal-article

Open Research Europe

Digital Passport Model Assessment Workbench: SHACL-based assessment, use-case coverage, and integration guidance for digital passport model ecosystems

Riccardo Boero, Miguel Las Heras Hernández

Digital Product Passports and Digital Material Passports are increasingly implemented through modular data model ecosystems that evolve across releases and interact with external sectoral models. This creates a practical model evaluation problem: model developers need reproducible evidence about model structure, constraint readiness, interoperability, use-case coverage, and integration risks before representative instance datasets are available. We present the Digital Passport Model Assessment Workbench (DP-AWB), a …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Cardiac safety of L-Annamycin: a pooled analysis of five clinical trials

Ziad Zalaquett, Stuart Waymack, Patrick Collier

Background Anthracyclines are highly effective chemotherapeutic agents but are limited by cumulative, dose-dependent cardiotoxicity, leading to strict lifetime exposure thresholds. L-Annamycin is a next-generation liposomal anthracycline designed to preserve antitumor efficacy while reducing cardiotoxicity. Methods We performed a pooled analysis of cardiac safety data from five sponsor- and investigator-initiated clinical trials evaluating L-Annamycin in acute myelogenous leukemia (AML) and metastatic soft tissue s …

03.09.2026journal-article

Frontiers in Oral Health

Validation of a commercial intraoral auto-segmentation algorithm against expert-annotated clinical data with comparison to a transparent algorithm

Rojin Adabdokht, Manuel Lagravere Vich, Thanandon Imaromkul, Kridsada Tosakparalerd, Victor de Miranda Ladewig, Wenji Cai, Chitian Ji, Hollis Lai

Introduction Artificial intelligence (AI)-based tooth segmentation has the potential to improve the efficiency and consistency of digital clinical workflows; however, the generalizability of commercially available algorithms on clinical datasets and their interpretability remain limited. Methods This study proposed a two-level evaluation method. It evaluated the performance of a black-box commercial algorithm using an expert-annotated clinical reference dataset of 126 intraoral scans representing diverse clinical p …

03.09.2026journal-article

Frontiers in Education

Application of the BOPPPS model combined with flipped classroom in clinical practice competency training for gastroenterology residents in standardized residency programs

Jiao Li, Juan Yang, Sheng Zheng

Background The bridge-in, objective, preassessment, participatory learning, postassessment, summary (BOPPPS) instructional model and flipped classroom pedagogy are increasingly recognized as effective active learning strategies in medical education. However, their combined application in gastroenterology residency training has not been systematically evaluated. This study investigated the impact of the BOPPPS + flipped classroom model on clinical practice competency, clinical thinking, self-directed learning, and t …

03.09.2026journal-article

Frontiers in Medicine

Work-related distress and professional quality of life in a medical-school workforce: a primary-care occupational-health perspective

Falah Mohammed Almarzooqi, Saif Al-Shamsi, Syed Fahad Javaid, Afaf Alblooshi, Faten AlRadini

Background Work-related distress may present in primary care through nonspecific physical, psychological, or functional complaints. This study assessed professional quality of life in a United Arab Emirates medical-school workforce through primary-care and occupational-health perspectives. Methods A cross-sectional electronic survey was conducted among employees of the College of Medicine and Health Sciences, United Arab Emirates University, between October 2025 and February 2026. The sampling frame comprised 373 e …

03.09.2026journal-article

Frontiers in Education

HarmonicThreads: a formative evaluation of a fabric-based digital musical instrument toward inclusive music-making

Ellie Nguyen, Franceli L. Cibrian

Background Inclusive music-making requires instruments that support varied bodies, abilities, musical backgrounds, and forms of participation. Digital musical instruments provide diverse approaches to sound creation, and fabric-based interfaces offer an alternative interaction modality that may support participation for some users and contexts. Their tactile and deformable properties enable forms of interaction that differ from conventional rigid or screen-based controllers and may offer inclusive possibilities in …

03.09.2026journal-article

Journal of Digestive Diseases

Clinical Impact of Endoscopic Ultrasound‐Guided Fine‐Needle Biopsy in Radiologically Suspected Pancreatic Neuroendocrine Tumors

Carolina González‐Abós, Ignacio Gil, Àngels Ginés, Guillem Soy, Oriol Sendino, Iván Archilla, Fabio Ausania

ABSTRACT Objectives Incidental diagnosis of pancreatic neuroendocrine tumors (PNETs) is increasing. Its surgical indication depends on the risk of progression, whereas histological features can be assessed by endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB). However, its systematic use remains a matter of debate. We aimed to analyze the impact of EUS‐FNB on therapeutic management in patients with radiologically suspected PNETs. Methods In this retrospective observational single‐center study, all patients w …

03.09.2026journal-article

Clinical Journal of Sport Medicine

Health-Related Quality of Life 5 to 15 Years Following Adolescent Sport-Related Injury: The SHRed Consequences of Injury Study

Chelsea L. Martin, Jean-Michel Galarneau, Keith O. Yeates, Araba Chintoh, Scott Ramsay, Carolyn A. Emery

Objectives: This study examined the association between adolescent (aged 11–18 years) sport-related concussion (SRC) or musculoskeletal (MSK) injury and long-term (ie, 5–15 years postinjury) health-related quality of life (HRQoL). Design: This was a substudy of a historical cohort study. Setting: This study was conducted in a university setting. Participants: Individuals who participated in adolescent sport 5 to 15 years before assessment were included in this study. Assessment of Risk Factors Variables: Reports of …

03.09.2026journal-article

Nutrients

Bioimpedance: From Body Composition Assessment to Emerging Technologies in Clinical Nutrition

Ruth Nekane Pita, Isabel María Fernández, Oibar Martínez, Jose Miguel Miranda

This review examines the physical foundations, predictive models, emerging technologies and recent research trends in bioimpedance for clinical nutrition. A bibliometric analysis of cumulative scientific production from 1980 to 2025 shows that weighted logistic models provide a good descriptive fit to the evolution of the literature (R2 ≥ 0.999). Bioimpedance research remains in an expanding phase, with its projected inflection point lying beyond 2026. These fits are descriptive and model-dependent: high coefficien …

03.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

ARTIFICIAL INTELLIGENCE, BLENDED LEARNING, AND DISTANCE EDUCATION: CONTRIBUTIONS OF AI TO ONLINE DISTANCE LEARNING

Marcelo Henrique Pinto, Angela Luci de Oliveira Amador, Eduardo Belarmino Dos Santos, Eliene Gomes de Souza, Kênya Maquarte Gumes Bregensk, Kely Eloir de Campos, Patricia de Cassia Silva Gontijo

The study addressed Artificial Intelligence (AI), blended learning, and Distance Education, emphasizing the possibilities and limitations of automated content generation applied to online learning. The research was guided by the following question: what were the possibilities and limitations of automated content generation through Artificial Intelligence in the context of online learning and Distance Education? The general objective was to analyze the possibilities and limitations of automated content generation th …

03.09.2026journal-article

Clinical Phytoscience

Nanocarrier-enabled restoration of miR-34a by Ailanthus excelsa Roxb. phytochemicals directly target NOTCH1 signaling to suppress cancer stemness in triple-negative breast cancer

Cletus Anes Ukwubile, Ahamefula Anslem Ahuchaogu, Anietie Eyo Robert, Hassan Braimah Yesufu, Jude Amakaeze Odugu, Patrick Akoji Ida, Emmanuel Oise Ikpefan

Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype associated with poor prognosis, metastasis, and limited targeted therapies. This study developed a folate-functionalized chitosan nanoparticle system targeting the miR-34a/NOTCH1 signaling axis and evaluated its anticancer potential using in vitro, in vivo, and bioinformatics approaches. Methods Nanoparticles were synthesized by ionic gelation and characterized for size, surface charge, polydispersity, and drug-rel …

03.09.2026journal-article

Current Environmental Health Reports

Assessing the Impact of Cool Roofs on Health and Wellbeing: A Scoping Review

Noah Bunkley, Melanie Stowell, Chris Bullen

Abstract Background Extreme heat poses a threat to the health and wellbeing of millions of people worldwide living in climate-vulnerable housing. Cool roofs are a potential passive-cooling housing retrofit solution that is affordable and scalable to reduce heat exposure and improve community health and wellbeing. Objective To conduct a scoping review to systematically identify and map the research addressing the effect of residential cool roofs on health and wellbeing, identify knowledge gaps, and inform the design …

03.09.2026journal-article

Journal of Risk and Financial Management

Exploring a Potential Capability–Adoption Gap in Digital Financial Adoption Intentions: Evidence from a Fragile Post-Crisis Economy

Jeanne Laure Mawad, Nouhad Mawad, Anthony Nehme

Digital finance research generally assumes that greater financial and technological capabilities lead to higher adoption of digital financial services. However, this assumption has rarely been examined in fragile economies where institutional trust and financial system stability have been severely disrupted. This study investigates whether capability-based explanations of digital financial adoption remain valid in a post-crisis environment. Drawing on a capability–behaviour–intention framework, the study examines t …

03.09.2026journal-article

Microbiology Resource Announcements

Genome assembly and annotation of two clinical Naegleria fowleri isolates from Costa Rica

Nina Allouch, Lissette Retana Moreira, Nalhyte Aurago, Elizabeth Abrahams Sandí, Isabel Marcelino

ABSTRACT Here, we report the genome assembly and annotation of two clinical isolates of Naegleria fowleri from primary amebic meningoencephalitis cases in Costa Rica in 2020 using Illumina sequencing. Each assembly comprised 37 reference-guided scaffolds, with genome sizes of approximately 28 Mbp and a GC content of 36.87%.

03.09.2026journal-article

Social Inclusion

Locked In, Logged Out: Digital Participation of Residents in Danish Carceral Facilities

Pavlos Chatzipolakis, Nina Boulus‐Rødje

Digital tools are no longer supplementary features of modern life but constitutive to it, and exclusion from digital participation increasingly means exclusion from public services, employment, and social life. For incarcerated residents, this exclusion compounds existing disadvantages and undermines the reintegration process that penitentiary institutions are expected to facilitate. This is particularly consequential in Denmark, one of the most digitalized societies in the world, where all civic services are acces …

03.09.2026journal-article

Studia Humanitatis Journal

Sociedad digital y transformación algorítmica del Estado: fundamentos conceptuales y jurídicos para el análisis de la inteligencia artificial en la sanidad pública

Aliaksandra Savostsikava

This article examines the origins and development of artificial intelligence (AI) in the digital society, highlighting its transition into a widely accessible tool with significant implications for all areas of society. Particular attention is paid to the legal challenges arising from the use of AI in public healthcare, including transparency, data protection, algorithmic bias, and liability for harm caused by automated systems.The study analyses international and European approaches to AI governance, including ini …

03.09.2026journal-article

Reviu Akuntansi, Manajemen, dan Bisnis

Digital Transformation and Firm Performance: The Moderating Role of CFO co-optation

Astrid Rudyanto, Vonny Carolina, Friska Firnanti, Indra Arifin Djashan

Abstract Purpose: This study tests whether digital transformation affects firm accounting performance in Indonesian manufacturing firms, and whether CFO co-optation moderates that effect. Research Methodology: The study draws a panel of 285 firm-year observations from 95 manufacturing firms listed on the Indonesia Stock Exchange between 2022 and 2024, sourced from audited annual reports and financial statements. The study measures digital transformation through text-mining keyword frequency in annual reports and co …

03.09.2026journal-article

Demidov Law Journal

Цифровая трансформация труда: баланс рабочего времени и времени отдыха

Aziza A. Matyakubova

The article is devoted to the study of the problems of legal regulation of the institutions of working time and leisure time in the era of digital transformation of the Russian Federation's economy. Based on statistical data and judicial practice, the author analyzes the most common digital control tools used by employers. The widespread use of social networks and messengers as means of work communication allows the author to identify the problems of "blurring the boundaries of working time and leisure time" The an …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Evaluating feasibility of ferritin assay harmonisation with commutable proof-of-concept reference materials and EQA-based monitoring

Moniek M. Bioch, Rogier M. Schoeman, Cas W. Weykamp, Hans van der Vuurst, Aldy W.H.M. Kuypers, Fokke A. Lindeboom, Marieke A.M. Frasa, Antonius E. van Herwaarden, Dorine W. Swinkels, Marc H.M. Thelen

Abstract Objectives Clinical interpretation of ferritin is hindered by between-assay differences, persisting despite the introduction of different generations of WHO standard. To aid harmonisation efforts, this study investigates the commutability of External Quality Assessment (EQA) materials, proof-of-concept reference materials (cRMs), and the newest generation of WHO standard (19/118). Methods Four multi-level serum-based cRMs, 50 clinical samples, four EQA materials, and WHO 19/118 were measured with Abbott Al …

03.09.2026journal-article

Clinical Spine Surgery

Biomechanical Comparison of Skip Laminectomy and Laminoplasty in the Lower Cervical Spine

Mert Arslan, Can Şensöğüt, Taner Arslan, Buğra Hüsemoğlu, Ceren Kizmazoglu, Ahmet Karakaşlı, Murat Yılmaz

Study Design: Controlled experimental biomechanical study using a sheep cervical spine model. Objective: To biomechanically evaluate and compare skip laminectomy and laminoplasty in the lower cervical spine, focusing on their influence on spinal stability. Summary of Background Data: Skip laminectomy and laminoplasty are 2 posterior cervical surgical techniques widely used for spinal canal decompression. Although their clinical outcomes have been compared, no previous study has biomechanically analyzed and compared …

03.09.2026journal-article

International Tax and Public Finance

When are digital services taxes optimal? Output taxes and profit shifting

Johannes Becker

Abstract Motivated by the introduction of digital services taxes (DSTs) in several European countries and the widespread use of revenue-based taxes where profit taxation is imperfect, this paper studies whether targeted output or commodity taxes can serve as surrogate profit taxes when firms avoid corporate taxation – such as by shifting profits to low-tax jurisdictions. The answer is a qualified yes. Output taxation of tax-avoiding firms is optimal when the resulting reduction in output mitigates tax avoidance. I …

03.09.2026journal-article

Journal of Global Social Transformation

Digital Technology Competencies and Teaching-Learning Engagement among University Faculty: A Thematic Analysis of Academics' Perspectives

Zarmina Khalid, Nargis Abbas

The present study aimed to investigate digital technology competencies of university faculty and factors affecting teaching-learning process in the context of digital technology integration in higher education Institutions of the Punjab, Pakistan. A qualitative approach was adopted, semi-structured interviews conducted to gain detailed insights into faculty member’s experiences, practices and views regarding the use of digital technologies in teaching. Participants were selected through purposive sampling based on …