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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Lasers in Medical Science

The role of bipolar radiofrequency in the treatment of vaginal laxity: a single-center cohort study in premenopausal women

Pablo González Isaza, Diana Velez, Manuela Cerón, Mary Ríos, Diana Carolina Bermúdez, Jahir Alexander Soto-Mora

Abstract Vaginal laxity is a prevalent condition that can impair sexual function. Bipolar radiofrequency (RF) is a minimally invasive treatment; however, prospective evidence remains limited. This study aimed to evaluate changes in both subjective and objective measures of vaginal laxity following bipolar RF. This prospective observational study enrolled premenopausal women with symptomatic vaginal laxity who received four intravaginal bipolar RF sessions. The primary outcome was the change from baseline to 6 month …

01.09.2026journal-article

ASM Case Reports

Toxoplasmosis-associated hemophagocytic lymphohistiocytosis during tumor-infiltrating lymphocyte therapy

Tariq Odeh, Priscilla Quach, Amin Mostofizadeh, Julia D. Hankins, Robert Hamilton-Seth, Chelsea Gorsline

ABSTRACT Background Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome triggered by infections, malignancies, or autoimmune disorders. Tumor-infiltrating lymphocyte (TIL) therapy requires lymphodepleting chemotherapy and interleukin-2, producing profound immunosuppression. While HLH-like syndromes have been characterized after chimeric antigen receptor T-cell therapy, HLH has not been reported in the setting of TIL therapy. Toxoplasma gondii is a recognized but uncommon parasitic trigge …

01.09.2026journal-article

Antibodies

Advances in Bispecific Antibodies and Antibody–Drug Conjugates for Colorectal Cancer Treatment

Maya G. Cappellino, Sean P. Sullivan, Peyton C. High, Tiffani A. Blackburn, Kendra S. Carmon

Bispecific antibodies (bsAbs) and bispecific antibody–drug conjugates (bsADCs) represent promising classes of emerging targeted therapeutics with the potential to overcome tumor heterogeneity and resistance in colorectal cancer (CRC). BsAbs can simultaneously engage multiple tumor antigens or immune cells or bind two distinct epitopes within a single target, enabling mechanisms of action beyond the capabilities of monoclonal antibodies. Bispecific T cell engagers facilitate targeted destruction of tumors through im …

01.09.2026journal-article

ACS Nano

Oncogenic KRAS Regulates Secretion of Extracellular Vesicles and Surface Membrane Charge via Regulation of Phosphatidylserine in Pancreatic Cancer

Paul A. Spezza, Kshipra S. Kapoor, Beatrice P. Pforr, Xin Luo, Kaira A. Church, Martin M. Bell, Bo Fan, Seoyun Kong, Elena V. Ramirez, Yi-Lin Chen, Fernanda G. Kugeratski, Sibani Lisa Biswal, Kathleen M. McAndrews, Florian Gebauer, Christoph Kahlert, Jacob T. Robinson, Raghu Kalluri

Abstract Extracellular vesicles (EVs) have the potential to be used as a liquid biopsy for cancer detection and treatment response assessment. Although the potential of EVs as disease-specific biomarkers has been promising, the rapid and specific enrichment of EVs from body fluids in a clinical setting remains challenging. To address this limitation, we developed a microfluidic electrophoresis (MEP) device for the label-free, charge-based enrichment of EVs from the serum of patients with pancreatic cancer (PaCa). W …

01.09.2026journal-article

Journal of Physical Activity and Health

Understanding the Effects of Cancer-Related Factors on the Association Between Physical Activity and Quality of Life in Breast Cancer Survivors

Erica Schleicher, Wendy Demark-Wahnefried, Gregory Pavela, Kevin Fontaine, Nataliya Ivankova, Maria Pisu, Michelle Y. Martin, Yu-Mei Schoenberger-Godwin, Robert A. Oster, Kelly Marie Kenzik, Laura Q. Rogers

Background : Breast cancer survivors often experience physical and mental side effects posttreatment, compromising their quality of life (QoL). The increasing number of survivors coping with long-term side effects creates public health concerns, emphasizing the need for supportive interventions. Although physical activity (PA) benefits cancer survivors, few studies examine the effect that cancer-related factors have on the relationship between PA levels and QoL among breast cancer survivors. Understanding the assoc …

02.09.2026journal-article

The Oncologist

67 Foundation Model Embeddings Identify Spatial Restructuring Associated with Immunotherapy Treatment Derived from Hemoxylin and Eosin Images

Alex Soupir, Steven Eschrich, Mitchell Hayes, Lauren Peres, Brandon Manley

Abstract Background Patients with clear cell renal cell carcinoma (ccRCC) who receive immunotherapy in the first line setting commonly respond to treatments yet the majority develop resistance. A minority of patients will present with primary resistance to immunotherapy, making predicting patients’ response to immunotherapy a critical milestone in deciding appropriate treatment plans given the expanding list of options available. Hemoxylin and Eosin (H&E) images are frequently obtained through clinical care and con …

02.09.2026journal-article

The Oncologist

50 Tumor–Myeloid Multicellular Programs Reveal ECM-Associated Macrophage Polarization in ccRCC

Katsuhiro Ito, Soki Kashima, Rishabh Rout, Zhaochen Ye, Nicholas Schindler, Zachary Yochum, Toni Choueiri, David Braun

Abstract Background Clear cell renal cell carcinoma (ccRCC) is characterized by a highly heterogeneous tumor immune microenvironment. However, how tumor-intrinsic programs shape immune cell states remains incompletely understood. We aimed to identify multicellular programs (MCPs) linking tumor and immune compartments and to define tumor-derived signals that modulate immune phenotypes. Methods We applied DIALOGUE to identify MCPs across tumor and non-tumor compartments, including CD8+ T cells, CD4+ T cells, regulato …

01.09.2026journal-article

Diseases of the Colon & Rectum

Delays in Diagnosis of Early-Onset Colorectal Cancer Across the United States: A Systematic Review

Maedeh Marzoughi, Evan Monge, Sarah Bradley, Mark P. MacEachern, C. Ann Vitous, Andrew J. Read, Pasithorn A. Suwanabol

BACKGROUND: Early-onset colorectal cancer is now the leading cause of cancer death among adults under 50, with delays in diagnosis cited as a potential contributor to patients being diagnosed more frequently at advanced stages than their older counterparts. Despite this, few studies have comprehensively evaluated factors associated with diagnostic delays among patients with early-onset colorectal cancer in the United States. OBJECTIVE: To synthesize factors contributing to early-onset colorectal cancer diagnostic d …

01.09.2026journal-article

Health Science Reports

Health Status in Informal Urban Settlements of Barishal, Bangladesh: Social Determinants, Environmental Risks, and Treatment‐Seeking Behavior as Structural Drivers

Md. Ohidur Zaman, Farjana Afroz, Nahida Sultana, Dipti Ranjan Sahu

ABSTRACT Background Rapid urbanization in low‐ and middle‐income countries has intensified health inequalities within informal settlements, yet empirical analyses often isolate behavioral factors from structural determinants. In Bangladesh, unplanned urban growth has produced vulnerable settlements where social inequalities intersect with infrastructural deficits, particularly in secondary coastal cities such as Barishal, a climate‐sensitive region characterized by migration, poverty, and weak municipal capacity. A …

03.09.2026journal-article

CPT: Pharmacometrics & Systems Pharmacology

Semi‐Mechanistic Modeling of S‐531011, a Humanized Anti‐ CCR8 Monoclonal Antibody, for Prediction of CCR8 Receptor Occupancy in Human Tumor Tissues

Daichi Yamaguchi, Wataru Nogami, Yudai Sonoda, Hitomi Morihara, Takayuki Katsube

ABSTRACT Semi‐mechanistic modeling approaches could be useful for optimal dose selection, and one of the approaches is pharmacokinetic (PK)/receptor occupancy (RO) model for monoclonal antibodies. This study aimed to develop a semi‐mechanistic PK/RO model of S‐531011, a humanized monoclonal antibody against human CCR8 and under development for the treatment of solid tumors, in order to predict human RO values in tumor tissues which are not available in the ongoing clinical study. The model consists of three compart …

01.09.2026journal-article

Coatings

Composition, Structure, Microhardness, and Ion-Release Behavior of Zn-Modified Ti-35Nb-2Ta-3Zr Alloy After Friction Stir Processing and Compression Plasma Flow Treatment

Ruslana Pavukova, Yi Mao, Yu-Wei Cui, Vladimir Uglov, Sergey Zlotski

Ti-35Nb-2Ta-3Zr (TNTZ) β-titanium alloy is attractive for biomedical applications because of its relatively low elastic modulus and composition based on nominally non-cytotoxic alloying elements; however, its surface hardness and intrinsic bioactivity remain limited. In this study, Zn nanoparticles were incorporated into the near-surface region of TNTZ by friction stir processing (FSP), followed by compression plasma flow (CPF) treatment in nitrogen. Cross-sectional scanning electron microscopy and energy-dispersiv …

01.09.2026journal-article

PLOS One

Association of MDM2 rs2279744 and rs937282 polymorphisms with breast cancer susceptibility and circulating MDM2 and p53 levels in Bangladeshi women: A case-control study

Mahim Hassan Chowdhury, Farzana Islam, Adiba Ayesha Khan, Md. Ayman Siddique, Nushaiba Binte Hasan, Mahinul Islam Samrat, Mehrin Haque Tanisha, Jarin Tasnim, Samiha Mahjabin, Md. Nazmul Islam, Md. Aminul Haque

Background The MDM2–p53 signaling pathway plays a central role in tumor suppression, and genetic variants that disrupt this pathway may influence breast cancer (BC) susceptibility. However, data from South Asian populations, particularly Bangladesh, remain limited. Methods A case–control study was conducted in Bangladeshi women, including BC patients and healthy controls (HCs). Genotyping of MDM2 polymorphisms was performed using PCR-based methods. Circulating MDM2 and p53 protein levels were measured using enzyme- …

01.09.2026journal-article

International Endodontic Journal

Tooth‐Level Radiation Dosimetry and Outcomes of Root Canal Treatment in Irradiated Patients: A Retrospective Cohort Study

Sandra Ming Shu Chen, Siwen Wu, Yu Fan Sim, Boon Fei Tan, Yoke Lim Soong, Victoria Soo Hoon Yu, Jeen‐Nee Lui

ABSTRACT Background Root canal treatment (RCT) is recommended for compromised teeth in patients with radiation therapy (RT) for head and neck cancer (HNC), to minimise extraction‐related osteoradionecrosis (ORN). However, literature on endodontic outcomes in irradiated patients is scarce. This retrospective clinical study aimed to investigate healing outcome, survival, and their associated prognostic factors in teeth that received non‐surgical RCT in irradiated HNC patients. Methods Patients who underwent RT for HN …

01.09.2026journal-article

Cancers

Electromagnetic Surgical Navigation for Accurate Pediatric Tumor Localization: A Preclinical Animal Cadaver Study

Jasper M. van der Zee, Marijn A. J. Hiep, Vera J. van Boheemen, Guus M. J. Bökkerink, Wout J. Heerink, Matthijs Fitski, Michiel A. J. van de Sande, Stefanie Veraa, Marc H. W. A. Wijnen, Harald C. Groen, Alida F. W. van der Steeg

Background: Localization of non-palpable, non-visible, and difficult location tumors in children can be surgically complex. Incomplete resections upstage the tumor, leading to a significant reduction in survival and the intensification of adjuvant treatment, affecting quality of life. Surgical navigation set-ups showed promising results in adults but have not yet been validated in complex pediatric oncology surgery. In this study, an in-house developed electromagnetic surgical navigation set-up was evaluated in a p …

01.09.2026journal-article

Frontiers in Immunology

Age and sex: dual drivers remodeling the anti-tumor immune microenvironment and shaping personalized immuno-oncology

Yipeng Wang, Tianshu Wang, Ying Xi, Yihan Wang, Yibo Bai, Tao Zhang

Despite breakthrough advancements in cancer immunotherapy, significant inter-individual heterogeneity in clinical outcomes persists, bringing the regulatory roles of intrinsic host biological variables into sharp focus. Accumulating fundamental and clinical evidence indicates that age and sex play crucial roles in determining tumor susceptibility, disease progression, and the remodeling of the anti-tumor immune microenvironment. This review systematically delineates the profound impacts of the dual dimensions of ag …

01.09.2026journal-article

Cancer Research

Fasting-Mimicking Diets Reprogram Cancer-Associated Fibroblasts to Reverse the Immunosuppressive Tumor Microenvironment in Breast Cancer

Junsheng Zhang, Ning Li, Rongrong Li, Yitian Chen, Charles R. Ashby, Yuhui Tang, Yajie Sun, Xiaoming Xie, Zhe-Sheng Chen, Lu Yang

Abstract Fasting-mimicking diets (FMD) have been reported to increase the antitumor efficacy in preclinical studies in various cancers. FMD can affect the tumor microenvironment (TME), and elucidating the mechanisms and cells mediating the effects of FMD may uncover combination treatment strategies. Here, we performed single-cell transcriptomic sequencing to characterize the TME changes induced by FMD intervention in a mouse model of spontaneous breast cancer. The sequencing data indicated that FMD suppressed tumor …

01.09.2026journal-article

Journal of the American College of Surgeons

Suction vs Water Seal for Initial Treatment of Traumatic Pneumothorax Trial (SEAL IT): A Pragmatic Cluster-Randomized Study

Eric O Yeates, Bradley M Dennis, David Xiao, Praveen Vimalathas, Mayur B Patel, Andrew Medvecz, Amelia Maiga, Stephen P Gondek, Allan B Peetz

Background: Chest tubes for traumatic pneumothorax are commonly managed with initial suction before transition to water seal, despite limited evidence supporting this practice. We hypothesized that initial water seal would reduce chest tube duration without increasing complications. Study Design: We conducted a single-center, pragmatic, month-based cluster-randomized study of adult trauma patients with pneumothorax requiring chest tube placement from October 2024 to May 2025. Patients with a hemothorax component >3 …

03.09.2026journal-article

Small Structures

Gold Nanorod‐Loaded Separable Microneedle Patches as NIR‐Responsive Immunosuppressant Delivery System for Psoriasis Synergetic Treatment

Wenzhao Li, Kexin Yi, Yu Wang, Jingjing Gan, Luoran Shang

As a chronic, immune‐mediated condition, psoriasis manifests through the dysregulated proliferation of keratinocytes and the recruitment of assorted inflammatory cells into the skin. Immunosuppressants and photothermal therapy are both effective strategies. However, their applications are often challenged by systemic side effects or low efficiency of topical therapies. To address this, we developed a synergistic treatment strategy using a near‐infrared (NIR)‐responsive separable microneedle patch for NIR‐triggered …

01.09.2026journal-article

JCO Global Oncology

Global Disparities in Melanoma Incidence, Mortality, and Mortality-to-Incidence Ratio: An Analytical Framework Using the Human Development Index

Roberto Paz-Manrique, Joseph A. Pinto, Bruno Muñante, Henry L. Gomez

PURPOSE This study aimed to evaluate global disparities in melanoma incidence, mortality, and the mortality-to-incidence ratio (MIR) across countries according to the Human Development Index (HDI) and selected socioeconomic indicators. METHODS We conducted an ecologic study using age-standardized melanoma incidence and mortality data from GLOBOCAN 2022 and socioeconomic variables—including HDI, education indicators, life expectancy, and gross national income—from the World Bank for 165 countries. MIR was calculated …

01.09.2026journal-article

Journal of Oncology Pharmacy Practice

CAR-T cell therapy in advanced practice nursing management. A Statistical and Large Language Model approach to highlight critical issues

Elsa Vitale, Luana Conte, Giuliana Nepoti, Camilla Munaretto, Giorgio De Nunzio, Anna Vaccaro

Aim To gather nurses’ perceptions nursing hematologic management on patients undergoing CAR-T cell therapy. A combined approach using statistical analysis and Large Language Model for open-ended questionnaire processing (LLMs) was adopted to analyze and interpret open-ended questionnaire responses, focusing on the critical issues in managing patients’ post-CAR T-cell therapy infusion. Design Observational questionnaire-based survey study. Methods We analyzed data through descriptive statistical methods and used gen …

04.09.2026journal-article

BMJ Open

Decision aids for life-sustaining treatment, including withholding or withdrawal and end-of-life care in emergency and intensive care settings: a scoping review protocol

Michihiro Tsubaki, Koiki Saito, Hanako Kanayasu, Ryoko Ikari, Kenshin Yamamoto, Ayano Yamane, Yoshiyasu Ito

Introduction Decisions regarding life-sustaining treatment and end-of-life care are among the most ethically complex and emotionally challenging decisions encountered in emergency departments and intensive care units. Such decisions frequently involve uncertainty regarding prognosis, limited time for deliberation and situations in which patients may lack decision-making capacity, requiring family members or surrogate decision-makers to participate in the decision-making process. Shared decision-making (SDM) has inc …

01.09.2026journal-article

Radiology: Imaging Cancer

Proof-of-Concept Study of Hyperpolarized [1- 13 C]Pyruvate MRI in Participants with Hepatocellular Carcinoma

Uffe Kjærgaard, Nikolaj Bøgh, Malene Aastrup, Mattias Hedegaard Kristensen, Nichlas Vous Christensen, Kim Sivesgaard, Steffen Ringgaard, Lotte Bonde Bertelsen, Esben Søvsø Szocska Hansen, Henning Grønbæk, Gerda Elisabeth Villadsen, Christoffer Laustsen

Hyperpolarized [1- 13 C]pyruvate MRI enabled noninvasive metabolic characterization of focal liver lesions, and alanine-indexed metrics emerged as biological markers of progression to hepatocellular carcinoma beyond CT/MRI–based Liver Imaging Reporting and Data System categorization.

01.09.2026journal-article

Revista Mexicana de Investigación Médica

Percepción del apoyo social en pacientes pediátricos con cáncer de Una Nueva Esperanza, Puebla.

Alfonso Elias González Acevedo, Elizabeth Mainou Reyes, Martha Eugenia Juárez Martínez, Rosalba Yazmin Barrera Tlapa, Jesús Meneses Hernández, Alfonso Carús Sánchez, Danya Montserrat Tello Vallejo, Yelitza Soledad Toscano Escobar, Brandon Robin Peña Bohórquez, Fátima del Rocío Sosa Pavón, Samantha Naomi Ramos Corona, Rosaura Sánchez Berber, Thomas Merluzzi, Ma. del Rocío Baños Lara

Childhood cancer has a negative impact on the lives of affected children, affecting them socially, emotionally, and in terms of their development. Social support (SS) influences a patient’s adaptation, adherence to treatment, and well-being; receiving SS from the time of diagnosis can prevent negative psychological consequences. Una Nueva Esperanza A.B.P. (UNE) is a nonprofit organization that supports low-income children with cancer by offering comprehensive treatment. The objective of this study was to determine …