Gold Nanorod‐Loaded Separable Microneedle Patches as NIR‐Responsive Immunosuppressant Delivery System for Psoriasis Synergetic Treatment

Vollständiger Abstract

Worum geht es in dieser Arbeit?

As a chronic, immune‐mediated condition, psoriasis manifests through the dysregulated proliferation of keratinocytes and the recruitment of assorted inflammatory cells into the skin. Immunosuppressants and photothermal therapy are both effective strategies. However, their applications are often challenged by systemic side effects or low efficiency of topical therapies. To address this, we developed a synergistic treatment strategy using a near‐infrared (NIR)‐responsive separable microneedle patch for NIR‐triggered photothermal activation and on‐demand immunosuppressant delivery. Gold nanorods (AuNRs), serving as both photothermal agents and drug nanocarriers, were loaded with an immunosuppressant and encapsulated into detachable microneedle tips. Upon NIR irradiation, the AuNRs induce localized hyperthermia, which provides direct thermal stimulation to psoriatic lesions and accelerates the release of the immunosuppressant at the target site. In a psoriasis mouse model, the system demonstrated significant therapeutic efficacy, effectively alleviating symptoms. This microneedle system synergistically combines controlled drug release and photothermal treatment, presenting a versatile and promising approach for managing psoriasis effectively, with significant potential for broader biomedical use.