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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Buildings

The Impact of Perceived Community Environmental Quality on Residents’ Psychological Well-Being from the Perspective of Homo Urbanicus Theory: The Mediating Role of Perceived Environmental Restorativeness and Age Differences Among Older Adults

Chenda Guo, Jiale Fei, Wenjia Li, Lujie Liu, Liusha Chen

With the advancement of healthy city development and community renewal practices, the influence of perceived community environmental quality on residents’ psychological well-being has attracted increasing attention. Previous research has shown that the built environment is closely related to residents’ well-being; however, most studies have focused on objective spatial elements or facility provision and have paid insufficient attention to the mechanisms through which subjective environmental perceptions operate in …

25.08.2026journal-article

Alzheimer Disease & Associated Disorders

Using a Survey to Monitor Participant Experience in a Population-Based Study of Older Adults

Isabella Wood, Erin Jacobsen, Tiffany Hughes, Mary Ganguli

Consumer surveys are increasingly used in business and clinical practice, but less so in human subjects research. Within a longitudinal, population-based study of older adults, we administered a survey to monitor participants' experiences and address potential challenges. We invited participants to provide feedback on their study experience following their annual interviews, using a survey with Likert-scale questions and open-ended comments. In the first round of surveys between 2022 and 2024, 82% responded who wer …

25.08.2026journal-article

Psychological Reports

The Role of Family Functioning and Sense of Coherence in the Relationship Between Social Support and Perceived Stress in Community-Dwelling Older Adults

Leandro da Silva-Sauer, André Luiz de Carvalho Braule Pinto, Gustavo Souza Zanatta, Andresa Cortez Guimarães, Ana Cláudia de Souza Pinto Oliveira, Bernardino Fernández-Calvo

This study examined how social support influences perceived stress in older adults, testing family functioning and sense of coherence (SOC) as serial mediators within a theoretically grounded model. Given the cross-sectional design, the analysis adopted an exploratory framework, conceptualizing SOC as a cognitive-emotional resource shaped by relational factors and instrumental in regulating individuals’ stress responses. Participants were 361 community-dwelling older adults in Brazil ( M = 67.32, SD = 5.77). Social …

25.08.2026journal-article

Nutrients

Associations of Meal Timing and Temporal Eating Patterns with Cardiovascular Disease Among Chinese Older Adults

Lingfang Wang, Jinghai Li, Jiaming Fang, Shulei Chen, Jingle Peng, Huiqing Ye, Hongying Shi

Background: Direct evidence linking meal timing to cardiovascular disease (CVD) remains limited. This study examined the associations of meal timing and temporal eating patterns with prevalent CVD among Chinese older adults. Methods: From September 2021 to October 2025, 1386 community-dwelling adults aged ≥60 years from various socioeconomic regions of China were interviewed face-to-face. Meal timing (breakfast, lunch, and dinner timing) and sleep–wake schedules (wake-up and bedtime) were collected using standardiz …

25.08.2026journal-article

Frontiers in Aging

Adaptive immune cells and kidney function in older adults: sex-specific associations in the health and retirement study (HRS)

Shannon M. Sullivan, Bibin Joseph, Shweta Sharma, Weihua Guan, Amy B. Karger, Jessica Faul, Bharat Thyagarajan

Background Chronic kidney disease (CKD) is characterized by chronic inflammation and immune dysregulation. Aging of the adaptive immune system, marked by a shift from naïve to memory T-cell phenotypes, is associated with systemic “inflammaging”, but sex-specific associations between these immunophenotypes and kidney function in older adults remain poorly understood. Methods We analyzed cross-sectional data from 8,970 participants (aged ≥56 years) in the 2016 Health and Retirement Study (HRS) Venous Blood Study. Sev …

25.08.2026journal-article

The Journal of Cardiovascular Aging

CARD10 deficiency attenuates myocardial infarction associated with enhanced cardiac fibroblast senescence

Yueyue Xu, Yiwei Yao, Yueyun Zhou, Ganyi Chen, Yafeng Liu, Yunfei Jiang, Xu Cao, Wanlin Li, Yide Cao, Wen Chen, Xin Chen

Aim: Myocardial infarction (MI) causes cardiomyocyte death and triggers tissue repair and remodeling processes orchestrated by multiple cell types, particularly cardiac fibroblasts (CFs). Caspase recruitment domain-containing protein 10 (CARD10) has been implicated in mitochondrial function and aneurysm formation; however, its role in MI is not clear. To investigate the potential role of CARD10 in MI and the underlying mechanisms. Methods: CARD10 expression and localization were analyzed by Western blot and immunof …

25.08.2026journal-article

European Journal of Health Law

The Directiveness of Advance Directives. Performing Euthanasia on Individuals with Severe Dementia

Jasper Doomen

Abstract This paper inquires whether performing euthanasia in accordance with an advance directive is acceptable in the case of individuals with severe dementia. Specifically, the Convention on the rights of persons with disabilities is examined to determine whether it provides the basis to perform euthanasia in these cases. The meaning of certain values in particular is analysed, namely, equality, (legal) personhood, autonomy, freedom, dignity and physical and mental integrity. The intricate aspect of the identity …

25.08.2026journal-article

Uluslararası Sağlık Bilimlerinde Disiplinler Arası Etkileşim Dergisi

The Role of NLRP3 Inflammasome in Aging and Age-Related Diseases

Ayşe BAŞARAN

The world's population is rapidly aging, and the number of age-related diseases is increasing. Researchers are focusing particularly on chronic low-grade inflammation as they strive to understand and address the complex mechanisms of aging. NOD-like receptor protein 3 (NLRP3), a key regulator of the innate immune response, initiates inflammation by recognizing pathogens and damage-related molecular patterns. Functional NLRP3 plays a role in age-related diseases. Investigating the mechanisms that regulate the NLRP3 …

25.08.2026journal-article

Current Oncology

Tumor Characteristics and Event Free Survival in Older and Younger Women with Early Breast Cancer

Samantha Kodikara, Alexis C. Wardell, Allison M. Deal, Annie Page, Hyman B. Muss, Kirsten A. Nyrop

Background: Age, race, body mass index (BMI), breast density, parity, smoking and alcohol use are associated with increased risk for breast cancer. These factors, as well as tumor characteristics, treatment regimens and comorbidities, are analyzed for associations with five-year event free survival (EFS) in a sample of women with Stage I-III breast cancer who received chemotherapy with curative intent. Methods: EFS was defined in terms of breast cancer recurrence, second primary, metastasis, and overall survival. A …

25.08.2026journal-article

Frontiers in Public Health

Mental health implications in the older adults of internet access in China

Chi Zhang, Lue Zhou, Xiaoyu Cheng

Social isolation is a significant factor contributing to mental health issues among the older adults, particularly in societies experiencing rapid population aging. Notably, digital technology offers an effective means to address this issue. However, little is known that how access to internet affects the mental health of the older adults. Based on the China Longitudinal Aging Social Survey (2018–2020) data, a national representative data, this study explored the impact of internet access on the older adults mental …

25.08.2026journal-article

Communicable Diseases Intelligence

ATAGI targeted review 2025: Immunisation considerations for immunocompromised people in Australia

Xia Wang, Phoebe Williams, Ketaki Sharma, Helen Quinn, Sanjay Jayasinghe, Clayton Chiu, Kristine Macartney, Katie Flanagan, Kristy Cooper, Benjamin Teh, Michelle Giles, Nigel Crawford

Vaccination plays a pivotal role in protecting people who are immunocompromised, and who may therefore be at increased risk of infectious diseases, including vaccine preventable diseases (VPDs). However, there are special challenges in clinical practice and the development of immunisation policies to accurately address the vaccination needs of this heterogeneous population. This review aims to highlight the immunisation needs and challenges of immunocompromised populations, and to summarise the rationale behind the …

25.08.2026journal-article

BJPsych Open

Insight into cannabis use disorder in people with psychotic disorders

Edward Chesney, Millie Lloyd, Sebastien Brodeur, Arsime Demjaha, Lisa Conlan, Ikram Slimani, Ayşe Doğa Lamper, Ananya Sarma, Will Lawn, Dominic Oliver, Tom P. Freeman, Robin Murray, Marta Di Forti, Amir Englund, John Strang, Philip McGuire

Background Cannabis use is common in people with psychosis and is associated with poor outcomes. Aims To assess insight into cannabis use disorder, perceptions about how cannabis use influences mental health and the desire to change cannabis use among people with psychotic disorders. Method Adults with a psychotic disorder and comorbid cannabis use disorder were asked about the impact of cannabis use on their illness and their desire to change cannabis use. Cannabis use disorder was determined using DSM-5 criteria. …

25.08.2026journal-article

Frontiers in Sports and Active Living

Effect of wearables with behavioral prompts on physical and cognitive outcomes in community-dwelling older adults: preliminary results of a pilot randomized controlled trial

Kar Yin Lee, Savannah Siew, Tat Lee Teo, Kuang Chua Chua, Junhong Yu, Rathi Mahendran, Iris Rawtaer

Introduction The global rise in life expectancy has driven research into aging-related vulnerabilities, particularly cognitive frailty. Physical activity interventions have been identified as a protective factor, and technology, such as wearable devices, may enhance engagement. This pilot RCT explores mobile phone applications and smartwatch-based interventions to promote physical activity and improve cognitive health in older adults. Methods This single-blind pilot RCT enrolled 53 adults aged 60–85 in Singapore th …

25.08.2026journal-article

Pain Medicine

Central Sensitization and Cognitive Vulnerability: A Neurobiological Framework for CNS Resilience and Brain Aging

Kevin V Hackshaw

Abstract Objective Preservation of central nervous system (CNS) resilience during midlife is increasingly recognized as an important determinant of healthy cognitive aging, as biological processes contributing to Alzheimer's disease and related dementias (ADRD) may begin decades before clinically apparent impairment. Identifying measurable physiological states associated with diminished CNS resilience during this period is therefore an important objective of brain-aging research. Central sensitization is a neurophy …

25.08.2026journal-article

International Journal of Molecular Sciences

Safety and Efficacy of Mesenchymal Stem Cell Therapy in Aging Frailty: A Systematic Review

Eleni Poutouri, Maria Sotiropoulou, Michael Potoupnis, Georgios Koliakos, Evanthia Kassi, Symeon Tournis, Panagiotis Anagnostis

Aging frailty is a multifactorial geriatric syndrome characterized by reduced physiological reserve across multiple interrelated systems, leading to increased vulnerability to adverse health outcomes. Mesenchymal stem cells (MSCs) have emerged as a potential therapeutic intervention due to their immunomodulatory and regenerative properties. This systematic review aimed to evaluate the available clinical evidence regarding the safety and efficacy of MSC administration in individuals with aging frailty. A systematic …

25.08.2026journal-article

Journal of College of Education

التباين المكاني للهدر الديموغرافي التعليمي لفئة صغار السن في قضاء الجبايش (لسنة 2025)

م,د. علاء شريجي هنيدو

تعد دراسة الهدر الديموغرافي التعليمي من المرتكزات الأساسية في جغرافية السكان، نظراً لارتباطها المباشر بكفاءة استثمار المورد البشري. فالهدر الديموغرافي هو انتاج سلوك فردي يتأثر بالبيئة الاجتماعية والامكانيات الاقتصادية وهو من الخصائص الأساسية للسكان، يهدف هذا البحث إلى تحليل التباين المكاني لظاهرة الهدر التعليمي المتمثلة بـ (الرسوب والتسرب المدرسي) لفئة صغار السن في قضاء الجبايش ووحداته الإدارية لعام (2025) وتكمن مشكلة البحث في رصد الفجوات التعليمية الناتجة عن تداخل العوامل الديموغرافية والاجتماعية والاقتصادية، التي …

25.08.2026journal-article

International Migration

‘People Recognise Us as the Bravest of the Brave’: Retired Gurkha Soldiers Negotiating Employment, Racialisation and Identity in Britain

Shovita Dhakal Adhikari, Louise Ryan

ABSTRACT This article aims to contribute new insights into ageing migrants and masculinity by drawing upon life story interviews with retired Nepali Gurkha soldiers settled in South‐East England. Less is known about middle‐aged and older migrants who migrate not to retire per se but to pursue a second or third career in later life. Our research adds new insights into how these men mobilise capitals to navigate new and unfamiliar job markets, post‐retirement, in their middle and older age. Drawing upon the concept o …

25.08.2026journal-article

Healthcare

Loss of Independence Among Racially and Ethnically Diverse Older Adults: An ICF-Based Analysis of NHATS

Young-Shin Lee, Seon-Hi Shin, Alison Moore, Leticia Camacho, Juan A. Cruz, Hee-Jin Jun

Background: Preventing mobility-related loss of independence (LoI) is a critical public health priority. While the drivers of LoI are complex, this study examines how personal, social, and environmental factors influence these outcomes to identify actionable preventive targets. We applied the International Classification of Functioning, Disability, and Health (ICF) framework to examine these pathways across racial and ethnic groups. Methods: Using 2023 National Health and Aging Trends Study (NHATS) data (N = 7106), …

25.08.2026journal-article

SLEEP

Dementia Risk in Patients with Comorbid Insomnia and Obstructive Sleep Apnea: A Propensity Score–Matched Cohort Study

Ping-Hao Chiang, Yao Te Tsai, Yang-Chi Lin, Hsueh-Yu Li, Chieh-Hsuan Tsai, Chia-Yu Hsu

Abstract Study Objectives Obstructive sleep apnea (OSA) and insomnia frequently co-occur as comorbid insomnia and sleep apnea (COMISA). While it has increasingly been recognized as a distinct clinical presentation, its cognitive consequences remain unclear. We evaluated the 5-year incident dementia risk associated with COMISA compared with OSA alone. Materials and Methods This retrospective propensity score–matched cohort study using electronic health records from the TriNetX US Collaborative Network. Adults with a …

25.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Napping Characteristics and Incident Dementia: Results From The National Health and Aging Trends Study

Kening Jiang, Alden L Gross, Catriona Tingsea Wu, Junxin Li, Halima Amjad, Emerson M Wickwire, Jennifer S Albrecht, Atul Malhotra, Chien-Yu (Irene) Tseng, Marc Kaizi-Lutu, Chunyu Liu, Christopher N Kaufmann, Adam P Spira

Abstract Background Whether daytime napping may be a risk factor for dementia, in addition to nighttime sleep disturbances, remains unclear. This study investigated longitudinal associations of napping characteristics with incident dementia among U.S. older adults. Methods Data came from the National Health and Aging Trends Study (NHATS). Napping characteristics were self-reported in a sleep module at round 3 (2013), including (1) frequency (non-napper, infrequent, frequent); (2) intention (non-napper, intentional, …

25.08.2026journal-article

Frontiers in Medicine

Changing epidemiology of non-occupational acute carbon monoxide poisoning and the increasing share of older adults during the clean heating transition: a 10-year emergency department study in rural Tianjin, China

Wei Kang, Yanqiu Du, Miao Zhao, Jisheng Yang, Jian Liang, Xin Wang, Xianjia Ning, Guohua Zhao

Background and Objective Non-occupational Acute Carbon Monoxide Poisoning (ACOP) remains a preventable emergency condition in northern rural China, where winter heating and indoor combustion have historically been important exposure sources. In rural Tianjin, the clean heating transition period was accompanied by a substantial decline in the overall incidence of non-occupational ACOP, while the residual burden shifted toward older adults and lifestyle-related exposure sources. However, whether this transition has c …

25.08.2026journal-article

Biopsychosocial Science and Medicine

“Be Good to Others and Treat People as you Would Like to be Treated Yourself.” A Mixed Methods Investigation of Positive Social Relationships and Cardiovascular Health in the MIDUS Study

Jennifer Morozink Boylan, Dakota W. Cintron, Julia K. Boehm

Objective: We analyzed qualitative data about social relationships and examined their quantitative associations with concurrent and prospective cardiovascular health (CVH). Methods: Cross-sectional analyses involved the Midlife in the United States (MIDUS) Study wave 2 (M2) and Refresher (MR) biomarker samples (N=2036). Longitudinal analyses involved participants with both M2 and MIDUS wave 3 (M3) biological data (N=650). Participants wrote responses to the question “What do you do to make your life go well?” Judge …

25.08.2026journal-article

Frontiers in Psychology

Toddlers’ symbolic play in dyadic mother–child and triadic mother–child-older-sibling interactions

Sharon Sherman, Naomi Havron

Symbolic play supports crucial aspects of early childhood development, including language and social-cognitive skills. Parent-child dyadic play has been shown to facilitate symbolic play development, but less is known about the addition of siblings (triadic interactions), which may present both opportunities and challenges. We examined toddlers' symbolic play across dyadic (mother-child) and triadic (mother-child-sibling) free-play interactions recorded through videoconferencing. Twenty toddlers (aged 1.5–2.5 years …

25.08.2026journal-article

The Open Psychology Journal

Intergenerational Co-Residence and Life Satisfaction: The Moderating Role of Productive Engagement among Older Adults

Mutia Aulia Dewi, Sri Redatin Retno Pudjiati

Introduction Living with adult children may provide emotional and instrumental support, thereby enhancing older adults' life satisfaction. However, it may also increase intergenerational conflict, potentially reducing life satisfaction. These mixed findings suggest that other factors, such as productive engagement, may influence the relationship between intergenerational co-residence and life satisfaction. Methods This study examined the moderating role of productive engagement on the relationship between intergene …