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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Mitochondrial Dynamics and Bioenergetic Reprogramming: Drivers of Cancer Therapy Resistance

Varsha Johariya, Vaibhav Singh, Rakesh Kore, Santosh Kumar, Ravichandran Veerasamy, Amit K. Tiwari, Harish Rajak

Abstract: Mitochondria, often referred to as the powerhouses of the cell, play a pivotal role in maintaining cellular homeostasis through the regulation of energy production, redox balance, and apoptosis. Recent evidence highlights the significance of mitochondrial dynamics, fusion, fission, biogenesis, and mitophagy, enabling cells to adapt to changing physiological and environmental conditions. Dysregulation of these dynamic processes alters mitochondrial function, promoting metabolic reprogramming, evasion of ap …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Determinants for antibiotic therapy less or more than 7 days in pediatric oncology patients with bacteremia: a global multicenter retrospective study

Griselda Escobedo-Melendez, Joseph Wardell, Parthasarathi Bhattacharyya, Joanna Acebo, Riyadi Adrizain, Bambang Ardianto, Martha Avilés, Maribel Baquera Arteaga, Shymaa Elsayed, Dolores Freire Jijon, Samanmalee Gunasekara, Asher Hancock, Hilda Hernandez, Kim Hoa, Reham Khedr, Yanina Lagala, Jacqueline Levy, Sergio Licona, Medalit Luna, Alejandra Nava, Genara Santana, Eneida Sánchez Medina, Meenakshi Devidas, César Villegas, Sheena Mukkada

Abstract Background Randomized trials support the non-inferiority of short-course (≤7 days) antibiotic therapy for bacteremia; however, these studies commonly exclude immunocompromised patients. Shorter regimens may reduce drug toxicity while optimizing resource utilization and patient quality of life. Evidence to guide treatment duration in immunocompromised children remains limited. Methods We conducted a global, multicenter retrospective study of bacteremia in children with cancer ≤18 years old treated between A …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Impact of Fidaxomicin De-Restriction on Clostridioides difficile Episodes in Hospitalized Pediatric Cellular Therapy Patients

Andrew Karnaze, Darra Drucker, Regina Orbach, Leila C Posch

Abstract Background Pediatric patients undergoing cellular therapy (CT) with hematopoietic cell transplantation (HCT) or chimeric antigen receptor T-cell (CAR-T) therapy are vulnerable to Clostridioides difficile infection (CDI). Recent guidelines recommend fidaxomicin treatment for first and recurrent uncomplicated CDI episodes in this population, though pediatric real-world data is limited. Fidaxomicin is narrower spectrum, dosed less frequently, and can be used for shorter durations versus enteral vancomycin. In …

29.08.2026journal-article

Medical Oncology

Risk-adapted first-line therapy selection in advanced EGFR-mutant NSCLC: a practical clinical algorithm integrating tumor biology and patient factors

Ashish Sharma, Joecelyn Kirani Tan, Harendra Kumar, Hareesha Rishab Bharadwaj

Abstract Advanced EGFR -mutant non-small cell lung cancer (NSCLC), specifically tumors harboring classical activating mutations (exon 19 deletions and L858R substitutions, which are the exclusive focus of this review), is no longer a single-treatment landscape. The MARIPOSA and FLAURA2 phase 3 trials have established that combination regimens of amivantamab plus lazertinib and osimertinib plus platinum-pemetrexed, respectively, extend both progression-free and overall survival compared with osimertinib monotherapy. …

29.08.2026journal-article

Antimicrobial Resistance & Infection Control

Antimicrobial therapy among hospitalized older adults with suspected infection and negative blood cultures

Galadriel Pellejero-Sagastizabal, Elena Morte-Romea, José Antonio Girón Ortega, José Ramón Paño-Pardo, Raquel Fernández Guerrero, Francisca Guerrero, Montserrat Montes de Oca, Silvia Jiménez-Jorge, Zaira R. Palacios-Baena, Jesús Rodríguez-Baño, Pilar Retamar-Gentil, NO-BACT Team, Montserrat Montes de Oca Arjona, Fátima Galán Sánchez, María Eugenia Rodríguez Mateos, José Antonio Girón-González, Andrés Martín Aspas, Claudio Sánchez Tembleque, Francisca María Guerrero Sánchez, Pilar Luque Gómez, José Luis Sierra, Santiago Letona Gimenez, Pilar Palacián, Nora Mariela Rodriguez, Mercedes Arenere Mendoza, Maria Ángeles Allende Bandrés, Raquel Fresquet Molina, Irene Navarro Pardo, Raquel Fernández Guerero, Zaira Palacios-Baena, Marina de Cueto, Margarita Beltrán García, María Luisa Cantón Bulnes, Lorenzo Roberto Suarti

Abstract Background Managing infections in older adults is challenging due to their unique characteristics, which often drives empirical antimicrobial use, increasing risks of adverse outcomes and antimicrobial resistance (AMR). Data on antimicrobial adequacy in older patients with suspected infection but negative blood cultures (BC) remain scarce, despite this being a common clinical scenario. Methods In this multicenter prospective cohort study (NO-BACT project) across three Spanish hospitals (2018–2019), we comp …

29.08.2026journal-article

BMC Cancer

Continued high mortality following diagnosis of HIV-associated Kaposi sarcoma in East Africa in the “Treat All” antiretroviral therapy era ― 2021-2024

Helen Byakwaga, Aggrey Semeere, Megan Wenger, Esther Freeman, Miriam Laker-Oketta, Elyne Rotich, Beatrice P. Mushi, Matthew Ssemakadde, Hilda Muwando, Bronia Mwine, Racheal Ayanga, Celestine Lagat, Sigrid Collier, Zainab Illonga, Robert Lukande, Philippa Kadama-Makanga, Pendo Ibrahim, Linda Chemutai, Toby Maurer, Charles Kasozi, Winnie Muyindike, Elia Mmbaga, David V. Glidden, Samson Kiprono, Kara Wools-Kaloustian, Andrew Kambugu, Jeffrey Martin

Abstract Background Stage at time of diagnosis and survival after diagnosis are critical parameters regarding control of any cancer in any geographical setting. In earlier research focusing on the initial years of the “Treat All” era (2016–2019), we found that HIV-associated Kaposi sarcoma (KS) in East Africa continued to be diagnosed at advanced stage of disease and conferred high mortality. Given the potential for broader implementation of “Treat All” as well as the announcement of National Comprehensive Cancer N …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Bridging therapy during delayed definitive radiotherapy in locally advanced head and neck squamous cell carcinoma: a prospective randomized study comparing induction TPF chemotherapy with oral metronomic chemotherapy

Ipsita Palui, Abhishek Basu, Sayani Poddar, Koushik Chatterjee

Background: Prolonged waiting periods before definitive radiotherapy remain a major challenge in the management of locally advanced head and neck squamous cell carcinoma (LA-HNSCC), particularly in resource-constrained healthcare settings. Bridging systemic therapy during this interval may help maintain disease control until definitive radiotherapy can be initiated. The aim of the study was to compare the efficacy and safety of induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy with oral metronom …

29.08.2026journal-article

International Journal of Molecular Sciences

Enhancer of Zeste Homolog 2 (EZH2): From Glioblastoma Biology to Potential Epigenetic Therapy

Jan Grzegorzewski, Maria Lindner, Dagmara Lisińska, Aleksandra Majchrzak-Celińska

Epigenetic dysregulation is a hallmark of glioblastoma (GBM) pathogenesis, with histone methylation playing a central role in chromatin remodeling and gene expression regulation. Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator responsible for histone methylation. It primarily functions as a transcriptional repressor and regulates signaling pathways associated with tumor progression. Importantly, EZH2 is frequently recruited to long non-coding RNA (lncRNA) scaffolds, including HOTAIR and AGAP2-AS1, …

29.08.2026journal-article

International Forum of Allergy & Rhinology

Impact of Highly Effective Modulator Therapy on Olfactory‐Specific Gene Expression in People With Cystic Fibrosis

Michael R. Xiang, Ankit Chauhan, Gina Hong, Denis Hadjiliadis, Daniel Dorgan, Michael M. Rey, Samantha Kane, James N. Palmer, Nithin D. Adappa, Noam A. Cohen, Michael A. Kohanski, Jennifer E. Douglas

ABSTRACT Background Chronic rhinosinusitis is common in people with cystic fibrosis (PwCF). Highly effective modulator therapy (HEMT) has been shown to improve sinonasal outcomes. However, prior studies failed to show improvement in objective olfaction with HEMT, and the impact of HEMT on olfactory‐specific quality of life has yet to be studied. Furthermore, the underlying changes in gene expression within the olfactory epithelium (OE) of PwCF remains poorly understood. Methods Single‐center cross‐sectional cohort …

29.08.2026journal-article

Dentistry Journal

Clinical and Esthetic Outcomes of Vestibular Socket Therapy: A Systematic Review and Meta-Analysis

Yasser Sherif Soliman, Nadine Gräfin von Krockow, Fatma E. A. Hassanein, Mihad Ibrahim, Abdelsalam ElAskary, Hossam Ismail

Background/Objectives: Vestibular socket therapy (VST) is a minimally invasive technique for immediate implant placement (IIP) in compromised extraction sockets that reconstructs the deficient buccal plate while preserving the crestal soft tissue. Despite growing clinical adoption, the randomized evidence on its predictability and biological performance remains limited. Methods: Following PRISMA 2020 and prospectively registered in PROSPERO (CRD420261288724), PubMed/MEDLINE and EMBASE were searched to January 2026 …

29.08.2026journal-article

Translational Medicine

Early discontinuation of dual antiplatelet therapy after PCI in patients at high bleeding risk: an OCT-guided clinical case

A. A. Prokhorikhin, Yu. V. Kukushkina, D. D. Zubarev, A. V. Gorbatykh, K. A. Rzaeva

Background. Optimizing the duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remains challenging, especially in patients with high bleeding risk and diabetes mellitus, where stent thrombosis risk is significantly increased due to delayed endothelialization. Objective. To demonstrate the safety of early DAPT discontinuation based on individual assessment of stent endothelialization using optical coherence tomography (OCT). Materials and Methods. We present a clinical case of …

29.08.2026journal-article

International Journal of Veterinary and Animal Research (IJVAR)

Evaluation of Transcutaneous Electrical Stimulation (TENS), Therapeutic Ultrasound (TU), and Low-Level Laser Therapy (LLLT) Applications for Physical Therapy in Neurological and Orthopedic Disorders in Cats and Dogs; 20 Cases

Aşkın Doğan, Sadık Yayla

This study aimed to evaluate the applications of transcutaneous electrical stimulation (TENS), therapeutic ultrasound (TU), and low-level laser therapy (LLLT) for physical therapy and rehabilitation (PTR) in cats and dogs with neurological and orthopedic disorders, and the results obtained from these applications. The study material consisted of 11 cats and 9 dogs (20 cases). Transcutaneous electrical stimulation (TENS), therapeutic ultrasound (TU), and low-level laser therapy (LLLT) were used for PTR in these case …

29.08.2026journal-article

ACS Applied Polymer Materials

Fabrication and Characterization of Tea Polysaccharide/ZIF-8 Dual-Functionalized Selenium Nanoplatform and Its Application for Synergistic Hepatocarcinoma Therapy

Senhe Qian, Wei Zhong, Zicheng Yang, Yonghai Ruan, Zhou Wang, Hong Li, Guangjun Nie, Rongyu Li

Abstract Selenium nanoparticles (SeNPs) exhibit promising antitumor activity and drug-loading capacity. However, their high instability and tendency to aggregate often lead to a loss of bioactivity. To address this issue, bioactive tea polysaccharides (TP) were employed as a template to synthesize stable TP@SeNPs (TPS), which were then loaded with the antitumor drug doxorubicin hydrochloride (DOX). Subsequently, the DOX@TP@SeNPs (DTPS) complex was encapsulated within a zeolitic imidazolate framework (ZIF-8), result …

29.08.2026journal-article

Maltepe Tıp Dergisi

Letrozole-Induced Hypersensitivity Pneumonitis: A Rare but Serious Pulmonary Complication in Breast Cancer Therapy

Beyza Ekinci, Eylem Tunçay, Elif Torun Parmaksız

65 yaşında, hipertansiyon ve meme kanseri öyküsü bulunan kadın hasta, onkoloji bölümü tarafından kliniğimize yönlendirildi. Başlangıçta asemptomatik olduğu bildirilen hastanın, son dönemlerde ilerleyici nefes darlığı ve öksürük şikayeti mevcuttu. Bir yıldır günde 2.5 mg letrozol kullanmaktaydı. Ayrıntılı sorgulamada, uzun süreli ev temizliği işi yaptığı öğrenildi. Bilgisayarlı tomografi (BT) taramalarında, bilateral kalıcı buzlu cam opasiteleri saptandı ve bu bulguların letrozol kaynaklı aşırı duyarlılık pnömonisin …

29.08.2026journal-article

BMC Geriatrics

A mixed-methods feasibility study of dog-assisted exercise therapy in geriatric inpatients

Lilly Joschko, Eva Jansen, Stefanie Weinert, Maximilian Hinse, Roland Zerm, Harald Matthes

Abstract Background Animal-assisted therapy (AAT) is a promising complementary approach in geriatric rehabilitation, but evidence on feasibility and patient experiences remains limited. Methods This exploratory, mixed-methods, two-arm randomized controlled parallel-group design (RCT) compared dog-assisted exercise therapy (intervention) to standard exercise therapy (active control) in geriatric inpatients during a two-week rehabilitation program. Quantitative data on mobility (TUG), depression (HADS-D) symptoms, mo …

29.08.2026journal-article

BMC Cancer

Prognostic value of circulating tumor DNA and copy-number alterations in patients receiving tandem [225Ac]Ac-/[177Lu]Lu-PSMA-617 therapy for metastatic castration-resistant prostate cancer: a prospective observational study

Mariam Amghar, Thomas Hielscher, Tobias Rausch, Hilal Özgür, Ulrike Bauder-Wüst, Hendrik Rathke, Frank Bruchertseifer, Alfred Morgenstern, Mareike Roscher, Vladimír Beneš, Clemens Kratochwil, Martina Benešová-Schäfer

Abstract Background Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) demonstrates clinical efficacy in metastatic castration-resistant prostate cancer (mCRPC), yet robust biomarkers for dynamic treatment monitoring and resistance remain lacking. We investigated circulating tumor DNA (ctDNA)-derived tumor fraction (TFx) and genome-wide copy-number alterations (CNAs) as non-invasive biomarkers of treatment response and resistance biology. Methods Seventy-eight patients with advanced mCRPC re …

29.08.2026journal-article

Diabetic Medicine

PPI and researcher perspectives of islet transplantation therapy for type 1 diabetes

Peter M. Jones, Sarah Gatward, Lesley Beadle, Amanda Panizza, Clare Blaydon‐Ellis, Sara Caxaria, Aidan Cruddace, Christine Deal, Ranna Patel, Alexander Silverstein, Lydia F. Daniels Gatward, Tzu‐Wen Hong, Rosie Sullivan, William T. Blackstone Whines, Aileen J. F. King, Shanta J. Persaud

Abstract Aims Islet transplantation offers the potential of a cure for type 1 diabetes ( T1D ), but the limited availability of human donor islets means that this therapy is currently only available to a small group of people with T1D who have intractable hypoglycaemia. The shortage of donor human islets has driven extensive research efforts to generate human islets from pluripotent stem cells ( SC ‐islets), and current protocols are producing SC ‐islets which are showing promising results in early clinical trials. …

29.08.2026journal-article

American Journal of Educational Leadership & Policy Studies

Causal Modeling of Occupational Hazards and Teaching Performance: The Mediating Roles of Job Satisfaction and Stress

Jerry De Leon Taay

Teachers’ working environment plays significant factors on their well-being and effectiveness in delivering quality education. This study investigates causal relationship between occupational hazards and teaching performance together with job satisfaction and stress as mediating variables among the public secondary school teachers in the Division of Oriental Mindoro. The study utilized a descriptive-correlational causal research design employing Structural Equation Modeling (SEM). The respondents of the study were …

29.08.2026journal-article

Probecell Science

Transferrin Receptor-Mediated Nanoparticle Delivery Across the Blood-Brain Barrier for Glioblastoma Therapy

Laxminarayan .

Glioblastoma (GBM) remains the most aggressive of primary brain tumours, with short patient survival despite improvements in surgical resection, radiotherapeutic and chemotherapeutic strategies. One of the main challenges for therapy is to transport anticancer drugs in a broad spectrum, prevent their premature systemic clearance and avoid harmful effects on the healthy part of tissues or organs, such as the blood-brain barrier (BBB), an important structure that limits therapeutic access to most anticancer drugs at …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Emergence hemodynamic changes and postoperative outcomes in hypertensive patients receiving antihypertensive therapy undergoing general anesthesia: an observational study

Nahin Mahmud, Ahsan Habib Khan, Debabrata Banik, Nazmul Huda Naim, M. Fahad

Background: Hypertensive patients undergoing general anesthesia often continue antihypertensive therapy through the perioperative period, yet whether the number of preoperative antihypertensive agents predicts the need for intraoperative anesthetic modulation or postoperative outcome remains unclear. This study aimed to characterise antihypertensive medication burden, anesthetic modulation requirement and postoperative adverse events in hypertensive patients undergoing general anesthesia. Methods: This prospective …

29.08.2026journal-article

Lung India

Impact of extent of lung disease on nutritional, physiological, functional, and psychosocial outcomes of pulmonary rehabilitation in patients with post-tuberculosis sequelae: A prospective study from Western India

Ramakant Dixit, Manudev Mehta

Background: Post-tuberculosis lung disease (PTLD) is increasingly recognized as a major cause of chronic respiratory morbidity in tuberculosis (TB) survivors. Pulmonary rehabilitation (PR) improves functional outcomes in PTLD, but the influence of disease extent on response to rehabilitation is underexplored, particularly in high-burden settings such as India. Methods: This prospective interventional study was conducted at our center, over 6 months. Sixty patients with radiologically confirmed post-tuberculosis seq …

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29.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Wearable inertial sensor assessment of kinematic characteristics during unilateral jump landings in elite volleyball players with patellar tendinopathy: a cross-sectional study

Benjamin Ben Zaki, Gauthier Desmyttere, Stéphane Perrey, Marc Julia, Gilles Dusfour

Abstract Background Patellar tendinopathy (PT) is a prevalent overuse injury in jumping athletes such as volleyball players, with a prevalence reaching up to 45%. It is thought to result, at least in part, from repetitive landing impacts that overload the tendon due to altered neuromuscular control and inadequate force absorption by the muscle-tendon unit. Wearable inertial sensor assessment offers an objective and field-deployable approach to characterize landing kinematics in this population. This study aimed to …

29.08.2026journal-article

Journal of Clinical Psychology

The Impact of Mindfulness as a Session‐Introduction on Symptoms and Alliance in Individual Cognitive‐Behavioral Therapy With Children and Adolescents: A Randomized Controlled Trial

Julia Kalmar, Ines Baumann, Elena Schleiting, Anne Grünert, Eva Vonderlin, Katajun Lindenberg, Andreas B. Neubauer, Thomas Heidenreich, Johannes Mander

ABSTRACT Objectives Mindfulness is increasingly being implemented in child and adolescent therapy. However, little is known about its effectiveness in individual settings within a clinical outpatient context. We investigated the effects of session‐introducing mindfulness interventions (IG‐M) compared to session‐introducing relaxation interventions (CG‐R) and no standardized session‐introduction (CG) on symptomatic outcome and therapeutic alliance in cognitive‐behavioral therapy using a randomized controlled design. …

28.08.2026journal-article

Medical & Biological Engineering & Computing

Impact of EMG-based interfaces for hand motor rehabilitation in stroke: A systematic review with evidence gap map and meta-analysis

Cristian D. Guerrero-Mendez, Natanael Pereira Batista, José Osmar Alves Filho, Carina Marconi Germer, Leonardo Abdala Elias

Abstract Electromyography (EMG)-based interventions have been proposed to improve hand/wrist motor recovery after stroke; however, their clinical value remains uncertain, as evidence for their effectiveness is inconsistent. This systematic review with meta-analysis evaluated the impact of different EMG-based rehabilitation approaches compared with non-EMG-based interventions in individuals with stroke. Seven databases were searched from inception to November 17, 2025, in accordance with PRISMA guidelines. Randomize …