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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Dementia

Polygenic score for sleep duration in relation to the risk of Alzheimer’s disease: results from the UK biobank

Angel T. Y. Wong, Sarah Floud, Gillian K. Reeves, Michael V. Holmes, Ruth C. Travis, Cornelia M. van Duijn, Aiden Doherty, Karl Smith-Byrne

Studies have suggested that sleep duration may be associated with Alzheimer’s disease risk; however, findings based on self-reported sleep duration are likely to be influenced by reverse causation and residual confounding bias. We derived weights for genetic variants associated with wearable-derived sleep duration using the LDpred2-auto method in 77,770 white British participants from the UK Biobank, following the generation of new genome-wide association summary statistics. We then used these weights to generate p …

27.08.2026journal-article

BMC Infectious Diseases

Factors associated with multidrug-resistant tuberculosis among people living with HIV in Addis Ababa, Ethiopia: a case-control study

Daniel Girma, Haymanot Berihun, Abel Temam, Abel Felege

Abstract Background Tuberculosis (TB) remains a leading cause of morbidity and mortality globally, particularly in developing countries. Multidrug-resistant TB (MDR-TB), defined as resistance to at least isoniazid and rifampicin, poses a serious public health challenge. People living with HIV (PLWHIV) are 16 times more likely to develop TB than HIV-negative individuals, and TB is the leading cause of death in this population. Despite this, evidence on the specific factors associated with MDR-TB among PLWHIV in Addi …

27.08.2026journal-article

Safety and Risk of Pharmacotherapy

Strategies for Replacing Potentially Inappropriate Medications in Older Adults According to the Beers Criteria

S. A. Mishinova

INTRODUCTION. In geriatrics, the practice of empirical symptomatic use of medications without establishing a definitive diagnosis has become entrenched, while clinical guidelines are focused on specific disease entities. The updated document “Alternatives to Specific Medications According to the American Geriatrics Society Beers Criteria (2023)," published in 2025 by the American Geriatrics Society, provides recommendations with a high level of evidence. However, their direct transfer into Russian clinical practice …

27.08.2026journal-article

Frontiers in Public Health

eHealth literacy in older patients with cardiovascular disease: latent profile analysis and associated factors

Mengjie Xu, Qianqian Sun, Qiping Chen, Ying Xia

Objective This study aimed to explore the potential latent categories of electronic health (eHealth) literacy among older patients with cardiovascular diseases and analyze the factors associated with eHealth literacy profiles. Methods From November 1, 2025 to April 15, 2026, we employed the convenience sampling method to conduct a survey on a total of 459 patients from a tertiary A hospital in China. The demographic information questionnaire and the Electronic Health Literacy Scale were employed to collect the soci …

27.08.2026journal-article

Frontiers in Nutrition

Diagnostic variability in sarcopenia and sarcopenic obesity among older adults: a clinical and public health challenge

Táscya Morganna de Morais Santos, Gabriel Soares Bádue, Nykholle Bezerra Almeida, Celina de Azevedo Dias, Jessiane Rejane Lima Santos, Piettra Moura Galvão Pereira, Enaiane Cristina Menezes, Fabiana Andréa Moura, João Araújo Barros-Neto

Introduction Sarcopenia and sarcopenic obesity (SO) are highly prevalent among older adults; however, the lack of standardized diagnostic criteria compromises epidemiological comparability and clinical practice. Therefore, this study aimed to evaluate differences in the prevalence and diagnostic agreement of sarcopenia and SO according to different indicators of muscle strength and adiposity. Methods A cross-sectional study was conducted among 870 community-dwelling older adults. The prevalence and diagnostic agree …

27.08.2026journal-article

INTER DISCIPLINA

El cuidado en los establecimientos de larga estadía para personas mayores (Elepem) en tiempos de pandemia: aportes del Centro Interdisciplinario de Envejecimiento

Carolina Guidotti González, Paula Cruz, Lucía Bogliaccini, Alicia Di Bartolomeo, Solange Santos, Javier Trujillo, Elizabeth Lariccia, Cynthia Olguín, Robert Pérez Fernández

The onset of the COVID-19 pandemic in 2020 had a significant impact on the living conditions of older adults residing in long-term care facilities (Elepem, for its Spanish acronym), making them one of the groups most affected in terms of mortality, age-based discrimination, and social exclusion. In Uruguay, the public health measures implemented to prevent transmisión —such as facility closures and the suspension of visits— while effective from an epidemiological standpoint, had negative consequences for residents’ …

27.08.2026journal-article

Frontiers in Nutrition

Comparative effects of pea protein vs. dairy proteins (α-lactalbumin and casein) on aminoacidemia, exercise performance, gut microbiota, hormonal responses, neurocognitive function, mood, and metabolic–inflammatory responses in older adults

Shuai Hao, Fulong Jin, Xiaowei Lei, Yichen He, Yin Liu

This narrative review comprehensively contrasts the physiological impacts of plant-based protein (focusing on pea protein isolates and matrices) vs. dairy-derived proteins (including intact casein and whey protein variants, emphasizing the rapid-digesting α-lactalbumin fraction). We establish a structured framework to separately report evidence from preclinical animal models and clinical human trials, evaluating acute (< 24 h) and chronic (>7 days) horizons across three domains: (i) neurocognitive function/mood, (i …

27.08.2026journal-article

The Gerontologist

From ‘Old Man Yells at Cloud’ to Geronto-Futurism: Co-Imagining Holography and Aging

Stefan Schweigler

Abstract This article explores the discursive, industrial, artistic, and practical interconnections between older people, aging, and holography, arguing that their nexus mutually shapes how both concepts are culturally constituted. Methodologically, the paper utilizes a discourse and representation analysis to examine a heterogeneous corpus of actual wave-optic holography and pseudo-holographic lens-optic phantasmagorias—collectively addressed as “(quasi-)holographic” phenomena. Dissolving the boundaries between cu …

27.08.2026journal-article

Frontiers in Endocrinology

Effectiveness of community—based Baduanjin combined with resistance training on cardiometabolic risk factors in older adults with type 2 diabetes: a 16-week randomized controlled trial

Fengfeng Liu, Xiaoxiang Zhu, Haokai Leng, Changzhou Chen

Background Baduanjin and resistance training improve metabolism and function; however, it is unclear whether their combination reduces cardiometabolic risk in older adults with type 2 diabetes mellitus (T2DM). This study aimed to determine the effects of 16-week BDJ combined with resistance training on cardiometabolic risk parameters in older adults with T2DM. Methods An assessor-blinded, randomized controlled. A total of 123 participants were enrolled and randomly assigned to either an intervention group (IG) that …

27.08.2026journal-article

Diabetes, Obesity and Metabolism

Real‐World Glycemic Outcomes of Open‐Source Automated Insulin Delivery During 12 Months Among People With Type 1 Diabetes Across Age Groups

Qiongyan Lin, Ziqing Lin, Ping Ling, Ying Ni, Mengyun Lei, Yanli Cao, Daizhi Yang, Wen Xu, Hongrong Deng, Yongwen Zhou, Jinhua Yan

ABSTRACT Aims To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12‐months open‐source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D). Methods This study included people with T1D who had used AAPS continuously for 12 months. Glycemic outcomes were assessed at 3, 6, and 12 months post‐initiation by age stratification (2–7, 8–12, 13–18, 19–30, 31–45, and > 45 years). Factors associated with achieving composite …

27.08.2026journal-article

Social Sciences

Loneliness in Older People in Requena del Tapiche (Peruvian Amazon): A Qualitative Study of Reflexive Thematic Analysis

María Teresa Murillo-Llorente, María Ester Legidos-García, Marcelino Pérez-Bermejo, Omar Cauli, Vanessa Ibáñez-del Valle

Background: Loneliness in older adults is a global public health problem. Although robust evidence exists regarding its consequences, the evidence base is marked by a bias towards high-income countries and urban contexts. The rural Peruvian Amazon is a territory virtually absent from the scientific literature on ageing and loneliness. Methods: We conducted a descriptive–interpretive qualitative study based on 34 semi-structured interviews with adults aged 60 years and over, recruited through Cáritas-Requena. Analys …

27.08.2026journal-article

Journal of Polymer Research

Radiation induced free radical stability and degradation behavior in GUR resin and 1900 resin types UHMWPE over 20 years of aging

Afsana Sharmin, Farhan Azim, Benjamin M. Walters, Muhammad S. Jahan

Abstract Radiation-induced free radical stability was evaluated using Electron Spin Resonance (ESR) for two medical-grade Ultra High Molecular Weight Polyethylene (UHMWPE) resins, GUR 4150 and 1900H, after 20 years of aging in air and vacuum at 23 °C, 37 °C, and 75 °C. Spectral analysis revealed oxygen-induced radicals in samples aged in air at 23 °C and 37 °C, with higher concentrations at 23 °C, whereas vacuum-aged samples retained primary radiation-induced radicals that decreased progressively with increasing te …

27.08.2026journal-article

Neuro-Oncology

37 Outcomes of a National Specialist Counselling Service for People Affected by Brain Tumours

Jen Boilestad, Joanna Moss

Abstract Introduction A brain tumour diagnosis profoundly affects physical, emotional and mental health. Surveys by The Brain Tumour Charity highlighted that 41% of people affected reported unmet emotional needs after diagnosis, and 91% shared that their mental health was impacted, yet less than half had access to counselling. In response, the Charity launched a free professional counselling service in 2022 to help patients and loved ones navigate the psychological challenges that accompany a brain tumour diagnosis …

27.08.2026journal-article

World Electric Vehicle Journal

A Hierarchical Multi-Timescale Method with Aging-Aware Capacity Correction for Low-Temperature State-of-Charge Estimation of Lithium-Ion Batteries

Yuting Feng, Lichuan Zhang, Nazerke Yermek, Hany M. Hasanien, Mohammed Alharbi, Chuanyu Sun, Mingming Ge, Xuan Meng

Accurate state-of-charge (SOC) estimation is essential for range prediction, power allocation, and operational safety in electric vehicles. Low-temperature operation introduces coupled effects of capacity degradation and polarization dynamics, which challenge conventional fixed-capacity models and single-timescale estimation methods. This paper proposes a hierarchical multi-timescale SOC estimation framework that combines data-driven capacity prediction, online parameter identification, and nonlinear state estimati …

27.08.2026journal-article

PLOS Aging and Health

The joint associations of pulmonary function and relative grip strength with metabolic syndrome in lung-healthy older adults: Cross-sectional findings from the Physical Activity and Aging Study

Joey M. Saavedra, Elizabeth C. Lefferts, Brian Downer, Duck-chul Lee

While lung disease is strongly associated with metabolic syndrome (MetS), the relationship between healthy pulmonary function and metabolic syndrome (MetS) in older adults remains unclear. It is also unknown if this association is independent of relative grip strength, a robust correlate of MetS. We examined the association between Z-score categories of the Forced Expiratory Volume in 1 second (FEV1) and prevalent MetS in a cohort of lung-healthy older adults. This cross-sectional study analyzed data from an ongoin …

26.08.2026journal-article

The Journal of Cardiovascular Aging

Machine learning model predicting new-onset acute kidney injury in fulminant myocarditis

Yongsheng Qu, Xin Zheng, Jing Zhang, Famin Ye, Jingjing Zhang

Aim: To develop and validate a SHapley additive exPlanations (SHAP)-interpretable machine learning (ML) model for predicting new-onset Acute kidney injury (AKI) after coronary care unit (CCU) admission in patients with Fulminant myocarditis (FM). Methods: This retrospective cohort study included 157 consecutive patients with FM admitted to the CCU of Fuwai Central China Cardiovascular Hospital between January 2018 and January 2026. Admission clinical data were used for model development and internal validation. ML …

26.08.2026journal-article

Longevity Horizon

The Centriole as a Candidate Division Counter in Stem-Cell Aging

Jaba Tqemaladze

Background. Replicative aging of stem cells requires a mechanism counting cell divisions. Centrioles — organelles with mother–daughter asymmetry and no de novo generation in most somatic cells — are candidate division counters: their geometry may accumulate mitotic-age information. Hypothesis. The centriole acts as a division counter in stem-cell aging: structural parameters (length, cartwheel integrity, daughter-relative positioning) change predictably with each division and contribute to senescence entry. Propose …

26.08.2026journal-article

Microbial Genomics

Genomic diversity of Pseudomonas aeruginosa causing bacteremic pneumonia in an intensive care unit, with emergence of an OXA-796-producing NDM-1 ST773 isolate

Kihyun Lee, Hyemin Chung, Kuenyoul Park, Sang-Ho Choi, Heungsup Sung

Pseudomonas aeruginosa bacteremic pneumonia carries exceptionally high mortality, yet there is a paucity of genomic characterization of the strains causing this infection. We performed hybrid sequencing (Illumina and Oxford Nanopore) of 12 non-redundant P. aeruginosa isolates from patients with severe bacteremic pneumonia admitted to the intensive care unit of a tertiary hospital between 2015 and 2023. The 12 isolates were assigned to nine distinct sequence types, suggesting that severe bacteremic pneumonia can ari …

26.08.2026journal-article

JAMA Network Open

Dementia Diagnosis Underreporting and Care Engagement and Planning Among Older Adults

Yuting Qian, Kyle A. Gavulic, Xi Chen

Importance Inadequate disclosure and stigma often leave patients with a documented dementia diagnosis unaware of their condition. Resultant patient underreporting creates a major barrier to the benefits of detection; however, the extent of underreporting, its associated factors, and care implications remain understudied. Objective To compare underreporting of dementia diagnosis with that of other diagnosed conditions among persons with probable dementia (PWPD), identify associated patient and care delivery factors, …

26.08.2026journal-article

Frontiers in Aging Neuroscience

Association of the hsCRP- triglyceride-glucose index (CTI) with early infarct growth rate in acute ischemic stroke due to large artery occlusion

Haiping Tang, Guojun He, Lei Li, Shuangfei You, Deming Li, Songjie Chen, Yan Guo, Yongqing Cheng, Shifu Sun

Background Rapid infarct growth in acute ischemic stroke (AIS) due to large artery occlusion (LAO) is associated with poor clinical outcomes despite successful recanalization. The hypersensitive C-reactive protein (hsCRP)-triglyceride-glucose (TyG) index (CTI), a novel biomarker integrating insulin resistance and systemic inflammation, may reflect a meta-inflammatory state that exacerbates ischemic injury. However, its relationship with early infarct growth rate (IGR) remains unexplored. This study aimed to investi …

26.08.2026journal-article

Working with Older People

Strengthening elder neglect prevention through community-based nursing: stakeholder perspectives from Indonesia

Nurhasanah Nurhasanah, Darmawati Darmawati, Hajjul Kamil, Marthoenis Marthoenis

Purpose Elder neglect is a complex and often hidden form of elder abuse influenced by family relationships, caregiver capacity and weaknesses in health and social service systems. Despite its growing public health significance, evidence on stakeholder perspectives to inform community-based prevention strategies remains limited, particularly in low- and middle-income countries. This study aims to explore stakeholder perspectives on the determinants, manifestations, prevention strategies and health system gaps relate …

26.08.2026journal-article

Revista da Associação Brasileira de Pesquisadores/as Negros/as (ABPN)

QUALIDADE DE VIDA EM PESSOAS IDOSAS NEGRAS COM DOENÇAS CRÔNICAS: UMA REVISÃO SISTEMÁTICA

Eusiene Furtado Mota Silva, Ana Hélia de Lima Sardinha, Patrícia Lima Queiroz, Rômulo Luiz Neves Bogéa

Este artigo analisa os fatores que influenciam a qualidade de vida de pessoas idosas negras com doenças crônicas, com foco nas desigualdades sociais e no impacto do racismo estrutural sobre a saúde física e o envelhecimento digno. A revisão sistemática, realizada conforme as diretrizes PRISMA, incluiu 30 estudos das bases Scopus, SciELO e BVS. Os achados revelam alta prevalência de doenças crônicas agravadas por barreiras de acesso, baixa renda e discriminação racial. Identifica-se uma lacuna científica sobre os ef …

26.08.2026journal-article

Revista da Associação Brasileira de Pesquisadores/as Negros/as (ABPN)

POPULAÇÃO NEGRA E PERDA AUDITIVA; UMA REVISÃO INTEGRATIVA

Fabiane De Barros, Célia Mariana De Souza, Sabrina Gonçalves, Márcia Machado, Adriana Unchalo, Maira Olchik, Adriane Teixeira

Revisão integrativa da literatura, com objetivo de analisar estudos audiológicos com participantes negros. Foi feita com artigos extraídos das bases de dados PubMed, Embase, Lilacs e Web of Science. A pergunta de pesquisa foi: 'Qual a prevalência da perda auditiva na população negra?'. Os descritores utilizados foram: Hearing Loss, Hearing Impairment, Hypoacus, Transitory Hearing Loss AND Black People OR African Continental Ancestry Group OR Black Person OR Negroid Race OR Negro OR Negroes. Foram incluídos estudos …