Association of the hsCRP- triglyceride-glucose index (CTI) with early infarct growth rate in acute ischemic stroke due to large artery occlusion

Vollständiger Abstract

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Background Rapid infarct growth in acute ischemic stroke (AIS) due to large artery occlusion (LAO) is associated with poor clinical outcomes despite successful recanalization. The hypersensitive C-reactive protein (hsCRP)-triglyceride-glucose (TyG) index (CTI), a novel biomarker integrating insulin resistance and systemic inflammation, may reflect a meta-inflammatory state that exacerbates ischemic injury. However, its relationship with early infarct growth rate (IGR) remains unexplored. This study aimed to investigate whether CTI is independently associated with early IGR in patients with anterior circulation LAO. Methods We conducted a prospective cross-sectional study of 247 patients with AIS due to anterior circulation LAO. CTI was calculated as the product of the TyG index and high-sensitivity CRP from fasting blood samples. Early IGR was defined as the baseline infarct core volume (rCBF