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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

In Utero Exposure to Dolutegravir-Based Antiretroviral Therapy Alters Growth and Metabolic Outcomes

Niyati Patel, Abhayavarshini Shridhar, Ryan D Ross

Abstract Background Approximately 5,000 women living with HIV give birth each year, with perinatal transmission occurring in less than 1% of cases. The World Health Organization (WHO) recommends dolutegravir (DTG) as first and second line antiretroviral therapy (ART), readily crossing the placenta, resulting in persistent exposure throughout development. In adults, DTG-based ART has been linked to metabolic changes, including alterations in bone mineral density and body composition. The effects of DTG exposure on b …

29.08.2026journal-article

Journal of Mechanics in Medicine and Biology

EARLY GAIT REHABILITATION WITH A TORQUE-ASSISTING HIP-WEARABLE ROBOT IN PARKINSON’S DISEASE AFTER ACUTE URINARY TRACT INFECTION–RELATED FUNCTIONAL DETERIORATION: A CASE REPORT

IN YOUNG CHOI, SEUNG ICK CHOI, HUI WOO YANG, NA YOUNG KIM

Evidence on effective gait rehabilitation strategies for patients with Parkinson’s disease (PD) who experience acute functional deterioration due to medical complications remains limited. We report a case of torque-assisting hip wearable robot training in a patient with PD during acute post-infectious gait deterioration. An 80-year-old woman with PD was admitted with acute gait deterioration following urosepsis. Upon admission, she was unable to stand or ambulate. In the levodopa ON state, her Berg Balance Scale (B …

29.08.2026journal-article

Nature Medicine

Dual antithrombotic therapy using potent antiplatelet inhibitors in atrial fibrillation and acute coronary syndrome: a randomized controlled trial

Konstantinos D. Rizas, Konstantinos Mourouzis, Dominik Rath, Christoph B. Olivier, Laura Elisa Villegas Sierra, Theofanis Korovesis, Amin Polzin, Amani Al Tawil, Reza Wakili, Lukas von Stuelpnagel, Katharina Mayer, Marion Janisch, Tanja Ulrich, Sarah Lang, Sebastian K. G. Maier, Florian Brattinger, Lorenz Bott-Flügel, Harilaos Bogossian, Konstantinos Iliodromitis, Luisa Freyer, Julius Steffen, Konstantin Stark, Elodie Eiffener, Lauren E. Sams, Tobias Petzold, Axel Linke, Felix M. Heidrich, Samuel Sossala, Saif Zako, Nikolaos Dagkonakis, Andreas Schäfer, Frank Edelmann, David M. Leistner, Mariya Maslarska, Fabian Knebel, Georg Nickenig, Blerim Luani, Tienush Rassaf, Hüseyin Ince, Ibrahim Akin

Abstract The selection of the optimal antithrombotic regimen in patients with atrial fibrillation and acute coronary syndrome remains challenging. Previous trials have demonstrated that dual antithrombotic therapy (DAT), consisting of direct oral anticoagulants (DOACs) plus a P2Y12 inhibitor, reduces bleeding compared to a triple-therapy regimen using vitamin K antagonists. However, subsequent meta-analyses have suggested an increased risk of ischemic events with DAT, particularly within the first month of treatmen …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Efficacy of hand arm bimanual intensive therapy on upper limb co-ordination in a child with Rett syndrome: a case report

Chaitanya Prem, Nimmy Achankunju, Priyanka N. Somaiya

Rett syndrome (RTT) is a severe, progressive, neurodevelopmental disorder, which affects predominantly females. RTT is characterized by developmental regression of spoken language and hand use that, with hand stereotypies and impaired ambulation, constitute the four core diagnostic features. Children with RTT exhibit significant impairments in purposeful hand use and bimanual coordination due to neurodevelopmental regression, yet structured bimanual intervention protocols are sparsely reported. The aim of the study …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Optimizing Empirical Antibiotic Therapy in Febrile Pediatric Oncology Patients through a Clinical Decision Pathway

Yamileth Arellano, Martha Avilés Robles, Fernando Ríosvelasco

Abstract Background Timely management of a child with cancer and fever (CCF) requires accurate evaluation and appropriate antibiotic selection to prevent infectious complications. Clinical decision tools, such as Clinical Decision Pathways (CDPs), are increasingly adopted in healthcare systems for their ability to standardize and optimize clinical practice. The aim of this study was to assess the effectiveness and utility of an adapted CDP for initial antibiotic selection in children with cancer and fever. Methods …

29.08.2026journal-article

International Ophthalmology

Home-based low-level light therapy using a commercial LED mask for dry eye disease

Luca Scuderi, Serena Fragiotta, Chiara Ciancimino, Gianluca Scuderi

Abstract Purpose Light-based therapies, including low-level light therapy (LLLT), have recently emerged as promising non-invasive approaches for dry eye disease (DED). This study evaluates the impact of a consumer-grade home-based LED Beauty Mask on DED parameters. Methods This retrospective observational cohort study included 20 postmenopausal women (20 eyes) diagnosed with moderate DED and MGD who underwent cosmetic treatment using the LED Beauty Mask Koled®. The device was used for 20-min sessions on alternate d …

29.08.2026journal-article

Dynamic Medical Theories

Relationship Between Low Back Pain, Somatotype, and Flexibility in Physiotherapy Students

Mine Argali Deniz, Demet Sencan Senol, Muhammed Furkan Arpaci, Ozden Canbay Gokcek

Aim: The aim of this study is to investigate the relationship between low back pain, somatotype, and flexibility (F) in physiotherapy students. Materials and Methods: 93 volunteer participants between the ages of 18- 40 were included in the study. The severity of participants’ low back pain was evaluated with the Visual Analog Scale (VAS). Trunk and lower extremity flexibility was measured using goniometry and a non-flexible tape measure. Somatotype analysis was performed using the Heath-Carter method. A p-value of

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Beyond the Grain: Correlating Imaging Findings with Mycetoma Pathogens to Optimize Timely diagnosis and Therapy

Mohammed Fadul, Mustaphaa Bahar, Mohamaed Mustfa, Ahmed Fahal, Amel Omer

Abstract Background Mycetoma is a devastating, progressively destructive neglected tropical disease highly endemic in Sudan, which holds the highest documented global case count (prevalence of 14.5/100,000). Clinically, it presents as a painless subcutaneous mass with sinuses and grain discharge. Frequent delayed presentation leads to high morbidity, disability, and often necessitates amputation. Advanced cases present a diagnostic challenge as their radiological appearance mimics osteosarcoma and other severe bone …

29.08.2026journal-article

Asian Journal of Medicine and Health

Virtual Reality-Based Interventions for Upper Limb Rehabilitation in Parkinson’s Disease: A Scoping Review and Critical Evidence Synthesis

Krishnendu P. G., Riyas Basheer K. B., Ismail Hazim, Athul Krishna K. R., Subhashchandra Rai, Femina Hameed V. A., Nishka S. Bolar, Mohammed Sanabin

Upper-limb dysfunction in Parkinson’s disease compromises dexterity, movement scaling, coordination and the performance of everyday tasks, yet rehabilitation research has historically prioritised gait and balance. Virtual reality (VR) can deliver repetitive, task-specific practice with augmented feedback, adaptable challenge and game-based engagement, but the clinical value of VR specifically for arm and hand rehabilitation remains uncertain. This scoping review mapped and critically synthesised evidence on VR-base …

29.08.2026journal-article

Jurnal Kesehatan Manarang

Association Between Peer Support And Positive SRQ-20 Screening Among Midwifery Students : A Cross-Sectional Study

Lia Mulyanti, Safitri Nurul, Prakasiwi Sherkia Ichtiarsi, Damayanti Fitriani Nur

The mental health of midwifery students is affected by academic pressure, social demands, and environmental factors. Peer support plays a crucial role in helping students cope with stress and maintain mental well-being. One in seven people aged 10–19 worldwide experiences a mental health problem, accounting for 13% of the disease burden. Often, these problems go unrecognized and untreated. Between 10 and 20 percent of adolescents experience psychological problems, and most adolescents experience symptoms that threa …

29.08.2026journal-article

Advanced Science

Integrated O 2 and H 2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang

ABSTRACT Impaired wound healing in diabetes is closely associated with cellular ferroptosis. Microneedle‐assisted gas therapy exerts molecular regulation of ferroptosis, representing a promising approach for accelerating diabetic wound healing. To date, O 2 and H 2 gas therapies have consistently been conducted independently and have never been integrated into a single system. Whether and how their synergy might be realized remains a defining challenge. Herein, we propose a concept of integrated O 2 and H 2 gas the …

29.08.2026journal-article

Diagnostics

Chronic Hypercapnic Respiratory Failure in COPD in Lithuania: National Registry Trends and Prehospital Emergency-Care Professionals’ Knowledge of Hypercapnia and Oxygen Therapy

Rasa Gauronskaitė, Anrenas Karvelis, Edvardas Danila, Rolandas Zablockis

Background/Objectives: Hypercapnic respiratory failure (HRF) is a serious complication of chronic obstructive pulmonary disease (COPD) and is associated with increased morbidity, mortality, and healthcare utilisation. National HRF trends among patients with COPD remain poorly characterised in Lithuania, and the knowledge of prehospital emergency-care professionals regarding oxygen therapy and hypercapnia has not been evaluated. Methods: This study comprised two components. First, a cross-sectional online survey ass …

29.08.2026journal-article

International Journal of Leading Research Publication

Formal Education Management Practices for Inmate’s Rehabilitation in Selected Correctional Facility in Kabwe, Zambia

Agness chisale

Abstract This study explored formal education management practices for inmate rehabilitation at a correctional facility in Kabwe. A qualitative approach was employed, utilizing semi-structured interviews and Focus Group Discussions (FGDs) to collect data. Grounded in the interpretivism paradigm, the study adopted a qualitative descriptive design. Heterogeneous sampling was used to intentionally select participants with differing key characteristics. Data were analysed using thematic inductive analysis, addressing a …

29.08.2026journal-article

Journal of Ayurvedic Herbal and Integrative Medicine

CARIES REMINERALIZATION THERAPY – AN IN VITRO EVALUATION OF THE EFFICACY OF THREE REMINERALIZING AGENTS BY SEM AND EDS ANALYSIS

Geeta IB, Pranjul Sharma, Rayala Lokesh, Urvashi Patel

Dental caries, by definition, is one of the most common diseases worldwide. It is dependent on biofilm, diet, and other factors. It causes mineral loss, disrupting the balance between demineralization and remineralization. This has led to the development of various treatment approaches for initial carious lesions. Remineralization requires a natural pathway to restore the mineral loss of hydroxyapatite (HAP) crystals. Many materials have been clinically evaluated and have demonstrated promising results.

29.08.2026journal-article

The Nursing Scope

Occupational Stress and Nursing Performance in In-Patient Care: Organizational Determinants in a Nigerian Tertiary Hospital

Abiodun FATUKASI

Background: Occupational stress remains a major challenge in nursing practice, particularly in inpatient care settings characterized by demanding workloads, complex clinical responsibilities, and resource constraints. Persistent workplace stress can adversely affect nurses’ performance, clinical decision-making, communication, and patient safety. Despite growing concerns about occupational stress among nurses, evidence regarding its organizational determinants and impact on nursing performance in Nigerian tertiary …

29.08.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: Surgical management of bilateral atypical tibial fractures associated with long-term bisphosphonate therapy in a cat

Justin Koh Wei Wong, Stephanie Colthurst

An eight-year-old, indoor, male neutered Oriental mix cat was presented with acute bilateral pelvic limb lameness without preceding trauma. The cat had received oral alendronate for 4.5 years for the management of idiopathic hypercalcaemia. Radiographs revealed bilateral, closed, comminuted proximal tibial and fibular fractures with cortical sclerosis. Staged bilateral open reduction and internal fixation were performed using orthogonal locking compression plates. Alendronate therapy was discontinued, and the cat r …

29.08.2026journal-article

ACR Open Rheumatology

Reduction of CXCR3 + CCR6 + CD4 + T Cells and IL ‐17+ RORγt + CD4 + T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

Addison Pacheco, Patricia Remalante‐Rayco, Nigil Haroon, Denis Poddubnyy, Robert D. Inman

Objective We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could determine their next biologic response. Methods At the clinician's discretion, 18 patients who did not respond to secukinumab were either switched to a tumor necrosis factor inhibitor (TNFi; n = 8) o …

29.08.2026journal-article

International Archives of Occupational and Environmental Health

The effort–reward imbalance model in policing: associations with mental health and work functioning among sworn and civilian employees

Bjørn Lau, Knut Inge Fostervold, Brita Bjørkelo

Abstract Objective The Effort–Reward Imbalance (ERI) model is widely used to explain work-related stress and its health consequences. In policing, ERI research has primarily focused on sworn officers, while civilian employees have received limited attention. The purpose of this study was to examine whether ERI variables are associated with mental health and occupational functioning among police employees, and whether these associations differ between sworn officers and civilian personnel. Methods This cross-section …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Image-guided bone marrow aspirate concentrate and platelet-rich plasma therapy for a chronic high-grade anterior cruciate ligament tear: a case report

Venkatesh Movva, Anand Alluru, Syed Khaleel, Sunitha Manne Mudhu, Vijayalakshmi Venkatesan

The anterior cruciate ligament (ACL) is a critical stabilizing structure of the knee joint, responsible for maintaining both anteroposterior and rotational stability. ACL injuries are among the most common sports-related ligamentous injuries to cause debilitating condition. Surgical reconstruction forms the end point of recommendation, nevertheless emerging techniques like orthobiologics using bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP) form alternate therapy. A 26-year-old male cyclist a …

29.08.2026journal-article

Cancers

Association of Prior Local Therapy with Outcomes Within Systemic Therapy Regimen Cohorts in Advanced Soft Tissue Sarcoma: A Retrospective Cohort Study

Ryotaro Ohkuma, Tomoyuki Ishiguro, Hirotsugu Ariizumi, Masahiro Shimokawa, Go Ikeda, Takahiro Yoshizawa, Yuya Hirasawa, Risako Suzuki, Toshiaki Tsurui, Emiko Mura, Rika Sasaki, Shuichi Komori, Kosuke Toyofuku, Masako Kato, Kanae Shimada, Shingo Miyamoto, Kouzou Murakami, Yoshihiro Nakagami, Kazuhiko Oshinomi, Yutaro Kubota, Hiroo Ishida, Takeshi Aoki, Masahiko Murakami, Kiyoshi Yoshimura, Satoshi Wada, Katsuhito Takahashi, Takuya Tsunoda, Atsushi Horiike

Background/Objectives: Evidence regarding associations between local therapy before an indexed systemic regimen and subsequent outcomes in advanced soft tissue sarcoma (STS) remains limited. We evaluated outcomes within four regimen-defined cohorts and explored associations with prior local-therapy history. Methods: This retrospective cohort included 75 patients with recurrent or metastatic STS who contributed 155 treatment episodes: doxorubicin (n = 44), trabectedin (n = 31), pazopanib (n = 42), and eribulin (n = …

29.08.2026journal-article

Medicina

Dynamics of Anti-HBc Serology During Anti-CD20 Therapy: Incidence, Timing, and Predictors of Anti-HBc Seroclearance in a Retrospective Cohort

Fatih Eren, Muhammed Abdurrahman Celik, Resul Akduman, Mete Yasar, Mehmet Refik Goktug, Gokhan Ocakoglu, Selim Gurel

Background and Objectives: Anti-hepatitis B core antibody (anti-HBc) is generally regarded as a lifelong serological marker of previous hepatitis B virus (HBV) infection. However, anti-HBc seroclearance has been increasingly reported in patients receiving anti-CD20 therapy, while its incidence, longitudinal serological dynamics, and clinical significance remain insufficiently characterized. In this study, we aimed to evaluate the incidence, timing, and predictors of anti-HBc seroclearance and investigate longitudin …

29.08.2026journal-article

Journal of Language, Literature & Social Affairs

Analyzing the Impact of Cyber Harassment, Cyber Stalking Victimization, and Cyber Gender Hate Speech on Social Wellbeing of Female University Students in Sialkot Pakistan

Khadija Shahbaz, Muhammad Umair Ashraf

This study's main objective is to examine how cyber stalking victimization, cyber harassment, and cyber gender hate speech affect female university students' social wellbeing. The goal of this study is to determine how response to these types of online harassment has a negative effect on female students' sense of safety, social interactions, and general well-being in digital contexts. The researcher gathered the data using a survey questionnaire and the quantitative research approach. In this study, a systematic/ra …

29.08.2026journal-article

Responsive Materials

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun

Abstract Ischemic stroke (IS) is one of the primary causes of global mortality and permanent neurological disability, and its clinical treatment is severely constrained by the intricate ischemic pathological cascade and the impermeable blood‐brain barrier (BBB). Cerebral ischemia and reperfusion trigger a series of pathological events including energy depletion, excitotoxicity, calcium overload, oxidative stress and neuroinflammation, accompanied by progressive BBB damage. These pathological processes exacerbate se …

29.08.2026journal-article

European Heart Journal

ESC Guidelines on prevention and rehabilitation in coronary heart disease and current practice: the EUROASPIRE VI survey

David A Wood, Catriona S Jennings, Kornelia Kotseva, Agnieszka Adamska, Iris Erlund, Sandra Ganly, Per-Henrik Groop, Susan Hennessy, Maarten J G Leening, Linda Mellbin, Kausik K Ray, Lars Ryden, Terhi Vihervaara, Victor Aboyans, Ana Abreu, Carlos Aguiar, Karl Andersen, Jolita Badariene, Jan Bruthans, Monika Burzynska, Almudena Castro Conde, Renata Cifkova, Furio Colivicchi, Kairat Davletov, Mirza Dilic, Elena Dimitrova, Maryna Dolzhenko, Vilnis Dzerve, Andrejs Erglis, Zlatko Fras, Baris Gungor, Peter Heuschmann, Piotr Jankowski, Iulia Kulcsar, Nebojsa M Lalic, Seppo Lehto, Dragan Lovic, Aldo P Maggioni, Fabrice MAC Martens, Lampros K Michalis

Abstract Background and Aims This observational study investigated whether patients with coronary heart disease (CHD) in Europe are achieving the standards set by prevention and rehabilitation guidelines. Variability was studied: (i) between countries; (ii) between geographical risk regions; and (iii) attendance at cardiac rehabilitation (CR) with outcomes. Methods Observational study between September 2024- February 2026 in 160 hospitals across 27 countries. Geographical risk regions were defined as high, moderate …