Medizin: neue Gesundheitspublikationen – Seite 38

03.09.2026journal-article

PLOS One

IFC-HFlowVAE: A self-enhancing generative framework with structural anchoring for imbalanced clinical data augmentation

Lu Yuwen, Shuyu Chen

Class imbalance and limited minority-class samples remain major challenges for developing reliable clinical diagnostic models, as insufficient observations often fail to capture complex minority-class distributions. Existing augmentation methods either rely on heuristic interpolation or suffer from instability when learning sparse and heterogeneous medical tabular data. This study proposes IFC-HFlowVAE, an iterative feedback and consensus framework built upon a flow-enhanced heterogeneous variational autoencoder fo …

03.09.2026journal-article

Magnetic Resonance Materials in Physics, Biology and Medicine

Age-dependent macromolecule signals in the human motor cortex and thalamus: implications for metabolites quantification at 7 T

Xinyu Liu, Gianna Nossa, Ying Xiao, Selin Scherrer, Sven Egger, Benedikt Lauber, Wolfgang Taube, Ulrike Dydak, Lijing Xin

Abstract Objective Macromolecular (MM) signals overlap with metabolite signals, but MM content differences across age and brain region and their influences on brain metabolites quantification have remained elusive. While most studies assume universal MM content when assessing neurochemical levels, region- and age-related MM differences could result in inaccurate quantification of metabolites. This study assesses MM differences linked to specific brain regions and age by analyzing their influence on metabolite signa …

03.09.2026journal-article

General Thoracic and Cardiovascular Surgery

Impact of preoperative nutritional status on longitudinal changes in pulmonary function and prognosis after lung cancer surgery

Kentaro Miura, Daisuke Nakamura, Sachie Koike, Shuji Mishima, Yukihiro Terada, Shunichiro Matsuoka, Hirotaka Kumeda, Takashi Eguchi, Kazutoshi Hamanaka, Kimihiro Shimizu

Abstract Objective Preoperative nutritional status is a known prognostic factor in lung cancer surgery. However, its effect on postoperative pulmonary function over time remains unclear. This study evaluated the association between preoperative nutritional status and longitudinal respiratory changes andoutcomes after curative resection. Methods Patients who underwent resection for non-small cell lung cancer between January 2020 and December 2024 were prospectively analyzed. Patients were classified by prognostic nu …

03.09.2026journal-article

International Journal of Clinical Pharmacy

A qualitative analysis to identify implementation strategies for a deprescribing clinical practice guideline using the CFIR-ERIC Matching Tool: perspectives from consumers and professional stakeholders

Hui Wen Quek, Xisco Reus, Kenneth Lee, Veronika Seda, Leon Adams, Osvaldo P. Almeida, Gillian E. Caughey, Jennifer Gowan, Kerryn Hart, Andrew Heredia, Anne-Marie Hill, Lisa Kalisch Ellett, Dina LoGiudice, Arduino A. Mangoni, Anthony Marinucci, Treasure McGuire, Nilufeur McKay, Vasi Naganathan, Christopher Ng, Maz Osborne, Kevan R. Polkinghorne, Constance D. Pond, Sepehr Shakib, Angela Shiu, Andrew Stafford, Tim Whitmore, Christopher Etherton-Beer, Amy Page

Abstract Introduction Deprescribing is the planned withdrawal or dose reduction of medicines when harms outweigh benefits or when they are no longer required. Following publication of the Clinical Practice Guideline for Deprescribing in Older People in September 2025, supporting its uptake into routine practice is a critical next step. Aim This study aimed to identify implementation strategies, informed by stakeholder-perceived barriers, to support the implementation of deprescribing guidelines. Method A qualitativ …

03.09.2026journal-article

PLOS Digital Health

Implementation of an opioid use disorder (OUD) machine-learning phenotype in real-time for the ADAPT clinical trial

Huan Li, Mark Iscoe, John Lutz, Carolina Diniz Hopper, Sabrina Fried, Josue Minaya, Caroline Raymond King, Olga Reykhart, Hyung Paek, Daniella Meeker, Edward R. Melnick, R. Andrew Taylor

We developed and deploy a real‑time, electronic health record‑integrated machine learning phenotype to identify emergency department patients with opioid use disorder for prospective clinical trial screening and buprenorphine initiation. We conducted a multi‑phase study across three emergency departments in a single United States health system from 2014 to 2025. Using visit‑level data available at or before triage, we trained a random‑forest classifier to estimate opioid use disorder risk and embedded scoring in th …

03.09.2026journal-article

Journal of Pediatric Hematology/Oncology

Oral Cyanocobalamin Treatment in Infants Under 1 Year With Nutritional Vitamin B12 Deficiency: A Retrospective Comparison of 500 and 1000 µg Dose Regimens

Gökçe P. Reis İskenderoğlu, Erol Erduran, Nilgün Eroğlu, Ayşenur Bahadır

Background: Vitamin B12 deficiency is a significant health problem in infancy, particularly in developing countries. Oral treatment has emerged as an alternative to intramuscular therapy, but optimal dosing in infants remains unclear. Methods: This retrospective study included 93 infants aged 1 to 12 months diagnosed with nutritional vitamin B12 deficiency. Patients received either 500 or 1000 µg oral cyanocobalamin. Laboratory parameters were evaluated at baseline, 2 months, and 4 months. Results: Both treatment g …

03.09.2026journal-article

Clinical Dermatology Review

Epidemiological Spectrum of Palmoplantar Dermatoses in Central India: A Hospital-based Cross-sectional Study

Surbhi Kashyap, Ajeet Singh, Satyaki Ganguly, Ritul Choudhary, Praveen Kumar

Abstract Context: Palmoplantar dermatoses are the skin disorders affecting the palms and soles – areas characterized by distinct anatomical, physiological, and environmental exposures. The clinical impact of these disorders is greater, owing to their often-visible nature, chronic course, and association with pain, functional impairment, and psychosocial distress. Aims: A comprehensive analysis of the clinical spectrum of palmoplantar dermatoses at a tertiary care setting in Central India, with particular focus on d …

03.09.2026journal-article

Clinical Pediatrics

The Doctor Will Zoom You Now: An Experiential Telemedicine Assessment for Pediatric Residents

Heather B. Howell, Jonathan Lebowitz, Jeffrey Wilhite, Chanelle Coble-Sadaphal, Meaghan McGrath, Rachel Ramsey, Lisa Altshuler, Sondra Zabar, Purnahamsi V. Desai

There has been increased use of telemedicine in clinical practice, but telemedicine curricula are not standard in pediatric residency training. We developed a 2-case, Virtual Objective Structured Clinical Exam (VOSCE) for pediatric residents with telemedicine learning objectives. Resident competency was assessed using a behaviorally anchored checklist, and residents completed a pre/post self-assessment. Less than half of the residents met mastery for the following behaviors: confirmation of patient identifiers, opt …

03.09.2026journal-article

Aesthetic Surgery Journal Open Forum

Quality Assessment of Systematic Reviews on Gluteal Augmentation Using a Measurement Tool to Assess Systematic Reviews (AMSTAR 2)

Elisa Bertulla, Edoardo Raposio

Abstract Background Gluteal augmentation has become increasingly popular in aesthetic surgery, with fat grafting, implants, and fillers as the main techniques. Objectives This study aims to assess the methodological rigor of available reviews using AMSTAR-2 and to explore associations with publication characteristics, including citations, journal impact factor, year of publication, and PRISMA adherence. Methods A systematic literature search of PubMed, Scopus, and the Cochrane Library was performed. Two authors ind …

03.09.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: Use of subconjunctival cyclosporine implants for treatment of feline eosinophilic keratoconjunctivitis: a case report

Lynn Willems, Jordan Kay Roberts

Case summary A 5-year-old neutered male domestic shorthair cat was presented for evaluation of chronic bilateral eosinophilic keratoconjunctivitis (EK). The patient had a history of recurrent corneal plaques and conjunctivitis that were initially managed with systemic and topical immunosuppressive therapy. Long-term disease control was limited by poor tolerance of topical ophthalmic medications, resulting in inconsistent treatment and repeated disease recurrence affecting both eyes. Over several years the cat was t …

03.09.2026journal-article

Monaldi Archives for Chest Disease

Treatment outcomes and factors associated with unfavorable outcomes among drug-resistant tuberculosis patients treated with a bedaquiline-based oral regimen

Oki Nugraha Putra, Julaeha Julaeha, Nurhayati Nurhayati, Telly Purnamasari, Nurul Damayanti, Dewi Ramdani, Ahmad Erlan, Paisal Paisal, Rini Sasanti Handayani, Nur Indah

The treatment success rate for drug-resistant tuberculosis (DR-TB) in Indonesia remains below the national target. Identifying factors associated with unfavorable treatment outcomes is essential to inform more targeted interventions. This retrospective study analyzed medical records of patients with DR-TB who received treatment at Surabaya Haji Hospital between 2020 and 2024. Demographic, clinical, behavioral, and treatment-related variables were evaluated in relation to unfavorable treatment outcomes, defined as a …

03.09.2026journal-article

Frontiers in Surgery

When microsurgery is not an option: staged delayed reverse sural artery flap with ischaemic preconditioning for limb salvage in an elderly patient with chronic post-traumatic osteomyelitis—a case report

Zhun Shen Tan, Adzim Poh Yuen Wen, Farzana Ansarutheen, Mohd Yazid Bajuri

Lower extremity reconstruction in elderly patients with post-traumatic osteomyelitis presents a formidable challenge. We report a 70-year-old female with hypertension, dyslipidaemia, and bilateral knee osteoarthritis who sustained a Gustilo-Anderson type IIIB open right ankle fracture with exposed calcaneus following a fall. The course was complicated by chronic osteomyelitis, managed with partial talectomy and total calcanectomy, antibiotic-impregnated cement spacer placement, cement exchange and prolonged culture …

03.09.2026journal-article

Frontiers in Natural Products

Antifungal and antibiofilm activity of crude hydroalcoholic extract and fractions of Myrcia neoobscura leaves against a clinical isolate of Candida krusei

Leticia Bachmann, Eduarda Rensi Botelho, Patrícia Helena Arrabal, Pâmela Elise Munzlinger, Patryne Luana da Silva Dantas, Larissa Mascarenhas Krepsky, Lucas Ferriolli Mariotto, Michele Debiasi Alberton, Tatiani Karini Rensi Botelho

Infections caused by biofilm-forming Candida sp. Are responsible for high morbidity and mortality rates. With the scarcity of therapeutic options and the increase in resistance to antifungal drugs, new treatment options are needed. Myrcia neoobscura is a tree endemic to the Atlantic Rainforest, belonging to the genus Myrcia , several of whose species have demonstrated important antifungal activities. The aim of this study was to evaluate the antifungal and antibiofilm activity of the crude hydroalcoholic extract an …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

ABCB5⁺ mesenchymal stem cells enable high-ratio cellular augmentation of bone grafts without loss of osteogenic function

Jakob Hofmann, Tim Niklas Bewersdorf, Ulrike Sommer, Kai Borcherding, Karsten Thiel, Christoph Ganss, Matthias Gerstner, Markus H. Frank, Gerhard Schmidmaier, Mark Andreas Kluth, Tobias Grossner

Abstract Autologous bone grafting remains the standard for reconstruction of bone defects but is constrained by limited graft volume and loss of osteogenic capacity when expanded with acellular materials. We hypothesized that allogeneic ABCB5⁺ mesenchymal stem cells (MSCs) can serve as a biologic cell source to augment bone marrow-derived MSC (BM-MSC) populations without impairing osteogenesis. Primary human BM-MSCs from five donors were combined with GMP-manufactured ABCB5⁺ MSCs at graded replacement ratios (0–95% …

03.09.2026journal-article

Clinical Kidney Journal

Rituximab therapy achieves comparable remission to cyclophosphamide in ANCA-associated vasculitis with severe KIDNEY involvement

Nishant Chaudhari, Azm Ul Hussain, Lee Quill, Joshua Harridine, Kashif Eqbal, Lorraine Harper, Dimitrios Chanouzas

Abstract Introduction The RAVE/RITUXIVAS trials established rituximab (RTX) therapy in ANCA-associated vasculitis (AAV). However, RAVE excluded patients with severe renal involvement (creatinine > 354 µmol/L). Whilst RITUXIVAS did not, treatment included RTX with 2 cyclophosphamide (CYC) pulses. This study reports outcomes in AAV patients with severe renal involvement treated with RTX alone compared to CYC, together with high dose steroids. Methods Data were collected retrospectively for all consecutive AAV present …

03.09.2026journal-article

Frontiers in Medicine

Case Report: A cluster of cases with rash associated with Chlamydia pneumoniae infection

Tianyi Wu, Gang Wang, Nannan Xu, Ke Xu, Gonghai Chen

We report a case of clustered rashes among teenagers associated by Chlamydia pneumoniae (CP) infection. Most patients only presented with rashes without significant fever or other respiratory tract symptoms. Metagenomic next-generation sequencing (mNGS) of blood samples identified the culprit - the nucleic acid sequence of CP was detected in the peripheral blood of the index case. The results of targeted next-generation sequencing (t-NGS) of throat swabs further supported the presence of CP. After antibiotic treatm …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Combined assessment of carotid intima–media thickness and epicardial fat thickness for cardiovascular risk stratification in asymptomatic South Indian adults

Ramesh Sankaran, Dolly Agarwal, Rahul Mittal, Shankar Srinivasan, Nagendra Boopathy Senguttuvan, Alex Karev, Sadhanandham Shanmugasundaram, Balasubramaniyan Jayanthi Venkata, Vinod Kumar Balakrishnan, Preetam Krishnamurthy, Sadagopan Thanikachalam, Murthy Jayanthi Satyanarayana

Background Carotid intima-media thickness (cIMT) and epicardial fat thickness (EFT) are non-invasive imaging markers associated with cardiovascular risk. This study evaluated the associations between cIMT, EFT, individual cardiovascular risk factors, cumulative cardiovascular risk-factor burden in asymptomatic adults undergoing routine cardiovascular health assessment. Methods A cross-sectional study was conducted in 925 asymptomatic adults aged ≥18 years undergoing routine cardiovascular health evaluations. Partic …

03.09.2026journal-article

Frontiers in Neurology

Interpretable machine learning–based prediction of 90-day mortality after endovascular treatment in acute large vessel occlusion stroke

Yuanfang Zhou, Xiaoxia Li, Guokuan Feng, Chuanhang Lin, Bao Liao

Background Despite high recanalization rates after endovascular treatment (EVT) for acute ischemic stroke due to large vessel occlusion (AIS-LVO), 15%−20% of patients still die within 90 days. Existing prognostic models predominantly target functional disability rather than mortality, and rarely incorporate calibration, clinical utility, or interpretability. We aimed to develop and internally validate interpretable machine learning (ML) models for dynamic post-EVT in-hospital prediction of 90-day all-cause mortalit …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Electrode perforation with normal pacemaker parameters leading to hemorrhagic shock: a rare case report of the “penetration-exit-re-entry” phenomenon

Zuoan Qin, Jian Yang, Li Luo, Shi Chen, Fei Yang

Background Permanent pacemaker implantation via subclavian vein puncture may induce rare but life-threatening iatrogenic vascular injury. Vascular perforation with pacing lead penetration-exit-re-entry trajectory accompanied by normal intraoperative pacing parameters is reported extremely rarely, which greatly increases the risk of missed diagnosis. Case presentation A 70-year-old female patient with complete atrioventricular block received dual-chamber pacemaker implantation. All intraoperative lead electrical ind …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Perfluorooctanoic acid–associated complement factor B upregulation and atrial fibrillation–related molecular alterations: integrated network toxicology, Mendelian randomization, molecular dynamics, and HL-1 cell analyses

Dan Li, Chuanfeng Bai, Jinping Zhao

Background Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant associated with cardiovascular dysfunction, but the molecular links between PFOA exposure and atrial fibrillation (AF) remain unclear. We aimed to prioritize a candidate mediator connecting PFOA with AF and examine its associated molecular effects in atrial cardiomyocytes. Methods PFOA-associated or computationally predicted genes from CTD, STITCH, and SwissTargetPrediction were integrated with AF-associated genes. Complement factor B …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Artificial Intelligence for Cerebral Aneurysm Management: Integrating Imaging, Hemodynamics, and Clinical Decision Support

Reza Bozorgpour, Pilhwan Kim, Jacob Rammer

Abstract Cerebral aneurysms are complex vascular lesions whose rupture can result in subarachnoid hemorrhage (SAH), a condition associated with substantial morbidity and mortality. Although current clinical risk assessment relies primarily on morphological characteristics such as aneurysm size and location, these factors alone are often insufficient for individualized rupture risk prediction. Advances in artificial intelligence (AI) and machine learning (ML) have enabled the integration of imaging, clinical, morpho …

03.09.2026journal-article

South Asian Journal of Cancer

A retrospective analysis of treatment patterns and outcomes in carcinoma of the external auditory canal

Bal Krishna Mishra, Akhil Kapoor, Anuj Gupta, Bipinesh Sansar, Ayushi Pragya, Aseem Mishra, Ashutosh Mukherji, Sambit S Nanda, Ankita Rungta Kapoor, Ajay Kumar Choubey, Arvind Suresh, Satyendra Narayan Singh, Shreya Shukla

Objectives: Carcinoma of the external auditory canal (EAC) is a rare form of head and neck cancer, which accounts for

03.09.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

INTELIGÊNCIA ARTIFICIAL EM HEMATOLOGIA LABORATORIAL: IMPACTO NO DIAGNÓSTICO

Éverton José Ferreira de Araújo, Janyerson Dannys Pereira da Silva, Danielle Yasmin Moura Lopes de Araujo, José Couras da Silva Filho, Marcelo Rodrigues Mendes, Pedro Simão da Silva Azevedo, Maria Luíza Passos Ribeiro Maia, Isadora Marques Silva Sousa, Mariana Isabela Beserra de Menezes

A inteligência artificial (IA) tem promovido avanços significativos na hematologia laboratorial ao ampliar a capacidade de processamento e interpretação de dados clínicos, morfológicos, imunofenotípicos e moleculares. O presente estudo teve como objetivo revisar a literatura científica acerca das aplicações da IA na hematologia laboratorial, destacando seu impacto no diagnóstico, suas principais contribuições, limitações e perspectivas futuras. Realizou-se uma revisão integrativa da literatura por meio de busca est …

03.09.2026journal-article

Journal of Travel Medicine

Orthopaedic Injuries among International Travellers in Nepal

Abhishek Shrestha, Ishwor Ghimire Padhya, Jasmine Shrestha, Pratigya Aryal, Prativa Pandey

Highlight/Teaser International travellers in Pokhara experience a considerable burden of orthopaedic injuries. This study describes their injury patterns, management, and outcomes, providing evidence to strengthen preventive advice, trauma preparedness, and clinical services in popular adventure-travel destinations.

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Aktuelle Forschung nach Fachgebiet

IFC-HFlowVAE: A self-enhancing generative framework with structural anchoring for imbalanced clinical data augmentation

Age-dependent macromolecule signals in the human motor cortex and thalamus: implications for metabolites quantification at 7 T

Impact of preoperative nutritional status on longitudinal changes in pulmonary function and prognosis after lung cancer surgery

A qualitative analysis to identify implementation strategies for a deprescribing clinical practice guideline using the CFIR-ERIC Matching Tool: perspectives from consumers and professional stakeholders

Implementation of an opioid use disorder (OUD) machine-learning phenotype in real-time for the ADAPT clinical trial

Oral Cyanocobalamin Treatment in Infants Under 1 Year With Nutritional Vitamin B12 Deficiency: A Retrospective Comparison of 500 and 1000 µg Dose Regimens

Epidemiological Spectrum of Palmoplantar Dermatoses in Central India: A Hospital-based Cross-sectional Study

The Doctor Will Zoom You Now: An Experiential Telemedicine Assessment for Pediatric Residents

Quality Assessment of Systematic Reviews on Gluteal Augmentation Using a Measurement Tool to Assess Systematic Reviews (AMSTAR 2)

EXPRESS: Use of subconjunctival cyclosporine implants for treatment of feline eosinophilic keratoconjunctivitis: a case report

Treatment outcomes and factors associated with unfavorable outcomes among drug-resistant tuberculosis patients treated with a bedaquiline-based oral regimen

When microsurgery is not an option: staged delayed reverse sural artery flap with ischaemic preconditioning for limb salvage in an elderly patient with chronic post-traumatic osteomyelitis—a case report

Antifungal and antibiofilm activity of crude hydroalcoholic extract and fractions of Myrcia neoobscura leaves against a clinical isolate of Candida krusei

ABCB5⁺ mesenchymal stem cells enable high-ratio cellular augmentation of bone grafts without loss of osteogenic function

Rituximab therapy achieves comparable remission to cyclophosphamide in ANCA-associated vasculitis with severe KIDNEY involvement

Case Report: A cluster of cases with rash associated with Chlamydia pneumoniae infection

Combined assessment of carotid intima–media thickness and epicardial fat thickness for cardiovascular risk stratification in asymptomatic South Indian adults

Interpretable machine learning–based prediction of 90-day mortality after endovascular treatment in acute large vessel occlusion stroke

Case Report: Electrode perforation with normal pacemaker parameters leading to hemorrhagic shock: a rare case report of the “penetration-exit-re-entry” phenomenon

Perfluorooctanoic acid–associated complement factor B upregulation and atrial fibrillation–related molecular alterations: integrated network toxicology, Mendelian randomization, molecular dynamics, and HL-1 cell analyses

Artificial Intelligence for Cerebral Aneurysm Management: Integrating Imaging, Hemodynamics, and Clinical Decision Support

A retrospective analysis of treatment patterns and outcomes in carcinoma of the external auditory canal

INTELIGÊNCIA ARTIFICIAL EM HEMATOLOGIA LABORATORIAL: IMPACTO NO DIAGNÓSTICO

Orthopaedic Injuries among International Travellers in Nepal