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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

JMIR Nursing

A One-Year Study Using Digital Biomarkers From Sensing Technologies to Assess Changes in Physical Activity Levels and Sleep Quality in Nursing Home Residents With Dementia: Observational Study

Lydia D Boyle, Monica Patrascu, Bettina S Husebo, Kristoffer Haugarvoll, Ole Martin Steihaug, Brice Marty

Abstract Background Proxy-rated questionnaires remain the standard for the assessment of activity and sleep for people with dementia living in nursing homes. Sensing technologies, such as wearables, can generate continuous data that provide quantitative insights into daily activities and behavioral and psychological symptoms, such as sleep disturbance. This study explores the use of sensing technologies in the detection of changes in physical activity levels and sleep behaviors over time. Objective This study aims …

28.08.2026journal-article

Medical Sciences

Reported Slowing in Walking and Everyday Activities and Long-Term Mortality in Older Adults: The NEDICES Population-Based Cohort Study

Julián Benito-León, Carla María Benito-Rodríguez, Álex Escolà-Gascón, Félix Bermejo-Pareja

Background: Objective gait speed, self-rated walking pace, and self-reported walking difficulty are consistently associated with mortality. Far less is known about the prognostic meaning of perceiving, or being told, that one has recently become slower in both walking and everyday activities. We examined whether reported slowing was associated with long-term all-cause mortality in older adults. Methods: The Neurological Disorders in Central Spain (NEDICES) study is a prospective population-based cohort of 5278 adul …

28.08.2026journal-article

Medicine

eGFR partially mediates the association between Dietary Inflammatory Index and all-cause mortality in older adults

Tingting Hu, Ying Zhang, Zhu Chen, Zhifen Zhang, Jun Su

This study examines the association between the Dietary Inflammatory Index (DII) and all-cause mortality in older adults and investigates the mediating role of estimated glomerular filtration rate (eGFR) using National Health and Nutrition Examination Survey data. We included 6300 participants aged ≥ 60 years from 9 National Health and Nutrition Examination Survey cycles (2001–2018). All-cause mortality (ascertained via linkage to the National Center for Health Statistics) was the primary endpoint. Cox proportional …

28.08.2026journal-article

Jurnal Psikologi

The Role of Self-Compassion in the Quality of Life of People Living with HIV/AIDS

Nada Nafisah, Nida Ul Hasanat

Individuals with chronic illnesses, including people living with HIV/AIDS (PLWHA), will continue to adapt and face various difficulties, including physical, social, and psychological problems throughout their lives. These difficulties can lower their quality of life. One way to cope with the situations PLWHA face is through self-compassion. Self-compassion is a positive construct within an individual that is associated with a kind, caring, and concerned approach to overcoming difficulties, pain, and suffering. This …

28.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Metabolomic Profiling of Telomere Length: Associations with Aging-related Phenotypes and Modifiable Lifestyle Factors in Chinese Older Adults

Tianpei Ma, Xunying Zhao, Ke Jiang, Lei Lin, Lanjin Xu, Nan Yang, Xin Chen, Qingwen Zhao, Xingyu Zhang, Haiyu Yan, Xinyang Dui, Jinyu Xiao, Mengyu Fan, Lu Long, Jiaqiang Liao, Tao Zhang, Xia Jiang, Jiayuan Li

Abstract Background Telomere length (TL) is a well-established biomarker of cellular senescence, yet the metabolic profile of TL and its associations with aging-related phenotypes and responses to modifiable lifestyle factors remain unclear. Methods TL was measured using quantitative real-time polymerase chain reaction (qPCR) in 282 participants from the West China Health and Aging Cohort (WCHAC). Plasma metabolites were analyzed using Liquid Chromatography-tandem Mass Spectrometry. TL-associated metabolic signatur …

28.08.2026journal-article

Aging Cell

Shelterin TPP 1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells

Lihui Wang, Bihan Zhao, Jiahui Yang, Ying Liang, Yitian Yao, Xiao Xiao, Long Yang, Jinghao Xia, Haoze Li, Ling Gao, Jun Zhang, Tianci Su, Hao Xu, Jiacheng Zhang, Hongyan Wang, Jun Liu, Xiaojing Hong, Jun‐Ping Liu

ABSTRACT Telomere shortening drives hair follicle senescence, yet successful reversal of this aging process has remained elusive. Here, we report that stem cell overexpression of Acd , the gene encoding TPP1 (telomere protection protein 1)—a shelterin component that recruits telomerase—accelerates hair regeneration in mice. Stabilization of TPP1 protein via topical application of TELODIN, a synthetic octapeptide that inhibits TPP1 degradation, similarly promotes hair regeneration. Mechanistically, increased TPP1 mo …

28.08.2026journal-article

Atmospheric Chemistry and Physics

Contrasting nighttime heterogeneous and daytime photochemical aging drive the optical evolution of black carbon

Yin Zhang, Jinghao Zhai, Yaling Zeng, Shao Shi, Baohua Cai, Ke Yang, Yu Yan, Xin Yuan, Tianlong Hu, Chen Wang, Tzung-May Fu, Lei Zhu, Huizhong Shen, Jianhuai Ye, Xin Yang

Abstract. Black carbon (BC) particles play a critical role in the climate system, yet their atmospheric aging processes and consequent optical impacts in real-world atmospheres remain insufficiently understood. In this study, we present integrated single-particle measurements using a single particle soot photometer (SP2) and a single-particle aerosol mass spectrometer (SPAMS) during a field campaign in urban Shenzhen, China. The mean refractory BC (rBC) mass concentration during the sampling period was 1.2 µg m−3, …

28.08.2026journal-article

Medicine

The global research of artificial intelligence on Alzheimer disease

Hong-Yan Wu, Xiao-Shan Wang, Mei Yang, Jing Cai

Background: With the increasing global prevalence of Alzheimer disease (AD), there has been heightened attention on the onset and progression of AD. Studies indicate that artificial intelligence (AI) has demonstrated potential in the early prediction and diagnosis of AD. However, current research still falls short in terms of data diversity and the application of personalized models. Objective: This manuscript utilizes bibliometric methods to explore the application trends and emerging frontiers of AI in AD researc …

28.08.2026journal-article

Frontiers in Nutrition

Lifestyle mediates the association between normal-weight visceral obesity and MASLD in older adults with hypertension and diabetes

Jun-Yan Xi, Yi-Jing Wang, Xiao-Heng Li, Rui-Qi Ming, Hua-Ling Yan, Xue-Qi Li, Jie Sun, Wei Hu, Jie Hu, Bo Yan, Jian-Jun Bai, Yi-Ning Xiang, Jing Gu, Xiao Lin, Gang Liu, Yuan-Tao Hao

Objective Older adults with coexisting hypertension and type 2 diabetes are at high risk for metabolic dysfunction-associated steatotic liver disease (MASLD). Normal-weight visceral obesity (NWVO)—excess visceral fat despite normal body mass index and waist circumference—is an overlooked risk factor. Lifestyle is modifiable, but its role in explaining the NWVO-MASLD association is unknown. We quantified the proportion of this association statistically mediated by unhealthy lifestyle patterns. Methods This retrospec …

28.08.2026journal-article

Frontiers in Medicine

Exercise adherence and wrist function recovery after distal radius fracture surgery in older adults: a 12 week prospective longitudinal study

Sunan Ji, Yiping Sun, Yu Zhu

Objective To explore the interactive relationship between wrist function recovery trajectory and exercise adherence in older patients after surgical treatment of distal radius fractures. Methods This study was a prospective, multicenter, observational study. A total of 230 older patients with distal radius fractures who underwent volar locking plate internal fixation at Nantong Sixth People's Hospital and Affiliated Hospital of Nantong University from February 2025 to February 2026 were enrolled. Wrist function was …

28.08.2026journal-article

Alzheimer Disease & Associated Disorders

Age-Dependent and APOE-Modified Associations Between Vascular Risk Factor Patterns and Cognitive Function

Yan Kong, Xian Li, Ruiqian Guan, Xin Wang, Ao Chen, Hongkun Zhang

Introduction: Vascular risk factors (VRFs) are established contributors to cognitive decline, yet they often co-occur in distinct patterns. Whether VRF pattern-cognition associations are modified by age or apolipoprotein E (APOE) genotype remains unclear. Methods: We analyzed 44,879 participants aged 60 to 90 years from the National Alzheimer’s Coordinating Center (NACC) with normal cognition or mild cognitive impairment (MCI). Latent class analysis (LCA) identified VRF patterns from 7 indicators: hypertension, dia …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Correction of facial skin aging signs using exosomes

T.N. Korolkova, I.A. Shepilova, T.G. Dovbeshko

Background. Skin aging is a multifactorial process caused by internal mechanisms and external influences. Gradual changes in the epidermis and dermis lead to impaired skin functions. Restoring these functions is an important task. Objective. Evaluation of the results of using a two-component complex with exosomes in patients with signs of facial skin aging. Material and methods. During this study, 22 patients (mean age 53.1±1.3 years) with Fitzpatrick skin phototypes I-III, wrinkles and other signs of facial aging …

28.08.2026journal-article

Revista Multidisciplinar Epistemología de las Ciencias

Conceptions philosophiques des identités de genre chez le peuple maya contemporain: femmes, hommes et complémentarité

Verónica García Rodríguez

This article analyzes, from the perspective of the Philosophy of Liberation and intercultural approaches, the philosophical conceptions underlying gender identities within the contemporary Maya people. It focuses particularly on the symbolic constructions of femininity and masculinity, as well as on the principle of gender complementarity that emerges from the Maya worldview. These identities are shaped through language, territory, and collective memory, in a critical dialogue with the processes of colonization and …

28.08.2026journal-article

BMC Geriatrics

Exploring the psychosocial needs and nutritional status of older adults with alcohol use disorder: a mixed-methods study (The OLA Study)

Stephanie Hughes, Rebecca Band, Zarah Linssen, Sophie Crouzet, Stephen Lim, Julia Sinclair

Abstract Background Alcohol-related hospital admissions are rising in England, particularly among individuals aged 65 and over. While alcohol intake and nutritional status are important factors in health outcomes, they are often overlooked. Loneliness, also common in this age group, is associated with poorer health and increased mortality. Objectives (1) To explore the clinical and sociodemographic characteristics, and nutritional status of older adults with alcohol use disorder (AUD) admitted to hospital. (2) Expl …

28.08.2026journal-article

Malignant tumours

The Geriatric-8 (G8) screening questionnaire as a predictor of anticancer therapy toxicity in elderly patients: a comprehensive analysis of current data

A. B. Elmurzaev, I. N. Danilov, I. V. Rykov, G. A. Chizh, T. P. Nikitina, S. O. Kuzin, O. S. Lokotosh, V. A. Mirgorodskaya

Introduction. Treatment of elderly cancer patients is challenging due to high risk of adverse events. Comprehensive Geriatric Assessment (CGA) is the gold standard but time-consuming. The G8 screening tool rapidly identifies patients requiring CGA. Aim. To summarize current evidence on the predictive value of the G8 for chemotherapy toxicity, assess its diagnostic accuracy, compare it with other geriatric scales, and evaluate its applicability in the Russian population. Materials and methods . A systematic search o …

28.08.2026journal-article

Asian Journal of Economics and Banking

Determinants of older adults' central bank digital currency use behaviour in Nigeria: implications for inclusive and sustainable finance

Adetumilara Iyanuoluwa Adebo, Kehinde Aladelusi

Purpose The study aimed to extend the Unified Theory of Acceptance and Use of Technology (UTAUT) to identify the determinants of Central Bank Digital Currency (CBDC) use behaviour among older adults by introducing components of self-transcendence and conservation values from the theory of basic human value. The moderating effect of Security value and the mediating effects of intention were also examined. Design/methodology/approach Quantitative data were collected from 310 older adults in Southwestern Nigeria. The …

28.08.2026journal-article

Brain Communications

Cumulative incidence and risk factors of dementia in Parkinson's disease and parkinsonism: a population-based study

Lorenzo Malfer, Aidan F Mullan, Elena Lynott, Colton Troxel, Farwa Ali, Eduardo E Benarroch, Bradley F Boeve, James H Bower, Rodolfo Savica

Abstract Cognitive impairment is among the most common non-motor symptoms in parkinsonism and Parkinson’s disease, ranging from subjective complaints to dementia. Although several predictive factors have been described, their prognostic relevance remains uncertain. This study aims to examine the predictive association between clinical features and the risk of dementia and determine the incidence of dementia in a population-based cohort of incident parkinsonism cases. Patients with parkinsonism onset between 1991 an …

28.08.2026journal-article

Medicine

Association of the geriatric nutritional risk index with mortality in patients with rheumatoid arthritis

Zhong Wen, Shunbing Wang, Yuzhi Li, Xin Tu, Quanbo Zhang, Yufeng Qing

To investigate the association of the geriatric nutritional risk index (GNRI) with all-cause and cardiovascular mortality among adults with rheumatoid arthritis (RA). Data were obtained from the National Health and Nutrition Examination Survey 2007 to 2018. The GNRI was evaluated continuously and categorically (< 98 vs ≥ 98). Survey-weighted Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals (CIs) for all-cause and cardiovascular mortality. Restricted cubic spline, comp …

28.08.2026journal-article

Journal of Science and Technology

Environmental Awareness among Young People: a Study on Sustainable Travel Practices among Gen Z Travelers in Ho Chi Minh City

Dang Thi Kim Phung, Ho Nhat Tien

Due to the increasing global significance of climate change the tourism sector is increasingly encouraged to adopt more sustainable practices. This exploratory study examined the environmental awareness and sustainable travel behavior of Generation Z travelers in Ho Chi Minh City, a rapidly developing urban destination facing growing environmental challenges. Based on survey data collected from 50 participants from 18-27, a noticeable gap between environmental awareness and self-reported sustainable travel behavior …

28.08.2026journal-article

Healthcare

Within-Person Longitudinal Associations Between Obesity-Related Eating Behaviors and Physical Activity Among Older Adults: A Three-Wave Random-Intercept Cross-Lagged Study

Shi Luo, Bin Chen, Xianxiong Li, Joston Gary

Objectives: This study examined the within-person longitudinal associations between obesity-related eating behaviors and physical activity among community-dwelling Chinese older adults. Methods: Three waves of data were collected at three-month intervals from 1256 adults aged 65 years or older across 17 urban and rural communities. Physical activity was measured using the Physical Activity Rating Scale-3, and obesity-related eating behaviors were assessed using the seven-item Sakata Eating Behavior Scale Short Form …

28.08.2026journal-article

BMC Geriatrics

Psychometric properties and age- and gender-specific normative values of the Patient Health Questionnaire-4 among older adults aged 60 years and above

Nikolay Dimitrov, Elmar Brähler, Andreas Hinz, Bjarne Schmalbach, Jörg M. Fegert, Markus Zenger

Abstract Background Mental health problems in older adults are often underrecognized despite their substantial impact on health and well-being. Brief, valid screening tools with age-specific normative data are needed for this growing population. This study examined the psychometric properties of the Patient Health Questionnaire-4 (PHQ-4) and established age- and gender-specific normative values for adults aged 60 years and older in Germany. Methods Data were drawn from four nationally representative face-to-face ho …

28.08.2026journal-article

Societies

Experiencing Healthy Aging Through Guided Smartphone Use: A Constructivist Grounded Theory Study of Older Adults in Brazil

Adriana Martins Gallo, Carlos Laranjeira, Juliane Pagliari Araujo, Wanessa Cristina Baccon, Francielle Renata Danielli Martins Marques, Jackeline Tiemy Guinoza Siraichi, Amira Mohammed Ali, Feten Fekih-Romdhane, Maria Aparecida Salci, Lígia Carreira

Digital technologies seem to contribute to health promotion and disease prevention, allowing older people to benefit from targeted health interventions supported by digital resources. The current study aimed to develop a substantive theory focusing on the experiences of older people who use smartphone technology daily and its repercussions on healthy aging. This qualitative study employed Charmaz’s constructivist grounded theory approach. Purposeful and theoretical sampling was used to recruit 37 older Brazilian pe …

28.08.2026journal-article

npj Aging

Aging-related transcriptomic signatures associated with recurrence following resection of stage I lung adenocarcinoma

Fares Darawshy, Cigdem Sevim Bayrak, Xianxiao Zhou, Kendrew Wong, Imran Sulaiman, Benjamin Kwok, Cecilia Chung, Alena Lukovnikova, Sofia Roldan, Benjamin G. Wu, Matthias C. Kugler, Yonghua Li, Rosemary Schluger, Destiny Collazo, Yaa Kyeremateng, Ray Pillai, Matthew Blaisdsell, Michelle Fridman, Alexander Bain, Marcus D. Goncalves, Chandra Goparaju, Daniel Sterman, Anil Vachani, Gregory David, Aristotelis Tsirigos, Bin Zhang, Christian V. Forst, Harvey Pass, Leopoldo N. Segal, Jun-Chieh J. Tsay

Abstract Age is an independent prognostic factor in early-stage non-small cell lung cancer, yet age-associated molecular differences and their association with cancer recurrence remain poorly understood. We investigated transcriptomic differences associated with aging and recurrence in stage I lung adenocarcinoma (LUAD). Bulk RNA sequencing was performed on tumor and adjacent normal lung tissue (NAT) from 126 patients with resected stage I LUAD. Differential expression, pathway enrichment, and multiscale embedded g …

28.08.2026journal-article

European Geriatric Medicine

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Paula Sobrini-Morillo, Isabelle Moens, Alfonso Cruz-Jentoft, Andrea Sebastiano Ciccone, Jugdeep K. Dhesi, Nicolas M. Gonzalez-Senac, Marije Hamaker, Cecilia Lund, Francesco Mattace-Raso, Nina Neuendorff, Siri Rostoft, David Shipway, Giuseppe Dario Testa, Anja Velghe, Harmke A. Polinder-Bos, on behalf of the SIG Perioperative Geriatric Medicine and the SIG Gero-Oncology of the European Geriatric Medicine Society

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The responses were summarized, and associations between comprehensive geriatric assessment (CGA) outputs, participation in oncological multidisciplinary team (MDT) meetings, and involvement in treatment decision-making were explored. Results A to …