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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Indian Journal of Veterinary Pathology

Prognostic biomarkers of cancer in animals: A systemic approach

Kavitha Rani B.

Cancer is a condition characterized by uncontrolled cell proliferation, tissue invasion and metastasis. Animal cancers, which are on rise in the recent past, resemble human cancers and serve as valuable models for comparative research in cancer biology and drug development. Biomarkers are defined as measurable molecules indicating biological processes, disease or treatment response to cancer. Historical evolution of biomarkers spans from simple protein markers like alpha-fetoprotein (AFP) to advanced microRNAs and …

01.09.2026journal-article

Journal of Vascular Anomalies

Reproductive Considerations In Patients Undergoing Treatment For Complex Lymphatic Anomalies

Adriana N. Vest, Selena U. Park, Kiley Hunkler, Luciana Daniela Garlisi Torales, Kwabena Aboagye, Deena Zeltser, Andrea Bowling, Clarisa R. Gracia, Alan DeCherney, Sarah E. Sheppard

Complex lymphatic anomalies (CLAs) are a spectrum of lymphatic malformations affecting multiple organ systems. These disorders are characterized by wide variability in presentation features, which often delays accurate diagnosis and complicates characterization and differentiation. Little is known about the gynecologic and reproductive effects of CLAs or their associated treatments, such as long-term systemic immunosuppressive medications and repurposed single-molecule inhibitors. In this case report, we discuss a …

02.09.2026journal-article

Cancer Medicine

Prognostic Value of Hemoglobin, Albumin, Lymphocyte, and Platelet Score in Locally Advanced Nasopharyngeal Carcinoma

JunMei Song, Lan Luo, Ting Liu, YuQing Lv, Qiulin Huang, Rensheng Wang, Jun Bie

ABSTRACT Objective To investigate the prognostic value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in patients with locally advanced nasopharyngeal carcinoma (LANPC) receiving concurrent chemoradiotherapy (CCRT), and to clarify its predictive significance for overall survival (OS), progression‐free survival (PFS), locoregional failure‐free survival (LRFFS), and distant metastasis‐free survival (DMFS). Methods Clinical data of 295 patients with LANPC who received CCRT between April 2021 and Apr …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Co-expression of the Mammaglobin (SCGB2A2) Gene With hsa-miR-184 and hsa-miR-190b Indicates Its Possible Role in Oncogenic Pathways in Breast Cancer

JUAN FELIPE ABELLA-DUQUE, LILIANA LÓPEZ-KLEINE, RAFAEL PARRA-MEDINA, SANDRA RAMÍREZ-CLAVIJO, CÉSAR PAYÁN-GÓMEZ

Background/Aim: Breast cancer is the most common cancer in women worldwide, and early detection remains a significant challenge. Recent studies have identified increased expression of Mammaglobin A (Q13296, Gene: SCGB2A2) mRNA in breast cancer, suggesting its potential as a disease marker, although its function is not fully understood. To elucidate Mammaglobin’s role, this study sought to identify co-expressed miRNAs and analyze the biological pathways they regulate. Materials and Methods: Using TCGAbiolinks and Fi …

01.09.2026journal-article

Theoretical and Natural Science

Therapeutic and Intervening Effects of Triptolide in Pancreatic Cancer and Their Molecular Mechanisms

Zeyu Song

Pancreatic cancer is a very aggressive digestive cancer that often appears subtly, is difficult to diagnose in its early stages, has a poor prognosis, is susceptible to chemotherapy resistance, and conventional comprehensive therapy cannot extend the life of patients. Triptolide is an extracted bioactive substance from Tripterygium wilfordii; it has shown good anti-tumour activity in pancreatic cancer and is thus considered a promising new natural anti-cancer drug. Review of the research progress and molecular mech …

01.09.2026journal-article

Advances in Autism

Effectiveness of mentalisation-based treatment for improving social cognition and emotional regulation in adults with borderline personality disorder or autism spectrum disorder: a systematic review

Sofía Fernández Medina, Janay Vidal Gutierrez, Andrea Duarte Díaz

Purpose This study aims to evaluate the effectiveness of mentalisation-based treatment (MBT) for emotional regulation and social cognition in adults with borderline personality disorder (BPD), and to determine the extent and quality of the available evidence on MBT in adults with autism spectrum disorder (ASD), characterising the imbalance in the evidence between these two diagnostic groups. Design/methodology/approach A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Rev …

01.09.2026journal-article

Cancer Research

Histone Lactylation Mediated by circRNA-Facilitated FXR1 Phase Separation Promotes Colorectal Cancer Progression

Tao Jiang, Jianquan Liu, Qihang Hu, Junwen Qi, Bowen Liu, Ning Ma, Yixin Xu, Long Zhang, Junnan Chen, Jun Song

Abstract Histone lactylation is an epigenetic modification triggered by lactate produced during glycolysis. In cancer, histone lactylation can coordinate metabolic and epigenetic states to promote tumor development and progression. In this study, we identified circ2891 as a driver of metabolic reprogramming and histone lactylation in colorectal cancer. In patients, circ2891 was aberrantly upregulated in tumors and correlated with poor outcomes. Elevated circ2891 potentiated aerobic glycolysis and lactate production …

01.09.2026journal-article

Radiology

Convergence of Local and Systemic Therapies: A Comprehensive Society of Interventional Oncology Framework for 90 Y Radioembolization with Immunotherapy in HCC

Rony Avritscher, Edward Kim, Valerie Chew, Ghassan K. Abou-Alfa, Ahmed Kaseb, Beau Toskich, Terence Gade, Mishal Mendiratta-Lala, Sunil Krishnan, S. Cheenu Kappadath, Riad Salem

New strategies combining yttrium 90 ( 90 Y) radioembolization and immune checkpoint inhibitor therapy for treatment of advanced-stage hepatocellular carcinoma show promising safety and improved tumor response rates, with 90 Y radioembolization modulating the tumor immune microenvironment and enhancing responsiveness to immunotherapy.

01.09.2026journal-article

Pediatric, Adolescent & Young Adult Cancer

Pediatric, Adolescent & Young Adult Cancer: Timely, urgent, and essential

Nirali N. Shah

Welcome to Pediatric, Adolescent & Young Adult Cancer : a timely, urgent, and essential resource dedicated to advancing cancer research, prevention, therapy, survivorship, and patient outcomes across pediatric, adolescent, and young adult oncology. In this inaugural editorial, Editor‐in‐Chief Nirali N. Shah shares her vision for the journal and the communities it aims to serve.

01.09.2026journal-article

Journal of Comparative Effectiveness Research

Methodological pitfalls in indirect treatment comparisons: insights from a recent systematic review and analysis for C3 glomerulopathy

Brian Hutton, James Fotheringham, Andrew Ervin, Raisa Sidhu, Corey Lourenco, Imtiaz A Samjoo, Chris Cameron, Bridget Dunne

Aim: Indirect treatment comparisons (ITCs), as outlined in NICE and ISPOR guidance, require careful evaluation of cross-trial heterogeneity to ensure valid comparisons, particularly in rare diseases with limited evidence. C3 glomerulopathy (C3G) is an ultra-rare, complement-mediated kidney disease with high unmet need, making appropriate application of ITC frameworks especially critical. This appraisal evaluates the feasibility of applying ITC principles to compare Phase III trials of iptacopan (APPEAR-C3G) and peg …

01.09.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

TRATAMENTO FARMACOLÓGICO DE ARRITMIAS CARDÍACAS COM O USO DA DIGOXINA

Analluyza Nunes Coelho Inocêncio, Ana Beatriz Dantas das Mercês

A pesquisa tem como objetivo relacionar dados científicos sobre o efeito farmacológico da digoxina no tratamento das arritmias cardíacas, abordando vias de administração, efeitos terapêuticos, colaterais e impactos na qualidade de vida. Trata-se de uma revisão integrativa da literatura realizada em seis etapas, com busca na Biblioteca Virtual em Saúde (BVS), abrangendo as bases LILACS, MEDLINE e BDENF. Utilizou-se a estratégia PICo para formular a pergunta norteadora. O recorte temporal compreendeu artigos publicad …

02.09.2026journal-article

The Oncologist

45 Targeting Lysyl Oxidase Inhibits Tumor Progression in Clear Cell Renal Cell Carcinoma

Burge Ulukan, Ozge Saatci, Ariel Madrigal, Minjun Kim, Wensheng Tian, Mustafa Soytas, Zohreh Mehrjoo, Ozlem Sahin, Kukkamadi Sreenivas, Chintada Nageswara Rao, Tamiko Nishimura, Virginie Pillon, Jean-Sebastian Anoma, Elizabeth Hill, Janusz Rak, Campbell McInnes, Morag Park, Fadi Brimo, Simon Tanguay, Ryan Charles Russell, Hamed Najafabadi, Yasser Riazalhosseini, Ozgur Sahin

Abstract Background Clear cell renal cell carcinoma (ccRCC) is defined by constitutive pseudohypoxia driven by von Hippel-Lindau (VHL) loss, pronounced intratumoral heterogeneity, and aberrant hypervascularity, features that collectively promote tumor progression and limit therapeutic durability. Although VEGF-targeted therapies and HIF-2α inhibitors have improved clinical outcomes, resistance frequently emerges, including mutations in the PAS-B binding pocket that impair drug efficacy. However, the mechanisms that …

01.09.2026journal-article

Intelligent & Human Futures

Explainable spatial AI analyzes tumor-immune interactions to predict immunotherapy outcomes and identify new targets

Gang Liu, Jia Wang, Jia Zhu

The effectiveness of immune checkpoint inhibitors (ICIs) heavily depends on the complex spatial interactions of cells within the tumor microenvironment (TME). However, existing predictive biomarkers generally lack spatial resolution and interpretability, making it difficult to guide clinical decisions or reveal actionable targets. This study aims to develop an interpretable spatial AI framework to systematically decode the tumor-immune spatial architecture, achieve high-accuracy predictions of immunotherapy respons …

01.09.2026journal-article

ACS Applied Nano Materials

Smart Hydrogel-Nanoparticle Platforms for Precision Drug Delivery and Tumor Microenvironment Modulation in Breast Cancer

Poulami Dutta, Dhruvi Dipakbhai Patel, Halak Shukla, Dewang Limaye, Jothiswaran VV, Juni Banerjee, Sonu Gandhi, Shuvomoy Banerjee

Abstract Breast cancer accounts for one in four cancers diagnosed in women and remains the leading cause of cancer-related mortality among women worldwide. The drug delivery system (DDS) has created an effective approach in cancer treatment. The current advancement is a combination of nanomaterials with modern nanotechnological strategies, revolutionizing the DDS. Hydrogels provide an exciting route for innovative DDS to deliver various molecules, including peptides, via transdermal, vaginal, nasal, ocular, oral, a …

01.09.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Hepatitis B and C Prevention, Screening, and Diagnostic Services at HIV Treatment Sites: International Epidemiology Databases to Evaluate AIDS

Mark H. Kuniholm, Gad Murenzi, Niharika Samala, Evy Yunihastuti, Gilles Wandeler, H. Nina Kim, Marie K. Plaisy, Hugo Perazzo, Christella Twizere, Francesca Odhiambo, Rohan Bopage, Guy Muula, Vincent Lo Re, Albert Minga, Alvaro López-Iñiguez, Dominique M. Nsonde, Charles Kasozi, Dewi K. Wati, Matthew P. Fox, Gregory D. Kirk, Eugene Messou, Carina Cesar, Peter V. Ebasone, Helen Byakwaga, Jeremy Ross, Cleophas Chimbetete, George A. Yendewa, Antoine Jaquet, Regina C. M. Succi, Fernanda Maruri, Ellen Brazier, on behalf of IeDEA

Background: Prevention, screening, and diagnostic services for hepatitis B virus (HBV) and hepatitis C virus (HCV) can prevent morbidity and mortality in people receiving HIV care. However, there is limited information about the availability of HBV and HCV services at HIV clinics globally. Methods: The International epidemiology Databases to Evaluate AIDS (IeDEA) conducted surveys of service delivery and practices at participating HIV treatment centers from 7 regions. We used 2023 survey data to measure availabilit …

01.09.2026journal-article

RETINAL Cases & Brief Reports

FULMINANT CLOSTRIDIUM SEPTICUM ENDOGENOUS ENDOPHTHALMITIS PRESENTING WITH INTRAOCULAR GAS IN A PATIENT WITH METASTATIC ENDOMETRIAL CANCER

Young Je Choi, Min Jeong Kwon, Hyun Goo Kang, Kang Hyun Kim, Min Kim

Purpose: To report a rare and fulminant case of Clostridium septicum endogenous endophthalmitis. Methods: A case report of a 52-year-old woman with metastatic endometrial cancer who developed sudden vision loss in the left eye 10 hours after presenting with dizziness, moderate fever, and a normal brain computed tomography scan. Results: The left eye had no light perception. Slit-lamp examination revealed corneal edema and mild anterior chamber inflammation. Owing to a limited fundus view, B-scan ultrasonography was …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Improving Diagnostic and Treatment Precision for Negative Symptoms of Schizophrenia using Quantitative Electroencephalography and Transcranial Direct Current Stimulation: A Case Report

Deepan Raj, Srinivas Rajkumar, Priya Sivashankar

Schizophrenia is a major mental illness associated with significant disability. Negative symptoms represent a key determinant of longterm morbidity and poor functional outcomes. This is a case report of a 22-year-old male presenting with poor functional recovery despite apparent resolution of psychotic symptoms (hallucinations and delusions) on antipsychotics. In follow-up his antipsychotic dose was up titrated along addition of anti-depressants with suspicion of primary negative vs depressive symptoms. He did not …

01.09.2026journal-article

Cancer Plus

Malnutrition in pediatric oncology critical care: Mechanisms, assessment, and nutrition support

Peiyu Huang, Zhixuan Deng

Children with cancer who require pediatric intensive care encounter overlapping metabolic insults from cancer biology, anticancer treatment, and critical illness. These insults may produce a dynamic malnutrition phenotype characterized by impaired intake or absorption, rapid lean-mass loss, micronutrient and electrolyte depletion, and assessment confounded by inflammation and fluid shifts. In this narrative review, we conducted a systematic search on PubMed/MEDLINE through August 11, 2026 and prioritize evidence in …

01.09.2026journal-article

University of Bisha Journal for Basic and Applied Sciences

TiO2 Quantum Dots Supported on Poly(Chloroaniline): Enhanced Photocatalytic Degradation and Recyclability for Wastewater Treatment

Ibrahem A. Ibrahem

A poly(chloroaniline)/TiO2 quantum-dot (ClAn/TiQD) hybrid photocatalyst was prepared by in situ oxidative polymerization to address the limited visible-light utilization and charge recombination commonly associated with TiO2-based systems in dye-bearing wastewater treatment. Structural and spectroscopic analyses confirmed retention of anatase TiO2 after hybrid formation, preservation of the conjugated polymer backbone, and interfacial coupling between TiQD and ClAn. TEM showed ClAn particles of 33–42 nm, TiQD domai …

01.09.2026journal-article

Journal of Medical Imaging and Radiation Oncology

Volumetric and Geometric Assessment of Offline Adaptation in Cervical Cancer External Beam Radiotherapy

Pereshin Moodaley, Karen Lim, Viet Do, Joseph Descallar

ABSTRACT Introduction Offline adaptive replanning is an appealing strategy in cervical cancer external beam radiotherapy (EBRT) to account for tumour shrinkage. It remains unclear whether volume reduction with adaptation improves geometric coverage in the presence of daily pelvic variation. This study evaluated the volumetric and geometric impact of offline EBRT adaptation in this setting. Methods Seventeen patients who completed definitive radio(chemo)therapy and brachytherapy were retrospectively assessed. An MRI …

01.09.2026journal-article

Mathematics

Advancing the Numerical Treatment of Caputo Fractional Lotka–Volterra Systems Through Non-Polynomial Spline Approximation and Neural Network Verification

Majeed Ahmad Yousif, Karwan S. Mohammed, Faraidun K. Hamasalh, Pshtiwan Othman Mohammed

This paper presents a modified non-polynomial fractional cubic spline (MNPFCS) method for solving fractional Lotka–Volterra prey–predator systems governed by the Caputo fractional derivative. The proposed method integrates non-polynomial spline interpolation with fractional calculus to obtain accurate numerical approximations for nonlinear coupled systems. The stability and convergence of the method are established theoretically. To further verify its effectiveness, the numerical solutions are compared with those p …

01.09.2026journal-article

Journal of Comparative Effectiveness Research

Zanubrutinib versus fludarabine, cyclophosphamide and rituximab in fit, treatment-naïve patients with chronic lymphocytic leukemia: a matching-adjusted indirect comparison

Talha Munir, Lianne Barnieh, Leyla Mohseninejad, Sheng Xu, Milica Jevdjevic, Walter Bouwmeester, Keri Yang

Aim: Fludarabine, cyclophosphamide and rituximab (FCR) is a first-line therapy for fit treatment-naive patients with chronic lymphocytic leukemia (CLL); however, its hematotoxicity and related infections necessitate more efficacious, safer treatments. Zanubrutinib is a highly potent and selective next-generation Bruton tyrosine kinase inhibitor approved for treatment-naive patients with CLL and small lymphocytic lymphoma. Given the absence of clinical trials providing head-to-head comparisons, the aim of this analy …

01.09.2026journal-article

Slovenian Journal of Public Health

A Comparative Analysis of the Economic Burden of Breast, Colorectal and Lung Cancer-Related Premature Mortality in Slovenia: Value-Added Decomposition by Occupation-Gender Groups

Tjaša Redek, Tanja Istenič, Petra Došenović Bonča, Ivica Ratoša, Andraž Perhavec, Daša Farčnik

Abstract Introduction This paper aims to estimate the value-added loss attributable to premature deaths from breast, colorectal and lung cancer in Slovenia using a novel methodology using linked employer-employee data, enabling value-added decomposition by occupation-gender groups. Methods The analysis is based on population-level microdata for the 2016–2022 period matched from several sources. Premature mortality costs are estimated using occupation- and gender-specific output losses rather than assuming uniform p …

01.09.2026journal-article

PAIN, JOINTS, SPINE

Changes In Individual Functional Assessment Of Cancer Therapy–General Items Following a 12-Week Tele-Rehabilitation Program In Oncology: a Secondary Analysis

Preksha Jain, Dr. Jafar Khan, Dr. Manoj U. Mahajan, Dr. Veenodini Warhade, Dr. M.S Satish, Dr. k m Annamalai

Introduction: Health-related quality of life (HRQOL) is a multidimensional outcome frequently used to evaluate rehabilitation interventions in oncology. Most tele-rehabilitation studies report improvements using total or domain-level scores of the Functional Assessment of Cancer Therapy–General (FACT-G) questionnaire; however, little is known about which individual patient-reported concerns are most responsive to structured tele-rehabilitation. Understanding item-level response patterns may provide clinically meani …