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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Discover Medicine

Navigating the sedation challenge in frail older patients undergoing endoscopic retrograde cholangiopancreatography: a narrative review

Koji Takahashi, Nana Yamada, Terunao Iwanaga, Takafumi Sakuma, Hidehiro Kamezaki

Abstract The global increase in life expectancy has resulted in a higher volume of endoscopic retrograde cholangiopancreatography (ERCP) procedures among frail older patients. Frailty, a multidimensional syndrome characterized by decreased physiological reserve, presents significant risks for sedation-related adverse events. Current sedation practices frequently rely on data derived from younger cohorts, often failing to account for the distinct pharmacokinetic and pharmacodynamic profiles associated with frailty. …

29.08.2026journal-article

Journal of Applied Polymer Science

The Effects and Mechanisms of Thermal Oxygen Aging on Trap Characteristics and Electrical Performance of Functional Group‐Grafted Materials for HVDC Cable Insulation

Xu Yang, Jingyang Sun, Jun You, Zhe Fu, Yuan Gao, Hong Zhao, Xuan Wang

ABSTRACT In this study, N‐allylaniline (NA), a functional monomer possessing both deep trap‐inducing and antioxidant capabilities, was grafted onto cross‐linked polyethylene (XLPE) to prepare XLPE‐g‐NA. Both XLPE and XLPE‐g‐NA were subjected to thermo‐oxidative aging, and their physicochemical and electrical properties before and after aging were systemically investigated. For pure XLPE, carbonyl groups introduced during thermo‐oxidative aging formed electron traps, which reduced the conductance current at low temp …

29.08.2026journal-article

International Journal of Public Health and Nursing

The Prevalence of Asymptomatic Bacteriuria among People Living in Public Compounds at Obinze Community of Imo State

E. Emeka Ikechukwu, E. Inya Joseph, J. Ofoegbu Chukwudi, E. Ogbonna Chinazom, H. Njoku Akudo, Chukwuemeka Njemanze Canice

The study was conducted between November 2024 and March 2025 using a well-structured questionnaire. Urine samples were collected after engaging Two Hundred (200) persons living in public compounds at Obinze, Imo State. The selected study group was given questionnaires to fill. The samples were collected with suitable sterile urine bottles and transported to the Microbiology Unit of Science Laboratory Technology Department FUTO, where they were processed and inoculated on cysteine lactose electrolyte-deficient media …

29.08.2026journal-article

Molecular Neurodegeneration

Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging

Emily Tom, Fangyuan Gao, Carolina N. Franco, Adrian Wong, Nathan Kemmerer, Zichen Wang, Amit Jairaman, Qianlan Xu, Yinyin Zhuang, Samuel W. Du, Grazyna Palczewska, Krzysztof Palczewski, Itay Budin, Shivashankar Othy, Xiaoyu Shi, Vera L. Bonilha, Johannes Schoeneberg, Karl J. Wahlin, Lauren V. Albrecht, Dorota Skowronska-Krawczyk

Abstract Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. In the retinal pigment epithelium (RPE), lipid dysregulation is strongly associated with aging and age-related macular degeneration (AMD), a neurodegenerative disease of the central nervous system, but the causal pathways remain unclear. Here, we identify reduced activity of the lipid elongase ELOVL2 as a centr …

29.08.2026journal-article

Applied Research in Quality of Life

Trajectories of Parent-Child Relationship Quality and Cognitive Function among Older Adults: Differences between Mothers and Fathers

Jeenkyoung Lee

Abstract The present study examined heterogeneity in trajectories of positive and negative parent–child relationship quality (RQ) and their associations with older parents’ cognitive function. Data came from 7,217 older adults ( M age = 73.57, SD = 9.38; 62% women) in the Health and Retirement Study, using pooled samples (2006/2008, 2010/2012, 2014/2016, 2018/2020). Growth mixture modeling identified five latent trajectory groups for both positive and negative RQ: high-stable (69%/5%), moderate (16%/23%), increasin …

29.08.2026journal-article

Maltepe Tıp Dergisi

Effect Clinical Characteristics and Outcomes of Acute Pulmonary Embolism in Older Adults: A Comparison of Patients Aged 65–75 Years and ≥75 Years

Gökçe Külah, Ayşe Çapar, Harun Çıtlak, Şeyma Başlılar

Amaç: Pulmoner emboli (PE), özellikle yaşlı gruplarda morbidite ve mortalitenin önemli bir nedenidir. Bu çalışmada, yaşın hastalık seyrine etkisini incelemek için 65 yaş ve üzeri PE hastalarının klinik, demografik ve laboratuvar bulguları karşılaştırılmıştır. Materiyal- metodlar: Bu retrospektif gözlem çalışması, PE tanısı ile hastaneye yatırılan 188 hastayı içermektedir. Hastaların demografik özellikleri, komorbiditeleri, laboratuvar parametreleri, ekokardiyografi bulguları ve klinik seyri hastane kayıtlarından el …

29.08.2026journal-article

Biomolecules

Beyond Lipid Lowering: A Narrative Review and Expert Perspective on Precision Cardiovascular Prevention in People with HIV After REPRIEVE

Pere Domingo, Paula Prieto

The spectrum of diseases in individuals with human immunodeficiency virus (HIV) receiving successful antiretroviral therapy has evolved over time. In the past, they developed opportunistic infections and malignancies, whereas today, cardiovascular disease is among the most common causes of illness and premature death. Traditional risk factors for atherosclerosis (hypertension, hyperlipidemia, smoking, diabetes, family history of heart disease) are more prevalent in people with HIV than in the general population. Ho …

29.08.2026journal-article

KAIRÓS-GERONTOLOGIA

Conhecer para cuidar: avaliando o conhecimento sobre a Doença de Alzheimer entre profissionais e acadêmicos

Vinicius Grassi Vieira Ramos, Mariane Lima de Souza, Marcelo De Souza Gorza

O envelhecimento populacional e o aumento dos quadros demenciais exigem profissionais capacitados, apesar de lacunas persistentes no conhecimento técnico. Este estudo avaliou o conhecimento sobre a Doença de Alzheimer entre profissionais e estudantes da saúde do Espírito Santo. Trata-se de estudo quantitativo e transversal, com 750 participantes, utilizando a Alzheimer’s Disease Knowledge Scale. Os resultados indicaram conhecimento moderado, com déficits nos fatores de risco e prevenção

29.08.2026journal-article

Quality of Life Research

The indirect effects of cognitive function in the association between stroke and quality of life among older adults in a rural community: A cross-sectional study

Memory Lucy Mtambo, Tin Tin Su, Devi Mohan, Narelle Warren, Kia Fatt Quek

Abstract Purpose We examined whether cognitive function statistically accounted for associations between stroke and quality of life (QOL). Methods A cross-sectional survey included adults aged ≥ 60 years in Segamat, Malaysia. Cognition was assessed using the Identification and Intervention for Dementia in Elderly Africans instrument, and QOL was assessed using the WHOQOL-BREF. Stroke survivors were matched 1:3 with non-stroke participants by propensity scores based on age, sex, and education. Stroke status was the …

29.08.2026journal-article

Journal of Ageing and Longevity

“I’m Not Sure if They’re Really Getting What I’m Saying”: Perspectives of Healthcare Professionals on the Need to Strengthen Sensory-Loss-Specific Healthcare for Older Adults During and Post COVID-19 in Canada

Atul Jaiswal, Shreya Budhiraja, Abinethaa Paramasivam, Sangeetha Santhakumaran, Shikha Gupta, Norman Robert Boie, Marie Savundranayagam, Claude Vincent, Edeltraut Kröger, Walter Wittich

Background: The COVID-19 pandemic and related public-health measures, including physical distancing and the use of personal protective equipment (PPE), disrupted routine healthcare communication and care delivery for older adults with combined hearing and vision loss, or dual sensory loss (DSL). Around 1.1 million older Canadians are living with DSL and rely on multimodal communication to support assessment and continuity of care. Objectives: This study explored healthcare professionals’ (HCPs) perspectives on olde …

29.08.2026journal-article

Studia Periegetica

Changes in Cognitive Function after a 14-Week Recreational Resistance Training Program in Older Adults: A Pilot Study

Szymon Lubkowski, Beata Pluta

This pilot randomized controlled trial examined cognitive changes after 14 weeks of supervised resistance training in recreationally active adults aged over 60 years. Twenty participants were randomly assigned to intervention or control groups (n=10 each). The intervention included two supervised 45-min weekly sessions, with increasing intensity using the Borg CR10 scale. Before and after the intervention cognitive functions were assessed using the Trail Making Test, Stroop Test, and Digit Span Test. Favourable cha …

29.08.2026journal-article

Nature Communications

Associations between diet quality, epigenetic aging and epigenome in two population-based cohorts

Juliana F. Tavares, Dan Liu, Valentina Talevi, Fabian Eichelmann, Franziska Jannasch, Matthias B. Schulze, N. Ahmad Aziz, Ute Nöthlings, Monique M. B. Breteler

Abstract Several dietary patterns have been associated with better health outcomes. However, the extent to which adherence to different so-called healthy diets overlaps, whether these dietary patterns are equally beneficial, and whether they are associated with similar DNA methylation profiles, remains unclear. Therefore, we investigate the overlap in adherence to ten diet quality scores, and examine the associations of these scores with both biological aging markers and DNA methylation profiles. We use data from t …

29.08.2026journal-article

International Journal of Research in Medical Sciences

The paradox of gender and depression in Indian geriatric outpatients: a study revealing higher depressive symptoms among males

Shweta Sharma, Abha Gupta, Satyam, Garima Chaudhary

Background: Epidemiological data from Western populations show a higher prevalence of depression in elderly women, attributed to biological and psychosocial factors. However, this pattern is challenged by sociocultural contexts that shape gender roles and aging experiences. The geriatric gender gap in depression within Indian clinical populations remains inadequately characterized. This study investigated gender-based differences in the prevalence and correlates of depressive symptoms in geriatric outpatients in No …

29.08.2026journal-article

International Social Research Nexus (ISRN)

People-to-People Diplomacy in South Asia: A Historical Study of SAARC's Cultural and Educational Initiatives

Surya Prakash. S, Dr. A. Vasantha

This article examines the historical evolution of people-to-people diplomacy within the South Asian Association for Regional Cooperation (SAARC), focusing on the institutional mechanisms through which the organization has attempted to build regional identity through culture and education rather than through formal political or trade agreements. While SAARC's record on economic integration and conflict resolution has been extensively studied and widely criticized, its parallel investment in cultural and educational …

29.08.2026journal-article

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences

How Does Walkability for Elderly People Differ between Hilly and Flat Urban Areas? A Case Study of Shin-Yurigaoka Station and Nagareyama-Otakanomori Station

Hinako Terado

Abstract. This study evaluates station-area environments that enable elderly people to walk comfortably in their daily lives. Conventional walkability assessments often emphasize street connectivity and proximity to destinations, but they do not fully capture walking burdens specific to elderly people, such as slopes and elevation differences. Therefore, this study examines whether some streets evaluated as central by Space Syntax within a street network are also streets that elderly people can walk on comfortably. …

29.08.2026journal-article

Journal of Clinical Medicine

Effects of High-Intensity Interval Training in Older Adults: A Systematic Review of Randomized and Non-Randomized Intervention Studies

Paula Moreira, Sérgio Ferreira, Nuno Domingos Garrido, António M. Monteiro, Pedro Afonso, Alexandra Malheiro, Joana Ribeiro, Pedro Forte

Background: High-intensity interval training (HIIT) is a time-efficient exercise strategy, but its effects in older adults remain incompletely established. Objective: Our objective is to synthesize evidence on the effects of HIIT and aerobic interval training (AIT) on cardiorespiratory, metabolic, functional, cognitive, psychological, and quality-of-life outcomes in older adults. Methods: This systematic review was reported in accordance with PRISMA 2020. PubMed, Scopus, and Web of Science were searched through 13 …

29.08.2026journal-article

Medicina

Serum Trace Elements and Self-Reported Physician-Diagnosed Tumor History: A Secondary Cross-Sectional Analysis of the Exposure Study on Susceptible People (SPES)

Carlo Buonerba, Paolo Montuori, Ernesto Esposito, Maria Triassi, Pellegrino Cerino

Background and Objectives: SPES was a 2016–2017 regional biomonitoring program. We conducted a secondary cross-sectional analysis of associations between current serum trace-element distributions and heterogeneous, self-reported physician-diagnosed tumor history, rather than registry-confirmed or incident cancer. Materials and Methods: Among 4137 questionnaire responders, 86 reported a tumor history. Mixed-effects logistic models for 20 channels were adjusted for age, sex, smoking, and geographic cluster and pooled …

29.08.2026journal-article

British Journal of Clinical Pharmacology

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

Louise Westberg Strejby Christensen, Anne Kirstine Boas, Emilie Clausen, Nicoline Elers Koch, Anne Byriel Walls, Lotte Stig Nørgaard, Michael Asger Andersen, Anissa Aharaz, Rikke Lundsgaard Nielsen, Olivia Bornæs, Juliette Tavenier, Baker Nawfal Jawad, Helle Gybel Juul‐Larsen, Esben Iversen, Ove Andersen, Lona Louring Christrup, Kim Peder Dalhoff, Morten Baltzer Houlind

Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely available. We evaluated the clinical relevance of pharmacogenomic (PGx) information for key pharmacogenes implicated in medication elimination in older adults presenti …

29.08.2026journal-article

BMC Medicine

24h movement behaviours in university students compared to working age and older adults: wearable-based evidence and cardiometabolic health implications

Ju Lynn Ong, Shuo Qin, Tara H Martin, Xin Yu Chua, Chun Siong Soon, Gizem Yilmaz, Lieng Hsi Ling, Falk Müller-Riemenschneider, Woon-Puay Koh, Michael WL Chee

Abstract Background Physical inactivity, sedentary behaviour and inadequate sleep are established risk factors for non-communicable diseases. Although older adults are traditionally expected to be less active and more sedentary than young adults, contemporary social, occupational and educational environments may have changed this. Here, we characterised 24-hour movement behaviours (physical activity [PA], sedentary behaviour [SB], and sleep) across adulthood using wearable devices and examined their cardiometabolic …

29.08.2026journal-article

Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics

An Explainable XGBoost Framework for Mortality Prediction in People Living with HIV Receiving Antiretroviral Therapy

Ni Putu Likayuni Viona, Ngakan Nyoman Kutha Krisnawijaya, Desak Nyoman Widyanthini

Mortality remains an important concern among people living with HIV (PLHIV) receiving antiretroviral therapy (ART), particularly when high-risk patients are not identified early. This study presents an explainable mortality prediction approach based on an optimized Extreme Gradient Boosting (XGBoost) classifier. A retrospective dataset containing 393 clinical records was analyzed. Before model training, duplicate entries were removed, missing values were imputed, categorical variables were encoded, and class imbala …

29.08.2026journal-article

Antibiotics

Specialty-Related Differences in Adherence to Antibiotic Therapy Guidelines for Infective Endocarditis in Older Patients

Lidvine Godaert, Claire Roubaud-Baudron, Emmanuel Forestier, Moustapha Dramé, the ENDOLA Study Group

Background/Objectives: Infective endocarditis (IE) is a condition with complex management, and several guidelines exist to guide clinicians. Adherence to these recommendations varies and could even be described as poor. The aim of this study was to determine whether the medical specialty of the unit that initiated first-line treatment for IE was associated with risk factors of non-adherence to the 2015 ESC treatment guidelines in a population of patients aged 75 years and over. Method: We analysed data from patient …

29.08.2026journal-article

International Journal of Environmental Research and Public Health

Urinary Organophosphate Metabolites and Laboratory-Derived Phenotypic Aging Acceleration in U.S. Adults: Evidence from NHANES 1999–2018

Rubaiya Anika, Matthew Untalan, Emanuela Taioli, Stephanie Tuminello

Biological aging, quantified through molecular and physiological biomarkers, provides a dynamic assessment of the aging processes. Although organophosphate (OP) pesticide exposure is known to disrupt cellular and metabolic functions, causing inflammation, its relationship with phenotypic (biological) aging acceleration (PAA) remains understudied. We examined data from 1999–2008 and 2015–2018 National Health and Nutrition Examination Survey to determine the relationship between OP and PAA. Urinary levels of 6 Dialky …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Awareness and Prevention of Congenital Cytomegalovirus (cCMV): A Mixed-Methods Evaluation of Knowledge and Communication Strategies for People of Childbearing Age

Tanisha Trivedi, Kinza Naeem, Jasleena Singh, Alejandra Arroyo, Madison Berg, Kathleen M Muldoon

Abstract Background Congenital cytomegalovirus (cCMV) is the most common congenital infection in the United States, disproportionately affecting vulnerable communities (Dietrich, 2019). In Arizona, an increasing proportion of births occur among young, non-White, and Hispanic/Latina women, yet there are no universal screening programs or standardized educational efforts addressing cCMV (Arizona Department of Health Services, 2022). Effective provider–patient communication and targeted public health programming are e …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Falls in the geriatric population with epilepsy: a narrative review

Sachin, Archana Verma, Alok Kumar

Epilepsy is a common neurological disorder in older adults, with incidence rising significantly after 60 years of age. Falls represent a major source of morbidity and mortality in this population and occur more frequently in individuals with epilepsy than in age-matched controls. The increased risk is multifactorial, resulting from seizure-related events, adverse effects of antiseizure medications (ASMs), and age-related physiological changes such as impaired balance, frailty, cognitive decline, and comorbidities. …