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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Allergy

Clinical phenotypes, endotypes, and biomarker profiles of immediate rituximab hypersensitivity reactions: a prospective pharmacovigilance study

Narapong Yotinnoratham, Wannada Laisuan, Kumutnart Chanprapaph, Silada Kanokrungsee, Chavachol Setthaudom, Supornchai Onpun, Pungjai Mongkolpathumrat, Supranee Buranapraditkun, Apinya Chungcharoenpanich, Nichapha Dechapaphapitak, Supa Oncham, Nattakirana Tongdee, Sananya Khamkaew, Ratchaya Lertnawapan, Jettanong Klaewsongkram

Background Rituximab (RTX) has been associated with immediate hypersensitivity reactions (HSRs) involving multiple phenotypes and endotypes. Objective To characterize the clinical phenotypes and endotypes of immediate RTX HSRs. Methods A prospective study was conducted as part of a pharmacovigilance program from July 2020 to December 2021. Participants who experienced immediate RTX HSRs were enrolled. Skin testing, basophil activation testing (BAT), IFN- γ ELISpot assays, and IgG anti-drug antibody (ADA) ELISA assa …

03.09.2026journal-article

Al-Kharaj: Jurnal Ekonomi, Keuangan & Bisnis Syariah

Determinasi Adopsi Financial Technology Syariah oleh Mahasiswa Generasi Z : Peran Digital Financial Literacy, Sharia Trust, dan Perceived Risk

Alan Reja Fadillah, Umiaty Hamzani, Syarif M. Helmi

This study aims to analyze the influence of digital financial literacy, sharia trust, and perceived risk on the adoption of Islamic financial technology (fintech) among Generation Z students. This research employed a quantitative approach using a survey method through online questionnaires distributed via Google Forms. The sampling technique used purposive sampling with a total of 228 Generation Z student respondents who had experience using digital financial services. The data were analyzed using SPSS through vali …

03.09.2026journal-article

Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia

Implementasi Mata Kuliah Akuntansi untuk UMKM Pulau-Pulau Kecil Perbatasan melalui Pendampingan Penggunaan Aplikasi Digital SI APIK pada Mitra UMKM di Kota Tiakur Kabupaten Maluku Barat Daya

Janet Wilsye Litualy

In Tiakur City, Southwest Maluku Regency, most MSMEs still face various financial management challenges, including low financial literacy, manual transaction recording, and suboptimal use of digital technology. These conditions make it difficult for MSME owners to prepare financial statements, determine business profits, and make sound business decisions. This situation prompted the Accounting Study Program (PSDKU) at Pattimura University to develop a course titled "Accounting for MSMEs in Small Border Islands (PPK …

03.09.2026journal-article

IPS Journal of Basic and Clinical Medicine

Kidney Function Responses to Ethanol Extracts of Chia Seed (Salvia hispanica L.) and Tiger Nut (Cyperus esculentus L.) in Alloxan-Induced Diabetic Rats

Chinyere S. Nwaka, Andrew C. Nwaka

Diabetic nephropathy is a common and progressive complication of poorly controlled diabetes mellitus, and there is growing interest in plant-derived agents that can slow or reverse this damage. This study evaluated the effect of ethanol extracts of chia seed (Salvia hispanica), tiger nut (Cyperus esculentus), and their combination on kidney function parameters in alloxan-induced diabetic rats. Sixty-three male Wistar rats were assigned to nine groups (n = 7): normal control (A), diabetic untreated (B), diabetic rat …

03.09.2026journal-article

Cosmetics

Effect of Topical HealFast Silver Ointment on Pain and Early Wound-Healing Parameters After Caesarean Section: A Randomized Placebo-Controlled Clinical Trial

Wafaa Uthman Ahmed, Bafreen hawez Hamadameen, Dastan Abdullah Salih, Shukur Wasman Smail, Abubakr Mohammed Amin, Mohammed Awat Ali

Background: Caesarean section is associated with postoperative pain and wound-related morbidity. Topical agents that promote early wound healing may enhance postoperative recovery. This randomized, placebo-controlled clinical trial evaluated the effect of HealFast Silver Ointment on pain and early wound-healing parameters after Caesarean section. Methods: Two hundred women who underwent Caesarean section were randomly allocated into two groups: a placebo group and a HealFast Silver Ointment group, each consisting o …

03.09.2026journal-article

RSS: Data Science and Artificial Intelligence

SurvSurf: a partially monotonic neural network for first-hitting time prediction of intermittently observed discrete and continuous sequential events

Yichen Kelly Chen, Sören Dittmer, Kinga Bernatowicz, Josep Arús-Pous, Kamen Bliznashki, John Aston, James H F Rudd, Carola-Bibiane Schönlieb, James Jones, Michael Roberts

Abstract We propose SurvSurf, a neural-network-based survival model for direct, simultaneous probabilistic prediction of first-hitting times of sequential events from baseline. Unlike existing models, SurvSurf is theoretically guaranteed to never violate the monotonic relationship between the cumulative incidence functions of sequential events, while allowing non-linear influence from predictors and time-dependent hazard ratio. It also incorporates implicit truths for unobserved intermediate events in model fitting …

03.09.2026journal-article

Journal of Pure and Applied Microbiology

Evaluating the Diagnostic Accuracy of Serological Tests for Brucellosis in Clinical Specimens

Hiba Sami, Kashish Noor, Parvez A. Khan, Lubna Zafar, Aamir Bin Sabir, Latif Zafar Jilani, S. Zeeshan Ahmad Hashmi, Haleema Ahmad, Adil Raza, Nazish Fatima

Brucellosis, a prevalent zoonotic disease in India, causes nonspecific symptoms. Humans contract it via infected animals or by consuming unpasteurized dairy products. This study evaluates the effectiveness of ELISA, Rose Bengal Plate Test (RBPT), and SAT in diagnosing brucellosis from clinical samples. A prospective study was conducted involving 218 patients with unknown fever, arthritis, and neurological symptoms. A detailed history was collected using a pre-designed questionnaire. This study aims to evaluate the …

03.09.2026journal-article

Texto Digital

Temporalidade e leitura literária: o caso da poesia combinatória de Pedro Barbosa na Electronic Literature Collection 3

Ana Marques Silva

A poesia combinatória de Pedro Barbosa, autor português e pioneiro da literatura digital a nível internacional, constitui um exemplo paradigmático e, podemos acrescentar, canónico, de literatura gerada por computador. Neste artigo, é considerada a questão da leitura literária em ambiente digital, tomando como exemplo a poesia de Pedro Barbosa e, mais particularmente, o modo como a mesma é apresentada na interface desenvolvida para o terceiro volume da Electronic Literature Collection. A problemática da leitura de p …

03.09.2026journal-article

American Journal of Audiology

Survey of Audiologists' Clinical Practice Patterns and Perceptions of Electrophysiological Assessments

Kelsey Mankel, Caitlin N. Price, Allie Austin, Mira Milman

Purpose: Electrophysiological assessments in audiology are used for neurodiagnostic evaluations, newborn hearing screenings, and estimating auditory thresholds when behavioral responses are unobtainable or unreliable. Nonetheless, evidence suggests that many electrophysiological tools remain underutilized. This study examined current practice patterns, perceptions, and barriers related to electrophysiological testing among audiologists in the United States. Method: An online survey distributed between January and A …

1 Zitationen
03.09.2026journal-article

JAMA Oncology

Bicistronic CD19/CD22 CAR T-Cell Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia

Xinyu Wan, Yanjing Tang, Jiaoyang Cai, Lili Song, Tianyi Wang, Wenjie Li, Liu Yang, Xiang Wang, Chengjuan Luo, Hua Zhu, Kang An, Meng Su, Jing Zhang, Jing Yang, Wenhua Shi, Chengming Fei, Weidong Shen, Rujun Jia, Xiaomin Yang, Junqian Tang, Junxian Wu, Jiakang Gu, Jiayi Mo, Jun Huang, Yue Li, Geyao Zhou, Lixia Ding, Jianwei Liang, Jun Wang, Zichao Zhou, Xiaodong Wang, Qing Cao, Jian Zhang, Hong Ren, Juan Qian, Peifang Xiao, Hailong He, Hui Jiang, Shaoyan Hu, Ningling Wang

Importance CD19-directed chimeric antigen receptor (CAR) T-cell therapy induces high remission rates in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL), but relapse, which is often due to antigen loss, remains a major challenge. Dual-targeting CD19/CD22 CAR T-cell strategies may be associated with reduced antigen-negative relapse and improved remission durability. Objective To evaluate the safety and efficacy of bicistronic CD19/CD22 CAR T-cell therapy in pediatric patients with relapsed or refra …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Effect of Health Education Intervention on Knowledge of Environmental Waste Management Among Residents of Bauchi State, Nigeria

Mohammed Inuwa

The study assessed the knowledge of environmental waste management among residents of Bauchi State, Nigeria. To achieve the two objectives ware identified to guide the paper The knowledge of environmental waste management among residents of Bauchi State, Nigeria before and after Health Education Intervention and attitude towards waste management among residents of Bauchi State, Nigeria before and after Health Education Intervention and in line with the research questions what are the knowledge of waste management a …

03.09.2026journal-article

Dementia

Social Interactions Between People Living With Dementia and Staff in Health and Social Care Settings: A Scoping Review

Stephanie Janka-Spurlock, Georgia Page, Gary Hodge, Helen Lloyd, Susie Pearce

Dementia is an umbrella term for progressive conditions affecting memory, thinking, communication and other cognitive functions. These changes can make social interaction challenging, particularly in unfamiliar or overstimulating environments . Although social interactions between staff and people living with dementia are recognised as an aspect of care, existing literature across health and social care settings largely focuses on general care needs and experiences rather than social interaction specifically. Conse …

03.09.2026journal-article

Public International and Private International Law

A Comparative Legal Analysis of the Regulation of Digital Financial Assets in Various Jurisdictions

Mekhriban E. Gulieva

In the era of digitalization and the widespread adoption of digital instruments, such as digital assets and payment instruments, monitoring compliance with national legislation by relevant executive authorities is particularly important. Competent and consistent application of procedural principles of control and supervision by relevant governmental bodies is essential for achieving a balance in relations between governmental bodies and society, as well as business members, while reducing excessive pressure on busi …

03.09.2026journal-article

COURT ADMINISTRATOR

Cloud Justice: The Digital Paradigm as a Response to Current Challenges of the Judicial System

Pavel B. Solyanko

This article examines the systemic problems of the Russian judicial system, manifested in the accusatory bias, regional asymmetry in the quality of justice, staff shortages and fragmentation of law enforcement practice. Based on the analysis of statistical data and specific cases (on the example of the case of K. Nosyrev), the impossibility of excluding them within the framework of the traditional, geographically linked model of legal proceedings is substantiated. A conceptual model of "Cloud Justice" is proposed, …

03.09.2026journal-article

Информационные и математические технологии в науке и управлении

Риск как имманентное свойство эргатических систем в эпоху цифровых двойников: от «цифрового Левиафана» к парадигме симбиотического управления

А.В. Бочков

Современный переход к «управлению, основанному на данных», опирающемуся на создание полномасштабных цифровых двойников сложных социально-экономических систем, сталкивается с фундаментальным вызовом. В статье доказывается, что оптимизационные задачи, решаемые для таких цифровых моделей, являются некорректными по отношению к оригиналу, поскольку ключевые объекты управления – эргатические системы – принципиально неформализуемы из-за наличия человеческого компонента. Риск в этой парадигме перестает быть внешней угрозой …

03.09.2026journal-article

The International Journal of Advanced Manufacturing Technology

A CFD-driven digital twin for automated mold sandblasting in digital manufacturing

Carlo Cravero, Alessandro Lamberti, Davide Marsano, Federico Conforti, Matteo Conforti

Abstract The manufacturing industry is facing increasing pressure to improve efficiency and sustainability in response to energy constraints and environmental regulations. Within this context mold cleaning represents a critical and energy-intensive step in resin-based component manufacturing. Although conventional manual sandblasting is widely adopted it is affected by poor repeatability limited process optimization and significant material and energy waste. The objective of this work is to develop and validate a p …

03.09.2026journal-article

Molecular Biomedicine

Artificial intelligence and ultra-high performance computing methods and experiments for drug discovery: virtual screening, deep learning, molecular dynamics simulations, ADMET modelling, and experimental validation

Lunna Li, Lianna D. Soriano, Welela M. Kedir, Felix L. Hoch, Desmond K. Loke

Abstract Recent years have witnessed considerable progress in computer-aided drug discovery, driven by the incorporation of computational technologies within both academic and pharmaceutical environments. This evolution is marked by a significant accumulation of data pertaining to detailed three-dimensional structural information, ligand properties, and their interactions with therapeutic targets. The augmentation of computational capabilities and the accessibility of extensive chemical libraries containing billion …

03.09.2026journal-article

Journal of Clinical Medicine

Effects of Physical Activity on Motor Development, Balance, and Psychosocial Well-Being in Children and Adolescents with Down Syndrome: A Systematic Review

Ignazio Leale, Manuel Gómez-López, Martina Macaluso, Daniela Smirni, Michele Roccella, Marianna Alesi, Giuseppe Battaglia

Background: Physical activity is relevant for physical and psychosocial development in children and adolescents with Down syndrome. However, evidence regarding the effects of structured physical activity interventions across different motor and psychosocial domains remains limited and heterogeneous. This systematic review aimed to examine the effects of structured physical activity interventions on motor and psychosocial outcomes in this population. Methods: The review was conducted according to PRISMA guidelines a …

03.09.2026journal-article

BMC Psychiatry

Substance use and co-occurring mental health conditions among adolescents and young adults in North America: a systematic review

Gemy Kuriakose, Jenny Seo, Negar Asgharipourzahmati, Ashley Lew, Rishika Daswani, Martha J. Ignaszewski, Roberto Sassi, Fiona Choi, Vijay Seethapathy, Reinhard Michael Krausz

Abstract Background Substance use and co-occurring mental health conditions are common among adolescents and young adults and represent an important clinical and public health concern in North America. Trauma exposure, psychiatric symptoms, and social adversity frequently co-occur with substance-related problems in this population. This systematic review aimed to synthesize evidence on prevalence patterns, associated clinical and psychosocial factors, and care-related implications described in the literature on ado …

03.09.2026journal-article

Journal of Clinical Microbiology

Development and evaluation of an ARTIC-based amplicon sequencing assay for whole-genome characterization of respiratory syncytial virus

Keri Smith, James Martinez, Harrison Yu, Jason Harrison, Caleb Umunna, Blake Bertrand, Michael Heck, Ellen N. Kersh, Nandhakumar Balakrishnan, Tonia Parrott, Arunachalam Ramaiah

ABSTRACT Respiratory syncytial virus (RSV), a ~15.2 kb negative-sense RNA virus, causes acute respiratory infections in infants and older adults. Its two subtypes, RSV-A and RSV-B, evolve rapidly, making ongoing monitoring of circulating strains essential. The Georgia Public Health Laboratory (GPHL) developed and evaluated an amplicon-based whole-genome sequencing (WGS) assay for RSV surveillance. A total of 214 de-identified remnant clinical specimens (102 RSV-A and 112 RSV-B) with RT-PCR C q values

03.09.2026journal-article

Texto Digital

Rethinking classical translation models in audiovisual translation: evidence from metaphor translation in chinese documentary subtitling

Yujie Cai, Sharmini Abdullah

This study evaluates the applicability of Classical Translation Models (CTMs) specifically Newmark’s (1988) procedures and Vinay and Darbelnet’s (1995) direct and oblique models within Audiovisual Translation (AVT). By analyzing 50 metaphorical expressions from the Chinese documentary A Bite of China, the research identifies a systemic inadequacy in CTMs. Their monosemiotic focus on textual equivalence fails to account for multimodal cues, intersemiotic coherence, and technical subtitling constraints. The findings …

03.09.2026journal-article

Uludağ Üniversitesi Tıp Fakültesi Dergisi

Retrospective Evaluation of Demographic and Clinical Features of Gastrointestinal Stromal Tumors

Nihal Yücel Çamcı, Nesrin Uğraş, Adem Deligönül, Özkan Kanat

This study aimed to retrospectively examine the demographic, clinical, and pathological characteristics; prognostic risk factors; treatments administered; clinical course; and survival times of patients diagnosed with gastrointestinal stromal tumors (GIST) and treated and followed up at Department of Medical Oncology at the Bursa Uludağ University Faculty of Medicine in Bursa. Medical records of 54 patients diagnosed with GIST between 2002 and 2017 were reviewed retrospectively through the hospital record system. T …

03.09.2026journal-article

Journal of Public Health and Primary Care

Digital Mental Health of “Greying Population” in India: A Narrative Review

Niraja Guru, Debabrata Tripathy, Shree Mishra, Ambika Sundas, Swayam Pragyan Parida

Abstract India’s aging population, expected to reach 19% by 2050, faces rising rates of chronic illnesses such as diabetes, hypertension, dementia, and mental health conditions, including depression. These challenges are compounded by social isolation and postretirement difficulties. Although the government promotes digital mental health initiatives, progress is slowed by resource limitations, infrastructure deficits, and urban–rural inequalities. This narrative review aims to examine existing digital mental health …

03.09.2026journal-article

Home Health Care Management & Practice

“They Don’t Seem to Care”: A Qualitative Study of Home Care Social Workers Views on Medicare Advantage

William Cabin

Objective: To determine if there is agreement—between a systematic literature review and home care social worker interviews—that current low utilization of Medicare home health social work services has an adverse impacts impact on patient care. Methods: This is a qualitative study based on in-person interviews of a convenience sample of 36 home care social workers from 6 different home health agencies in New York City between April 9, 2026, and May 29, 2026. It is a follow-up to a similar study on home care nurses …