EUVIMEDEuropean Health Evidence
Uhr 7/7Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Medizin · Seite 3

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Indian Journal of Nuclear Medicine

Selective Internal Radiation Therapy for Hepatocellular Malignancies: Existing Evidence and Advances

Priyanka Yadav, Jaya Shukla

Selective Internal Radiation Therapy (SIRT) is a locoregional treatment for primary and secondary liver neoplasms that spares the surrounding parenchyma while selectively delivering a high radiation dose to the tumour tissue. It functions by injecting radioactive microspheres into the hepatic artery supplying the tumour. SIRT has emerged as a valuable locoregional treatment for liver cancers, including unresectable hepatocellular carcinoma (HCC) and some liver-dominant metastases, such as neuroendocrine tumours and …

03.09.2026journal-article

Frontiers in Child and Adolescent Psychiatry

Acceptability and feasibility of the Ushirikiano treatment model for Kenyan adolescents: a pilot randomized controlled trial

Nabila Amin Ali, Shillah Mwaniga Mwavua, Obadia Yator, Joseph Kathono, Anja C. Huizink, Manasi Kumar

Introduction Adolescents in low- and middle-income countries experience high rates of common mental disorders (CMDs) but have limited access to adolescent-friendly, evidence-based care. While Interpersonal Psychotherapy for Adolescents (IPT-A) is effective, brief group IPT-A delivered through task-shifted, stepped-care has not been rigorously evaluated in Kenyan primary care. Methods We conducted a pilot randomized controlled trial to examine the acceptability, feasibility, and preliminary effectiveness of the Ushi …

03.09.2026journal-article

Frontiers in Immunology

Emerging CAR-Treg and regulatory T cell therapies for inflammatory bowel diseases: a systematic review of a new era of treatment

Fabio Suarez-Trujillo, Theodore S. Steiner, Javier P. Gisbert, María Chaparro

Background Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by dysregulated mucosal immunity. Despite major advances in therapies, a high proportion of patients do not achieve or sustain remission. Cellular immunotherapies have emerged as a mechanistically distinct therapeutic strategy with potential relevance for refractory disease. In the present paper, the authors aim to evaluate the rationale and current evidence supporting chimeric antigen receptor (CAR)-engineered immune ce …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Application of the combined technique of novel transseptal puncture guidewire and steerable sheath in left atrial appendage occlusion: a preliminary feasibility case series

Mei Liang, Wen Jia Wang, Peng Yu Wang, Qing Gu

Objective Transseptal puncture (TSP) is a critical step in left atrial appendage occlusion (LAAO) but presents certain technical challenges. Conventional puncture needles, due to their inherent rigidity, often cause unpredictable needle tip “bouncing” or upward migration at the moment of septal puncture, resulting in a high or suboptimal puncture site, which subsequently compromises the coaxial alignment between the sheath and the left atrial appendage (LAA). This study aims to evaluate the safety and feasibility o …

03.09.2026journal-article

Frontiers in Medicine

Intrauterine device migration into the bladder with resultant bladder stone formation: a case report

Meilian Chen, Hongmei Xiao, Fei Lai, Yingxue Bai, Yixue Zhou, Xuelian Tan, Limei Wu, Haixia Jiang

Objective To investigate the possible aetiology, clinical characteristics, diagnostic and therapeutic approaches, and prognosis of intrauterine device (IUD) migration into the bladder. Case report A 39-year-old woman presented with recurrent symptoms of urinary urgency and dysuria. Computed tomography scans (CT) revealed that one arm of the IUD had migrated into the bladder, causing bladder stones. The patient underwent transurethral bladder lithotripsy and stone removal, laparoscopic bladder repair, and hysterosco …

03.09.2026journal-article

Frontiers in Medicine

Isolated gastrointestinal hereditary angioedema associated with a pathogenic SERPING1 variant arising de novo: a case report

Ziyu Yuan, Weipeng Lin, Yue Zheng, Xizi Yuan, Ming Luo, Lingyu Fu, Haiyan Zhang

Hereditary angioedema (HAE) is a rare genetic disorder typically characterized by cutaneous and submucosal edema. Cases presenting exclusively with gastrointestinal symptoms, devoid of concurrent or historical cutaneous or upper airway manifestations, are uncommon. This atypical presentation poses a considerable diagnostic challenge and often leads to a marked delay in diagnosis, particularly in patients without a family history. We report the case of a 28-year-old female with an over 6-year history of recurrent, s …

03.09.2026journal-article

El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam

Analysis of Non-Menopatic Patient Loyalty at Dr. Rm. Soedjarwadi Regional Mental Hospital, Central Java Province

Asril Aziz Rahmatullah, Sudarwati Sudarwati, Oong Ridhoi

This study aims to analyze the influence of service quality, facilities, rates, location, and hospital image on the loyalty of non-mental patients at Dr. RM. Soedjarwadi Mental Hospital, Central Java Province. This study used a quantitative method with a survey approach. The study population was all non-mental patients who had received services at Dr. RM. Soedjarwadi Mental Hospital, Central Java Province, with the criteria of having received treatment at least twice. Data were collected using a questionnaire compi …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Treatment shortening and relapse control in drug-susceptible pulmonary tuberculosis: a network meta-analysis of randomized trials

Fengjie Tang, Juan Li, Qihuan Ma, Shasha Tao, Ling Zhou, Yanmei Feng

Drug-susceptible pulmonary tuberculosis (DS-PTB) is conventionally treated with a 6-month multidrug regimen, but prolonged treatment may compromise adherence, prompting efforts to develop shorter and effective therapeutic strategies. However, the comparative long-term effectiveness of alternative regimens, particularly their ability to prevent relapse, remains uncertain. We systematically searched multiple databases from inception through August 31, 2025, for randomized controlled trials enrolling adolescents and a …

03.09.2026journal-article

Frontiers in Drug Delivery

Hyaluronidase-enhanced delivery in gene therapy and regenerative medicine for improved vector, cell, and cargo access

Patrick E. Sewell, Christopher Jensen

Efficient delivery of gene therapy vectors and regenerative cargo to the central nervous system (CNS) is limited by the hyaluronic acid (HA)-rich extracellular matrix (ECM). Adeno-associated virus (AAV) particles, mesenchymal stem cells (MSCs), multilineage-differentiating stress-enduring (MUSE) cells, and small extracellular vesicles (sEVs) must traverse the HA-rich ECM of the nasal submucosa, the perineural and perivascular compartments, and brain parenchyma to reach CNS targets. Dense ECM imposes viscosity, ster …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility and tolerability of ketamine as adjunctive rescue therapy for refractory neonatal status epilepticus: a case report of a late preterm infant with multifocal hemorrhagic brain injury

Chiara Gulisano, Alessia Pepe, Elisabetta Amadori, Samuele Caruggi, Daniele Caratozzolo, Lino Nobili, Pasquale Striano, Luca Antonio Ramenghi, Andrea Calandrino

Background Neonatal status epilepticus (NSE) is a life-threatening neurological emergency associated with high mortality and long-term neurodevelopmental morbidity. Although phenobarbital remains the recommended first-line antiseizure medication (ASM), followed by agents such as phenytoin or levetiracetam, seizure control is not always achieved. Ketamine, a non-competitive N methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a potential rescue therapy for refractory status epilepticus because of its uniq …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

From particle count to residence time: a kinetic framework for atherogenic risk

Esteban Larronde

Two sequential advances have narrowed the gap between lipid measurement and atherogenic mechanism. Mendelian randomization established that coronary risk tracks apolipoprotein B (ApoB) particle count, not cholesterol content: when natural discordance exists between low-density lipoprotein cholesterol (LDL-C) and ApoB, risk follows ApoB reduction independently of LDL-C. The 2026 ACC/AHA dyslipidemia guideline formalized this advance, placing ApoB above LDL-C as a risk measure in discordance contexts. That particle-c …

03.09.2026journal-article

Frontiers in Oncology

Exploring traditional Chinese medicine to enhance the efficacy and reduce toxicity of immunotherapy for non-small cell lung cancer from the perspective of “spleen deficiency”: a trial protocol for mechanism and clinical evidence

Cunya Li, Xiaonan Zhang, Shujuan Fu, Pantong Wu, Zhiying Wang, Zhixian Zhong, Yi Zhong

Introduction Although immune checkpoint inhibitors (ICIs) have changed the treatment landscape of advanced non-small cell lung cancer (NSCLC), their low response rates and immune-related adverse reactions (irAEs) remain serious challenges. Traditional Chinese medicine believes that “spleen deficiency” is the core pathogenesis of advanced lung cancer, and its corresponding immune suppression and metabolic disorders may be related to the efficacy of ICIs. This paper aims to explore the clinical application status and …

03.09.2026journal-article

Exploration of Medicine

A computational pathology-based AI framework for predicting PD-L1 expression and prognosis in HNSCC

Yingying Cui, Chuanyang Ding, Long Li, Xinjia Cai

Aim: To investigate interobserver variability in programmed cell death ligand 1 (PD-L1) combined positive score (CPS) assessment in head and neck squamous cell carcinoma (HNSCC) and to develop an artificial intelligence (AI)-based model for predicting PD-L1 expression and patient prognosis from hematoxylin and eosin (H&E)-stained slides. Methods: Fifty HNSCC specimens were independently evaluated for PD-L1 by pathologists with different experience levels. Agreement was assessed using Fleiss’ and Cohen’s κ. Whole-sl …

03.09.2026journal-article

Frontiers in Adolescent Medicine

Testicular adrenal rests tumours in congenital adrenal hyperplasia: unraveling prevalence, risk factors and new therapeutic horizons in adolescents

Irene Tizianel, Giulia Bovo, Pierluigi Mazzeo, Filippo Ceccato, Mattia Barbot

Testicular adrenal rest tumours (TARTs) are benign intratesticular lesions occurring in males with classic congenital adrenal hyperplasia (CAH), with a prevalence ranging from 0% to 94% depending on age, disease severity and screening method. Although TARTs are non-malignant, their characteristic location can lead to compression of seminiferous tubules causing infertility. Adolescence represents a critical and particularly vulnerable window for TART development and progression. Besides ACTH chronic stimulation, whi …

03.09.2026journal-article

L'Endocrinologo

Biomarcatori nell’orbitopatia basedowiana: nuove prospettive per diagnosi, prognosi e terapia personalizzata

Silvia Corrias, Marina Porcu, Francesco Boi, Filippo Lixi, Giuseppe Giannaccare, Giulia Lanzolla

Sommario L’identificazione di biomarcatori rappresenta una delle principali sfide irrisolte nell’orbitopatia basedowiana (OB). In assenza di indicatori biologici validati, la valutazione della malattia rimane essenzialmente clinica. Le crescenti evidenze relative a biomarcatori sierologici, lacrimali e tissutali delineano nuove prospettive per la diagnosi precoce, la stratificazione dei pazienti, il monitoraggio terapeutico e l’implementazione di approcci personalizzati.

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Translating analytical performance into clinical misclassification risk: a probabilistic framework for HbA 1c interpretation

Lorenza Fagnani, Rita Tennina, Pierangelo Bellio, Patrizia Frascaria, Marco Rossi, Sabrina Viggioni, Moira Tucceri Cimini, Consuelo Scimia, Alessandra Piccirilli, Mariagrazia Perilli, Fabio Antonelli, Giuseppe Celenza

Abstract Objectives Using HbA 1c for diabetes diagnosis directly links analytical uncertainty to patient classification. Since traditional performance metrics provide limited insight into these clinical implications, we developed a probabilistic framework to translate HbA 1c concentrations and components of analytical uncertainty into clinically interpretable diagnostic risk. Methods The framework was applied to 100,472 HbA 1c results obtained from a real-world Laboratory Information System. Analytical bias, analyt …

03.09.2026journal-article

Frontiers in Dental Medicine

Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives

Ana Carolina Aparecida Rivas, Mario Taba, Paola Gomes Souza

Curcumin, the active polyphenol in turmeric (Curcuma longa), is well-known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising therapeutic agent for a range of diseases, including neuroinflammatory conditions and periodontal disease. Periodontitis, a prevalent oral disease, is associated with chronic inflammation and bacterial infection. Curcumin has demonstrated antibacterial effects against periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas g …

03.09.2026journal-article

Frontiers in Medicine

Time-Series modeling for predicting mortality risk in intensive care unit patients with pulmonary inflammation

Yihai Zhai, Ruixin Xu, Haisu Lu, Siying Lv, Liqin Mo

Objective This study aims to evaluate dynamic changes in pneumonia-related mortality risk among ICU patients using time-series models and develop interpretable predictive models for early mortality assessment. Methods Data were obtained from the MIMIC-IV and eICU Collaborative Research Database. The MIMIC-IV cohort was split into training and testing sets (7:3 ratio), with external validation conducted using the eICU cohort. Missing data were handled using forward filling and multiple imputation. LSTM was used to e …

03.09.2026journal-article

Frontiers in Medicine

Design, implementation, and evaluation of a programmatic assessment model in an emergency medicine residency: a mixed-methods study

İbrahim Ulaş Özturan, Dilek Kitapcioglu, Prattama Santoso Utomo, Cansu Alyesil Ozturan, Nurettin Özgür Doğan, Elif Yaka, Serkan Yılmaz, Murat Pekdemir, Levent Altıntaş

Background Programmatic assessment (PA) is widely endorsed in postgraduate medical education, but empirical accounts of real-world implementation in emergency medicine (EM) remain limited and are concentrated in North American settings. We piloted and evaluated the design, implementation, and outcomes of a PA model in an EM residency at a high-volume tertiary care center in Türkiye. Methods A mixed-methods study was conducted over an eight-month pilot (November 2024–June 2025). Program design and evaluation followe …

03.09.2026journal-article

Frontiers in Oncology

Analysis of clinical features and outcomes in a Chinese cohort with ALK fusion across pan-cancer: a retrospective study

Meng Zhang, Yi Feng, Xue Du, Changda Qu, Meizhu Meng, Meiying Ye, Min Liang, Ziran Yang, Wenjuan Gong, Xingyu Ma, Jialiang Guo, Wenmei Li, Shuqin Jia

Background ALK fusions are validated oncogenic drivers, yet their molecular heterogeneity and therapeutic implications remain poorly characterized. This study defined the landscape of ALK fusion partners, EML4-ALK variants, and co-mutations and their impact on treatment responses in a large Chinese pan-cancer cohort. Methods We retrospectively analyzed 16,335 consecutive pan-cancer patients via next-generation sequencing to identify ALK fusions. Clinical characteristics, fusion partners, co-mutations, and treatment …

03.09.2026journal-article

Sage Sphere International Journal

Cirugía laparoscópica versus cirugía robótica en la resección de tumores hepáticos: resultados y beneficios clínicos

Joel Sebastian Chango Yosa, Kelvin Alejandro Torres Quezada, Mario Gabriel Salas Martínez, Dana Isabel Morales Figueroa, Alonso Patricio Espinoza Ayala

Introducción: La resección hepática constituye el tratamiento principal de diversos tumores hepáticos. Los abordajes laparoscópico y robótico han ampliado las posibilidades de cirugía mínimamente invasiva, especialmente en procedimientos técnicamente complejos. Objetivo: Sintetizar la evidencia científica sobre los resultados y beneficios clínicos de la cirugía laparoscópica versus robótica en la resección de tumores hepáticos. Metodología: Se realizó una revisión bibliográfica narrativa mediante búsquedas en PubMe …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Perimenopause as a potential window of cardiometabolic remodeling in heart failure with preserved ejection fraction: a missed opportunity for prevention

Faith Adedayo Adejumo, Oluwayimika Oluwatobi Obielodan, Fiyinfoluwa Adetoye, Nicholas Aderinto

Heart failure with preserved ejection fraction (HFpEF) disproportionately affects women and has emerged as one of the most prevalent forms of heart failure worldwide. Although the marked increase in HFpEF incidence after menopause is well recognized, the biological events that initiate disease development remain poorly defined. Most mechanistic and clinical investigations have focused on postmenopausal women or established HFpEF, leaving the menopausal transition comparatively underexplored despite growing evidence …

03.09.2026journal-article

Frontiers in Health Services

Patient misidentification and data integrity risks in ultrasound imaging: a case report using multi-framework incident analysis

Benedicta Osei-Donkor, Abdallah Hassoun, Md Shafiqur Rahman Jabin

Background Digital imaging workflows depend on accurate scheduling, patient identity reconciliation, and reliable metadata continuity to ensure safe image storage and retrieval. Disruptions in these processes may not directly affect image acquisition but can delay access to imaging information and pose significant patient safety risks. Objective To examine a recurrent ultrasound workflow failure that compromised downstream image availability and to identify practical strategies for preventing recurrence. Methods A …