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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

npj Parkinson's Disease

Identifying the neural correlates of voluntary stopping in people with Parkinson’s disease using a Virtual Reality gait paradigm

Eileen Gülke, Christopher Coppin, John Azizi, Hanna Braaß, Lachlan Churchill, Yanqiu Tian, Simon J. G. Lewis

Abstract Freezing of Gait (FOG) is a disabling feature of Parkinson’s disease (PD). However, the neural mechanisms underlying voluntary stopping impairments remain unclear. This study used a validated Virtual Reality (VR) gait paradigm to investigate the neural correlates of cued voluntary stopping in 15 PD participants with FOG, 10 PD participants without FOG, and 12 healthy controls. PD participants were assessed on and off dopaminergic medication. Blood-oxygen-level-dependent (BOLD) signals during voluntary stop …

03.09.2026journal-article

AIDS

Circulating markers of organ damage associate with COPD in people with HIV: an exploratory proteomic analysis

Lennart Riemann, Lena Böger, Carina Dahl, Timo Gemoll, Sandra Steffens, Charisis Totsikas, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Christine Happle, Georg M.N. Behrens

Background: People with HIV (PWH) develop chronic obstructive pulmonary disease (COPD) more frequently and at younger ages than the general population, yet the circulating proteomic correlates of COPD in PWH remain poorly characterized. Methods: We applied a targeted 92-plex organ damage proteomics panel (Olink Organ Damage) to compare serum protein profiles between 38 PWH with established COPD and 49 PWH without COPD, enrolled in a prospective observational cohort. Results: Differential abundance analysis adjusted …

03.09.2026journal-article

People and Nature

Plurality in transformative change: Three co‐created pathways toward nature‐positive Europe(s)

Mara de Pater, Aniek Hebinck, Symke Nieboer, Anita Lazurko, Robbert Biesbroek, Laura Pereira, Elizabeth Díaz‐General, Aron Teunissen, Samia Baadj, Anna Chilton, Seweryn Krupnik, Richard Kock, Klemetti Näkkäläjärvi, W. Mathijs Rozemuller, Eirini Sakellari

Abstract The accelerating decline of biodiversity necessitates transformative change to protect nature and society, which requires innovative actions and governance strategies. This paper advances the conceptual understanding of transformative change by identifying patterns of change in three co‐created transformative pathways for a nature‐positive Europe, furthers participatory futuring methodologies and identifies patterns of change that can inform anticipatory governance. Three distinct pathways for a nature‐pos …

03.09.2026journal-article

American Journal of Audiology

A Qualitative Study of the Hearing Aid Step-Counting Feature in Active Older Adults

Mohamed Rahme, Paula Folkeard, Abigail Naus, Susan Scollie

Purpose: The use of hearing aid–based step counting may offer objective measurement of activity, but there is little published literature on the perspectives of older adult users in using this feature. The purpose of this study was to qualitatively describe the experiences and motivation for using a hearing aid step-counting feature in a sample of active older adults. Method: A prospective qualitative research design was employed with the use of focus groups with active older adult participants who were fitted with …

03.09.2026journal-article

Frontiers in Human Neuroscience

The association between nonverbal fluency and anomia treatment outcomes in people with post-stroke aphasia

Deena Schwen Blackett, Victoria A. Diedrichs, Alexandra Zezinka Durfee, Courtney C. Jewell, Stacy M. Harnish

Introduction Many people with aphasia experience concomitant executive functioning deficits, and the literature supports a role of executive functioning in treatment response. However, the optimal executive functioning assessment for measuring this impact is unclear, as is the extent to which outcomes (e.g., acquisition, generalization) may be impacted differently. The present retrospective study aimed to determine the degree to which nonverbal fluency, one measure of executive functioning with minimal language dem …

03.09.2026journal-article

Geriatrics

A Patient- and Function-Centric Model/Approach for Hypoglycemia Management in Older Adults

Kannayiram Alagiakrishnan, Laurie Mereu, Gulelala Rahim, Mahua Ghosh, Albert Vu

Diabetes-related hypoglycemia contributes substantially to increased morbidity, mortality, health-care utilization, and reduced quality of life. Older adults with diabetes represent a heterogeneous group of patients who need individualized blood glucose targets to avoid hypoglycemia. Since the elderly present with varying degrees of functional and cognitive status and individualized health needs, their management varies among individuals. Complicating this, the hypoglycemia risk in older adults treated with insulin …

03.09.2026journal-article

Frontiers in Digital Health

A pilot study of at-home online cognitive screening prior to primary care wellness visits for older adults

Louisa Thompson, Charles Eaton, Sarah Prieto, Molly Lawrence, Stephanie Czech, Jennifer Rosenbaum, David Anthony, Rabin Chandran, Lauren Kelly, Ivy Ngo, Arnold Goldberg, Caitlin Gillooly, Caroline Richardson, A. Rani Elwy, Richard N. Jones, Dorene M. Rentz

Background Improved methods of cognitive testing are urgently needed for primary care settings faced with a growing older adult population and higher rates of dementia. We tested the feasibility and acceptability of a novel online cognitive test that can be completed at home prior to an annual exam. Methods 32 older adults completed testing at home on personal devices 1–4 weeks prior to an annual exam with their primary care provider. Additional cognitive screening was completed in-clinic to provide preliminary val …

03.09.2026journal-article

Perspectives on Psychological Science

Aging as a Continuation of Development: A Hypothesis and Framework

Fabian-Xosé Fernandez, Sara N. Burke, Lynn Nadel

Prevailing theories of cognitive aging depict late life as a period of compensatory decline—an effort to preserve performance despite progressive neural deterioration. We propose instead that aging represents a continuation of development: a genetically conserved, adaptive reorganization of memory systems that parallels the brain’s earlier-life transitions. Drawing on convergent molecular, network, behavioral, and comparative evidence, we argue that the well-documented decline in episodic-memory precision reflects …

03.09.2026journal-article

Audiology Research

Relationships Among Hearing, Auditory Processing, and Cognition: A Study of Older Adults

Kristina Mullins, Jennifer Jones Lister, Aryn L. Harrison Bush, Laura Conover, Nasreen Sadeq

Background/Objectives: Beginning in mid-life, age-related cognitive decline may negatively affect overall hearing health. Thus, understanding the relationship between hearing and cognition is of critical importance. Although the relationship has received considerable attention, and numerous theories have been posited to explain it, questions remain. Research indicates that 50% of older Americans grapple with severe hearing loss, affecting their daily communication, while Alzheimer’s disease, a prevailing cause of d …

03.09.2026journal-article

Discourse & Communication

The unpushed button: The material-semiotic distribution of communicative inequity in a geriatric emergency ward

Marsha P. Shams, Marc Sabbe, Antoon Cox

Effective communication is central in emergency settings, yet is still underexplored particularly in relation to the material and spatial resources through which care is delivered. Drawing on 30 hours of ethnographic observation in a Belgian geriatric emergency ward, this paper examines how everyday objects and ward layout perpetuate communicative asymmetries that can lead to exclusion among older patients. The paper draws on Goffman’s (1981) participation framework, embodied-and-material accounts of interaction (G …

03.09.2026journal-article

PLOS One

Feasibility and effects of a multicomponent program incorporating esports on physical and cognitive function among older adults: A non-randomised pilot trial

Yuta Nemoto, Fumie Otsuka, Shihoko Suzuki, Saori Kataoka, Tomoko Nakanishi, Takuya Ueda, Susumu Ogawa, Sumika Karasawa, Mikiko Shimaoka, Hiroto Narimatsu, Ung-il Chung

Background Esports (competitive and organised video gaming) may enhance physical and cognitive health in older adults. The aim of this study was to examine the feasibility and effects of a multicomponent program incorporating esports on physical and cognitive function in community-dwelling older adults. Methods This parallel, non-randomised controlled trial was conducted in Yokosuka, Kanagawa, Japan. Twenty-six participants who 1) were aged 60 years or older, 2) had no cognitive impairment, 3) had no major health p …

03.09.2026journal-article

Frontiers in Dementia

Mapping intersectionality in dementia care research: a decadal scoping review

Martina Roes, Franziska Laporte Uribe, Simone Anna Felding, Georgina Charlesworth, Nicole Müller, Saloua Berdai, Jem Bhatt, Kuebra Altinok, Viktoria Peters-Nehrenheim

Background In the past decade, an increasing number of studies have addressed health care disparities and the complex determinants of care for diverse populations. At the same time, it remains unclear how social categories (e.g. gender, ethnicity, migration status, socioeconomic position) intersect with health care disparities for people living with dementia and may lead to experiences of inequity and inequality. Aim This scoping review analyzes the use of intersectionality frameworks and intersection analyses in d …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Inflammation and delirium in critically Ill patients: a review

Liang Li, Xiaoli Wang, Jialin Liu

The high prevalence and adverse impact of delirium in critically ill patients necessitate a deeper understanding of its mechanisms. This review explores the pivotal interplay between systemic inflammation and delirium, examining how insults like age, pain and surgery orchestrate neuroinflammation and delirium through microglial activation and blood-brain barrier disruption. Our synthesis identifies a spectrum of inflammatory and neuronal injury biomarkers with prognostic value and evaluates the burgeoning field of …

03.09.2026journal-article

npj Primary Care Respiratory Medicine

Barriers and facilitators to RSV vaccine acceptance among pregnant women and older adults in Hong Kong: a qualitative study guided by the Theoretical Domains Framework

Claire Chenwen Zhong, Man Kin Yim, Zehuan Yang, Vera MW Keung, Chung Yi Lo, Xiaoshu Zhang, Mingtao Chen, Junjie Huang, Martin CS Wong

Abstract Respiratory syncytial virus (RSV) poses a significant health risk to pregnant women, infants, and older adults, yet vaccine uptake remains suboptimal globally. This study aimed to explore the barriers and facilitators influencing RSV vaccine acceptance among pregnant women and older adults in Hong Kong. A qualitative design was employed, involving semi-structured interviews with pregnant women and older adults in Hong Kong. The interview guide was informed by the Theoretical Domains Framework (TDF) to capt …

03.09.2026journal-article

BMC Health Services Research

Associations between physical activity in adulthood and utilisation of municipal home and long-term healthcare services in older age: the HUNT study

Aslaug Angelsen, Sigrid Nakrem, Bjørn Heine Strand, Linn Beate Strand

Abstract Background Physical activity is a key component in public health frameworks to maintain functional ability through ageing. In Norway, healthcare services such as home health nursing and long-term institutional stays for older adults account for a significant amount of healthcare expenditures, but little is known about the association between physical activity levels through adulthood and utilisation of these services later in life. To this end, we wanted to explore an association between physical activity …

03.09.2026journal-article

Frontiers in Psychiatry

Potentially inappropriate medications in older outpatients with depression: a cross-sectional study comparing the Beers criteria and the Chinese criteria

Hong Jiang, Xiaojuan Zhou, Pinpin Feng, Zhongni Xia, Wenjuan Yang, Bing Han, Meiling Zhang, Qinqin Zhao

Objective To determine the prevalence of PIMs and identify associated factors in older Chinese outpatients with depression, using a combined evaluation based on the 2023 Beers criteria and the 2017 Chinese criteria. Methods A cross-sectional study was conducted at a provincial tertiary psychiatric hospital in China, enrolling older outpatients (≥ 65 years) diagnosed with depression. PIM status was identified according to the 2023 Beers criteria and the 2017 Chinese criteria. Logistic regression analyses were perfor …

03.09.2026journal-article

Frontiers in Pharmacology

Targeting skin aging: anti-senescent potential and key enzyme modulation of Lavandula essential oils

Jorge M. Alves-Silva, Joana Domingues, Fernanda Delgado, Teresa Ribeiro, Teresa Cruz, Lígia Salgueiro, Henrique Girão, Mónica Zuzarte

Introduction Skin aging is an inherent biological process linked to chronological aging that can be accelerated by external factors. Cellular senescence and skin enzymes are crucial players in this process and, therefore, relevant preventive and therapeutic targets. In this scenario, aromatic plants and their essential oils have gained attention as promising agents in the management of skin aging. The present study aims to explore the anti-senescent potential of Lavandula stoechas subsp. luisieri and Lavandula pedu …

03.09.2026journal-article

Research Connections

Integrating AI-Informed Risk Prediction with Applied Psychological Interventions to Improve Dementia Care Outcomes

Kelechi Ngozi Eluigwe, Nelyn Akunna Okoye, Olayinka Lukman Olatunji, Christian Takyi Mensah, Emmanuel Appiah, Emmanuel Nana Oware Acquah, Genevieve Donkor Armah, Emmanuel Adu Sarfo, Onyinyechukwu Uzoamaka Oka

Abstract Objectives Delayed risk identification, heterogeneous disease trajectories, and poor alignment of psychosocial interventions with patient and carer needs continue to challenge dementia care. Artificial intelligence (AI) offers promise for improving dementia risk prediction, while psychological interventions remain important for supporting individuals with dementia and their carers. Methods This narrative review presents a conceptual synthesis integrating evidence from published studies on AI-based dementia …

03.09.2026journal-article

Frontiers in Systems Biology

Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum

Andrea Angarita-Rodríguez, Johan H. Largo-González, Julián Pérez-Mejía, Daniel Balcazar, Viviana Vargas-López, Jason A. Papin, Andrés Pinzón, Janneth González

Introduction Mild cognitive impairment (MCI) represents a prodromal stage of Alzheimer’s disease (AD), but the metabolic mechanisms underlying early neuronal dysfunction remain incompletely understood. GABAergic neurons, which maintain excitatory–inhibitory balance and network stability, exhibit early vulnerability during neurodegeneration, although the metabolic alterations associated with their dysfunction remain poorly characterized. Methods We developed a context-specific genome-scale metabolic model (GEM) of h …

03.09.2026journal-article

International Journal of STD & AIDS

Anti–IL-17 therapy in people living with HIV who have cutaneous psoriasis: A four-patient case series

Melike Merve Güçlü, Fatma Aslı Hapa, Fatma Elif Yıldırım

Aim To describe the clinical, immunological, virological and safety outcomes observed during anti–IL-17 therapy in patients living with HIV who had cutaneous psoriasis. Method Four patients living with HIV who had cutaneous psoriasis and were treated with anti–IL-17 agents were included in this case series. Psoriasis Area Severity Index (PASI) scores, CD4 cell counts, HIV RNA levels, treatment duration and adverse events were obtained from medical records. Results Three patients received secukinumab and one receive …

03.09.2026journal-article

People and Nature

Caring with forests: Human and more‐than‐human care in forest occupations in Germany

Sebastian Garbe

Abstract Drawing on ongoing ethnographic and participatory action research within forest occupations in Germany, this paper develops the concept of ‘caring with forests’ to theorise the mutual, multidimensional relationships of care that emerge between humans and more‐than‐human beings in environmental protest settings. Departing from a personal encounter during fieldwork at a forest occupation resisting sand and gravel extractivism, the article argues that forest occupations constitute sites and conditions that en …

03.09.2026journal-article

Psicologia: Reflexão e Crítica

Spanish version of the personal experience of aging scale: psychometric analyses from classical and network psychometrics approaches in a Chilean sample

Oscar Terán-Mendoza, Vicente Cancino

Abstract Background How people experience aging is linked to health, well-being, and engagement in later life, but Spanish-language measures for capture self-perceptions of aging in Latin America remain limited. Objective To adapt the Personal Experience of Aging Scale (PEAS) into Spanish and evaluate its psychometric properties in Chilean adults aged 50 and older. Methods The instrument was translated into Spanish, and content validity was examined by expert judges. Two independent community samples from Chile (ex …

03.09.2026journal-article

Frontiers in Aging Neuroscience

Data-driven subtyping of Parkinson’s disease using MRI: current insights, challenges, and future directions

Anupa A. Vijayakumari, Ken E. Sakaie, Hubert H. Fernandez, Benjamin L. Walter

Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder marked by diverse motor and non-motor symptom profiles. Traditional symptom-based subtyping shows limited stability and lacks clear biological grounding. Integrating magnetic resonance imaging (MRI) with machine learning (ML) offers a promising avenue for defining biologically informed PD subtypes. This narrative review synthesizes evidence from MRI-based subtyping studies that used structural (T1-weighted), diffusion, functional, or multimodal …

03.09.2026journal-article

Frontiers in Psychiatry

Clinical characteristics and neuropsychiatric profiles of young-onset dementia: a retrospective cross-sectional study at a tertiary care center in Northern Thailand

Sirivipa Jekpoo, Kittithatch Booncharoen, Supisara Prompila, Tinakon Wongpakaran, Huali Wang, Nahathai Wongpakaran

Background Data on young-onset dementia (YOD) in Thailand remain limited. We aimed to describe clinical presentation, general cognitive performance, neuropsychiatric symptoms, neuroimaging features, and selected laboratory findings across YOD subtypes in a tertiary-care cohort in Northern Thailand. Methods We conducted a retrospective cross-sectional study of 295 individuals with YOD (symptom onset < 65 years) treated at Chiang Mai University Hospital (2010–2025). Data extracted included demographics, presenting co …