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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

電腦學刊

Single-Channel Speech Enhancement Method Based on Deep Neural Networks

Wen Fan, Wei-Yu Liang, Duo-Duo Han, Wei Huang, Han-Jiao Meng

In practical voice communication and processing, speech signals are extremely sensitive to background noise, equipment noise, and interference from complex environments, leading to a decline in speech quality and clarity. This, in turn, affects the overall performance of downstream systems such as speech recognition, speech coding, and human-computer interaction. Therefore, researching efficient and robust single-channel speech signal enhancement methods has significant theoretical and practical implications. With …

31.08.2026journal-article

SA Journal of Industrial Psychology

Work–life balance and occupational stress among South African engineers: An examination of the mediating roles of perceived organisational support and job demands

Johannes N. Pretorius, Petrus A. Botha

Orientation: Work–life balance (WLB) and occupational stress (OS) are two pressing issues in the South African engineering environment, largely driven by high job demands (JD) and scarce organisational resources, respectively. Research purpose: This study aimed to investigate the relationship between WLB and OS, and whether this relationship is mediated by perceived organisational support (POS) and JD among South African engineers. Motivation for the study: Despite various studies on WLB and OS across the globe, th …

31.08.2026journal-article

Physiotherapy Canada

Associations Between Mobility Capacity and Walking Performance in Community-Dwelling Older Adults With Outdoor Walking Limitations

Sabrina A. Schlickmann Gil, Ruth Barclay, Nancy M. Salbach, Sandra C. Webber

Abstract Purpose: To determine relationships between mobility capacity and walking performance in older adults with outdoor walking limitations. Method: This cross-sectional study involved secondary analysis of baseline data from the Getting Older Adults Outdoors (GO-OUT) study (115 females, 53 males; mean age of 74.6 [SD 7.0] years). Mobility capacity tests included 6-minute walk test (6MWT), 10-metre walk test (10MWT), 30-second sit-to-stand (30sSTS), and Mini-BESTest. Walking performance included peak 30-minute …

31.08.2026journal-article

The Korean Gerontological Research Society

Development of a Generative AI-Assisted Digital Language-Cognitive Rehabilitation Content Prototype for Older Adults with Mild Dementia

Yeonghye Park, Shinhye Park

This study aimed to develop a generative AI-assisted, web-based digital language-cognitive rehabilitation content prototype for older adults with mild dementia and to describe its development process, structure, and initial revisions. ChatGPT was not used as an intervention system that automatically analyzed user performance or adjusted task difficulty in real time. Instead, it served as a development support tool for generating initial drafts of linguistic stimuli, task items, instructions, and feedback messages. …

31.08.2026journal-article

Public Health Journal

Effectiveness of Endorphin Massage in Reducing Labor Pain During the Active Phase of the First Stage of Labor at Independent Midwifery Practice (PMB) E, Mustika Jaya, Bekasi (2025–2026)

Emilia Emilia

Excessive and prolonged labor pain can lead to anxiety, psychological distress, labor complications, and even maternal and neonatal mortality. Therefore, it is necessary to manage labor pain using non-pharmacological methods, such as endorphin massage. This study aims to determine the effectiveness of endorphin massage in reducing labor pain during the active phase of the first stage of labor among women giving birth at PMB E Mustika Jaya, Bekasi.This study employed a quasi-experimental method with a one-group pre- …

31.08.2026journal-article

Frontiers in Medicine

Combined pelvic floor training and hormonal therapy for endometriosis pain recurrence: a propensity score-matched study

Jie Song, Hui Dong, Zhen Chen

Background Endometriosis (EMS) causes debilitating pain and reduces quality of life. Whether pelvic floor muscle training (PFMT) provides independent, additive benefits beyond standard postoperative hormonal suppression remains unknown. Methods A retrospective cohort study was conducted on 446 women with surgically confirmed EMS between June 2022 and May 2024. Patients were categorized into five groups: PFMT-only ( n = 98), PFMT+long-term adjuvant progestogen (PFMT+LAP; n = 91), PFMT+combined oral contraceptives (P …

31.08.2026journal-article

Archives of The Medicine and Case Reports

Green-Laser-Flanged Intrascleral Fixation of a Secondary Intraocular Lens in Aphakia with Reduced Endothelial Reserve: Rapid Visual Rehabilitation, a +1.00 Dioptre Prediction Error, and a Minimum Reporting Data Set

Ade John Nursalim, Yovita

Background: Aphakia without capsular support is decided largely by the state of the corneal endothelium. Objective: To present the result with a structured audit of the record and a numbered minimum data set for reporting laser-flanged intrascleral fixation. Methods: A 60-year-old man was referred twelve months after left phacoemulsification complicated by posterior capsule rupture, with no lens implanted. Best-corrected acuity with a +10.00 D aphakic spectacle was 20/200 (1.00 logMAR), uncorrected acuity was count …

31.08.2026journal-article

Journal of the European Academy of Dermatology and Venereology

Five‐year survival impact of adjuvant anti‐ PD ‐1 therapy in a nationwide cohort of stage III melanoma

Marie B. Weitemeyer, Neel M. Helvind, Shawez Khan, Pernille Bidstrup, Karina D. Steffensen, Adam Andrzej Luczak, Lars Bastholt, Henrik Schmidt, Inge Marie Svane, Marco Donia, Lisbet R. Hölmich, Eva Ellebaek

Abstract Background Adjuvant anti‐PD‐1 therapy improves recurrence‐free survival in resected stage III melanoma, but its impact on survival remains uncertain. Objective To evaluate the association of adjuvant anti‐PD‐1 therapy with overall survival (OS) and melanoma‐specific mortality (MSM) in patients with stage III melanoma. Methods Five‐year OS and MSM were compared between stage III melanoma patients diagnosed before (pre‐cohort: June 2016–May 2018, n = 450) and after (post‐cohort: January 2019–December 2020, n …

31.08.2026journal-article

Vibration

Occurrence and Health Relevance of Occupational Single-Shock Exposure of the Hand–Arm System—An Epidemiological Exploration

Elke Ochsmann, Alexandra Corominas Cishek, Uwe Kaulbars

Background: Single-shock exposure to the hand–arm system is a distinct form of occupational mechanical exposure that is rarely assessed separately from continuous vibration. Due to methodological challenges and the lack of standardized definitions, epidemiological evidence on its prevalence and health relevance remains limited. Objectives: This study aimed to explore the occurrence of occupational single-shock exposure in a general working population and to examine its association with self-reported hand–arm health …

31.08.2026journal-article

Revista Tópicos

INFORMATIONAL SILENCE AND SYMBOLIC LEGITIMACY: A DIAGNOSIS OF THE DISCLOSURE OF OCCUPATIONAL HEALTH AND SAFETY IN FEDERAL INSTITUTES OF EDUCATION, SCIENCE AND TECHNOLOGY

Carla Regina Pires, Tatiane Denise Camargo Alves, Beatriz Côrte Real Rodrigues, Fabianne Banderó Schuster, Emerson Luiz Flores de Oliveira

Este estudo analisa a divulgação de informações sobre Saúde e Segurança no Trabalho (SST) nos Relatórios de Gestão dos Institutos Federais de Educação, Ciência e Tecnologia, utilizando os indicadores da norma internacional GRI 403 como referência analítica e a teoria institucional como lente interpretativa. A pesquisa caracteriza-se como qualitativa, descritiva e aplicada, fundamentada em análise documental dos Relatórios de Gestão referentes ao exercício de 2022 de dez Institutos Federais brasileiros; Foram examin …

31.08.2026journal-article

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

The Role of Nutrition Therapy in the Management of Chronic Pain

Hatice Tuğçe Berberoğlu, Muteber Gizem Keser Gümüş

Chronic pain is defined as pain lasting longer than three months or recurring in nature and is considered a major public health problem affecting millions of people worldwide. This condition, which significantly reduces quality of daily life and may lead to physical, psychological, and social problems, can negatively affect individuals' lives over the long term. Although the mechanisms underlying the development of chronic pain have not yet been fully understood, recent scientific studies suggest that certain biolo …

31.08.2026journal-article

Brain Sciences

Efficacy and Safety of Photobiomodulation Therapy for Motor Symptoms in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Joao Mariano, Eneidy Piña Mojica, Andrés Soto-Rodríguez, Anna Carolyna Gianlorenço, Kevin Pacheco-Barrios, Felipe Fregni

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder causing disabling motor dysfunction and substantial socioeconomic burden. Photobiomodulation (PBM), a noninvasive red/near-infrared light therapy, has shown preclinical promise, but its clinical efficacy and safety in PD remain uncertain. Objectives: To systematically evaluate the efficacy and safety of PBM on motor outcomes in PD. Methods: This PRISMA-compliant systematic review was prospectively registered in PROSPERO (CRD42026141126 …

31.08.2026journal-article

PLOS One

Computational identification and evaluation of Adenium obesum phytochemicals as potential EGFR inhibitors for targeted therapy against non-small-cell lung cancer

Md. Naziur Rahman, Abu Yousuf Hossin, Shahriar Mannan Imon Talukder, Mt. Sumaiya Siddika, Md. Harun-Ur-Rashid, Shahanaz Parveen, Md. Ridwanul Islam, Md. Yeamin Hossain, Mahfuj Ahmed, Brototi Chakraborty Dyuti, Zarin Tabassum, Ajoy Kumer

Non-small-cell lung cancer (NSCLC) remains the leading cause of lung cancer–related mortality, largely driven by aberrant activation of the epidermal growth factor receptor (EGFR). Despite the clinical success of EGFR tyrosine kinase inhibitors (TKIs), intrinsic and acquired resistance, coupled with safety concerns, highlight the need for novel, safer inhibitors. Natural products represent an underexplored source of structurally diverse bioactive compounds with favorable biocompatibility. In this study, a comprehen …

31.08.2026journal-article

Acute and Critical Care

Peripheral administration of 11.7% hypertonic saline and phlebitis risk in acute ischemic stroke requiring hyperosmolar therapy in South Korea

Beom-Seok Seo, Hyesuk Hong, Jong Hwa Hong, Jisu Jung, Hyunsoo Kim

Background: Hypertonic saline (HTS) is used for hyperosmolar therapy in acute ischemic stroke (AIS) but is traditionally administered via central venous catheter to minimize vascular complications. Procedural burden and urgency often necessitate peripheral administration in practice. We investigated phlebitis risk associated with peripheral 11.7% HTS in AIS patients requiring hyperosmolar therapy.Methods: This retrospective study included 200 AIS patients receiving hyperosmolar therapy with mannitol (January 2022–D …

31.08.2026journal-article

Physiotherapy Canada

The Role of Physiotherapists on Family Health Teams: Understanding Active Interprofessional Team Members’ Perspectives

Alyssa Benitez, Aly Knox, Brooke Hogben, Adam Ziabari, Phillip Park, Rahul Manikonda, Euson Yeung, Charlotte Anderson

Abstract Purpose: Family Health Teams (FHTs) were established in 2005 to increase access to health care and collaborative decision-making. It remains unclear how effective this care model is for socio-economically and culturally diverse areas like Scarborough, Ontario. This study aimed to (1) understand administrators’ and practitioners’ perspectives on how FHTs are operating in this region; and (2) illuminate the current and potential roles of physiotherapists within FHTs to address diverse health needs in the Sca …

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31.08.2026journal-article

Natural and Life Sciences Communications

Occupational Health Risks from Pesticide Exposure: Evidence from Thai Farmers

Pronrumpa Kanjanasingh, Thittaya Ngamsang, Preechaya Tajai

Several pesticides are widely used in agriculture, yet many farmers lack adequate knowledge and protective practices, increasing risk of exposure and related health effects. This study aimed to screen health risks and analyze the factors affecting pesticide exposure among farmers in Chachoengsao Province, Thailand. Cross-sectional study was performed. Data were collected from 177 farmers who volunteered to participate. For pesticide exposure, 81.92% of farmers currently use pesticides, 57.25% sprayed pesticides the …

31.08.2026journal-article

Journal of Cognitive Psychotherapy

Development and Pilot Testing of Internet-Delivered Cognitive Behavioral Therapy for Anxiety and Obsessive-Compulsive Disorders in Autistic Adolescents

Jessica Szu-Chi Cheng, Jolie B. Held, Callie G. Murphy, Ogechi “Cynthia” Onyeka, Andrew G. Guzick, David B. Riddle, Leandra N. Berry, Robin P. Goin-Kochel, Marianna C. Messerli, Jeffrey A. Carter, Mariana Vazquez, Erika S. Trent, Peter J. Boedeker, Troy Quast, Eric A. Storch

Anxiety disorders are prevalent in autistic adolescents, yet barriers to treatment access exist. The current article describes (a) the development of an internet-delivered, therapist-assisted cognitive behavioral therapy protocol adapted for autistic adolescents with co-occurring anxiety and/or obsessive-compulsive disorder and (b) preliminary feasibility, acceptability, and effectiveness data. Ten autistic adolescents between the ages of 11 and 17 were enrolled. Based on qualitative feedback and quantitative data …

31.08.2026journal-article

Frontiers in Pediatrics

Association of depressive symptoms with sweat chloride variability and medication possession ratio during long-term Elexacaftor/Tezacaftor/Ivacaftor therapy in adolescents and young adults with cystic fibrosis

Michael Lorenz, Mariya Pavlova, Katja Erler, Anika Nader, Anne Moeser

Introduction Elexacaftor/tezacaftor/ivacaftor (ETI) sustainably improves lung function (FEV₁), quality of life and sweat chloride (SC) levels in people with cystic fibrosis (pwCF). Psychological comorbidities may impair treatment adherence. This study assessed ETI adherence using SC and medication possession ratio (MPR) and evaluated the impact of depressive symptoms. Methods In this retrospective observational study, 34 pwCF aged 12–21 years (median 17.3) initiating ETI between 2020 and 2022 were included. SC and …

31.08.2026journal-article

Journal of Veterinary Emergency and Critical Care

Use of Intralipid Therapy and Therapeutic Plasma Exchange in the Management of Cholecalciferol Rodenticide Exposure in a Dog: A Case Report

Tanvi A. Kamat, Kara D. Altman, Emma Donnelly, Neus Elias Santo‐Domingo

ABSTRACT Objective To describe the presentation and outcome of a case of suspected cholecalciferol rodenticide intoxication managed with both intralipid emulsion (ILE) and therapeutic plasma exchange (TPE). Case Summary A 3‐year‐old, neutered female, crossbreed dog presented for acute‐onset vomiting and lethargy after suspected exposure to cholecalciferol rodenticide. Severe hypercalcemia was observed without other identifiable causes found upon investigation. Standard therapy for hypercalcemia was initiated, but r …

31.08.2026journal-article

TAMADDUN NURI JURNALI

ЦИФРОВАЯ СРЕДА ДЛЯ СВОБОДНОЙ РЕЧИ: АВТОРСКАЯ ПЛАТФОРМА “ГОВОРИ-КА” В ОБУЧЕНИИ РУССКОМУ ЯЗЫКУ

Гулчехра Жабборова

The article presents the author’s digital “Speak Up” platform designed to develop fluent, confident, and accurate Russian speech. The platform is based on the principle of moving from knowledge of language rules to independent speech production. The article describes the author’s model for organizing a digital speech environment that integrates lexical, grammatical, and communicative practice through the sequence “understand → try → speak → correct → engage in communication”.

31.08.2026journal-article

Journal of Inherited Metabolic Disease

Phase 3 Randomized Trial Results of DTX401 AAV Gene Therapy for the Treatment of GSDIa

John J. Mitchell, Jose E. Abdenur, Foekje de Boer, Monica Boyer, Margo Sheck Breilyn, María‐Luz Couce, Diva D. De Leon, Terry G. Derks, Areeg El‐Gharbawy, Andrea B. Haijer‐Schreuder, Karen Loechner, Nicola Longo, Allan M. Lund, Miguel Angel Martinez Olmos, Shawn E. McCandless, Bibiana Mello de Oliveira, Malaya Mount, Nicole Muschol, Kristina Pytlak, Kadakkal Radhakrishnan, Rebecca Riba‐Wolman, David F. Rodriguez‐Buritica, Alessandro La Rosa, Alessandro Rossi, Heather Saavedra, René Santer, Brian Shayota, G. Peter A. Smit, Carolina F. Moura De Souza, Melanie M. van der Klauw, David A. Weinstein, Joseph I. Wolfsdorf, Anne Blake, Andrew A. Grimm, Deepali Mitragotri, Syeda Rahman, Diane M. Turner‐Bowker, Richard Collis

ABSTRACT Glycogen storage disease type Ia (GSDIa) is a rare, life‐threatening inherited carbohydrate metabolism disorder caused by biallelic pathogenic G6PC gene variants resulting in deficiency of glucose‐6‐phosphatase. DTX401 is an investigational AAV8 vector containing the human G6PC gene. DTX401‐CL301 is a pivotal, phase 3, double‐blind, randomized, placebo‐controlled trial of DTX401 in patients ≥ 8 years with GSDIa. The primary endpoint was percent change from Baseline to Week 48 in daily cornstarch intake for …

31.08.2026journal-article

Medicina

Prognostic Value of the Modified Glasgow Prognostic Score in Patients with Metastatic Renal Cell Carcinoma Receiving Nivolumab as Second-Line Therapy: A Multicentre Retrospective Cohort Study

Sedat Biter, Ertuğrul Bayram, Tolga Köşeci, Mehmet Cihan İçli, Ahmet Melih Arslan, Faruk Recep Özalp, Nadiye Sever, Ahmet Ünsal, Nargiz Majidova Altuntaş, Mustafa Seyyar, Gülhan Dinç, Mahmut Büyükşimşek, Mehmet Türker, Şendağ Yaslıkaya, Mehmet Mutlu Kıdı, Yasemin Aydınalp Camadan, Umut Kefeli, Mehmet Uzun, Hasan Çağrı Yıldırım, Hüseyin Salih Semiz, Mustafa Erman, İsmail Oğuz Kara

Background and Objectives: The modified Glasgow Prognostic Score (mGPS)—a composite of serum C-reactive protein (CRP) and albumin—simultaneously reflects systemic inflammatory activity and nutritional reserve. Its specific prognostic role in patients with metastatic renal cell carcinoma (mRCC) treated with nivolumab in the second-line setting has not previously been examined in a large multicentre cohort. The aims of this study are to determine whether baseline mGPS independently predicts overall survival (OS) and …

31.08.2026journal-article

Nano Letters

An Oral Biomimetic Hydrogel for Colon-Localized and Tumor-Targeted Sonodynamic Therapy of Colorectal Cancer

Zeyang Tian, Jie Yang, Ya-Xuan Zhu, Han Lin, Jianlin Shi

Abstract Oral drug delivery systems show great promise for colorectal cancer (CRC) therapy but are limited by poor gastrointestinal stability, insufficient colon localization, and low tumor targeting. Here, we report an oral biomimetic hydrogel platform, SAM/Au-TiO2@Gel, for colon-localized and tumor-targeted sonodynamic therapy of CRC. Au deposition enhances the sonodynamic reactive oxygen species (ROS) generation capability of TiO2, while Staphylococcus aureus membrane (SAM) coating improves tumor targeting and u …