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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Oriental Journal Of Chemistry

Synthesis and Biological Evaluation of Pyrazole Derivatives as Anti-Amyloid and Anti-Inflammatory Agents for Alzheimer’s Therapy

Mansi Mishra, Sushma Verma, Khushboo Mishra, Anita D. Kadam, Souvik Sur, Gayatri Katole, Rashmi Sharma, Ajay Kumar Yadav, Jannat Ul Firdaus

Alzheimer's disease (AD) remains a devastating neurodegenerative disorder with no disease-modifying therapies available, largely due to its complex, multifactorial pathophysiology involving amyloid β (Aβ) aggregation, tau hyperphosphorylation, chronic neuroinflammation, oxidative stress, and proteasomal dysfunction. This review comprehensively evaluates the synthesis and biological evaluation of pyrazole derivatives as promising multi-target-directed ligands (MTDLs) for Alzheimer's therapy. The pyrazole scaffold, w …

31.08.2026journal-article

Frontiers in Endocrinology

Negative pressure wound therapy versus standard wound care for diabetic foot ulcers: a systematic review and meta-analysis of healing and limb outcomes

Chao Niu, Kunpeng Fu, Xiuxiao Chen, Yanyang Wang

Background Diabetic foot ulcers (DFUs) are major diabetes-related complications that often require prolonged wound care, debridement, or limb-salvage surgery. Negative pressure wound therapy (NPWT) is widely used as an adjunct, but its comparative effectiveness remains debated. Objective To meta-analyze the efficacy and safety of NPWT versus standard wound care in adults with DFUs. Methods PubMed/MEDLINE, Cochrane CENTRAL, EMBASE, and Web of Science were searched from January 2000 to January 2025 for randomized, qu …

31.08.2026journal-article

Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi

Artificial Intelligence Readiness and Rehabilitation Technology Use Among Physiotherapists: A Cross-Sectional Study

Ece Acar, Meryem Sevim, Derya Bıçaklar

Aim: This study aimed to evaluate physiotherapists' artificial intelligence (AI)-related characteristics and rehabilitation technology-related characteristics and to identify factors independently associated with rehabilitation technology use during patient follow-up.Methods: This cross-sectional study included 140 physiotherapists actively practicing in Türkiye. Data were collected using a structured questionnaire assessing sociodemographic, rehabilitation technology-related, and AI-related characteristics, togeth …

31.08.2026journal-article

ACS Applied Materials & Interfaces

Solvent Polarity-Directed Morphological Transformation of Zinc Porphyrin Assemblies for Enhanced Photodynamic Therapy of Glioblastoma

Jichao Chen, Manzhen Wang, Xingmei He, Qinqin Ma, Qingxiang Zhu, Yisheng Liu, Guan Huang, Chenbo Wang, Jiajie Sun, Yong Zhong

Abstract Glioblastoma is one of the most aggressive brain cancers with poor prognosis. Photodynamic therapy (PDT) is an efficient and noninvasive strategy for glioblastoma treatment. Porphyrins represent common photosensitizers for PDT but suffer from poor water solubility and low reactive oxygen species (ROS) yield. Herein, we report a porphyrin photosensitizer with enhanced ROS via a cascade fabrication involving the self-assembly of zinc meso-tetra(4-pyridyl)porphyrin (ZnTPyP) into tetragonal nanorods (NRs), fol …

31.08.2026journal-article

The Indonesian Biomedical Journal

Combination of Insulin and UC-MSCs Secretome Therapy Demonstrates A Trend of Liver Injury Improvement in Diabetic Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) Rat Model

Shirly Gunawan, Siufui Hendrawan, Olivia Marcelina, Jennifer Lheman, Hans Ulrich Baer

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) coexists with diabetes mellitus and presents a significant therapeutic challenge due to its complex metabolic and hepatic pathology. Insulin therapy remains the cornerstone for glycemic management, but its effects on hepatic steatosis is inconsistent. Complementary therapies are needed to address this limitation. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) secretome has emerged as therapeutic approach for metabolic disease due …

31.08.2026journal-article

Journal of Mechanics in Medicine and Biology

A CNN-BILSTM-BASED DEEP LEARNING FRAMEWORK FOR PILATES-INTEGRATED ROBOT-ASSISTED SPORTS REHABILITATION: BIOMECHANICAL MOTION MODELING AND OUTCOME EVALUATION

HONGMEI ZHAO, YANG ZHOU, MIN LIAO

The integration of Pilates into sports rehabilitation has shown potential for improving core stability, flexibility, and motor control. However, traditional rehabilitation methods lack real-time motion analysis, personalized feedback, and biomechanical modeling capabilities. This study proposes a deep learning-based optimization framework for motion analysis and quality assessment in robot-assisted Pilates fusion exercise rehabilitation. The framework constructs a spatiotemporal modeling model integrating Convoluti …

31.08.2026journal-article

Neurorehabilitation and Neural Repair

Fatigue in Neurological Rehabilitation: Why Brain Diversity and Population Diversity Matter

Thorsten Rudroff

Background: Fatigue affects 50% to 90% of patients with multiple sclerosis, Parkinson’s disease, stroke, ME/CFS, and long COVID and represents a primary barrier to rehabilitation participation yet remains poorly understood despite decades of research. The Problem: Systematic examination of recent comprehensive reviews reveals a dual diversity failure. Brain diversity is underexamined: fatigue, fundamentally a central nervous system symptom, is assessed predominantly through questionnaires (95%-100% of studies) and …

31.08.2026journal-article

Advances in Communication and Swallowing

Speech and Language Therapy Interventions Throughout the Oral Cavity Cancer Pathway: A Scoping Review

Kate Baker, Sinead Rothrie, Grainne Brady, Susanne Cruickshank, Justin Roe

Objective The anatomical location of oral cavity cancer (OCC), plus its usual treatment options of surgery with or without (chemo-)radiotherapy, may impact profoundly on speech and swallowing outcomes. The aim of this scoping review was to identify and summarise speech and language therapy (SLT) intervention types and service delivery models employed in OCC over the last 25 years, in order to summarise current practice. Method Systematic searches were conducted in three databases and via Google Scholar for papers p …

31.08.2026journal-article

International Political Science Review

Political cultural roots of assertive foreign policy roles: A cross-country speech analysis (2000–2024)

Cerem I. Cenker-Özek, B. Toygar Halistoprak

This study explores the political cultural foundations of assertive foreign policy roles. By utilizing cultural dimensions widely used in comparative behavioral research, it shows how leaders’ emphasis on different cultural frames influences their choice of assertive foreign policy roles differently. For this purpose, the study uses a novel, longitudinal dataset comprising 2000 speech texts delivered between 2000 and 2024 by leaders in Germany, Russia, Türkiye, the UK, and the US. The findings provide evidence of a …

31.08.2026journal-article

Human Systems Management

The dual impact of AI adoption on job performance: A social exchange perspective and the moderating role of occupational self-efficacy

Salim khan, Mohammad Nasar Khan, Fawad Khan

Background & Purpose Despite the rapid adoption of AI in the hospitality industry, few studies have examined its impact from the reciprocal exchange perspective. By applying the social exchange theory, the study examines how the positive and negative perceptions of AI adoption affect the trust formation between employees and the employer, leading to different impacts on job performance. Additionally, we investigate the boundary effect of occupational self-efficacy across these relationships. Research Methods To tes …

31.08.2026journal-article

International Journal of Science and Research Archive

DIGITAL STORYTELLING AS A STRATEGIC TOOL FOR COUNTERING MISINFORMATION, HATE SPEECH, AND CONFLICT ESCALATION ONLINE

Ramatu Abubakar Binyamin, Frank Kwamla Nyamede

Digital communication has transformed how societies produce, circulate, and interpret information, creating opportunities for participation while accelerating misinformation, hate speech, polarization, and conflict escalation. This study examines the potential of digital storytelling as a strategic communication intervention for countering harmful online narratives and strengthening conflict prevention. The study adopts an integrative analytical approach that synthesizes scholarship on digital storytelling, misinfo …

31.08.2026journal-article

Applied Sciences

Five-Year Occupational Radiation Exposure of Nuclear Medicine Personnel: Whole-Body, Skin, Estimated Eye Lens, and Extremity Dosimetry in Southwestern Hospital of Saudi Arabia

Mohammed A. Jowhari, Sarah M. Al-Mamar, Anwar I. Al-Qaflah, Nouf K. Al-Mazmumi, Al-Hanouf A. Al-Rasasmeh, Saeed Mueed Al-Qahtani, Mohammad Sayed, Ismail M. Moafa, Mansour M. Alqahtani

Occupational radiation exposure in nuclear medicine (NM) is heterogeneous because personnel handle unsealed radionuclides and work near injected patients. This five-year retrospective study characterised whole-body Hp(10), whole-body Hp(0.07), ring Hp(0.07), and estimated eye-lens Hp(3) in six NM staff over 20 quarterly monitoring cycles (2020–2024). TLD-100 whole-body and ring dosimeters were analysed, and Hp(3) was estimated from collar-level Hp(0.07), with two alternative surrogates examined in sensitivity analy …

31.08.2026journal-article

Proceedings of the National Academy of Sciences

Interpreting vaccine-associated survival differences in immune checkpoint inhibitor therapy

René Karadakic, Nancy L. Keating, Michael L. Barnett

Recent studies proposed that SARS-CoV-2 mRNA vaccination may sensitize tumors to immune checkpoint inhibitor (ICI) therapy through immune modulation. Using 100% national Medicare fee-for-service claims data, we evaluated whether survival differences among vaccinated patients receiving ICIs were specific to mRNA vaccines. Among 121,676 beneficiaries initiating systemic anticancer therapy, including 10,824 initiating ICIs, vaccination near treatment initiation was associated with lower mortality across mRNA COVID-19, …

31.08.2026journal-article

NeuroSci

Persistent Post-Concussion Syndrome Following Motor Vehicle Collision: A 27-Month Longitudinal Case Study of Multimodal Rehabilitation

Kenneth Jay, Mary Shaya, Jonathan Walker

Persistent post-concussion syndrome (PPCS) develops in 10 to 30 percent of patients following mild traumatic brain injury (mTBI), yet the most effective management approach remains an open question. This report describes a 37-year-old female who sustained a motor vehicle collision and was followed prospectively over 27 months. Structured evaluation at baseline identified dysfunction across oculomotor, vestibular, autonomic, cognitive, and neurophysiological domains. An intensive multimodal rehabilitation programme …

31.08.2026journal-article

Annals of Pediatric Endocrinology & Metabolism

Bisphosphonate therapy for thalassemia-related bone disorders in children and young adults: a systematic review

Ghea Mangkuliguna, I. Wayan Andrew Handisurya, Nicholas Adrianto

Skeletal complications represent a major morbidity in transfusion-dependent thalassemia (TDT), particularly among children and young adults. Osteopenia and osteoporosis arise from marrow expansion, iron overload, endocrine dysfunction, and vitamin D deficiency, leading to impaired bone mass accrual. Although bisphosphonates are widely used in osteoporosis, their role in thalassemia has not been systematically appraised. This review aims to evaluate the role of bisphosphonates in pediatric and young adult patients w …

31.08.2026journal-article

Frontiers in Endocrinology

Injection-site pain after switching from somatrogon to somapacitan in children reporting pain or discomfort during once-weekly growth hormone therapy: a prospective single-arm switch study

Hideyuki Iwayama, Kohei Kawahara, Sachiko Kitagawa, Ryosuke Miyamoto, Junko Takagi, Yoshinori Ito, Akihisa Okumura

Background Once-weekly growth hormone (GH) formulations, such as somatrogon and somapacitan, may reduce the burden of treatment, but injection-site pain can affect treatment preference. Clinical data on patient-reported injection-site pain and preference after switching between once-weekly GH formulations remain limited, particularly in children who experience injection-site pain. Objective To describe changes in perceived injection-site pain and treatment preference after switching from somatrogon to somapacitan i …

31.08.2026journal-article

Jurnal Ilmiah Psikologi Terapan

Stress caregiver informal elderly: Can it be reduced with emotion regulation therapy?

Dimas Prastia Putra, Sri Muliati Abdullah

Caring for older adults places substantial physical and emotional demands on informal caregivers and may increase stress. This pilot randomized controlled trial examined whether Emotion Regulation Therapy (ERT) reduces stress and improves emotion regulation among women informal caregivers of older adults. Twenty eligible participants were randomly assigned to an experimental group (n = 10) or control group (n = 10). Stress and emotion regulation were assessed using the Perceived Stress Scale-10 and Emotion Regulati …

31.08.2026journal-article

Advanced Science

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou

ABSTRACT Radiotherapy (RT) is widely used as an adjuvant treatment after surgical resection for osteosarcoma, but its efficacy is often limited by insufficient radiosensitization and an immunosuppressive tumor microenvironment that restricts systemic antitumor immunity and promotes recurrence and metastasis. Here we report an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of post …

31.08.2026journal-article

African Journal of Hospitality, Tourism and Leisure

Role of leisure in the rehabilitation of stroke survivors

Issahaku Adam, Addae Boateng Adu-Gyamfi

Despite leisure’s therapeutic efficacy, few studies have focused on how leisure contributes to the rehabilitation of stroke survivors, particularly in the context of African countries. Using the Benefits Theory of Leisure Wellbeing and interview data from 41 stroke survivors, this study examines the role of leisure in the rehabilitation of stroke survivors. The findings revealed that leisure contributed to the rehabilitation of the stroke survivors by improving their psychological, emotional, and physical health. H …

31.08.2026journal-article

Bioinformation

Low level laser therapy for suprabony defects: A clinical study in India

Aishwarya Duble

Periodontal flap surgery effectively manages suprabony periodontal defects; however, adjunctive therapies may further improve healing and clinical outcomes. Therefore, it is of interest to assess the effectiveness of low-level laser therapy (LLLT) as an adjunct to flap surgery in 30 patients with chronic periodontitis. Clinical parameters, including plaque index, gingival index, probing pocket depth and clinical attachment level, were evaluated at baseline and after 3 and 6 months. Both groups showed significant im …

31.08.2026journal-article

Journal of Psychosocial Rehabilitation and Mental Health

The Mediating Role of Occupational Dysfunction in the Recovery Process from Difficulty in Daily Life Among People with Severe and Persistent Mental Illness

Aki Watanabe, Takayuki Kawaguchi, Mai Sakimoto, Yuya Oikawa, Keiichiro Furuya, Taichi Matsuoka, Sosei Yamaguchi

Abstract Psychosocial rehabilitation strategies should be expanded to address difficulties as a component of the recovery process for people with mental illness. However, empirical evidence remains limited because few longitudinal studies have examined occupational dysfunction, defined as negative experiences in daily activities, as a factor associated with recovery. This study aimed to examine the influence of difficulty in daily life and occupational dysfunction on changes in the recovery process in individuals w …

31.08.2026journal-article

Clinical Practice and Cases in Emergency Medicine

Unna Boot Therapy Reduces Emergency Department Use in an Unhoused Patient: A Case Report

Ariana Coba Clementel, Frank Ross

Introduction: Venous leg ulcers disproportionately affect people experiencing homelessness and contribute to recurrent emergency department (ED) use. Standard wound care protocols often require daily dressing changes and leg elevation, which are unrealistic in unstable housing environments. Case Report: A 71-year-old male with a 10-year history of venous leg ulcers and 15 ED visits achieved complete wound epithelialization after four months of weekly Unna boot compression therapy, despite eviction during treatment. …

31.08.2026journal-article

電腦學刊

Single-Channel Speech Enhancement Method Based on Deep Neural Networks

Wen Fan, Wei-Yu Liang, Duo-Duo Han, Wei Huang, Han-Jiao Meng

In practical voice communication and processing, speech signals are extremely sensitive to background noise, equipment noise, and interference from complex environments, leading to a decline in speech quality and clarity. This, in turn, affects the overall performance of downstream systems such as speech recognition, speech coding, and human-computer interaction. Therefore, researching efficient and robust single-channel speech signal enhancement methods has significant theoretical and practical implications. With …

31.08.2026journal-article

SA Journal of Industrial Psychology

Work–life balance and occupational stress among South African engineers: An examination of the mediating roles of perceived organisational support and job demands

Johannes N. Pretorius, Petrus A. Botha

Orientation: Work–life balance (WLB) and occupational stress (OS) are two pressing issues in the South African engineering environment, largely driven by high job demands (JD) and scarce organisational resources, respectively. Research purpose: This study aimed to investigate the relationship between WLB and OS, and whether this relationship is mediated by perceived organisational support (POS) and JD among South African engineers. Motivation for the study: Despite various studies on WLB and OS across the globe, th …