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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Nano Research

Natural polyphenol modified ZIF boosted the efficiency of berberine for diabetic kidney disease therapy

Hengjie Zhang, Yutong Zou, Mengxin Wang, Ming Gong, Haiyan Wang, Qing Yang, Xingyuan Li, Xiaoting Chen, Xiting Zou, Yiwen Li, Zhipeng Gu, Fang Liu

Abstract Diabetic kidney disease (DKD) represents a major diabetes-related complication and is among the most important causes of end-stage renal disease (ESRD). Current therapies mainly focus on glycemic control but seldom reverse established renal injury. Berberine (BBR) shows promise for DKD through glucose-lowering, anti-inflammatory, and antioxidant effects, yet its translation is limited by poor bioavailability and rapid metabolism. Here, we developed ZIF-BBR-BPNs, a nanoparticle system that encapsulates BBR …

01.09.2026journal-article

Reports

Non-Alcoholic Wernicke–Korsakoff Syndrome After a Whipple Procedure: Delayed Recognition, Neuropsychological Findings, and Rehabilitation Follow-Up: A Case Report

Ülkü Figen Demir, Fatmanur Karakuş Dilbaz, Nur Banu Memur, Cahit Keskinkılıç, Aylin Hasanefendioğlu Bayrak, Muharrem Battal

Background and Clinical Significance: Wernicke encephalopathy (WE) is a potentially reversible neurological emergency caused by thiamine deficiency. Although classically associated with alcohol use, it may also occur after gastrointestinal surgery and prolonged nutritional compromise, where diagnosis can be obscured by postoperative delirium or metabolic encephalopathy. Case Presentation: A 58-year-old woman with no history of alcohol use underwent a Whipple procedure for pancreatic head adenocarcinoma. Her postope …

01.09.2026journal-article

JMIR Research Protocols

Refining and Assessing Gender-Tailored Group Therapy for Veteran Men With Military Sexual Trauma: Protocol for a Mixed Methods Study

Jonathan Yahalom, Erin P Finley, Sheila O'Brien, Brandon C Yarns, Lindsey L Monteith, Ariel J Lang, Alison B Hamilton

Abstract Background Military sexual trauma (MST) among veteran men is common, underreported, and associated with substantial psychological morbidity. Despite evidence that gender-related distress and shame pertaining to masculinity contribute to treatment avoidance and dropout, MST interventions within the US Department of Veterans Affairs have not been developed specifically for men. Objective The objective of this study is to develop a gender-tailored group psychotherapy for veteran men with histories of MST. Gui …

01.09.2026journal-article

Journal of Occupational Health

Current Practice in Ionizing-Radiation Health Examinations at Occupational Health Institutions in Japan: A Nationwide Questionnaire Survey

Hiroko Kitamura, Tatsuo Nagata, Takashi Moritake

Abstract Objectives To characterize the implementation of ionizing-radiation health examinations at occupational health institutions in Japan and examine how these practices are implemented and interpreted within the current legal framework. We also identified operational factors that may influence their contribution to evaluating radiation-related health effects, fitness for work judgments, and occupational radiation protection. Methods A cross-sectional online questionnaire survey was conducted from January 28 to …

01.09.2026journal-article

PLOS One

LED red light therapy for relief of primary dysmenorrhea: An open, single-group target value clinical trial

Bin Yi, Dandan Wang, Ling Wei, Jun He, Qian Yu, Lei Wu, Yilin Wang, Yajuan Wang, Nan Song, Li Guo

Objective To evaluate the efficacy and safety of LED red light therapy in alleviating primary dysmenorrhea. Methods A total of 119 patients with primary dysmenorrhea were enrolled in 2022. The intervention was LED red light therapy administered 7 days before menstruation. Clinical outcomes were assessed after three menstrual cycles. Results After three cycles of treatment, the mean reduction rate in the Visual Analog Scale (VAS) score was 63.62%. The overall effective rate of the device was 98.32%. The total score …

02.09.2026journal-article

The Oncologist

1 Pembrolizumab Plus Belzutifan Versus Pembrolizumab Plus Placebo as Adjuvant Therapy for Renal Cell Carcinoma: Patient-Reported Outcomes in LITESPARK-022

Thomas B Powles, Toni K Choueiri, Jose A Karam, Cristina Suarez, Wesley Yip, Rana R McKay, Thomas Ferguson, Pooja Ghatalia, Christian Caglevic, Jad Chahoud, Roberto Iacovelli, Hans Hammers, Carlos Rojas, Rui Kang, Todd L Saretsky, Manish Sharma, Joseph E Burgents, Robert J Motzer

Abstract Background The randomized, double-blind, phase 3 LITESPARK-022 study (NCT05239728) showed significant disease-free survival benefit with the addition of belzutifan to adjuvant pembrolizumab in participants with clear cell renal cell carcinoma (ccRCC) at increased risk of recurrence following surgery. We present patient-reported outcome (PRO) findings for LITESPARK-022. Methods Adults with ccRCC stage M0 and intermediate-high or high risk of recurrence after nephrectomy or stage M1 with no evidence of disea …

01.09.2026journal-article

Journal of Applied Dentistry and Oral Sciences

Rehabilitation of Endodontically Treated Teeth with Extensive Coronal Destruction Using Modified Ferrule-containing Endocrowns Fabricated from Different Restorative Materials: A Case Series

Divakar S, Manu Rathee, Sandeep Singh, Sujata Chahal, Sarthak Singh Tomar

Background Preservation of remaining tooth structure has become an important consideration in the rehabilitation of endodontically treated teeth. Extensive coronal destruction following root canal therapy may compromise retention, fracture resistance, and the long-term prognosis of conventional restorations. Endocrowns provide a conservative restorative option for such cases and can be selected based on the amount of remaining tooth structure, functional requirements, esthetic demands, and economic considerations. …

01.09.2026journal-article

International Wound Journal

Hyperbaric Oxygen Therapy for Diabetic Foot Ulcers in Sub‐Saharan Africa: A Critical Review of Clinical Evidence, Health‐System Feasibility and Public Health Implications

Matthew Chibunna Igwe, Esther Ugo Alum, Alphonsus Ogbonna Ogbuabor, Yibala Ibor Oboma, Onyinyechi Bede‐Ojimadu, Charles Iyore Idehen

ABSTRACT Diabetic foot ulcers are an important cause of morbidity, amputation, disability and healthcare expenditure in sub‐Saharan Africa, where limitations in preventive foot care, referral pathways, vascular services, multidisciplinary wound care and financial protection may contribute to poor outcomes. This critical narrative review evaluates the potential role of systemic hyperbaric oxygen therapy as an adjunct to standard diabetic foot ulcer care in sub‐Saharan Africa by integrating evidence on clinical effec …

01.09.2026journal-article

JIHAD : Jurnal Ilmu Hukum dan Administrasi

The Effectiveness of Rehabilitation for Narcotics Users: A Legal Analysis of Law Number 35 of 2009 on Narcotics

Fauzi Jamal, Appe Hutauruk, Hotman Sinambela, Sunarno

The implementation of rehabilitation for narcotics users in Indonesia continues to demonstrate a gap between the legal framework and law enforcement practices. Although Law Number 35 of 2009 on Narcotics mandates medical and social rehabilitation for narcotics addicts and victims of narcotics abuse, its implementation remains inconsistent due to disparities in legal interpretation, limited access to integrated assessments, unequal rehabilitation facilities, and inadequate post-rehabilitation services. This study ai …

01.09.2026journal-article

Retina

DEXAMETHASONE IMPLANT AND AFLIBERCEPT COMBINATION THERAPY VERSUS AFLIBERCEPT MONOTHERAPY FOR DIABETIC MACULAR EDEMA

Irene Park Kim, Christine Orndahl, Caroline Nyaiburi, Rajiv Anand, David Callanan, Deborah Chong, Lori Coors, Timothy Fuller, Andrew McClellan, Wayne Solley, Robert Wang, Patrick Williams, Yoshihiro Yonekawa, Ashkan Michael Abbey

Purpose: To compare combined dexamethasone implant and intravitreal aflibercept (AFB) to AFB monotherapy treatment in diabetic macular edema (DME). Methods: This open-label randomized clinical trial involved randomization of patients with DME (n = 50) to pro re nata treatment with combined dexamethasone and AFB or AFB alone according to prespecified retreatment criteria. Best-corrected visual acuity, central subfield retinal thickness (CST), and adverse events were monitored monthly for 48 weeks. Results: The combi …

01.09.2026journal-article

Pharmaceuticals

Temporal Dynamics of Polyp Regression and Retreatment Burden in As-Needed VEGF Inhibitor Therapy: A 24-Month Study

Misa Kimura, Yoichi Sakurada, Yoshiko Fukuda, Yumi Kotoda, Kenji Kashiwagi

Purpose: This study aimed to evaluate how the temporal dynamics of polyp regression influence 24-month outcomes in eyes with polypoidal choroidal vasculopathy (PCV) treated with as-needed vascular endothelial growth factor (VEGF) inhibitors. Methods: Sixty-three eyes of 63 patients were included. All patients initially received three monthly intravitreal injections of either aflibercept (2 mg) or brolucizumab, followed by as-needed treatment for 24 months. The selection of a VEGF inhibitor depends on time. Indocyan …

01.09.2026journal-article

Journal Human Research in Rehabilitation

Teaching and Learning Practices in Multigrade Classes in Primary Education

Eliza Avdiu, Diellza Kelmendi, Nita Bakija-Haraçija

This article aims to examine practices in multigrade teaching with a particular focus on how teachers model and plan learning content in multigrade classrooms and its relevance, as an important phenomenon in the schools of many European countries. Our study uses a qualitative model through semi-structured interviews and participatory classroom observations. Data sources include perceptions of 10 teachers serving in common classes 0-2 (preschool, first grade, and second grade), grades 3-4 (third and fourth grade), a …

01.09.2026journal-article

Market Infrastructure

ESG-ПІДХОДИ ДО РОЗВИТКУ ПРИРОДООРІЄНТОВАНОЇ РЕАБІЛІТАЦІЇ У СФЕРІ ТУРИЗМУ ТА ГОСТИННОСТІ

Ю.Б. Миронов, І.І. Тучковська

The article explores the theoretical and applied principles of implementing ESG approaches in the development of nature-based rehabilitation (NBR) in the field of tourism and hospitality. It is substantiated that the integration of environmental, social and management components of ESG (Environmental, Social, Governance) creates a basis for the formation of sustainable tourism products focused on preserving natural resources, improving the quality of life of the population and ensuring the long-term competitiveness …

01.09.2026journal-article

Frontiers in Signal Processing

TF-Mamba-DPHNet: a time-frequency state-space and dual-path interaction framework with hybrid cross-scale feature calibration for speech enhancement

Shaik AreefaBegam, Sunnydayal Vanambathina

Introduction Speech enhancement plays a fundamental role in improving the perceptual quality and intelligibility of speech signals degraded by noise. Conventional U-Net architectures effectively capture local spectral information but struggle to model long-range dependencies and may allow residual noise to propagate through skip connections. Transformer-based networks can model global contextual dependencies and generate high-quality enhanced speech; however, their limited capacity to preserve fine-grained high-fre …

01.09.2026journal-article

Nursing Open

Association Between Midwifery Students' Awareness of Global Climate Change and Their Attitudes and Behaviours Toward Medical Waste

Sultan Esra Sayar

ABSTRACT Aim This study aimed to determine whether midwifery students' awareness of global climate change is associated with their attitudes and behaviours toward medical waste management. Design This study employed a descriptive cross‐sectional design. Methods The study was conducted during the 2025–2026 academic year at Atatürk University. The sample consisted of volunteer midwifery students enrolled across all academic years. Data were collected using a sociodemographic questionnaire, the Global Climate Change A …

02.09.2026journal-article

BMJ Open

Does stereotactic ablative body radiotherapy (SABR) added to continued systemic therapy improve time to treatment failure compared with physician’s choice of systemic therapy in oligoprogressive ER-positive, HER2-negative advanced breast cancer? Study protocol for a multicentre, randomised, open-label phase II trial in Australian tertiary cancer centres (AVATAR-II)

Emma Connolly, Michelle White, Shankar Siva, Mathias Bressel, Adrienne See, Kate Hunter, Jennifer Tan, Vanessa Panettieri, Daphne Day, Keelan Byrne, Amelia McCartney, Kate Webber, Katrina Woodford, Steven David

Introduction Oligoprogressive disease (OPD) is a clinically significant pattern of progression observed in patients with oestrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer treated with endocrine therapy (ET) and cyclin-dependent kinase (CDK) 4/6 inhibitors. Stereotactic ablative body radiotherapy (SABR) is an emerging strategy that may ablate resistant subclones and prolong the benefit of systemic therapy. The AVATAR-II trial investigates whether the ad …

31.08.2026journal-article

Annals of Rehabilitation Medicine

Association of Daily Activity Regularity With Functional Recovery in Patients With Stroke and Spinal Cord Injury: A Prospective Actigraphy Study

Yu-Hsuan Lin, Chen Lin, Chueh-Hung Wu, Hsiang-Chih Chang, Huey-Wen Liang, Shao-Yu Chen, Kuan-Lin Sung, Wei-Chen Hsu

Objective: To determine whether the stability of daily physical activity, quantified by interdaily stability (IS), is associated with activities of daily living (ADL) recovery during inpatient neurorehabilitation, independent of overall activity level, we examined the association between physical activity stability and ADL recovery.Methods: This prospective study recruited 161 patients with stroke or spinal cord injury (mean age: 62.4±14.8 years; 42% female) from two hospitals. Physical activity was assessed using …

31.08.2026journal-article

JMIR Nursing

Train-the-Trainer Evaluation of Technology-Enhanced Learning in Preservice Midwifery Education in Nigeria: Qualitative Descriptive Study

Isabella Garti, Nadyen Shikpup, Ophelia Tonto, Michelle Gray, Halima Musa Abdul, Awwal Mohammed Ladan

Abstract Background Midwifery education in Nigeria is undergoing a transformation in pedagogical approach. Existing traditional teaching materials are being supplemented by digital technology-enhanced learning resources; however, educators’ limited pedagogical capacity may hinder their adoption. Thus, train-the-trainer (TTT) workshops were implemented to build capacity among midwifery educators to prepare them for the implementation of a digital learning platform across 20 institutions in Nigeria. Objective This st …

31.08.2026journal-article

An Idea Health Journal

Rehabilitation and Reconstruction Plan (2022-2024): The Implementing of Central Sulawesi Governor’s Regulation in Sigi Regency

Vidyanto Vidyanto, Muhammad Rizki Ashari, Christin Florensia Melang, Muhammad Ryman Napirah, Muhammad Nasir, Arwan Arwan

Background: Central Sulawesi is one of the most disaster-prone regions in Indonesia. In Sigi Regency, Beka Village experienced repeated floods between 2018 and 2021, while post-disaster rehabilitation and reconstruction following the 2018 disaster reached only 70.77 percent, leading to the issuance of Central Sulawesi Governor Regulation No. 4 of 2022. This study aimed to analyze the implementation of rehabilitation and reconstruction policies in Beka Village. Methods: A qualitative case study approach was used inv …

31.08.2026journal-article

Hong Kong Physiotherapy Journal

Differences in upper limb neural mechanosensitivity between young adults with and without forward head posture

Haifah Nitayarak, Nurainee Adam, Titiya Khamtip, Sanpawat Petchkarn, Kritakarn Duangjun, Tipawan Liabsuetrakul

Background: Prolonged electronic device use is linked to forward head posture (FHP), which may increase neural mechanosensitivity and risk of upper limb neural dysfunction in young adults. Most research focuses on painful FHP with neural mechanosensitivity, which may obscure the true effects of FHP. Objective: To compare neural mechanosensitivity and cervical range of motion (CROM) between asymptomatic young adults with and without FHP, and examine correlations of neural mechanosensitivity across upper limb nerves. …

31.08.2026journal-article

Perspectives of the ASHA Special Interest Groups

Profiling Cognition and Speech in Individuals With Parkinson's Disease Seeking Speech Therapy

Jean Marie Priscott, Cristina Pino, Elizabeth Schoen Simmons, Rui Liu, Ciara Leydon

Purpose: The primary objective of this study was to develop a preliminary cognitive profile of people with Parkinson's disease (PWPD) and dysphonia seeking speech therapy. The secondary objective was to compare voice deficits among individuals with Parkinson's disease (PD)-related dysphonia with and without cognitive impairments. Method: The cognitive profile of 10 male and five female PWPD, aged 54–77 years, was assessed using Level I (screening) and Level II (comprehensive battery of neuropsychological tests) tes …

31.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Two-Year-Olds' Acquisition of Novel Adjectives in Prenominal and Predicative Sentence Frames

Madelyn Cecilia Escario, Marielle Ngoma, Sudha Arunachalam

Purpose: The purpose of this experimental study was to determine whether toddlers could learn novel adjective meanings when the adjectives appeared prenominally (e.g., “This is a fip cup”) and/or when they appeared predicatively (e.g., “This cup is fip ”). Method: Two-year-olds ( N = 64) participated online on the Children Helping Science platform. They were randomly assigned to either the prenominal or predicative condition, and they viewed videos that introduced novel adjectives in that position in the context of …

31.08.2026journal-article

Bioinformation

Immediate implant placement in extraction sockets using i-PRF–enhanced bone grafts and amniotic membrane with zirconia crown rehabilitation: A clinical and digital radiographic evaluation

Swapnaneel Pradhan

Immediate implant placement remains challenged by marginal bone loss and peri-implant soft tissue instability despite its clinical advantages. Therefore, it is of interest to evaluate the effectiveness of i-PRF–enhanced bone grafts combined with amniotic membrane in 100 patients undergoing immediate implant placement and zirconia crown rehabilitation. Patients receiving i-PRF, bone graft and amniotic membrane showed significantly better plaque index, gingival index, probing depth, implant stability and marginal bon …

31.08.2026journal-article

Frontiers in Endocrinology

Negative pressure wound therapy versus standard wound care for diabetic foot ulcers: a systematic review and meta-analysis of healing and limb outcomes

Chao Niu, Kunpeng Fu, Xiuxiao Chen, Yanyang Wang

Background Diabetic foot ulcers (DFUs) are major diabetes-related complications that often require prolonged wound care, debridement, or limb-salvage surgery. Negative pressure wound therapy (NPWT) is widely used as an adjunct, but its comparative effectiveness remains debated. Objective To meta-analyze the efficacy and safety of NPWT versus standard wound care in adults with DFUs. Methods PubMed/MEDLINE, Cochrane CENTRAL, EMBASE, and Web of Science were searched from January 2000 to January 2025 for randomized, qu …