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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Pediatric Hematology/Oncology

Oral Cyanocobalamin Treatment in Infants Under 1 Year With Nutritional Vitamin B12 Deficiency: A Retrospective Comparison of 500 and 1000 µg Dose Regimens

Gökçe P. Reis İskenderoğlu, Erol Erduran, Nilgün Eroğlu, Ayşenur Bahadır

Background: Vitamin B12 deficiency is a significant health problem in infancy, particularly in developing countries. Oral treatment has emerged as an alternative to intramuscular therapy, but optimal dosing in infants remains unclear. Methods: This retrospective study included 93 infants aged 1 to 12 months diagnosed with nutritional vitamin B12 deficiency. Patients received either 500 or 1000 µg oral cyanocobalamin. Laboratory parameters were evaluated at baseline, 2 months, and 4 months. Results: Both treatment g …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Artificial Intelligence for Cerebral Aneurysm Management: Integrating Imaging, Hemodynamics, and Clinical Decision Support

Reza Bozorgpour, Pilhwan Kim, Jacob Rammer

Abstract Cerebral aneurysms are complex vascular lesions whose rupture can result in subarachnoid hemorrhage (SAH), a condition associated with substantial morbidity and mortality. Although current clinical risk assessment relies primarily on morphological characteristics such as aneurysm size and location, these factors alone are often insufficient for individualized rupture risk prediction. Advances in artificial intelligence (AI) and machine learning (ML) have enabled the integration of imaging, clinical, morpho …

03.09.2026journal-article

South Asian Journal of Cancer

A retrospective analysis of treatment patterns and outcomes in carcinoma of the external auditory canal

Bal Krishna Mishra, Akhil Kapoor, Anuj Gupta, Bipinesh Sansar, Ayushi Pragya, Aseem Mishra, Ashutosh Mukherji, Sambit S Nanda, Ankita Rungta Kapoor, Ajay Kumar Choubey, Arvind Suresh, Satyendra Narayan Singh, Shreya Shukla

Objectives: Carcinoma of the external auditory canal (EAC) is a rare form of head and neck cancer, which accounts for <0.2% of the total head and neck cancer burden. The treatment typically involves a multidisciplinary approach, with surgery being the cornerstone for early-stage disease, while advanced-stage cases often require radiation therapy and chemotherapy. The presented retrospective analysis examines 15 patients to identify the optimal therapeutic strategies for managing EAC. Material and Methods: This retr …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

ABCB5⁺ mesenchymal stem cells enable high-ratio cellular augmentation of bone grafts without loss of osteogenic function

Jakob Hofmann, Tim Niklas Bewersdorf, Ulrike Sommer, Kai Borcherding, Karsten Thiel, Christoph Ganss, Matthias Gerstner, Markus H. Frank, Gerhard Schmidmaier, Mark Andreas Kluth, Tobias Grossner

Abstract Autologous bone grafting remains the standard for reconstruction of bone defects but is constrained by limited graft volume and loss of osteogenic capacity when expanded with acellular materials. We hypothesized that allogeneic ABCB5⁺ mesenchymal stem cells (MSCs) can serve as a biologic cell source to augment bone marrow-derived MSC (BM-MSC) populations without impairing osteogenesis. Primary human BM-MSCs from five donors were combined with GMP-manufactured ABCB5⁺ MSCs at graded replacement ratios (0–95% …

03.09.2026journal-article

Clinical Kidney Journal

Rituximab therapy achieves comparable remission to cyclophosphamide in ANCA-associated vasculitis with severe KIDNEY involvement

Nishant Chaudhari, Azm Ul Hussain, Lee Quill, Joshua Harridine, Kashif Eqbal, Lorraine Harper, Dimitrios Chanouzas

Abstract Introduction The RAVE/RITUXIVAS trials established rituximab (RTX) therapy in ANCA-associated vasculitis (AAV). However, RAVE excluded patients with severe renal involvement (creatinine &gt; 354 µmol/L). Whilst RITUXIVAS did not, treatment included RTX with 2 cyclophosphamide (CYC) pulses. This study reports outcomes in AAV patients with severe renal involvement treated with RTX alone compared to CYC, together with high dose steroids. Methods Data were collected retrospectively for all consecutive AAV pres …

03.09.2026journal-article

ACS Applied Materials & Interfaces

Non-Annealing Treatment Mechanism of Electron Transport Layers for High-Performance Inverted Perovskite Solar Cells

Jiangping Xing, Weixuan Liu, Haifan Zhou, Qinghua Cao, Deping Xiong, Aliaksandr Smirnov, Xiaoli Zhang, Hui Liu

Abstract Inverted perovskite solar cells (IPSCs) have presented great potential in the photovoltaic field due to their outstanding optoelectronic properties. However, the widely used electron transport layer of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) in IPSCs presents some issues such as poor passivation effect, insufficient film coverage, and suboptimal energy-level alignment, and the influence of annealing treatment of PCBM on device performance has rarely been investigated. Therefore, in this work, we …

03.09.2026journal-article

Developmental Medicine & Child Neurology

Risk factor profiles in infants born preterm and at term with cerebral palsy in Argentina: Findings from the Argentine Cerebral Palsy Register

M. Mercedes Ruiz Brunner, Carla Gil, María Elisabeth Cieri, Ana Laura Condinanzi, L. Johana Escobar Zuluaga, Federico Sanchez, Gulam Khandaker, Israt Jahan, Nadia Badawi, Eduardo Cuestas

Aim To describe the patterns of co‐occurrence between previously documented risk factors and gestational age in infants with cerebral palsy (CP) registered in the Argentine Cerebral Palsy Register (Registro Argentino De Parálisis Cerebral [RAR‐PC]). Method This register‐based, cross‐sectional study analysed data from individuals with confirmed CP registered in the RAR‐PC. Family interviews and medical record reviews were conducted. The variables analysed included CP characteristics, a predefined set of prenatal, pe …

03.09.2026journal-article

Journal of Travel Medicine

Orthopaedic Injuries among International Travellers in Nepal

Abhishek Shrestha, Ishwor Ghimire Padhya, Jasmine Shrestha, Pratigya Aryal, Prativa Pandey

Highlight/Teaser International travellers in Pokhara experience a considerable burden of orthopaedic injuries. This study describes their injury patterns, management, and outcomes, providing evidence to strengthen preventive advice, trauma preparedness, and clinical services in popular adventure-travel destinations.

03.09.2026journal-article

Frontiers in Surgery

When microsurgery is not an option: staged delayed reverse sural artery flap with ischaemic preconditioning for limb salvage in an elderly patient with chronic post-traumatic osteomyelitis—a case report

Zhun Shen Tan, Adzim Poh Yuen Wen, Farzana Ansarutheen, Mohd Yazid Bajuri

Lower extremity reconstruction in elderly patients with post-traumatic osteomyelitis presents a formidable challenge. We report a 70-year-old female with hypertension, dyslipidaemia, and bilateral knee osteoarthritis who sustained a Gustilo-Anderson type IIIB open right ankle fracture with exposed calcaneus following a fall. The course was complicated by chronic osteomyelitis, managed with partial talectomy and total calcanectomy, antibiotic-impregnated cement spacer placement, cement exchange and prolonged culture …

03.09.2026journal-article

Frontiers in Natural Products

Antifungal and antibiofilm activity of crude hydroalcoholic extract and fractions of Myrcia neoobscura leaves against a clinical isolate of Candida krusei

Leticia Bachmann, Eduarda Rensi Botelho, Patrícia Helena Arrabal, Pâmela Elise Munzlinger, Patryne Luana da Silva Dantas, Larissa Mascarenhas Krepsky, Lucas Ferriolli Mariotto, Michele Debiasi Alberton, Tatiani Karini Rensi Botelho

Infections caused by biofilm-forming Candida sp. Are responsible for high morbidity and mortality rates. With the scarcity of therapeutic options and the increase in resistance to antifungal drugs, new treatment options are needed. Myrcia neoobscura is a tree endemic to the Atlantic Rainforest, belonging to the genus Myrcia , several of whose species have demonstrated important antifungal activities. The aim of this study was to evaluate the antifungal and antibiofilm activity of the crude hydroalcoholic extract an …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Electrode perforation with normal pacemaker parameters leading to hemorrhagic shock: a rare case report of the “penetration-exit-re-entry” phenomenon

Zuoan Qin, Jian Yang, Li Luo, Shi Chen, Fei Yang

Background Permanent pacemaker implantation via subclavian vein puncture may induce rare but life-threatening iatrogenic vascular injury. Vascular perforation with pacing lead penetration-exit-re-entry trajectory accompanied by normal intraoperative pacing parameters is reported extremely rarely, which greatly increases the risk of missed diagnosis. Case presentation A 70-year-old female patient with complete atrioventricular block received dual-chamber pacemaker implantation. All intraoperative lead electrical ind …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Perfluorooctanoic acid–associated complement factor B upregulation and atrial fibrillation–related molecular alterations: integrated network toxicology, Mendelian randomization, molecular dynamics, and HL-1 cell analyses

Dan Li, Chuanfeng Bai, Jinping Zhao

Background Perfluorooctanoic acid (PFOA) is a persistent environmental pollutant associated with cardiovascular dysfunction, but the molecular links between PFOA exposure and atrial fibrillation (AF) remain unclear. We aimed to prioritize a candidate mediator connecting PFOA with AF and examine its associated molecular effects in atrial cardiomyocytes. Methods PFOA-associated or computationally predicted genes from CTD, STITCH, and SwissTargetPrediction were integrated with AF-associated genes. Complement factor B …

03.09.2026journal-article

Frontiers in Neurology

Interpretable machine learning–based prediction of 90-day mortality after endovascular treatment in acute large vessel occlusion stroke

Yuanfang Zhou, Xiaoxia Li, Guokuan Feng, Chuanhang Lin, Bao Liao

Background Despite high recanalization rates after endovascular treatment (EVT) for acute ischemic stroke due to large vessel occlusion (AIS-LVO), 15%−20% of patients still die within 90 days. Existing prognostic models predominantly target functional disability rather than mortality, and rarely incorporate calibration, clinical utility, or interpretability. We aimed to develop and internally validate interpretable machine learning (ML) models for dynamic post-EVT in-hospital prediction of 90-day all-cause mortalit …

03.09.2026journal-article

Frontiers in Medicine

Case Report: A cluster of cases with rash associated with Chlamydia pneumoniae infection

Tianyi Wu, Gang Wang, Nannan Xu, Ke Xu, Gonghai Chen

We report a case of clustered rashes among teenagers associated by Chlamydia pneumoniae (CP) infection. Most patients only presented with rashes without significant fever or other respiratory tract symptoms. Metagenomic next-generation sequencing (mNGS) of blood samples identified the culprit - the nucleic acid sequence of CP was detected in the peripheral blood of the index case. The results of targeted next-generation sequencing (t-NGS) of throat swabs further supported the presence of CP. After antibiotic treatm …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Combined assessment of carotid intima–media thickness and epicardial fat thickness for cardiovascular risk stratification in asymptomatic South Indian adults

Ramesh Sankaran, Dolly Agarwal, Rahul Mittal, Shankar Srinivasan, Nagendra Boopathy Senguttuvan, Alex Karev, Sadhanandham Shanmugasundaram, Balasubramaniyan Jayanthi Venkata, Vinod Kumar Balakrishnan, Preetam Krishnamurthy, Sadagopan Thanikachalam, Murthy Jayanthi Satyanarayana

Background Carotid intima-media thickness (cIMT) and epicardial fat thickness (EFT) are non-invasive imaging markers associated with cardiovascular risk. This study evaluated the associations between cIMT, EFT, individual cardiovascular risk factors, cumulative cardiovascular risk-factor burden in asymptomatic adults undergoing routine cardiovascular health assessment. Methods A cross-sectional study was conducted in 925 asymptomatic adults aged ≥18 years undergoing routine cardiovascular health evaluations. Partic …

03.09.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: Use of subconjunctival cyclosporine implants for treatment of feline eosinophilic keratoconjunctivitis: a case report

Lynn Willems, Jordan Kay Roberts

Case summary A 5-year-old neutered male domestic shorthair cat was presented for evaluation of chronic bilateral eosinophilic keratoconjunctivitis (EK). The patient had a history of recurrent corneal plaques and conjunctivitis that were initially managed with systemic and topical immunosuppressive therapy. Long-term disease control was limited by poor tolerance of topical ophthalmic medications, resulting in inconsistent treatment and repeated disease recurrence affecting both eyes. Over several years the cat was t …

03.09.2026journal-article

Aesthetic Surgery Journal Open Forum

Quality Assessment of Systematic Reviews on Gluteal Augmentation Using a Measurement Tool to Assess Systematic Reviews (AMSTAR 2)

Elisa Bertulla, Edoardo Raposio

Abstract Background Gluteal augmentation has become increasingly popular in aesthetic surgery, with fat grafting, implants, and fillers as the main techniques. Objectives This study aims to assess the methodological rigor of available reviews using AMSTAR-2 and to explore associations with publication characteristics, including citations, journal impact factor, year of publication, and PRISMA adherence. Methods A systematic literature search of PubMed, Scopus, and the Cochrane Library was performed. Two authors ind …

03.09.2026journal-article

Monaldi Archives for Chest Disease

Treatment outcomes and factors associated with unfavorable outcomes among drug-resistant tuberculosis patients treated with a bedaquiline-based oral regimen

Oki Nugraha Putra, Julaeha Julaeha, Nurhayati Nurhayati, Telly Purnamasari, Nurul Damayanti, Dewi Ramdani, Ahmad Erlan, Paisal Paisal, Rini Sasanti Handayani, Nur Indah

The treatment success rate for drug-resistant tuberculosis (DR-TB) in Indonesia remains below the national target. Identifying factors associated with unfavorable treatment outcomes is essential to inform more targeted interventions. This retrospective study analyzed medical records of patients with DR-TB who received treatment at Surabaya Haji Hospital between 2020 and 2024. Demographic, clinical, behavioral, and treatment-related variables were evaluated in relation to unfavorable treatment outcomes, defined as a …

03.09.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

<b>INTELIGÊNCIA ARTIFICIAL EM HEMATOLOGIA LABORATORIAL: IMPACTO NO DIAGNÓSTICO</b>

Éverton José Ferreira de Araújo, Janyerson Dannys Pereira da Silva, Danielle Yasmin Moura Lopes de Araujo, José Couras da Silva Filho, Marcelo Rodrigues Mendes, Pedro Simão da Silva Azevedo, Maria Luíza Passos Ribeiro Maia, Isadora Marques Silva Sousa, Mariana Isabela Beserra de Menezes

A inteligência artificial (IA) tem promovido avanços significativos na hematologia laboratorial ao ampliar a capacidade de processamento e interpretação de dados clínicos, morfológicos, imunofenotípicos e moleculares. O presente estudo teve como objetivo revisar a literatura científica acerca das aplicações da IA na hematologia laboratorial, destacando seu impacto no diagnóstico, suas principais contribuições, limitações e perspectivas futuras. Realizou-se uma revisão integrativa da literatura por meio de busca est …

03.09.2026journal-article

Journal of Hand Surgery (European Volume)

Targeted tenosynovial biopsy during carpal tunnel release for detection of transthyretin amyloid deposits

Nicolas Bigorre, Alexandre Petit, Jérome Brunet, Fabrice Rabarin, Julien Jeanneteau

Introduction: Carpal tunnel syndrome is increasingly recognized as an early musculoskeletal manifestation of transthyretin amyloidosis. Tenosynovial biopsy during carpal tunnel release may detect transthyretin amyloid deposits, but the yield of a targeted strategy remains uncertain. Methods: We conducted a single-centre comparative before-after study of 347 patients undergoing carpal tunnel release with tenosynovial biopsy. The non-targeted cohort was recruited between October 2021 and July 2023 and the targeted co …

03.09.2026journal-article

Clinical Research in Cardiology

Gaps in lipid management among high-risk patients without prior MI or stroke: the VESALIUS-REAL global study

Queenie Chan, Jaimini Cegla, Ulrich Laufs, Jan H. Cornel, Gaetano M. De Ferrari, Emil Hagström, Huei-Kai Huang, José Lopez-Miranda, Suna Avcil, Corinne Brooks, Thomas Cars, Adrienne Y. L. Chan, Celine S. L. Chui, Michael Duxbury, Edward Chia-Cheng Lai, David Neasham, Andreas Ochs, James O’Kelly, Gabriel Paiva da Silva Lima, Naomi Reimes, Swati Sakhuja, Shih-Chieh Shao, Ju-Young Shin, Mahendra Sibartie, Ilona Verburg, Matthew J. Budoff, Kyung Woo Park, Kenichi Tsujita, Kai Hang Yiu, Nafeesa Dhalwani, Ian C. K. Wong

Abstract Background Real-world evidence on lipid-lowering therapy (LLT) use and low-density lipoprotein cholesterol (LDL-C) control in patients at high cardiovascular (CV) risk without prior myocardial infarction (MI) or stroke remains limited. We evaluated LLT use, treatment intensification, LDL-C monitoring, and LDL-C goal attainment across North America, Europe, and Asia-Pacific. Methods VESALIUS-REAL is a retrospective observational study using a common protocol across 11 databases between 2017 and 2022. Eligib …

03.09.2026journal-article

Clinical Microbiology Reviews

Human vascular pythiosis: pathogenesis, diagnosis, and evidence-informed management

Nitipong Permpalung, Sadeep Medhasi, Pattama Torvorapanit, Rongpong Plongla, Navaporn Worasilchai

SUMMARY Human vascular pythiosis is a rare, life-threatening angioinvasive infection caused predominantly by the oomycete Pythium insidiosum . Unlike ocular or cutaneous pythiosis, the vascular form is defined by arterial wall invasion, long-segment thrombosis, limb ischemia, aneurysmal complications, and high risks of amputation and death. Although P. insidiosum is broadly distributed in freshwater environments, reported human vascular disease remains concentrated in Thailand, indicating that exposure alone is ins …

03.09.2026journal-article

European Journal of Clinical Microbiology & Infectious Diseases

Diagnosis of pneumococcal pneumonia using quantitative PCR targeting lytA and piaB in adult patients with community-acquired pneumonia

Nienke Paternotte, Willem R. Miellet, Tessa Nieuwenhuijsen, Rob Mariman, Wil A. van der Reijden, Wouter Rozemeijer, Elisabeth A.M. Sanders, Dominic Snijders, Cornelis H. van Werkhoven, Marc J.M. Bonten, Krzysztof Trzciński, Wim G. Boersma

Abstract Purpose Accurate diagnosis of pneumococcal pneumonia remains challenging due to suboptimal sensitivity of conventional microbiological methods. Molecular techniques may improve Streptococcus pneumoniae detection, but their clinical utility remains uncertain. Methods In this prospective observational study, we compared conventional diagnostics with qPCR-based detection of lytA and piaB genes in nasopharyngeal, oropharyngeal, saliva, and sputum samples collected from adults with community-acquired pneumonia …

03.09.2026journal-article

Journal of Clinical Medicine

Association Between DLCO and Echocardiographic Right Ventricular–Pulmonary Arterial Coupling in Idiopathic Pulmonary Fibrosis

Francesca Coppi, Susan Darroudi, Giulia Renda, Alessandra Lodeserto, Arianna Maini, Damiano De Cesare, Youssef Othman, Martina Mercati, Dalia Caleffi, Filippo Gozzi, Francesco Marangi, Dario Andrisani, Federica Andolfi, Alessio Baccarani, Daniela Aschieri, Anna Vittoria Mattioli, Francesco Fedele, Enrico Clini, Stefania Cerri, Gianluca Pagnoni

Background: Idiopathic pulmonary fibrosis (IPF) is frequently complicated by pulmonary vascular involvement and right ventricular (RV) dysfunction, both of which adversely affect prognosis. The relationship between impaired gas exchange and echocardiographic indices of RV function, particularly the TAPSE/PAPs (tricuspid annular plane systolic excursion/systolic pulmonary artery pressure) ratio as a marker of RV–pulmonary arterial (RV–PA) coupling, has not been fully characterized. Methods: We retrospectively evalua …