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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Medical Sciences

The Gut–Immune–Brain Axis in Aging: Integrating Immunosenescence, Inflammaging, and Neuroinflammation for Precision Medicine

Dejana Bajić, Jelena Vučković, Nikolina Pupovac, Danijel Slavić, Mirjana Stojšić, Nikola Hodoba, Nemanja Todorović, Milica Plazačić, Nataša Milošević

Background: Population aging is accompanied by progressive immune remodeling, chronic low-grade inflammation, and increased susceptibility to neurodegenerative diseases. Although the microbiota–gut–brain axis is increasingly recognized as a regulator of neuroimmune homeostasis, mechanisms linking age-associated dysbiosis with immunosenescence, barrier dysfunction, and brain aging remain incompletely understood. This review integrates current evidence into the proposed Gut–Immune–Brain Resilience Axis (GIBRA), a sys …

31.08.2026journal-article

Annals of Rehabilitation Medicine

Digital Health Approaches to Geriatric Rehabilitation: A Narrative Paper

Changwon Moon, Pamela Bregasi, Aminreza Khandan, Bijan Najafi

Rapid population ageing is widening the gap between geriatric rehabilitation needs and constrained care capacity. Digital health offers new ways to deliver rehabilitation beyond traditional settings, but its role and limitations in geriatric practice remain unclear. To provide a narrative synthesis of how digital health can support geriatric rehabilitation, highlighting advances, challenges, and future directions. We conducted a narrative review of digital health approaches in geriatric rehabilitation, informed by …

31.08.2026journal-article

European Geriatric Medicine

Feasibility, acceptability, and preliminary effects of the Join4Joy approach for older adults living in nursing homes: a multicentre mixed-methods feasibility study

Erika Karkauskiene, Laura Coll-Planas, Andrea Fuente-Vidal, Damaso Sanchez, Nadine Barth, Dhayana Dallmeier, José Luis Socorro-Cumplido, Maria Giné-Garriga, Paolo Caserotti, Guillaume Lefebvre, Javier Jerez-Roig

Abstract Purpose Nursing home residents increasingly enter care with advanced frailty, multimorbidity, and functional dependence, underscoring the need for engaging, adaptable physical activity (PA) programmes. Join4Joy is a co-created approach designed to promote movement and social connection among older adults through enjoyable activities. This study examined its feasibility, acceptability, and preliminary effects across five nursing homes in Spain, France, and Germany. Methods This multicentre mixed-method stud …

31.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Associations of diabetes status and physical activity with cognitive impairment and hippocampal volume in older adults

Ryoki Mori, Hideyoshi Kaga, Yuki Someya, Hitoshi Naito, Hiroki Tabata, Eri Takagi, Toshiki Kogai, Shota Sakamoto, Saori Kakehi, Yuya Nishida, Ryuzo Kawamori, Hirotaka Watada, Yoshifumi Tamura

Abstract Context Type 2 diabetes mellitus (DM) is a major risk factor for cognitive decline, whereas physical activity (PA) is associated with better cognitive health. We examined associations of DM status and PA level with cognitive impairment and hippocampal volume. Design and Setting This cross-sectional study included 1,615 community-dwelling older adults from the Bunkyo Health Study. PA was assessed using the International Physical Activity Questionnaire and classified as moderate-or-higher or low. Participant …

31.08.2026journal-article

Boletim de Conjuntura (BOCA)

TRANSIÇÃO DE JOVENS COM DEFICIÊNCIA PARA O MUNDO DO TRABALHO: CONTRIBUIÇÕES DA EDUCAÇÃO BÁSICA, DO APOIO FAMILIAR E DAS POLÍTICAS PÚBLICAS

Julia Aparecida da Silva Casagrande, Joel Haroldo Baade

A inserção profissional de jovens com deficiência constitui um dos principais desafios da educação inclusiva contemporânea, especialmente no que se refere à construção de trajetórias que articulem escolarização, autonomia e participação social. Embora o Brasil tenha avançado na consolidação de políticas públicas voltadas ao direito à educação e ao trabalho, persistem desafios relacionados à transição entre a educação básica e o mundo do trabalho, indicando a necessidade de compreender os fatores que favorecem esse …

31.08.2026journal-article

AIDS

LDL-C target achievement in people living with HIV: impact of combination lipid-lowering therapy. A retrospective cohort analysis

Marcella Manicardi, Jovana Milic, Giuseppe Esposito, Marianna Menozzi, Giuseppe Mancini, Gian Luca Cuomo, Lorenzo Benassi, Elisabetta Delmonte, Severino Ambrosio, Cristina Mussini, Giuseppe Boriani, Giovanni Guaraldi

Background: Real-world low-density lipoprotein cholesterol (LDL-C) target attainment remains low in people with HIV (PWH). Updated ESC/EAS 2025 guidelines underscore the need to reassess treatment patterns in clinical practice. Methods: Retrospective observational longitudinal study including PWH ≥40 years, evaluated twice between 2020 and 2025 at the Modena HIV Metabolic Clinic, with complete laboratory and clinical follow-up data. Objective was to evaluate the real-world use and effectiveness of different lipid-l …

31.08.2026journal-article

Physiotherapy Canada

Ankle Muscle Power and Balance Performance in Older Adults

Dominique Arsenault, Tanya D. Ivanova, S. Jayne Garland

Abstract Purpose: This cross-sectional descriptive study sought to determine the influence of ankle power on balance performance. Method: Twenty healthy older adults (≥ 70 years; 11 men, 9 women; mean age of 76.6 [SD 5.5] years) with no prior debilitating injuries, neurological disorders, or respiratory diseases participated. Ambulatory balance was assessed using the Community Balance and Mobility Scale (CB&M, out of 96) – a performance-based functional outcome measure. Average power about the ankle joint was measu …

31.08.2026journal-article

Journal of Medical Internet Research

Changing Technology Use, Confidence, and Support Needs Among Older Adults in United Kingdom Retirement Villages: Mixed Methods Study

Angela Higgins, Steve Benford, Michelle Hall, Holly Blake, Kevan Murray, Praminda Caleb-Solly

Abstract Background Assistive technologies can support independent living among older adults, helping manage health and maintain independence, but uptake is often constrained by attitudes, confidence, and socioeconomic factors. The COVID-19 lockdowns accelerated technology use across all age groups, offering a natural experiment to examine changes in adoption. Objective This study aimed to examine changing patterns of technology use in older adults, to provide insight as to how service providers can support the use …

31.08.2026journal-article

Journal of Medical Internet Research

The Technologies, Applicability, and Trade-Offs of AI in Palliative Care for Older Adults: Scoping Review

Lei Huang, Menglu Xu, Ying Yang, Yi Tian, Zhongkang Xu, Yixuan Wang, Anning Hou, Lili Zhu, Yan Lin, Lina Wang, Yifei Zhao, Shuhong Wei, Peng Wang, Lin Peng

Abstract Background The rapid advancement of AI has introduced new opportunities for palliative care. However, its context-specific applicability and the trade-offs related to it use for older adults with multimorbidity, functional decline, and complex care needs remain unclear. Objective This review aimed to characterize the applicability of AI in palliative care for older adults and synthesize its potential benefits and limitations. Methods A scoping review was conducted following the framework of Arksey and O’Ma …

31.08.2026journal-article

Alzheimer Disease & Associated Disorders

Representation of Alzheimer Disease and Related Dementias in a Statewide Population Genomics Cohort

Janet Horn, Sara Knox

Alzheimer Disease and Related Dementias (ADRD) affect more than 125,000 individuals in South Carolina, yet equitable representation in population genomics initiatives remains a concern. We conducted a cross-sectional descriptive analysis of 247 In Our DNA SC participants aged 50 to 89 years with at least 1 ADRD-related diagnosis, identified using ICD-10 codes, to characterize demographic and clinical features and to compare the cohort with statewide ADRD estimates. Most participants were aged 65 years or older (82. …

31.08.2026journal-article

Chulalongkorn Medical Journal

Factors Associated with Colorectal Cancer Screening Decision-Making among Older Adults at the Comprehensive Geriatric Clinic, King Chulalongkorn Memorial Hospital, Thai Red Cross Society

Chalisa Thanapura, Nawasiri Siriprasert, Thacha Pithayapibulpong, Bhorn-Ake Manasvanich, Vichai Viriyautsahakul

Abstract Background: The incidence of colorectal cancer (CRC) in Thailand is constantly increasing, and is highest in individuals aged 60-75 years. However, the number of older individuals undergoing CRC screening remains suboptimal. Objective: This study aimed to identify factors associated with CRC screening decision-making among Thai older adults attending the Comprehensive Geriatric Clinic at King Chulalongkorn Memorial Hospital. The secondary objective was to identify factors associated with the choice of scre …

31.08.2026journal-article

PLOS One

Predicting risk of progression of early to late AMD in the aging eye through imaging and multimodal evaluation: PRIME study protocol

Ali Forouhari, Chui Ming Gemmy Cheung, Low Lian Leng, Noa Gilead, Usha Chakravarthy, Kelvin Yi Chong Teo

Background Age-related macular degeneration (AMD) is a leading cause of vision impairment globally and demonstrates substantial variation regarding progression and clinical subtypes across populations. This paper describes the methodology of our study, designed to establish the natural history of AMD in Asian elderly and to identify predictors of progression from early signs of AMD to late AMD over a 5-year period. Methods This prospective, longitudinal cohort study aims to recruit 1500 participants from community- …

31.08.2026journal-article

Academia Neuroscience and Brain Research

Gut dysbiosis and complement-mediated neuroinflammation in vascular dementia

Süheyla Ünal

Vascular dementia (VaD), the second most common form of dementia after Alzheimer’s disease, is increasingly understood as a heterogeneous disorder in which cerebrovascular injury interacts with endothelial dysfunction, blood–brain barrier disruption, systemic inflammation, and neuroimmune activation. This hypothesis-generating narrative review examines whether gut dysbiosis may contribute to VaD-relevant neuroinflammatory cascades through the microbiota–inflammation–leaky gut–leaky brain axis. In this framework, th …

31.08.2026journal-article

Korean Association of Health and Medical Sociology

Embodied Temporality and Care: A Life History Study of Middle-Aged and Older Adults with Severe Diabetes

Korean Association of Health and Medical Sociology, Hyang Soo Kim, Ye Sung Lee, Young Su Park

This study explores how socioeconomically marginalized people living with severe diabetes experience and make sense of their illness and lives, and how these experiences shape their self-understanding of illness, practices of care, and future orientation. To address this question, the life histories of four low-income adults in their fifties and sixties living with severe diabetes were analyzed. The findings are as follows. First, diabetes narratives unfold within multiple, intersecting temporalities, including clo …

31.08.2026journal-article

International Journal of Environmental Research and Public Health

Adult Vaccination and Healthy Aging in the UAE: Uptake, Determinants, and Policy Perspectives

Areeba Irfan, Jinnu Jimmy, Zahraa Farhad, Anugraha Lisa Ciju, Reel Louai, Aadith Soorya Arunkumar Maivizhichelvi, Liju Susan Mathew, Sneha Reji, Jayakumary Muttappallymyalil

Adult vaccination is a critical component of preventive healthcare, reducing morbidity and mortality from vaccine-preventable diseases. Despite established recommendations, adult immunisation coverage remains suboptimal, particularly for vaccines beyond influenza and COVID-19. In the United Arab Emirates (UAE), limited evidence exists regarding adult vaccine uptake and determinants influencing immunisation behaviour within its diverse population. Understanding vaccine-specific coverage and associated sociodemograph …

31.08.2026journal-article

Life

The Preservation of Functional Reserve: A Control Systems Framework for Human Aging

Robert T. O’Leary

The dominant clinical manifestation of aging is not mortality but the progressive depletion of functional reserve—the surplus physiological capacity separating independent function from disability. Existing geroscience frameworks describe molecular aging in detail yet give the point-of-care clinician little basis for prioritizing targets. We reframe functional aging as a control systems problem in which aging is modeled as progressive instability within a coupled, bidirectional mitochondrial–epigenetic axis. That a …

31.08.2026journal-article

FEBS Open Bio

Cell surface CD11c as a neutrophil aging marker molecule

Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki

Neutrophils exhibit substantial functional heterogeneity shaped by both developmental stage and cellular maturation, but their mechanisms remain incompletely defined. CD11c (ITGAX) is traditionally considered as a cell surface marker of dendritic cells. We recently reported that it is highly expressed intracellularly in neutrophils and contributes to their maturation; however, its role at the cell surface is unclear. Here, we showed that surface CD11c expression level was heterogeneous across neutrophils, enabling …

31.08.2026journal-article

Geohuman: People, Place, and Power

Mapping Fishing Locations Based on Fishermen's Local Ecological Knowledge in Kahyapu Village, Enggano Island

M Fikro Habibullah, Akbar Abdurrahman Mahfudz, Ali Muqsit, Eko Nofridiansyah, Ana Ariasari

Enggano Island is one of the outermost islands in Bengkulu Province and has high biodiversity. Kahyapu Village is one of the fisheries centers on Enggano Island. Mapping fishing locations is important because it documents and visualizes the local knowledge of fishermen through easy-to-understand maps. This study aimed to identify and map the fishing locations of Kahyapu Village fishermen based on their experience and local knowledge, using participatory mapping methods and Sea Surface Temperature (SST) and chloroph …

31.08.2026journal-article

Journal of Korean Gerontological Nursing

Regional differences in health status and its associations with health behaviors and healthcare utilization among older adults in the context of the COVID-19 pandemic: A cross-sectional study using the 2019~2020 Korean Community Health Survey

Jieun Lee

Purpose: The financial independence rate (FIR) is an important regional factor that may be associated with older adults’ health status in the context of the COVID-19 pandemic. However, a comprehensive examination of older adults’ health status, healthcare utilization, and health behaviors by residential area is lacking. This study aimed to analyze regional differences in health status (including physical and mental health) among older adults across two survey years (2019 and 2020), and to examine its associations w …

31.08.2026journal-article

Frontiers in Medicine

Positioning equity at the core of European dementia research: a pan-European co-produced perspective from the PANEUCARE consortium

Maria Isabel Cardona, Clarissa Giebel, Anthony Scerri, Anthea Innes, Ninoslav Mimica, Osman Kučuk, T. Rune Nielsen, Jūratė Macijauskienė, Birute Bartkevičiūtė, Carolien Smits, Carmel Geoghegan, Soraya Moradi-Bachiller, Anne Marie Rokstad, Iva Holmerova, Elżbieta Trypka, Ágnes Egervári, Raluca Sfetcu, Marija Taneska, Péter Hegedűs, Iryna Shevchenko, Svetlana Iloski, Thanos Chatzikostopoulos, Jochen René Thyrian

Dementia care across Europe is characterized by substantial regional disparities in research participation, funding, and care practices, which challenge the development of equitable and inclusive research agendas. The PANEUCARE consortium adopted a pan-European, co-produced approach that integrates professional expertise with the perspectives of people living with dementia and caregivers to identify priorities for a more equitable dementia research landscape. Insights were generated through two workshops with demen …

31.08.2026journal-article

Cells

Use of Neuronal-Enriched Extracellular Vesicles to Distinguish Cognitive Impairment Levels and Sex Differences in People with HIV

Norina Tang, Fan Xia, Heather Freasier, Phyllis C. Tien, Marshall J. Glesby, Daniel Merenstein, Audrey L. French, Heather McKay, Monica M. Diaz, Igho Ofotokun, Jordan E. Lake, Joseph B. Margolick, Eun-Young Kim, Steven R. Levine, Margaret A. Fischl, Wei Li, Jeremy Martinson, Lynn Pulliam

Cognitive impairment still occurs despite well-controlled HIV but with milder symptoms. People with and without HIV have different neuronal protein changes that may differentiate the asymptomatic neurocognitive impairment (ANI) condition from normal cognition (NPN) and mild neurocognitive disorder (MND). Plasma neuronal-enriched extracellular vesicles (nEVs) were isolated from people with HIV (PWH) with NPN, ANI, or MND, and HIV seronegative controls with NPN (HIV−). Two different platforms were used to delineate p …

31.08.2026journal-article

Geriatrics

Prevalence of Sarcopenia and Factors Associated with Body Composition and Protein Intake in Institutionalized Older Adults from Three Long-Term Care Facilities in Loja, Ecuador: A Cross-Sectional Study

Ana Sofía Vivanco-Zárate, Mateo Julián Sánchez-Sánchez, Estefanía Bautista-Valarezo

Background/Objectives: Sarcopenia is a common public health problem in older adults and is associated with an increased risk of morbidity and mortality, particularly in institutionalized populations. This study aimed to determine the prevalence of sarcopenia in institutionalized older adults, assess the adequacy of protein intake in terms of quantity and quality, and identify factors associated with its presence. Methods: An observational, analytical, cross-sectional study was conducted in three institutional care …

31.08.2026journal-article

World Journal of Advanced Research and Reviews

Integrated health services for older people: A systematic literature review

Aba’a Djampene Divine H., Essi Marie-José., Mbezele Essomba Thérèse H., Abossolo Essi Johanne A, Ciaffi laura

Background: The framework for integrated person-centered health services provides a public health response to global challenge, the rapid aging of the population. It relies on primary health care in order to be accessible to a large number of patients. However, connections with specialized geriatric care are necessary as well as collaboration between health professionals and social services. Little data exists on the elements required to implement this integrated care. The objective of this work is to identify in t …

31.08.2026journal-article

Journal of Korean Gerontological Nursing

Fall-related factors in older adults by frailty status: A cross-sectional study

Jiyeon Kim

Purpose: This descriptive study aimed to identify the factors associated with falls in older adults according to frailty status. Methods: Data from 9,955 older adults in the 2023 National Survey of Older Koreans were analyzed. Differences in demographic, socioeconomic, and health-related behaviors by frailty status were evaluated using the Rao-Scott X2 test. A complex-sample general linear model was used to evaluate the frequency of falls. Complex-sample multiple logistic regression analyses were performed with fal …