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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Analytical Chemistry

Ultrasensitive Breath Analysis of Lung Cancer Biomarkers Using a Carboxyl-Functionalized Hyper-cross-linked Polymer–Based SPME Coupled with GC─MS

Huanhuan Li, Mingyu Wang, Mingwei Wang, Hongyuan Yan

Abstract Exhaled breath analysis offers a noninvasive route for disease screening, yet its practical implementation is constrained by ultratrace analyte levels, high humidity, and limited selectivity of existing enrichment materials. Herein, we report the rational design of a carboxyl-functionalized hyper-cross-linked polymer (HCPs-COOH) as a high-performance solid-phase microextraction (SPME) coating and its integration into a two-step preconcentration workflow for breath analysis. The HCPs-COOH exhibits an ultrah …

02.09.2026journal-article

International Journal of Secondary Metabolite

Evaluation of the anti-carcinogenic effect of tea tree oil (Melaleuca alternifolia) on SK-BR-3 breast cancer cells

Mehmet Fatih Seyhan, Hümeyra Dağdagül, Özge Nur Eroğlu, İrem Okumuş

Breast cancer cells that overexpress HER2 are related to poorer survival outcomes compared to HER2-negative tumors and are recognized for their higher aggressiveness. The study aimed to evaluate the possible effects of Melaleuca alternifolia (tea tree oil, TTO), a plant known for its broad antimicrobial and anticancer characteristics, on cell viability, cell migration, and oxidative stress in SK-BR-3 cells, which represent HER2+ breast cancer, for the first time. The efficacy of different concentrations of TTO on c …

02.09.2026journal-article

Ibnosina Journal of Medicine and Biomedical Sciences

Mechanistic Insights into IL-17 Pathway Modulation in Breast Cancer by Pteridaceae Bioactive Compounds: A Network Pharmacology and Molecular Docking Approach

Purodhika Gupta, Pankaj Sharma, Ashish K. Yadav, Priya Bansal, Abhishek Kumar

Abstract This study assessed the pharmacological prospects of Pteridaceae phytoconstituents using an integrated network pharmacology (NP) and computational molecular docking (MD) strategy. Various peer-reviewed literature databases, including ScienceDirect, PubMed, Scopus, and Google Scholar, were used to gather bioactive constituents reported from this family. Absorption, Distribution, Metabolism, Excretion and Toxicology (ADMET) parameters, drug-likeness rules, and bioavailability scores were evaluated using Swis …

02.09.2026journal-article

Neuro-Oncology Practice

Dutch Linguistic Intraoperative Protocol Extended: new standardized items and tasks for language monitoring in awake glioma surgery for mild to severe aphasia

Marike Donders-Kamphuis, Arnaud Vincent, Saskia Mooijman, Ellen Collée, Clemens Dirven, Rob Nabuurs, Bram Bulté, Dorien Vandenborre, Evy Visch-Brink, Elke De Witte, Djaina Satoer

Abstract Background Awake surgery is the standard treatment for low-grade glioma patients in eloquent areas, but also seems to result in better surgical outcomes in glioblastoma patients. The Dutch Linguistic Intraoperative Protocol (DuLIP) is a validated tool for intraoperative language monitoring. However, in clinical practice, there is a need for additional items and tasks. Therefore, we aimed to develop and standardize an extended version of DuLIP (DuLIP-Extended). Methods We developed 1) Extra items for word r …

02.09.2026journal-article

Phytotaxa

Fungal diversity in landfill soil from a waste treatment plant in Hebei, China with the description of Scytalidium asiaticum sp. nov. (Helotiales, Ascomycota)

YU-HONG LU, PENG-WEI SU, JI-HANG JIANG, YUAN YAO, LI-WEI ZHOU

Soil is one of the most favored habitats for fungi, but fungal diversity from plastic-contaminated soil has rarely been explored. This study focused on landfill soil at a waste treatment plant in Hebei, China, resulting in the isolation of 62 strains. These strains were identified to 25 species, belonging to the genera Alternaria, Aspergillus, Beauveria, Cephalotrichum, Cladosporium, Fusarium, Gliomastix, Marquandomyces, Metarhizium, Mortierella, Mucor, Paraphaeosphaeria, Penicillium, Pseudogymnoascus, Scytalidium, …

02.09.2026journal-article

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

Redefining atrial fibrillation treatment success: patient-defined goals for arrhythmia burden and health-related quality of life

Alexander E. Kolomaya, Brian Zenger, Michael Torre, Andrew Redd, T. Jared Bunch, Trudie Lobban, Morgan M. Millar, Jonathan P. Piccini, John A. Spertus, Rachel Hess, Benjamin A. Steinberg

Background: Despite the use of atrial fibrillation (AF) cutoff of 30s as the standard for success in most AF clinical trials, patients consider an AF Severity Scale (AFSS) of ≤ 5 or AF duration ≤ 1 hour as treatment success. Prevalence and factors associated with these patient-defined endpoints are unknown. Methods: We performed a cross-sectional analysis using a single-site cohort of AF patients. We report rates of patient-defined treatment success (AFSS ≤ 5 or AF burden ≤ 1 hour) and multivariable analyses to ide …

02.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Personal Talc Use and Incident Lung Cancer

Maya S. Deshmukh, Kaitlyn G. Lawrence, Dale P. Sandler, Katie M. O’Brien

Abstract Background: Talc is a known risk factor for some lung diseases because of its small particle size, commonly aerosolized form, and possible contamination with asbestos, a known lung carcinogen. Personal talc-based body powder use is common among US women, but the association between talc use and lung cancer has not been studied in nonoccupational settings. Methods: At enrollment (2003–2009), Sister Study participants reported talc use in the last year and at ages 10 to 13 years. We used Cox proportional haz …

02.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Risk of Bladder Cancer among Male Participants Reporting Nocturia in the Cancer Prevention Study II

Charlie Zhong, Matthew Masters, Sidney M. Donzella, Donald L. Bliwise, Helen M. Parsons, Erika Rees-Punia

Abstract Background: It is believed that contact of the urothelial lining to carcinogens induces mutations that lead to cancer. Nocturia, waking up at night to urinate, may void carcinogens and reduce the risk of bladder cancer. Methods: The Cancer Prevention Study II Nutrition Cohort is a prospective study of cancer incidence that enrolled participants in 1992 with biennial follow-up beginning in 1997. Cases were ascertained through state cancer registry, medical record verification, or death certificate. Cox mode …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

ENVIRONMENTAL ASPECTS OF COMBINED DEPRESSURIZATION AND ELECTROMAGNETIC HEATING METHOD FOR HYDRATE EXTRACTION

Z. Xiao, A.N. Gulkov

Deep-sea natural gas hydrate resources have attracted widespread attention as a new type of energy source, and how to develop natural gas hydrates safely and effectively is currently the focus of research. The most commonly used extraction method for deep-sea natural gas hydrates is the depressurization method, but it faces problems such as the formation of secondary hydrates in the wellbore during the later stages of extraction. Therefore, we have incorporated electromagnetic heating technology into the depressuri …

02.09.2026journal-article

Biosensors

Monitoring EML4-ALK Biomarkers via a Microfluidic Assay for Treatment Efficacy Assessment

Shaked Doron, Lev Brio, Matan Krasner, Efrat Barbiro-Michaely, Doron Gerber

Monitoring prognostic biomarkers is essential for evaluating cancer treatment efficacy in real time. Here, we present a rapid, proof-of-concept microfluidic assay for cancer biomarker quantification and functional therapy evaluation. The assay requires only 5 µL of sample, eliminates tedious sample manipulation, and uses commercial antibodies to track both biomarker concentration and functional activity. We demonstrated the successful detection of VEGF and EML4-ALK proteins in both lung cancer cell culture supernat …

02.09.2026journal-article

Qualitative Health Research

I Want to Live More : Self-Talk Under the Pressure of Breast Cancer

Brigita Vilč, Emilia Mazurek, Renata Martinec, Ivan Milas, Goran Šimić, Marina Šagud

In this study, self-talk is conceptualized as a self-regulatory intrapersonal communication process that integrates emotional, cognitive, and social dimensions. Unlike prior studies that focus on the frequency or valence of self-talk, as well as the effectiveness of psychoeducational interventions, nearly always using quantitative methods, this study uses a qualitative approach to identify dynamic transitions and socio-contextual embedding of self-talk across the breast cancer trajectory. Adopting the interpretive …

02.09.2026journal-article

Angewandte Chemie International Edition

In Situ Peptide Assembly for Cancer Therapy

Guowei Liang, Xianbao Sun, Yu Ma, Tiantian Xia, Xiaotong Cheng, Gaolin Liang

ABSTRACT Peptides have emerged as promising anticancer agents due to their biocompatibility and functional versatility, such as tumor targeting and cell penetrating capabilities. However, their clinical application is often limited by poor stability and rapid clearance. To overcome these drawbacks, peptide assembly strategies have been developed. Early approaches utilized preassembled peptide nanomaterials, but these approaches faced challenges in circulation and tumor penetration. Recently, in situ peptide assembl …

02.09.2026journal-article

Oncology Reviews

Beyond tobacco: understanding the growing burden of lung adenocarcinoma in women

Michael Christian A. Virata, Rizal Michael Ramos Abello, Edroico Mari Beltran Brillante, Jasmine Soco Interior, Patrick Reyes Relacion, Ryan Gabriel C. Molen, Eryll Paolo M. Alea, John Cedric P. Mojica

Primary lung adenocarcinoma is the most common histological subtype of lung cancer. It disproportionately affects female sex, especially never-smokers. The rising incidence among females without a smoking history suggests roles for hormonal, genetic, and environmental factors. We conducted a comprehensive literature review using several databases. We examined global epidemiology data, molecular mechanisms, hormone-related pathways, and new diagnostic and therapeutic approaches. The findings show that estrogen signa …

02.09.2026journal-article

Breast Cancer Research

Genomic and transcriptomic landscape of overweight Chinese breast cancer reveals NOTCH2 mutation–mediated endocrine resistance and therapeutic strategies

Chao Chen, Yan-Lin Gu, Yun-Xiao Ling, Hui-Meng Li, Xin-Yi Sui, Li Liao, Xin Hu

Abstract Background Obesity (OB) and overweight (OW) are common in patients with breast cancer and are associated with inferior outcomes, yet their impact on tumor molecular architecture remains incompletely understood. This study aimed to define the genomic and transcriptomic features of breast cancer in OW/OB Chinese patients and to identify clinically relevant biomarkers and prognostic models for this population. Methods We performed targeted sequencing of matched tumor–blood samples from 3924 Chinese female pat …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

IMPROVING THE METHOD FOR DETERMINING THE FUEL GAS CONSUMPTION FOR COMPRESSION USING PHYSICALLY MOTIVATED FEATURES

V.O. Smolnikov, D.A. Godovsky

This paper addresses the pressing issue of improving the energy efficiency of gas transportation systems by developing a highly accurate method for predicting fuel gas consumption by gas compressor units at booster compressor stations. To assess the operating efficiency of booster compressor station equip-ment, a method for reliably determining the fuel gas consumption of gas compressor units is required. Traditional methods of standardization and forecasting, based on industry standards, are characterized by signi …

02.09.2026journal-article

JAMA Network Open

Historical Redlining and Spatiotemporal Patterns in Breast Cancer Screening

Md Atikur Rahman, Isuru Ratnayake, Sam Pepper, Derrick Asante, Brahian Cano Urrego, Susan Beckman, Leah Lambart, Dinesh Pal Mudaranthakam

Importance Geographic variation in breast cancer screening may reflect persistent structural inequities in access to preventive care. Understanding whether historical redlining remains associated with screening, independent of contemporary social vulnerability, neighborhood conditions, and geographic access, is critical for targeting interventions within cancer center catchment areas. Objectives To examine the association between historical redlining and breast cancer screening prevalence, accounting for social vul …

1 Zitationen
02.09.2026journal-article

Small

Specific Adsorption of Tumor‐Affinity Proteins to Improve Tumor Accumulation for Targeted Imaging and Therapy

Xiaoyao Xiong, Sijia Li, Yumin Li, Kangzheng Wang, Suying Xu, Chang Guo, Leyu Wang

ABSTRACT Nonspecific protein adsorption on nanocarriers leads to the formation of a protein corona, which promotes macrophage phagocytosis and attenuates delivery efficacy. We report a new surface engineering strategy to functionalize nanoplatforms by introducing trifluoroethyl sulfoxide, which not only effectively inhibits the adsorption of macrophage‐friendly proteins (ascribed to the hydrophilic sulfoxide group) but also promotes the specific adsorption of tumor‐affinity proteins (attributed to the trifluoroethy …

02.09.2026journal-article

Academy for Practical Oncology

A clinical case of performing risk-reducing surgery with simultaneous implant reconstruction with a mutation in the BRCA1 gene

E. M. Kungurtseva, D. A. Ryabchikov, N. V. Chanturiya, A. N. Khakimov, T. T. Khaidarov, E. S. Makarov, M. G. Filippova

The article highlights the issue of the possibility of performing risk-reducing mastectomy as a cancer prevention for hereditary diseases. A review of the scientific literature has been conducted confirming the advantage of this operation. A clinical case of bilateral subcutaneous mastectomy with simultaneous implant reconstruction in the presence of a mutation in the BRCA1 gene is described.

02.09.2026journal-article

British Journal of Haematology

BCMA versus GPRC5D bispecific antibodies in relapsed/refractory multiple myeloma: A systematic review and meta‐analysis guiding treatment selection

Qi Liang, Shutong Liu, Chunhua Li, Zhijian Liang, Lianxin Zhu, Weida Wang, Zhongjun Xia, Limei Zhang, Yang Liang, Yun Wang

Summary Bispecific antibodies (BsAbs) targeting B‐cell maturation antigen (BCMA) or G protein‐coupled receptor, class C, group 5, member D (GPRC5D) represent effective options for relapsed or refractory multiple myeloma (RRMM), yet direct comparative evidence remains limited. We performed a systematic review and meta‐analysis of studies evaluating BCMA‐ or GPRC5D‐targeted BsAbs in RRMM. Thirty studies comprising 3218 patients were included. Random‐effects models were used to pool efficacy and safety outcomes, follo …

02.09.2026journal-article

Journal of Cancer Research and Clinical Oncology

Optimized surgical treatment and study management for oncology patients in East Saxony (MISSION4Sax): study protocol of a multicentre pilot study

Christin Richter, Anne Döring, Floris Berg, Michelle Roost, Andreas Hasselberg, Carola Martin, Hannes Schlieter, Daniela Piontek, Olaf Schoffer, Jochen Schmitt, Jürgen Weitz, Grit Krause-Jüttler, Johanna Kirchberg

Abstract Purpose MISSION4Sax aims to develop and pilot new concepts for cross-sectoral oncological care, data integration and networking between maximum care centres and rural practitioners in medical underserved, enabling access to guideline-based therapy, innovative surgery, and clinical trials. Methods This pilot project is an exploratory multicentre, prospective longitudinal study. It assesses the feasibility, acceptability, implementation and data-quality aspects of the proposed care model and study infrastruc …

02.09.2026journal-article

Sosiaalilääketieteellinen Aikakauslehti

Äitiysneuvolassa työskentelevien ammattilaisten käsityksiä inkontinenssin ennaltaehkäisystä ja hoidosta

Tuulia Lahtinen, Marjaana Jones, Tiina Vaittinen, Pilvikki Absetz

The prevention and treatment of incontinence within maternity clinic services is significant from both individual and societal perspectives. Incontinence causes health and social disadvantages for individuals, but it also contributes to environmental burden and economic costs for society. These negative impacts can be reduced by investing in measures of early prevention and treatment. In this article, we examine how health care professionals working in maternity clinics describe the prevention and treatment of inco …

02.09.2026journal-article

World Economy and Management research

MicroRNA-234-3p inhibits the progression of ovarian cancer by regulating the WNK2/Ras/MEK/ERG signaling pathway tears or tendinopathy: a double-blind randomized controlled trial

Manyun Sun, Weixin Li, Qi Liu, Juan Shi

Ovarian cancer (OC) is the most lethal gynecological malignancy, characterized by late diagnosis, high recurrence rates, and limited effective targeted therapies. MicroRNAs (miRNAs) play critical roles in OC progression by post-transcriptionally regulating oncogenes and tumor suppressors. In this study, we investigated the expression, function, and molecular mechanism of miR-234-3p in OC. We found that miR-234-3p was significantly downregulated in OC tissues and cell lines compared with normal ovarian epithelium. O …

02.09.2026journal-article

Annals of African Medicine

Quantitative Apparent Diffusion Coefficient (ADC) Mapping as a Preoperative Biomarker for Tumor Grade and Myometrial Invasion in Endometrial Carcinoma

Kamlesh Kumar Ratre, Manish Kumar, Priya Singh, Priti Kumari

Abstract Background: The decision to perform systematic lymphadenectomy in endometrial carcinoma (EC) depends heavily on preoperative staging. We investigated the utility of diffusion-weighted imaging (DWI) and quantitative apparent diffusion coefficient (ADC) mapping to noninvasively predict the presence of EC and its histological tumor grade. Materials and Methods: This prospective case–control study included 30 women with histopathologically confirmed EC (cases) and 30 women with normal endometrium (controls). P …

02.09.2026journal-article

Translational Psychiatry

Treatment response prediction in major neurocognitive disorder with depression using the scalp-to-cortex distance of TMS targets: implications for personalized dose estimation

Hanna Lu, Sandra Sau Man Chan, Suk Ling Ma, Arthur Dun-Ping Mak, Lin Shi, Li Zhang, Linda Chiu Wa Lam

Abstract Neuronavigated repetitive transcranial magnetic stimulation (rTMS) has shown encouraging efficacy in treating various brain disorders. However, substantial inter-individual heterogeneity in treatment response remains a major challenge. In this secondary analysis of a randomized clinical trial, we examined the predictive performance of transcranial features in relation to output measures and responses to rTMS treatment. Fifty-five elderly patients with depression and cognitive impairments were randomly assi …