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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Clinical Medicine

Reference Estimates of Mean Tear Film Lipid Layer Thickness Measured with LipiView® and LipiView II® in Healthy Adults: A Systematic Review and Meta-Analysis

Maria Sobol, Jacek Pniewski

Background/Objectives: Tear film lipid layer thickness (LLT) is an important parameter of ocular surface function and can be objectively measured using LipiView ocular surface interferometry. However, reference LLT estimates in clinically healthy populations remain inconsistent. This systematic review and meta-analysis aimed to estimate pooled reference LLT values and explore potential sources of variability. Methods: A systematic search of PubMed, Scopus, and Web of Science was performed according to PRISMA 2020 g …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

A Resource-Efficient End-to-End Multimodal AI Framework for Automated PET-CT Report Generation and TNM Staging in Breast Cancer

Dibya Prakash, Venkatesh Rangarajan, Manoj Kumar

Objectives: Positron Emission Tomography-Computed Tomography (PET-CT) is integral to breast cancer staging. However, manual interpretation is time-consuming and subject to inter-observer variability. While artificial intelligence has shown promise in lesion detection and standardised uptake value (SUVmax) quantification, existing approaches are fragmented and do not generate complete TNM-aligned structured reports. Consequently, there remains a need for an integrated framework capable of translating PET-CT data int …

03.09.2026journal-article

Frontiers in Oncology

Factors associated with clinical research participation among Medicare beneficiaries with prostate cancer in the United States

Ryan A. Hankins, Alysha M. McGovern, Abimbola O. Williams, Virgil H. Simons, Sean P. Collins, Deepak Kumar

Introduction Clinical research participation among patients with prostate cancer remains limited, and demographic, clinical, and contextual factors may influence opportunities for participation. Although disparities in prostate cancer diagnosis and treatment are well documented, less is known about the factors associated with clinical research participation in this population. This study examined patient-level and contextual factors associated with clinical research participation among older Medicare beneficiaries …

03.09.2026journal-article

Frontiers in Education

Qualitative and probability-based analysis of student open-ended responses on academic stress and mental health

Jyoti Badge, Krishna Thakkar

Likert-scale instruments capture how much stress students report, but not what shape that stress takes. We present a thematic and probability-based analysis of open-ended survey responses from 217 graduate students at a private university in central India, collected in July 2025. Students described how academic stress had affected their mental health and proposed institutional changes they considered necessary. Seven stressor themes were extracted through inductive coding following the Braun and Clarke framework. A …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Multidisciplinary management of severe odontogenic maxillofacial multi-space infection in a patient with HIV–syphilis coinfection and advanced immunosuppression: a case report

Jieying Li, Yuanyong Feng, Xueqiang Guo, Wei Shang, Kai Zhou

Background HIV–syphilis coinfection poses a substantial challenge in the management of severe odontogenic infections, with few reports addressing maxillofacial multi-space infections in this setting. Case presentation A 50-year-old man developed severe left maxillofacial multi-space infection one week after molar extraction, presenting with respiratory distress, trismus, elevated C-reactive protein (235.20 mg/L), computed tomography evidence of gas-forming abscesses, reactive HIV antibody, positive syphilis serolog …

03.09.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

CEA-targeted fluorescence endoscopy for the detection of high-grade dysplasia and early invasive rectal cancer: A proof-of-concept trial

M. I. Warmerdam, T. H. Dijkhuis, D. J. G. Linders, C. M. W. Pesch, A. S. L. P. Crobach, A. Matoshi, K. Basiliya, S. H. van den Berg, F. Cailler, K. C. M. J. Peeters, F. A. Holman, J. S. D. Mieog, A. L. Vahrmeijer, D. E. Hilling, J. J. Boonstra

Abstract Purpose Accurate recognition of high-grade dysplasia (HGD) and early invasive carcinoma (IC) within colorectal polyps is essential for selecting the preferred local resection technique. However, optical endoscopic diagnosis can be challenging, particularly in large and advanced polyps. This study investigates whether carcinoembryonic antigen (CEA)-targeted near-infrared fluorescence (NIRF) imaging can distinguish polyps containing HGD/IC from polyps solely containing low-grade dysplasia (LGD), given prior …

03.09.2026journal-article

Frontiers in Digital Health

Objective quantification of suckling biomechanics in infants with and without tongue-tie using hydraulic differential-pressure recording and machine learning

Lene Dahl Siggaard, Serguei Chiriaev, Anders Kramer Knudsen, Torben Lildholdt

Introduction Objective assessment of infant suckling biomechanics remains limited despite decades of pressure-based measurement research, and tongue-tie (ankyloglossia) is still largely evaluated using semi-quantitative anatomical scoring. We developed a hydraulic differential-pressure device — the electronic baby bottle (EBB) — designed to record real-time net intraoral mechanical load during nutritive suckling through a fluid-filled sensing cavity with a controlled air inclusion coupled to a differential pressure …

03.09.2026journal-article

Frontiers in Oncology

Risk factors, severity-related factors, and clinical outcomes of immune checkpoint inhibitor-associated pneumonitis in elderly patients with lung cancer

Ying Hu, Shuhua Chen, Yingying Lu, Lingjuan Yang

Objective This study aimed to investigate the clinical characteristics, risk factors, severity-related factors, and clinical outcomes of immune checkpoint inhibitor-associated pneumonitis (CIP) after immune checkpoint inhibitor (ICI) treatment in elderly patients with lung cancer, providing evidence for risk identification and nursing management during ICI therapy. Methods Clinical data from 206 elderly patients with lung cancer who received ICI therapy at the Second Affiliated Hospital of Naval Medical University …

03.09.2026journal-article

Frontiers in Public Health

Exploring the factors associated with diabetes and hypertension complications among refugees living in Egypt

Noura Seada, Sungsoo Chun

Introduction Non-communicable diseases (NCDs) account for 74% of global deaths, with high global prevalence of diabetes and hypertension. Egypt hosts over 1 million refugees and asylum seekers, with systematic difficulties in the access to healthcare services. This study assessed factors associated with Type 2 Diabetes (T2D) and Hypertension (HTN) complications among Syrian and Sudanese refugees in Egypt, focusing on healthcare access, sociodemographic characteristics, lifestyle, and health behaviors. Methods This …

03.09.2026journal-article

Frontiers in Public Health

Online-dominant self-management is associated with lower, while hybrid mode is associated with higher, quality of life: a community-based cross-sectional study

Xuanyu Wang, Fan He, Qinli Zhang, Yang Meng, Ting Chen, Ye Zhu

Background Health-related quality of life (HRQoL) is an important outcome measure for evaluating community health interventions. Exploring effective community-based health self-management strategies is of practical significance in the context of population aging. This study compared the associations of different activity delivery modes (hybrid online-offline, offline-dominant, and online-dominant) implemented within community health self-management groups on residents’ HRQoL, and explored associations with activity …

03.09.2026journal-article

Discover Public Health

A scoping review protocol on knowledge, perceptions and attitudes toward cervical cancer among Ghanaians

Isaac Aidoo Erzuah, Christiana Asiedu, Amidu Alhassan, Ernest Addae

Abstract Introduction Cervical malignancy remains a major public health challenge in low- and middle-income countries, with sub-Saharan Africa bearing a disproportionate burden of disease. In Ghana, cervical cancer incidence and mortality remain high despite the availability of effective preventive measures, including human papillomavirus (HPV) vaccination and screening. Knowledge, perceptions, and attitudes influence uptake of cervical cancer prevention services, yet evidence from Ghana remains limited. This scopi …

03.09.2026journal-article

The Indonesian Journal of International Clinical Legal Education

Legal Education and Child-Responsive Digital Reporting Systems for School Bullying Victims

Anis Widyawati, Diyah Satya Retnani

School bullying remains a significant challenge in educational institutions, affecting children's psychological well-being, academic performance, and access to justice. Despite the existence of legal protection frameworks and anti-bullying policies, many cases remain unreported due to fear of retaliation, limited legal awareness, social stigma, and the absence of child-friendly reporting mechanisms. This study aims to examine the role of legal education as the foundation for developing child-responsive digital repo …

03.09.2026journal-article

Frontiers in Public Health

Mortality trends and influencing factors of mental disorders among urban and rural residents in China between 2009 and 2021: a longitudinal study with projections to 2030

Kaiyao Shen, Chenghao Wu, Wenhui Kong, Xu Wang, Yujie Zhao, Xueying Wang, Shan Hong, Hui Li

Introduction Mental disorders pose a major public health challenge in China, with marked urban–rural disparities in resources and outcomes. However, long-term mortality trends, their influencing factors, and future projections across urban and rural areas remain underexplored. This study aimed to analyze these mortality trends, identify relevant factors, and project mortality to 2030 using national data from 2009 to 2021. Methods Data were extracted from the China Health Statistical Yearbook , the China Health and …

03.09.2026journal-article

International Journal of Law Management & Humanities

Constitutional Rights in Action: An Analysis of Public Protests and Their Impact on Law and Governance

B Priyadharshini, K Rajeshkumar

Protest is an essential component of a democratic society and plays a significant part in securing the meaningful participation of citizens in the governance of the country. In India the right to express dissent and to assemble peaceably provides citizens with an important means of communicating grievances, questioning governmental policy and demanding accountability. The constitutional recognition of freedom of speech and expression under Article 19(1)(a) and of the right to assemble peaceably and without arms und …

03.09.2026journal-article

British Journal of Nursing

Individuals with intellectual disability and complex epilepsy: a case study of diagnostic overshadowing

Andrew Boyle, Natasha Spassiani, Valerie Houghton, Ruth Paterson

People with intellectual disability have a higher prevalence of epilepsy, care complexity, comorbidity and polypharmacy than the general population. These patients are often found to be on multiple medications without a clear rationale for ongoing prescriptions. Recent evidence has highlighted the ongoing exposure to avoidable health inequalities and premature death in this population group, in which medicines management can play an influential role. This article aims to identify practical interventions to mitigate …

03.09.2026journal-article

Frontiers in Immunology

The transformative impact of ultra-rapid nanopore sequencing in precision medicine

Sarah Grasedieck, Brendan J. Keating, Stephen Yip, James Lan, Karen R. Sherwood, Paul A. Keown

Nanopore sequencing has emerged as a transformative technology, offering unprecedented speed, ultra-long reads, and portability at a comparatively low cost. These attributes are fundamentally reshaping clinical diagnostics and personalized medicine. This review synthesizes the technological advancements driving nanopore sequencing and elucidates its pivotal applications in time-sensitive areas such as HLA matching in transplantation, infectious disease management, pharmacogenomics, and oncology. Nanopore sequencing …

03.09.2026journal-article

American Journal of Audiology

Clinical Prevalence and Impact of False Air–Bone Gaps in Clinical Audiometry: A Study of 1,000 Ears

Shai Chordekar, Liron Kariv, Nir Fink

Purpose: Accurate hearing loss classification depends on air–bone relationships; however, “false” air–bone gaps (ABGs) in sensorineural hearing loss (SNHL) frequently compromise diagnostic clarity. By shifting the focus from ABG magnitude to clinical prevalence, this study uses the prevalence of clinical ABGs (≥ 15 dB) as a primary metric to quantify diagnostic ambiguity in routine practice and to evaluate the efficacy of bone-conduction (BC) testing at frequencies where frequent false ABGs occur. Method: We retros …

03.09.2026journal-article

BMC Health Services Research

Improving kangaroo mother care in a rural Kenyan hospital: a multi-component implementation strategy to strengthen neonatal care delivery

John Strutner, Natalie Ash, Giles Hayden

Abstract Background Neonatal mortality remains a leading contributor to under-five mortality globally, particularly in low- and middle-income countries (LMICs). Kangaroo mother care (KMC) is an effective, low-cost intervention for improving outcomes among preterm and low birth weight infants; however, implementation remains inconsistent in resource-limited settings. Methods We conducted a quality improvement study at a rural Kenyan hospital using three sequential six-week cycles. Interventions addressed key barrier …

03.09.2026journal-article

PLOS Digital Health

Deep learning for blood glucose prediction: Reproducibility challenges and factors affecting differential performance

Baiying Lu, Biratal Wagle, Zhaohui Liang, Yanjun Cui, Temiloluwa Prioleau

Blood glucose prediction is a critical component of next-generation diabetes technologies, such as artificial pancreas systems, where reliable performance is essential for safety and effectiveness. Although deep learning methods have achieved promising advances in this area, a critical gap remains in understanding the reproducibility and generalizability of these methods. To contextualize the gap, this study reviewed 67 recent papers that proposed a deep learning method for glucose prediction to identify key reprod …

03.09.2026journal-article

Journal of Intensive Care Medicine

Pan Immune Inflammation Value in Identifying Sepsis High-Inflammatory and Immunosuppressive Phenotype

Xiao Zhu, Qing Lu, Xin Liu, Xianxiang Zeng

Background The Pan-Immune Inflammation Value (PIV) is a potential indicator of immune phenotypes in sepsis. Objective To explore the association between PIV and clinically defined high-inflammatory and immunosuppressive phenotypes in sepsis and to evaluate its potential predictive value. Methods Clinical data from 156 patients with sepsis were retrospectively analyzed. Patients were divided into high inflammatory (n = 82) and immunosuppressive (n = 74) groups based on their immune status. The clinical data and labo …

03.09.2026journal-article

Quality of Life Research

Capturing quality of life in pouch anal and vaginal fistula: development of PAVF-QoL-14, a patient-reported outcome measure

Lillian Reza, Laith Alrubaiy, Lara Bapir, Nusrat Iqbal, Charlene Sackitey, Easan Anand, Sally Hughes, Mina Babbar, Rali Marinova, Petya Marinova, Pearl Avery, Phillip Lung, Ailsa Hart, Sue Clark, Phil Tozer

Abstract Introduction Perianal pouch fistula can significantly affect quality of life, yet no disease-specific patient reported outcome measure (PROM) exists. We have developed and validated a 14-item PROM—the Pouch Anal and Vaginal Fistula Quality of Life scale (PAVF-QoL-14). Methods COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidance for PROM development was used to develop and validate PAVF-QoL-14. A systematic literature review and semi-structured patient interviews ( …

03.09.2026journal-article

Frontiers in Public Health

Drugs in the environment, viruses in the balance: a review of the untold nexus of pharmaceuticals and virology

Ahmed Abd Zaid, Allal Ouhtit

Objectives The pervasive contamination of aquatic and terrestrial ecosystems by active pharmaceutical ingredients (APIs) is a well-documented environmental challenge. However, the impact of this pollution on the most abundant biological entities on Earth viruses has remained a critical blind spot. This review provides the first integrated synthesis of the bidirectional nexus between pharmaceutical pollution and environmental virology. Methods A comprehensive literature search was conducted in PubMed, Web of Science …

03.09.2026journal-article

Frontiers in Public Health

A comparative evaluation of generative AI chatbots for patient-oriented advice on painful diabetic peripheral neuropathy: safety, accuracy, guideline concordance, actionability, and readability

Lina Gu, Zhaole Gong, Xiaoli Qian, Ling Miao, Zhengfeng Gu

Background Patients with painful diabetic peripheral neuropathy (PDPN) increasingly use generative artificial intelligence chatbots for information on symptoms, treatment, foot care, and when to seek professional help. Their usefulness depends on safety, accuracy, guideline concordance, actionability, and readability. Objective To compare five publicly accessible generative AI chatbots in answering standardized patient-oriented questions about PDPN. Methods: Sixty standardized English-language questions covering ei …

03.09.2026journal-article

Healthcare

Development and Validation of a Sitting-Balance Confidence Scale for Individuals with Spinal Cord Injury

J. P. Barfield, Jacqueline M. LaBarbera, Kelly Werts, Kaida Lou, Yinghao Pan

Background/Objectives: Participation in sport and daily activities among individuals with spinal cord injury (SCI) is influenced not only by physical capacity but also by psychological factors such as balance confidence. Existing measures primarily assess performance or fear of falling, leaving a gap in evaluating how perceived balance impacts activity choice. This study aimed to (1) develop a Patient-Reported Sitting Balance Confidence (PR-SBC) interview instrument to enable therapists to assess and evaluate non-a …