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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Neuroscience

Amino acid profiles and clinical phenotypes in young children with autism spectrum disorder

Ilaria Serati, Luca Lalli, Andrea Riccardo Dallapiccola, Pietro Baso, Martina Tosi, Francesca Brustia, Maria Paola Canevini, Michele Mussap, Livia Pisciotta, Emilia Ricci, Maura Rossi, Marco Di Dario, Maria Cristina Straface, Amanda Papa, Sabrina Fede, Salvatore Fazzone, Elena Spada, Federica Gioia, Roberto Longo, Pierangelo Veggiotti, Gianvincenzo Zuccotti, Cristina Cereda, Bruno Mario Cesana, Simona Ferraro

Introduction In 394 children with autism spectrum disorder (ASD), we investigated the association between plasma amino acid (AA) concentrations and clinical phenotypes. Methods Multivariable logistic regression models were used to evaluate the associations between 22 AAs and clinical features, reporting odds ratios. Results The median age at diagnosis was 3.5 years (interquartile range: 2.8–4.6 years) for boys and 3.1 years (interquartile range: 2.3–3.8 years) for girls; 81.5% of the participants were boys. A 25-un …

03.09.2026journal-article

Parasitology Research

Persistence of Theileria orientalis Chitose genotype on a closed dairy farm: possible vertical transmission and limited clearance after buparvaquone treatment

Mengyang Li, Tian Xie, Huan Liu, Li Tian, Jingjiao Yan, Chunlei Du, Chuanwen Wang, Haiyong Hui, Junlong Liu

Abstract Theileria orientalis comprises tick‑borne protozoan parasites that can cause substantial economic losses in cattle. We previously reported an outbreak of oriental theileriosis associated with mixed T. orientalis Ikeda and Chitose infection on a closed dairy farm. However, the predominant genotype and the mechanisms underlying long-term persistence under closed-herd management remain unclear. In December 2024, conventional PCR detected T. orientalis in 41 of 147 periparturient cows; sequencing of MPSP ampli …

03.09.2026journal-article

Frontiers in Surgery

Optimizing ambulatory groin hernia repair in public healthcare frameworks: a prospective analysis of predictive factors for discharge failure

Jihen Krichen, Asma Sghaier, Rana Dhouib, Slah Souii, Maissa Tioumi, Sihem Sindi, Bilel Faidi, Khalil Ben Salah

Background Outpatient groin hernia repair is widely recommended globally due to clinical and socioeconomic efficiency, yet it remains underutilized in developing healthcare systems like Tunisia. This study aimed to evaluate the feasibility of a newly implemented day-surgery clinical pathway for groin hernias and identify specific predictors associated with outpatient discharge failure. Methods A prospective, observational cohort study was conducted at a Tunisian tertiary hospital between September 2023 and April 20 …

03.09.2026journal-article

Clinical and Translational Imaging

Dynamic PSMA total-body PET/CT in prostate cancer: technical principles and clinical potential

Yongkang Shuai, Irene Brusa, Riccardo Mei, Stefano Fanti

Abstract Background The incidence of prostate cancer continues to rise worldwide. While conventional static PET/CT provides semi-quantitative metrics, total-body PET/CT enables voxel-level dynamic imaging and parametric imaging, demonstrating great potential for clinical applications in prostate cancer. Therefore, this review synthesizes the technical principles of dynamic PSMA total-body PET/CT and its emerging clinical applications in prostate cancer, providing a novel clinical insight for individualized patient …

03.09.2026journal-article

Gastric Cancer

Clinical impact of CT-defined sarcopenia on long-term oncological outcomes in gastric cancer: validation of muscle mass cut-offs established according to EWGSOP recommendations

Jasmin Hasanovic, Paul Friedrich Esslinger, Veronika Lummer, Heiner Nebelung, Leo Misera, Ralf-Thorsten Hoffmann, Johanna Kirchberg, Marius Distler, Jürgen Weitz, Daniel E. Stange, Felix Merboth

Abstract Background Sarcopenia is an important prognostic factor in gastrointestinal malignancies, but CT-based definitions vary. This study evaluated recently published computed tomography (CT)-based cut-offs for skeletal muscle index (SMI) and psoas muscle thickness normalized to height (PMTH), derived from a young, presumably healthy reference population according to recommendations of the European Working Group on Sarcopenia in Older People (EWGSOP), in patients undergoing surgery for gastric cancer. Methods Th …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure

Chunxiao Zhao, Jiahao Liu, Juanjuan Xin, Qun Liu, Ying Zhang, Xiaochun Yu, Junhong Gao

Cardiovascular diseases rank as the global primary cause of mortality. Heart failure (HF) represents a progressive cardiac syndrome triggered by structural or functional myocardial damage that compromises ventricular systolic output. Intracellular calcium homeostasis underpins cardiomyocyte excitation-contraction coupling. Calcium overload and dysregulated calcium handling act as central pathogenic forces driving HF progression. Sympathetic β 1 -adrenergic receptor (β 1 -AR) and parasympathetic M 2 muscarinic acety …

03.09.2026journal-article

Frontiers in Public Health

Traditional Chinese medicine reimbursement reform in China: implementation progress, policy constraints, and optimization strategies

Fazheng Zhao, Yichi Chen, Xin Tong

Introduction As the inheritance, innovation, and development of TCM advance, medical insurance reimbursement policies are intended to improve access, guide service structure, and support high-quality development. This study examines the implementation progress, policy constraints, and optimization paths of TCM reimbursement reform in China. Methods The study analyzes publicly available national and regional policy documents, together with secondary literature, to synthesize the policy design, implementation arrange …

03.09.2026journal-article

Biology

Biological Foundation Models for Complex Disease Research and Clinical Translation

Tiana Noll-Walker, Yong Chen

Complex diseases, including cancer, rare genetic disorders, neurodevelopmental and psychiatric conditions, and neurodegenerative diseases, arise from interactions among genetic variation, gene regulation, and cellular states that are difficult to capture using a single data type or biological scale. Biological foundation models address this challenge by treating nucleotides and genes as tokens and learning representations that can be transferred to downstream biomedical and clinical tasks. In this review, we examin …

03.09.2026journal-article

ACS Applied Materials & Interfaces

Delivery of CAR T Cells in a Magnesium-Functionated Hydrogel Boosts Peritoneal Metastasis Treatment

Junlin Li, Xutao Liu, En Ren, Ziyan Liao, Huipeng Zhang, Qiujun Qiu, Jiaqi Shi, Xin Gong, Wenyue Lv, Zhen Gu, Hongjun Li

Abstract Chimeric antigen receptor (CAR) T cells show limited efficacy in solid tumors due to suppressive factors in the tumor microenvironment. In this study, we identified extracellular magnesium (Mg2+) as a pharmacologically modulable regulator of CAR T activity. Mg2+ supplementation increased early activation and augmented cytotoxic readouts, including IFN-γ secretion and target-cell lysis. To localize this cue, we engineered a phosphorylated hyaluronic-acid hydrogel ionically cross-linked by Mg2+ (HA-Mg Gel), …

03.09.2026journal-article

Biology

Deconstructing the Alternative Lengthening of Telomeres: Integromics Prioritizes Five Master Hubs Dictating Clinical Survival and Therapeutic Vulnerabilities

Isaac Armendáriz-Castillo, Santiago Guerrero, Andrés Herrera-Yela, Jhommara Bautista, Andrés López-Cortés

The Alternative Lengthening of Telomeres (ALT) pathway drives replicative immortality in aggressive malignancies, particularly sarcomas and gliomas. Clinical ALT stratification has relied on screening for structural ATRX and DAXX mutations. However, this genotypic approach fails to capture the dynamic macro-reprogramming required to sustain ALT. Here, we established and validated a 28-gene transcriptomic signature that captures the ALT-associated transcriptomic phenotype of the ALT phenotype. Using multivariate Cox …

03.09.2026journal-article

Sensors

Mechanical Fault Diagnosis of High-Voltage Circuit Breakers Based on Multi-Sensor Gramian Angular Field and Deep Residual Network

Xining Li, Hanyan Xiao, Ke Zhao, Lei Sun, Tianxin Zhuang, Haoyan Zhang, Hongwei Mei

The mechanical reliability of high-voltage circuit breakers (HVCBs) is crucial for power-grid stability, yet traditional diagnostic methods rely heavily on manually extracted scalar features that can discard transient information. This paper presents a mechanism-aware diagnostic pipeline that combines synchronized coil-current, contact-travel, and spring-pressure measurements; Variational Mode Decomposition (VMD); kinematics-driven Region of Interest (ROI) alignment; Gramian Angular Field (GAF) encoding; RGB channe …

03.09.2026journal-article

Annals of Plastic Surgery

Reconstruction of the Pelvic Floor With a Gluteus Maximus–Including Posterior Thigh Flap After Total Pelvic Exenteration

Yoshihiko Tamanoi, Kakuru Otsubo, Tomoyuki Koike, Kenichi Kokubo, Ayato Hayashi

Background: Total pelvic exenteration (TPE) creates a massive pelvic dead space associated with a high risk of severe postoperative complications. We evaluated the clinical outcomes of pelvic floor and perineal reconstruction using a modified posterior thigh flap including the gluteus maximus muscle in patients undergoing TPE for anal canal cancer. Patients and Methods: We retrospectively reviewed 4 male patients who underwent this reconstruction at our institution between April 2020 and March 2025. Clinical outcom …

03.09.2026journal-article

PLOS Global Public Health

The impact of social protection interventions on treatment and socioeconomic outcomes of tuberculosis-affected people and households in low income, high burden settings: A systematic review and meta-analysis

Mollie Hudson, Heather Todd, Talemwa Nalugwa, Ann Schraufnagel, Canice Christian, Delia Boccia, Tom Wingfield, Priya B. Shete

Tuberculosis (TB) is the leading cause of death due to infectious disease worldwide. Social protection interventions can benefit TB-affected households. We conducted a systematic review and meta-analysis to quantify the effectiveness of social protection on TB treatment and socioeconomic outcomes. We identified articles published from January 2012 to December 2025 by searching PubMed (includes MEDLINE), Embase, and Web of Science. We included studies that described at least one social protection intervention and re …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Lipoprotein(a) measurement: challenges and opportunities

John H. Contois

Abstract Lipoprotein(a) [Lp(a)] is a causal, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. New guidelines recommend testing everyone at least once in a lifetime, and with new drugs specifically targeting Lp(a) on the horizon, accurate measurement remains vitally important. Yet, its measurement has for decades been challenging because of apolipoprotein(a) size heterogeneity, imperfect calibration strategies, and mixed use of mass (mg/dL) vs. molar (nmol/L) uni …

03.09.2026journal-article

Frontiers in Immunology

Exploring type 2 inflammation and disease complexity: perspectives of a clinical immunologist

Yuval Tal, Limor Rubin, Ariel Munitz, Irit Adini

Type 2 inflammatory diseases are often grouped together as a single immunological entity, driven by shared cytokines and overlapping pathways. This framework has led to the development of biologic therapies targeting upstream epithelial-derived “alarmins”, including thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and interleukin (IL)-25. These mediators promote downstream cytokine responses, most notably IL-4, IL-5, and IL-13, which orchestrate type 2 inflammation across multiple tissues. Despite these sh …

03.09.2026journal-article

Frontiers in Medicine

Exploring the qualities and adaptive professional capabilities required of physicians for disaster response through perspective transformation among physicians in Fukushima, Japan

Megumi Yasuda, Rintaro Imafuku, Kaho Hayakawa, Maham Stanyon, Takuya Saiki

Background The Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant accident confronted health care professionals with profound uncertainty and ethical dilemmas. However, it remains unclear how physicians made sense of these extreme experiences, reconsidered their assumptions, values and professional roles, and came to recognize and embody the qualities and adaptive professional capabilities required for disaster response. Aim Through the narratives of physicians in Fukushima, Japan, this study …

03.09.2026journal-article

Antimicrobial Agents and Chemotherapy

Phage-first treatment results in subpopulation-driven collateral sensitivity to beta-lactams in an extensively drug-resistant Pseudomonas aeruginosa

Claire Han, Karishma Patel, Haoran Gao, Jacob T. Sanborn, Thomas D. Nguyen, Jack F. Klem, Brian M. Ho, Patrick D. Kenney, Yanan Zhao, Troy D. Wood, Dwayne R. Roach, Liang Chen, Nicholas M. Smith

ABSTRACT Nosocomial Pseudomonas aeruginosa infections are among the most challenging infections to treat, and resistance to last-line agents, including polymyxins and aztreonam-based therapies, risks a future with limited or no clinical treatment options. Bacteriophages (phages) have emerged as a promising therapeutic option, both in cocktails and when given in combination with antibiotics. In this study, we show that the synergy between a lipopolysaccharide (LPS)-specific phage and antibiotics is driven by clinica …

03.09.2026journal-article

Frontiers in Immunology

Digital assessment in myasthenia gravis: evidence, validation, and a proposed framework for autoimmune heterogeneity, remote monitoring, and clinical endpoints

Mengyi Wang, Yanpeng Huang, Zhibo Chai, Zhaoqing Li, Wenjun Qiao, Weifeng Xie

Myasthenia gravis (MG) is an antibody-mediated autoimmune disorder of the neuromuscular junction in which weakness fluctuates across symptom domains, daily activities, and treatment cycles. Established measures such as the Quantitative Myasthenia Gravis score, Myasthenia Gravis Composite, Myasthenia Gravis Activities of Daily Living scale, and MG-specific quality-of-life instruments remain the principal clinical anchors, but intermittent assessments may miss intraday variability, exertional fatigability, and change …

03.09.2026journal-article

The Kaohsiung Journal of Medical Sciences

Development of a Nomogram‐Based Clinical Estimation Model for Pathological Upstaging in Patients With Preoperative Ductal Carcinoma In Situ

Yu‐Hua Chen, Chung‐Liang Li, Ping‐Fu Yang, Hui‐Hua Hsiao, Fang‐Ming Chen, Sin‐Hua Moi

ABSTRACT Preoperative diagnosis of ductal carcinoma in situ (DCIS) may be followed by pathological upstaging to invasive ductal carcinoma (IDC) upon surgical excision, a discrepancy that significantly impacts surgical planning and decisions regarding sentinel lymph node biopsy (SLNB). This retrospective study aimed to evaluate clinical indicators associated with such upstaging and develop a nomogram‐based clinical estimation model for risk stratification. We reviewed medical records of all consecutively diagnosed p …

03.09.2026journal-article

Cirugía Andaluza

Bifid ureteral system in cytoreduction surgery

B Alejandre Ovejero, I Arjona Medina, D Rodríguez Morillas

Resumen La duplicación ureteral es una anomalía congénita común, especialmente en mujeres, que se caracteriza por la presencia de dos uréteres en un riñón. Esta condición puede generar complicaciones como infecciones, litiasis o reflujo vesicoureteral. El objetivo es presentar un caso clínico de duplicación ureteral bilateral, hallada de forma incidental. Se presenta a una mujer de 50 años con diagnóstico de carcinoma de ovario, quien, durante la cirugía de citorreducción mostró duplicación ureteral bilateral sin q …

03.09.2026journal-article

Turkish Journal of Gastroenterology

Lumen-Apposing Metal Stent in the Treatment of Persistent Dysphagia due to Cervical Radiation Therapy

Eren Yilmaz, Mucahit Ergul, Oguz Ozturk, Kadir Can Acun, Emir Tuğrul Keskin, Orhan Coskun, Ilhami Yuksel

Cite this article as: Yilmaz E, Ergul M, Ozturk O, et al. Lumen-apposing metal stent in the treatment of persistent dysphagia due to cervical radiation therapy. Turk J Gastroenterol. Published online September 3, 2026. doi: 10.5152/tjg.2026.26290.

03.09.2026journal-article

Journal of Patient Safety

Closing the Gap: Physician Perspectives on EMR Changes Needed to Support Safe Clinical Care

Vittoria S. von Petersdorff, David Schwappach

Objectives: This study aimed to systematically assess the changes physicians identify as needed in their EMRs to better support safe clinical practice. Methods: Data were obtained from a national survey on EMR usability and patient safety conducted among Swiss physicians in 2024. Responses to the open-ended question “What should change in ‘MySystem’ to better support you in working safely?” were categorized inductively. When a respondent mentioned more than 1 change, these were split into separate statements. Inter …

03.09.2026journal-article

AVANCA | CINEMA

The Two Levels of the Treatment of Time in Christopher Nolan’s Films: The Narrative and Its Cinematic Treatment

Radhika Khanna, Hervé Zénouda, Tathagata Mitra

The question of time is central to Christopher Nolan’s films — Following (1998), Memento (2000), and Tenet (2020). Nolan often uses ‘time’ as a central narrative device in his films through non-linear storytelling. We use the cognitive theory of relevance to examine Nolan’s varied use of temporal deconstruction to build his cinematic narratives. He creates a dynamic of suspense through an extreme temporal deconstruction produced through film editing. This affects cognition and emotion with an experiential dimension …