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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Current Organic Chemistry

Nicotinamide Derivatives: Synthetic Strategies and their Emerging Role in Anticancer Therapy

Mayur M. Karanjekar, Vaishnavi S. Chaudhari, Kalyani R. Thombre, Krishna Radheshyam Gupta, Milind Janrao Umekar

Abstract: Nicotinamide-containing heterocycles are gaining increasing interest in medicinal chemistry due to their potential applications in cancer drug development. Their structural characteristics significantly influence both biological activity and therapeutic efficacy. The purpose of this review is to summarize recent advancements in the synthesis of nicotinamide derivatives and to evaluate their reported anticancer activities against various cancer types. Different synthesis methods for nicotinamide-based comp …

01.09.2026journal-article

Journal of Applied Physiology

Sex hormones and menopause hormone therapy predict muscle strength across the lifespan

Rachel N. Logue Cook, Adina F. Turcu, Carrie A. Karvonen-Gutierrez, Sandra K. Hunter

We demonstrate that sex hormone concentrations are associated with age-related declines in muscle strength across the lifespan. Bioavailable testosterone was a predictor of handgrip strength, whereas total testosterone was not in both males and females, and estradiol was a strong predictor of strength in females during midlife and older age. Furthermore, menopause hormone therapy may have beneficial effects on strength maintenance in older females, particularly in sedentary females.

01.09.2026journal-article

International Journal of Sport Communication

From Heart-Speech to Hate-Speech: A Discourse Analysis of Nationalism on Social Media in Vietnam

Trung Quang Dao, Kien Van Phan, Quy Le Dinh Nguyen, Son Bao Tran

This study analyzes nationalist discourse on social media in Vietnam through the case of the 2024 Southeast Asian football final between Vietnam and Thailand, alongside the controversy surrounding a Vietnamese girl wearing a Thai jersey to support the rival team. Drawing on theories of imagined communities, Critical Discourse Analysis, and verbal aggression, the research examines 20 posts and 238 public comments on Facebook during the 16 days following the match. The findings identify four main discourse groups: po …

01.09.2026journal-article

Journal of the American Heart Association

Clopidogrel Versus Dual‐Antiplatelet Therapy for Long‐Term Maintenance After Coronary Stenting in Ischemic and Bleeding Birisk Patients With Acute Coronary Syndromes and Diabetes: A Prespecified Subgroup Analysis of the OPT‐BIRISK Trial

Dali Zhang, Yi Li, Miaohan Qiu, Yujie Zhou, Shaoliang Chen, Hanjun Pei, Jinghua Liu, Biao Xu, Yaling Han, Gregg W. Stone

Background Among patients with acute coronary syndromes at both high bleeding and ischemic risk (birisk), extended clopidogrel monotherapy after 9 to 12 months of dual‐antiplatelet therapy reduces bleeding without increasing ischemia. Whether this benefit extends to birisk patients with diabetes is unknown. Methods This prespecified subgroup analysis of the OPT‐BIRISK (Optimal Antiplatelet Therapy for High Bleeding and Ischemic Risk Patients) trial included birisk patients with acute coronary syndrome who had compl …

02.09.2026journal-article

The Oncologist

17 Preclinical Study of Anti-CAIX/CD70 DFIR CAR-T Cell Therapy Secreting Anti-PD-1/CTLA-4 Bispecific Payload for Advanced Clear Cell Renal Cell Carcinoma Treatment

Yufei Wang

Abstract Background Clear cell renal cell carcinoma (ccRCC) remains difficult to cure due to tumor antigen heterogeneity, on-target off-tumor (OTOT) toxicity risks, and a profoundly immunosuppressive tumor microenvironment (TME). While the combination of anti-PD-1 (nivolumab) and anti-CTLA-4 (ipilimumab) demonstrated clinical benefit in intermediate- and poor-risk RCC, durable responses remain limited. CAR-T cell therapy offers a promising approach but is constrained by single-antigen targeting and T cell exhaustio …

01.09.2026journal-article

Chemistry – A European Journal

Localized Prostate Cancer Therapy: Tumor Microenvironment‐Activated Spermine Hydrogel With Real‐Time Autonomous Fluorescence Sensing

Ho‐Fai Chau, Wing‐Sze Tam, Gengguo Deng, Yik Hoi Yeung, Christine Yim Ping Wong, Ka Lo Cheng, Zhengxiao Liu, Lijia Yao, Yi Wang, Angelo H. All, Chi‐Fai Ng, Jinming Di, Ka‐Leung Wong

ABSTRACT Prostate cancer (PCa) remains a significant clinical challenge, particularly in localized therapy, where unmet medical needs persist for effective and targeted treatments. This study introduces an innovative solution by developing the first responsive spermine (Spm) hydrogel with an autonomous sensing function, designed to advance local therapy for PCa. Our hydrogel effectively loads Spm and releases Spm in the acidic tumor microenvironment (TME), providing a responsive therapeutic platform. Incorporating …

01.09.2026journal-article

TAJ: Journal of Teachers Association

Effectiveness of Early Multidisciplinary Rehabilitation on Functional Recovery and Quality of Life in Stroke Survivors

Tamjid Ali, Abdus Sabur, Quazi Tamanna Haque

Background: Timely, coordinated rehabilitation after stroke is widely advocated, yet comparative evidence on early multidisciplinary versus conventional models in South Asian tertiary settings remains limited. Objective: This study evaluated whether an early multidisciplinary rehabilitation model improves functional recovery and quality of life compared with conventional stroke rehabilitation. Methods: A prospective comparative cohort of 168 stroke survivors (18–65 years) was enrolled at the Department of Physical …

01.09.2026journal-article

Frontiers in Applied Mathematics and Statistics

Topological analysis of hemodynamic response to cardiac resynchronization therapy

Aina Ferrà Marcús, Carles Casacuberta, Josep Vives, Joan Guich, Gerard Amorós-Figueras, Jose M. Guerra

The Mapper algorithm is a qualitative method in topological data analysis that constructs graphs from point clouds by combining dimensionality reduction and clustering. We apply Mapper, together with quantitative graph indices proposed in this work, to compare the effects of left ventricular epicardial and endocardial biventricular pacing in a swine model of pacing-induced non-ischemic cardiomyopathy. Distributions of four hemodynamic variables from a previous study were analyzed using Mapper, complemented by numer …

01.09.2026journal-article

Frontiers in Medicine

Hemoporfin photodynamic therapy for port-wine stains in children: a prospective study

Jun Cheng, Hanxiang Bai, Hua Yuan, Yun Zou, Mengyu Huang, Zhiping Wu, Ronghua Fu

Introduction Hemoporfin photodynamic therapy is a promising treatment for port-wine stains. However, its efficacy and safety in pediatric cases remain controversial. This study investigated the efficacy and safety of porphyrin photodynamic therapy for treating port-wine stains in children. Methods In this prospective study, 140 children with port-wine stains were included and all patients received hemoporfin photodynamic therapy at least twice. Their demographic characteristics, treatment outcomes, and adverse even …

01.09.2026journal-article

ASM Case Reports

Toxoplasmosis-associated hemophagocytic lymphohistiocytosis during tumor-infiltrating lymphocyte therapy

Tariq Odeh, Priscilla Quach, Amin Mostofizadeh, Julia D. Hankins, Robert Hamilton-Seth, Chelsea Gorsline

ABSTRACT Background Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome triggered by infections, malignancies, or autoimmune disorders. Tumor-infiltrating lymphocyte (TIL) therapy requires lymphodepleting chemotherapy and interleukin-2, producing profound immunosuppression. While HLH-like syndromes have been characterized after chimeric antigen receptor T-cell therapy, HLH has not been reported in the setting of TIL therapy. Toxoplasma gondii is a recognized but uncommon parasitic trigge …

01.09.2026journal-article

Acupuncture & Electro-Therapeutics Research: International Journal of Integrated Medicine

Clinical Outcomes Associated With Adjunctive Electroacupuncture During Standard Exercise Rehabilitation in Individuals With Spinal Cord Injury: A Retrospective Propensity Score-Matched Cohort Study

Ying Zhang, Xianhong Zuo, Liwen Guo, Guoqing Zheng, Xinming Yang

Objective This article aims to examine whether adjunctive electroacupuncture was associated with more favorable rehabilitation outcomes among individuals with spinal cord injury (SCI) receiving standard exercise rehabilitation. Methods In this single-center retrospective cohort study, 174 patients with SCI treated between January 2020 and December 2025 were screened. After 1:1 propensity score matching for age, sex, body mass index, injury level, broad etiology (traumatic vs non-traumatic), and American Spinal Inju …

01.09.2026journal-article

Global Trade and Customs Journal

Accountability Without Paralysis: WTO Farewell Speech Insights for UNCITRAL’s Appellate Design

Nguyen Luu Lan Phuong, Hua Li

The collapse of the World Trade Organization (WTO) Appellate Body (AB) has raised fundamental questions about how appellate mechanisms in international dispute settlement should be institutionally designed. While existing scholarship has primarily focused on the political causes of the crisis, less attention has been paid to the structural lessons the experience offers for the design of future appellate systems, particularly in the context of ongoing reform discussions within United Nations Commission on Internatio …

01.09.2026journal-article

Journal of Clinical Sport Psychology

A Collaborative Rapid Response to Abuse in U.K. Gymnastics Using Group Focused Acceptance and Commitment Therapy-Based Program

Misia Gervis, Lara Baker-Power, Aura Goldman, James Mackenzie

Although abuse is commonplace within sport, the abuse scandal in gymnastics has left many current and ex-gymnasts traumatized by their experiences. When the scandal emerged, we recognized an immediate need for support for survivors of this abuse within British Gymnastics; this paper documents our response. This paper presents practice-based evidence on how a focused acceptance and commitment therapy-based intervention program was designed and delivered to four different groups: parents/guardians, older ex-gymnasts, …

01.09.2026journal-article

Arthritis Research & Therapy

Elevated pro-BNP and low-grade inflammation are associated with low bone mineral density in systemic sclerosis, a case control study

Kerstin Lillpers, Kristofer Andréasson, Seyed Morteza Najibi, Anthony D Woolf, Roger Hesselstrand, Kristina E Åkesson, Meliha C Kapetanovic

Abstract Background Bone mineral density (BMD) is compromised in patients with systemic sclerosis (SSc) compared to the background population, yet the underlying disease related factors are less known. This study evaluates SSc disease-related features and predictability for BMD along with established risk factors for low BMD in SSc patients compared to controls. Methods The study includes 211 SSc patients, 182 women and 29 men (mean age 61 yrs, mean disease duration 9 yrs) regularly followed at the Skåne University …

01.09.2026journal-article

Colorectal Disease

Early ileocaecal resection versus biologics therapy for localized Crohn disease: A systematic review and meta‐analysis

Sara Bravin, Ana L. R. S. Menegat, Brenda L. R. S. Menegat, Omar Kasimieh, Henrique Wiederkehr

Abstract Aim Early ileocaecal resection has recently emerged as a feasible alternative to biologics in patients with localized Crohn's disease unresponsive to standard therapy. However, early resection is not widely implemented in clinical settings, and data on its comparison to biologics therapy are limited. Methods We searched PubMed, Scopus and Cochrane for randomized clinical trials (RCTs) and observational studies comparing early ileocaecal resection to biologics therapy in patients with localized Crohn's dise …

01.09.2026journal-article

Cancers

Claudin 18.2 Positivity Thresholds and Candidate Populations for Targeted Therapy in Pancreatic Ductal Adenocarcinoma: A Real-World Retrospective Cohort

Güner Akgüner, Elif Haznedaroğlu Benlioğlu, Özgen Ahmet Yıldırım, Ayşegül İlhan Güleşen, Batuhan Günel, Ata Türker Arıkök, Ömür Berna Çakmak Öksüzoğlu, Kadriye Bir Yücel

Background/Objectives: Claudin 18.2 (CLDN18.2) is expressed in a substantial proportion of pancreatic ductal adenocarcinoma (PDAC) and has emerged as a promising therapeutic target. However, the positivity threshold for enrollment in CLDN18.2-directed trials remains undefined, and ongoing studies use different criteria. We quantified how different CLDN18.2 thresholds influence the size of the candidate population within the same PDAC cohort. Methods: In this retrospective single-center study, CLDN18.2 was assessed …

01.09.2026journal-article

Blood Advances

Sustaining Cell Therapy Quality through Shared Responsibility: A Call for Equitable FACT Inspectorate Participation

Suzanne Birnley, Michele W Sugrue, Angelica Vivero, R. Alejandro Sica, Elias Kalouche, Daniel Kota, Donna Salzman, Renee Smilee, Ibrahim Ahmed, Arunkumar Modi, Guy Klamer, Phillip Johnson, Joseph Lynch, Phyllis Warkentin, Folashade Otegbeye

This paper highlights a critical challenge in the FACT peer-accreditation system: a growing imbalance between the rising number of accredited and applicant organizations and the limited pool of volunteer inspectors. This imbalance places a disproportionate burden on current inspectors, concentrates accreditation expertise within a small subset of programs, and threatens the efficiency of the peer-review model. The paper presents compelling evidence that organizations contributing to the inspectorate gain measurable …

01.09.2026journal-article

„Law • Education • Security”

Internet censorship regulations as a tool for restricting freedom of speech. Actions taken by the European Commission and Polish legislators

Paweł Opitek

The article focuses on the issue of Internet censorship as a tool limiting freedom of speech in the context of the activities of the European Commission and the Polish legislature. The first section discusses the importance of freedom of speech for civil society and its guarantees in the Constitution of the Republic of Poland. This is followed by an analysis of the threats to such freedom in the European Union and Poland, namely attempts to ideologise so-called 'hate speech' and expand its parameters, censorship of …

01.09.2026journal-article

Plastic and Reconstructive Surgery - Global Open

Use of Biophysical Stimulation Therapy in Surgically Treated Acute Scaphoid Fractures

Carmine Scarlato, Macarena Vizcay, Nicoletta Denami, Andrea Ghezzi, Giorgio Eugenio Pajardi

Background: Scaphoid fractures remain challenging because of the bone’s limited vascularity, particularly at the proximal pole. Although surgical fixation represents the standard of care for displaced and high-risk fractures, pulsed electromagnetic field (PEMF) stimulation has been proposed as a noninvasive adjunctive therapy, with osteogenic, anti-inflammatory, bone-healing, and regenerative effects. Methods: This multicenter retrospective cohort study, conducted in accordance with the strengthening the reporting …

01.09.2026journal-article

Alzheimer Disease & Associated Disorders

Speech-in-Noise Hearing Impairment and Incident Dementia

Cong Peng, Guoqing Gong, Zhetian Chen, Jingwei Wu, Dan Liu, Bin Chen

Objective: Hearing impairment is considered an important modifiable risk factor for dementia, but whether its association with incident dementia is consistent across inherited susceptibility profiles remains unclear. Methods: This prospective cohort study included 80,287 UK Biobank participants aged 40 to 69 years at baseline with valid Digit Triplet Test measurements, genetic data, linked follow-up data, and complete prespecified covariates. Hearing function was quantified using the better-ear speech reception thr …

01.09.2026journal-article

Rehabilitation Nursing Journal

Hypertension Self-Management and Stroke Recovery Among Rural Adults in the Stroke Belt: A Mixed-Methods Study

Mudasir Andrabi, Betty Key, Chaitali Dagli, Kayla Glass-Lucena, Stephanie Hart, Susan Appel, Chen Lin, Karlene Ball

Purpose: To assess hypertension-related knowledge, self-management behaviors, and post-stroke needs among African American (AA) stroke survivors in rural Alabama. Design: Cross-sectional, mixed-methods study. Methods: Using convenience sampling, we recruited 25 AA stroke survivors aged 50 years or older from three rural counties in Alabama. Quantitative data were collected using the Hypertension Knowledge-Level Scale (HK-LS), hypertension Self-Care Activity Level Effects (H-SCALE), and the Southampton Stroke Self-M …

02.09.2026journal-article

The Oncologist

83 Preclinical Evaluation of LNK001: Stringent AND-Gate Fidelity and Potent Efficacy of a Dual-Antigen CAIX/ENPP3 CAR T Cell Therapy for Clear Cell Renal Cell Carcinoma

Mark Wallet, Rebecca Larson, Yogin Patel, Janette Sutton, Bryan Smith, Colin Farrell, Angeles Estelles, Zeynep Wheeler, Kazuteru Hasegawa, Benjamin Bauer, Jakob McBroome, Diego Vargas-Inchaustegui, Alexander Bankovich, Regina Lin

Abstract Background Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of hematologic malignancies but have struggled to achieve safe and effective outcomes in solid tumors. On-target off-tumor (OTOT) toxicity has historically limited single-antigen approaches in clear cell renal cell carcinoma (ccRCC), where promising targets such as CAIX are also expressed on critical normal tissues. To overcome this, we developed the Logic-gated INtracellular networK (LINK) platform, a Boolean AND-gate a …

01.09.2026journal-article

Journal of Oncology Pharmacy Practice

CAR-T cell therapy in advanced practice nursing management. A Statistical and Large Language Model approach to highlight critical issues

Elsa Vitale, Luana Conte, Giuliana Nepoti, Camilla Munaretto, Giorgio De Nunzio, Anna Vaccaro

Aim To gather nurses’ perceptions nursing hematologic management on patients undergoing CAR-T cell therapy. A combined approach using statistical analysis and Large Language Model for open-ended questionnaire processing (LLMs) was adopted to analyze and interpret open-ended questionnaire responses, focusing on the critical issues in managing patients’ post-CAR T-cell therapy infusion. Design Observational questionnaire-based survey study. Methods We analyzed data through descriptive statistical methods and used gen …