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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Clinical Medicine

Effects of Physical Activity on Motor Development, Balance, and Psychosocial Well-Being in Children and Adolescents with Down Syndrome: A Systematic Review

Ignazio Leale, Manuel Gómez-López, Martina Macaluso, Daniela Smirni, Michele Roccella, Marianna Alesi, Giuseppe Battaglia

Background: Physical activity is relevant for physical and psychosocial development in children and adolescents with Down syndrome. However, evidence regarding the effects of structured physical activity interventions across different motor and psychosocial domains remains limited and heterogeneous. This systematic review aimed to examine the effects of structured physical activity interventions on motor and psychosocial outcomes in this population. Methods: The review was conducted according to PRISMA guidelines a …

03.09.2026journal-article

Current Pain and Headache Reports

Evolving Treatment Options for Spinal Pain: Balancing Innovation and Affordability in Regenerative Medicine

Annu H. Navani, Sudhir A. Diwan, Douglas P. Beall, Edward S. Rubin, Ahmed I. Anwar, Alan D. Kaye

Abstract Purpose of Review Regenerative approaches for treating spinal pain hold great clinical promise but have the potential to disrupt healthcare upending the cost paradigm of pharmacologic care or interventional procedures. Regenerative approaches have higher upfront costs but may offer long-lasting, even curative benefits. In today’s healthcare system, it is important to understand the cost-effectiveness of regenerative approaches using mesenchymal stem cells (MSC), platelet-rich plasma (PRP), and other biolog …

03.09.2026journal-article

Pakistan Journal of Positive Psychology

Pathways to Borderline Personality Traits: Parental Differential Treatment, Adverse Childhood Experiences, and Loneliness among Emerging Adults

Zarish Zaman, Saba Sajjad

In this study, emerging adults’ PPDT, ACEs, and loneliness on developing BPT were studied. Purposive sampling was used to choose 240 emerging adults, ages 18- 25 years. Standardized tools including Sibling Inventory of Differential Experience–Revised (SIDE-R), Adverse Childhood Experiences Questionnaire (ACE-Q), UCLA Loneliness Scale Version 3, McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD) were used to collect the data. Results showed that maternal and paternal differential affection had …

03.09.2026journal-article

Journal of Clinical Medicine

Fluoroless Workflow for Pulsed Field Ablation of Atrial Fibrillation Using the Sphere-9 and VARIPULSE Catheters

Rachita Kour, Anthony Costa, Shakeel Jamal, Fayaz Hakim, Hassaan Imtiaz, Khalil Kanjwal

Background: Catheter ablation is the most effective rhythm-control strategy for symptomatic atrial fibrillation (AF). A fluoroless approach eliminates ionizing radiation exposure for patients, operators, and laboratory staff and removes the ergonomic burden of leaded protective garments. Pulsed field ablation (PFA) is a predominantly non-thermal energy modality with a distinct safety profile, now addressed in dedicated international consensus documents. Several PFA catheters are natively integrated with three-dimen …

03.09.2026journal-article

TH Open

The Inflammation–Thrombosis Genetic Axis in Abdominal Aortic Aneurysm: A Shared Roadmap to Precision Medicine

Yanfei Yang, Yuhang Liu, Yuexin Chen

Abstract Abdominal Aortic Aneurysm (AAA) is characterized by persistent inflammation, extracellular matrix loss, and intraluminal thrombus formation, yet the genetic links among these processes remain incompletely defined. Here, we examine evidence that genetic variation can influence inflammatory and thrombotic responses at the same time. Findings from genome-wide association studies are considered alongside transcriptomic, proteomic, single-cell, epigenetic, and experimental data. Particular attention is given to …

03.09.2026journal-article

Frontiers in Medicine

Complete blood count-derived myeloid-lymphoid inflammatory phenotype in rheumatoid arthritis complicated by acute myocardial infarction: an age- and sex-balanced retrospective study

Jing Zhang, Ji Li, Yuwei Wang, Lina Zhang, Di Jin, Sheng-Guang Li, Yuhua Yan

Background Rheumatoid arthritis (RA) is associated with excess cardiovascular morbidity, including acute myocardial infarction (AMI). Routine complete blood count (CBC)-derived inflammatory indices are clinically accessible, but their value for characterizing cardiovascular comorbidity in RA remains incompletely defined. We examined whether CBC-derived markers form a coordinated myeloid-lymphoid inflammatory phenotype associated with AMI in patients with RA. Methods We retrospectively analyzed 110 healthy controls, …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Systemic immune-inflammation index as a prognostic marker in heart failure with non-dialysis chronic kidney disease: a two-cohort derivation and validation study with head-to-head comparison against natriuretic peptides

Tao Chen, Manyang Chen, Mingzhu Hong, Minghui Zhu, Can Chen

Introduction Heart failure (HF) and chronic kidney disease (CKD) frequently coexist and share chronic low-grade inflammation, oxidative stress, and thrombotic activation. Natriuretic peptides remain the cornerstone of HF prognostication, but their interpretation is confounded by reduced renal clearance, leading to false elevations and attenuated prognostic specificity in CKD. The systemic immune-inflammation index (SII), derived from routine blood counts, integrates neutrophil-driven inflammation, lymphocyte-mediat …

03.09.2026journal-article

Frontiers in Immunology

Development and external validation of a clinical-genetic risk identification model for rheumatoid arthritis-associated interstitial lung disease

Wei Fan, Wei Bo, Xuanhua Yu, Xiaojuan Gao, Jinmei Huang, Yi Zhang, Shufan Wu, Xuyan Chen, Liangjing Lu, Hanlin Yin

Objective This study aimed to develop and externally validate a clinical risk identification model for prevalent rheumatoid arthritis-associated interstitial lung disease (RA-ILD) using multicenter Chinese patient cohorts. We also evaluated the discriminative value of MUC5B polymorphisms (rs35705950 and rs868903) in a combined clinical-genetic model for this purpose. Methods A multicenter, two-phase design was adopted. A total of 446 patients with rheumatoid arthritis (RA) from five medical centers were retrospecti …

03.09.2026journal-article

Frontiers in Neuroscience

Amino acid profiles and clinical phenotypes in young children with autism spectrum disorder

Ilaria Serati, Luca Lalli, Andrea Riccardo Dallapiccola, Pietro Baso, Martina Tosi, Francesca Brustia, Maria Paola Canevini, Michele Mussap, Livia Pisciotta, Emilia Ricci, Maura Rossi, Marco Di Dario, Maria Cristina Straface, Amanda Papa, Sabrina Fede, Salvatore Fazzone, Elena Spada, Federica Gioia, Roberto Longo, Pierangelo Veggiotti, Gianvincenzo Zuccotti, Cristina Cereda, Bruno Mario Cesana, Simona Ferraro

Introduction In 394 children with autism spectrum disorder (ASD), we investigated the association between plasma amino acid (AA) concentrations and clinical phenotypes. Methods Multivariable logistic regression models were used to evaluate the associations between 22 AAs and clinical features, reporting odds ratios. Results The median age at diagnosis was 3.5 years (interquartile range: 2.8–4.6 years) for boys and 3.1 years (interquartile range: 2.3–3.8 years) for girls; 81.5% of the participants were boys. A 25-un …

03.09.2026journal-article

Parasitology Research

Persistence of Theileria orientalis Chitose genotype on a closed dairy farm: possible vertical transmission and limited clearance after buparvaquone treatment

Mengyang Li, Tian Xie, Huan Liu, Li Tian, Jingjiao Yan, Chunlei Du, Chuanwen Wang, Haiyong Hui, Junlong Liu

Abstract Theileria orientalis comprises tick‑borne protozoan parasites that can cause substantial economic losses in cattle. We previously reported an outbreak of oriental theileriosis associated with mixed T. orientalis Ikeda and Chitose infection on a closed dairy farm. However, the predominant genotype and the mechanisms underlying long-term persistence under closed-herd management remain unclear. In December 2024, conventional PCR detected T. orientalis in 41 of 147 periparturient cows; sequencing of MPSP ampli …

03.09.2026journal-article

Frontiers in Surgery

Optimizing ambulatory groin hernia repair in public healthcare frameworks: a prospective analysis of predictive factors for discharge failure

Jihen Krichen, Asma Sghaier, Rana Dhouib, Slah Souii, Maissa Tioumi, Sihem Sindi, Bilel Faidi, Khalil Ben Salah

Background Outpatient groin hernia repair is widely recommended globally due to clinical and socioeconomic efficiency, yet it remains underutilized in developing healthcare systems like Tunisia. This study aimed to evaluate the feasibility of a newly implemented day-surgery clinical pathway for groin hernias and identify specific predictors associated with outpatient discharge failure. Methods A prospective, observational cohort study was conducted at a Tunisian tertiary hospital between September 2023 and April 20 …

03.09.2026journal-article

Clinical and Translational Imaging

Dynamic PSMA total-body PET/CT in prostate cancer: technical principles and clinical potential

Yongkang Shuai, Irene Brusa, Riccardo Mei, Stefano Fanti

Abstract Background The incidence of prostate cancer continues to rise worldwide. While conventional static PET/CT provides semi-quantitative metrics, total-body PET/CT enables voxel-level dynamic imaging and parametric imaging, demonstrating great potential for clinical applications in prostate cancer. Therefore, this review synthesizes the technical principles of dynamic PSMA total-body PET/CT and its emerging clinical applications in prostate cancer, providing a novel clinical insight for individualized patient …

03.09.2026journal-article

Gastric Cancer

Clinical impact of CT-defined sarcopenia on long-term oncological outcomes in gastric cancer: validation of muscle mass cut-offs established according to EWGSOP recommendations

Jasmin Hasanovic, Paul Friedrich Esslinger, Veronika Lummer, Heiner Nebelung, Leo Misera, Ralf-Thorsten Hoffmann, Johanna Kirchberg, Marius Distler, Jürgen Weitz, Daniel E. Stange, Felix Merboth

Abstract Background Sarcopenia is an important prognostic factor in gastrointestinal malignancies, but CT-based definitions vary. This study evaluated recently published computed tomography (CT)-based cut-offs for skeletal muscle index (SMI) and psoas muscle thickness normalized to height (PMTH), derived from a young, presumably healthy reference population according to recommendations of the European Working Group on Sarcopenia in Older People (EWGSOP), in patients undergoing surgery for gastric cancer. Methods Th …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure

Chunxiao Zhao, Jiahao Liu, Juanjuan Xin, Qun Liu, Ying Zhang, Xiaochun Yu, Junhong Gao

Cardiovascular diseases rank as the global primary cause of mortality. Heart failure (HF) represents a progressive cardiac syndrome triggered by structural or functional myocardial damage that compromises ventricular systolic output. Intracellular calcium homeostasis underpins cardiomyocyte excitation-contraction coupling. Calcium overload and dysregulated calcium handling act as central pathogenic forces driving HF progression. Sympathetic β 1 -adrenergic receptor (β 1 -AR) and parasympathetic M 2 muscarinic acety …

03.09.2026journal-article

Frontiers in Public Health

Traditional Chinese medicine reimbursement reform in China: implementation progress, policy constraints, and optimization strategies

Fazheng Zhao, Yichi Chen, Xin Tong

Introduction As the inheritance, innovation, and development of TCM advance, medical insurance reimbursement policies are intended to improve access, guide service structure, and support high-quality development. This study examines the implementation progress, policy constraints, and optimization paths of TCM reimbursement reform in China. Methods The study analyzes publicly available national and regional policy documents, together with secondary literature, to synthesize the policy design, implementation arrange …

03.09.2026journal-article

Biology

Biological Foundation Models for Complex Disease Research and Clinical Translation

Tiana Noll-Walker, Yong Chen

Complex diseases, including cancer, rare genetic disorders, neurodevelopmental and psychiatric conditions, and neurodegenerative diseases, arise from interactions among genetic variation, gene regulation, and cellular states that are difficult to capture using a single data type or biological scale. Biological foundation models address this challenge by treating nucleotides and genes as tokens and learning representations that can be transferred to downstream biomedical and clinical tasks. In this review, we examin …

03.09.2026journal-article

ACS Applied Materials & Interfaces

Delivery of CAR T Cells in a Magnesium-Functionated Hydrogel Boosts Peritoneal Metastasis Treatment

Junlin Li, Xutao Liu, En Ren, Ziyan Liao, Huipeng Zhang, Qiujun Qiu, Jiaqi Shi, Xin Gong, Wenyue Lv, Zhen Gu, Hongjun Li

Abstract Chimeric antigen receptor (CAR) T cells show limited efficacy in solid tumors due to suppressive factors in the tumor microenvironment. In this study, we identified extracellular magnesium (Mg2+) as a pharmacologically modulable regulator of CAR T activity. Mg2+ supplementation increased early activation and augmented cytotoxic readouts, including IFN-γ secretion and target-cell lysis. To localize this cue, we engineered a phosphorylated hyaluronic-acid hydrogel ionically cross-linked by Mg2+ (HA-Mg Gel), …

03.09.2026journal-article

Sensors

Mechanical Fault Diagnosis of High-Voltage Circuit Breakers Based on Multi-Sensor Gramian Angular Field and Deep Residual Network

Xining Li, Hanyan Xiao, Ke Zhao, Lei Sun, Tianxin Zhuang, Haoyan Zhang, Hongwei Mei

The mechanical reliability of high-voltage circuit breakers (HVCBs) is crucial for power-grid stability, yet traditional diagnostic methods rely heavily on manually extracted scalar features that can discard transient information. This paper presents a mechanism-aware diagnostic pipeline that combines synchronized coil-current, contact-travel, and spring-pressure measurements; Variational Mode Decomposition (VMD); kinematics-driven Region of Interest (ROI) alignment; Gramian Angular Field (GAF) encoding; RGB channe …

03.09.2026journal-article

Biology

Deconstructing the Alternative Lengthening of Telomeres: Integromics Prioritizes Five Master Hubs Dictating Clinical Survival and Therapeutic Vulnerabilities

Isaac Armendáriz-Castillo, Santiago Guerrero, Andrés Herrera-Yela, Jhommara Bautista, Andrés López-Cortés

The Alternative Lengthening of Telomeres (ALT) pathway drives replicative immortality in aggressive malignancies, particularly sarcomas and gliomas. Clinical ALT stratification has relied on screening for structural ATRX and DAXX mutations. However, this genotypic approach fails to capture the dynamic macro-reprogramming required to sustain ALT. Here, we established and validated a 28-gene transcriptomic signature that captures the ALT-associated transcriptomic phenotype of the ALT phenotype. Using multivariate Cox …

03.09.2026journal-article

PLOS Global Public Health

The impact of social protection interventions on treatment and socioeconomic outcomes of tuberculosis-affected people and households in low income, high burden settings: A systematic review and meta-analysis

Mollie Hudson, Heather Todd, Talemwa Nalugwa, Ann Schraufnagel, Canice Christian, Delia Boccia, Tom Wingfield, Priya B. Shete

Tuberculosis (TB) is the leading cause of death due to infectious disease worldwide. Social protection interventions can benefit TB-affected households. We conducted a systematic review and meta-analysis to quantify the effectiveness of social protection on TB treatment and socioeconomic outcomes. We identified articles published from January 2012 to December 2025 by searching PubMed (includes MEDLINE), Embase, and Web of Science. We included studies that described at least one social protection intervention and re …

03.09.2026journal-article

Annals of Plastic Surgery

Reconstruction of the Pelvic Floor With a Gluteus Maximus–Including Posterior Thigh Flap After Total Pelvic Exenteration

Yoshihiko Tamanoi, Kakuru Otsubo, Tomoyuki Koike, Kenichi Kokubo, Ayato Hayashi

Background: Total pelvic exenteration (TPE) creates a massive pelvic dead space associated with a high risk of severe postoperative complications. We evaluated the clinical outcomes of pelvic floor and perineal reconstruction using a modified posterior thigh flap including the gluteus maximus muscle in patients undergoing TPE for anal canal cancer. Patients and Methods: We retrospectively reviewed 4 male patients who underwent this reconstruction at our institution between April 2020 and March 2025. Clinical outcom …

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Lipoprotein(a) measurement: challenges and opportunities

John H. Contois

Abstract Lipoprotein(a) [Lp(a)] is a causal, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. New guidelines recommend testing everyone at least once in a lifetime, and with new drugs specifically targeting Lp(a) on the horizon, accurate measurement remains vitally important. Yet, its measurement has for decades been challenging because of apolipoprotein(a) size heterogeneity, imperfect calibration strategies, and mixed use of mass (mg/dL) vs. molar (nmol/L) uni …

03.09.2026journal-article

Clinical and Translational Oncology

Prognostic modeling of overall survival in metastatic pancreatic cancer: an inflammation-based tool validated in PANTHEIA-SEOM cohort

Vilma Pacheco-Barcia, Axel Mariño-Mendez, María Ángeles Vicente Conesa, María de Toro Carmena, Paula Cerdà Serdà, Carmen Guillen-Ponce, Mónica Benavente Lucas, Raquel Hernández San Gil, Ángela Lamarca, Javier Gallego, Maria Luisa Soriano Tabares de Nava, Jorge Hernando, Elena Brozos-Vazquez, Ana López-Alfonso, Jorge Adeva, Ismael Ghanem, Sandra Soriano, Javier Soto-Alsar, Andrés Muñoz, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas

Abstract Purpose To develop and internally validate the PANTHEIA-SIRI prognostic model, which integrates log-transformed systemic inflammation response index (SIRI) with clinical predictors, to estimate overall survival (OS) in metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with first-line chemotherapy. Methods We used data from the multicenter PANTHEIA-SEOM registry. OS was defined from chemotherapy start. The model was fitted as a Weibull accelerated failure time model in the survival-analysis popula …