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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Oncology

Beyond the snapshot: continuous optical surface monitoring reveals non-linear temporal dynamics and postural stability window in free-breathing breast radiotherapy

Wenlingjie Huang, Ying Peng, Tiandi Zhao, Jinna Li, Haitao Sun, Ruilin Zhang, Jiashuang Zhang, Ping Jiang, Junjie Wang

Purpose This study aimed to evaluate the clinical consistency between AlignRT surface monitoring and fan-beam computed tomography (FBCT)–based single-timepoint volumetric verification in free breathing (FB) breast radiotherapy, and to quantitatively characterize the nonlinear temporal dynamics of intrafractional motion. Materials and methods A retrospective analysis was conducted on 485 FB volumetric modulated arc therapy (VMAT) fractions from 38 patients treated following breast conserving surgery. Intrafractional …

03.09.2026journal-article

Frontiers in Immunology

Emerging CAR-Treg and regulatory T cell therapies for inflammatory bowel diseases: a systematic review of a new era of treatment

Fabio Suarez-Trujillo, Theodore S. Steiner, Javier P. Gisbert, María Chaparro

Background Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by dysregulated mucosal immunity. Despite major advances in therapies, a high proportion of patients do not achieve or sustain remission. Cellular immunotherapies have emerged as a mechanistically distinct therapeutic strategy with potential relevance for refractory disease. In the present paper, the authors aim to evaluate the rationale and current evidence supporting chimeric antigen receptor (CAR)-engineered immune ce …

03.09.2026journal-article

Frontiers in Child and Adolescent Psychiatry

Acceptability and feasibility of the Ushirikiano treatment model for Kenyan adolescents: a pilot randomized controlled trial

Nabila Amin Ali, Shillah Mwaniga Mwavua, Obadia Yator, Joseph Kathono, Anja C. Huizink, Manasi Kumar

Introduction Adolescents in low- and middle-income countries experience high rates of common mental disorders (CMDs) but have limited access to adolescent-friendly, evidence-based care. While Interpersonal Psychotherapy for Adolescents (IPT-A) is effective, brief group IPT-A delivered through task-shifted, stepped-care has not been rigorously evaluated in Kenyan primary care. Methods We conducted a pilot randomized controlled trial to examine the acceptability, feasibility, and preliminary effectiveness of the Ushi …

03.09.2026journal-article

Frontiers in Oncology

Perioperative CALLY dynamics after curative gastrectomy for gastric adenocarcinoma: associations with nodal tumor burden, textbook surgical outcome, and disease-free survival

Adem Ozcan, Gizem Gunes

Background The C-reactive protein–albumin–lymphocyte index (CALLY) integrates inflammation, nutrition, and cellular immunity. Its relationships with nodal tumor burden and within-patient postoperative recovery after gastrectomy remain unclear. Methods This retrospective cohort included 188 patients undergoing R0 gastrectomy for non-metastatic gastric adenocarcinoma. Preoperative CALLY was evaluated in relation to metastatic lymph node count, lymph node ratio (LNR), log odds of positive lymph nodes (LODDS), and pN s …

03.09.2026journal-article

Frontiers in Oncology

Case Report: High-grade supratentorial CNS neoplasm with EP300::BCOR fusion in an adult: expanding the morphologic and molecular spectrum of BCOR-fused tumors

Samer Abdulkader-Sande, Alberto Garrido, Andrea Durán-Cameselle, Concepción Fiaño-Valverde, Luis Ruiz-de Almiron, Brais Perez, Isaura Fernandez-Perez

Tumors of the central nervous system harboring alterations of BCOR comprise a heterogeneous and evolving group of neoplasms. CNS tumors with BCOR internal tandem duplication are recognized as a distinct WHO entity, whereas tumors harboring EP300/CREBBP::BCOR/BCORL1 fusions represent an emerging and less clearly defined group with overlapping but non-identical morphologic and immunophenotypic features. We report a 42-year-old man with a supratentorial high-grade CNS neoplasm initially interpreted as a glial tumor wi …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Primary inferior vena cava leiomyosarcoma with hepatic metastases initially misinterpreted as primary hepatic leiomyosarcoma – ultrasonographic features and diagnostic insights

Yimei Deng, Yu Song, Shasha Shi, Rui Cong

Background Leiomyosarcoma of the inferior vena cava is a rare and malignant soft tissue tumor. Diagnosis is often delayed due to non-specific symptoms. Imaging is crucial, yet preoperative differentiation remains challenging. Case presentation A 59-year-old woman presented with a two-year history of right upper quadrant pain. Initial ultrasound revealed a large, well-defined, hypoechoic hepatic mass (10.6 × 7.8 cm) with heterogeneous echotexture featuring multiple strip-like hyperechoic regions and irregular anecho …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Treatment shortening and relapse control in drug-susceptible pulmonary tuberculosis: a network meta-analysis of randomized trials

Fengjie Tang, Juan Li, Qihuan Ma, Shasha Tao, Ling Zhou, Yanmei Feng

Drug-susceptible pulmonary tuberculosis (DS-PTB) is conventionally treated with a 6-month multidrug regimen, but prolonged treatment may compromise adherence, prompting efforts to develop shorter and effective therapeutic strategies. However, the comparative long-term effectiveness of alternative regimens, particularly their ability to prevent relapse, remains uncertain. We systematically searched multiple databases from inception through August 31, 2025, for randomized controlled trials enrolling adolescents and a …

03.09.2026journal-article

Frontiers in Oncology

Exploring traditional Chinese medicine to enhance the efficacy and reduce toxicity of immunotherapy for non-small cell lung cancer from the perspective of “spleen deficiency”: a trial protocol for mechanism and clinical evidence

Cunya Li, Xiaonan Zhang, Shujuan Fu, Pantong Wu, Zhiying Wang, Zhixian Zhong, Yi Zhong

Introduction Although immune checkpoint inhibitors (ICIs) have changed the treatment landscape of advanced non-small cell lung cancer (NSCLC), their low response rates and immune-related adverse reactions (irAEs) remain serious challenges. Traditional Chinese medicine believes that “spleen deficiency” is the core pathogenesis of advanced lung cancer, and its corresponding immune suppression and metabolic disorders may be related to the efficacy of ICIs. This paper aims to explore the clinical application status and …

03.09.2026journal-article

Frontiers in Cell and Developmental Biology

Artificial-intelligence- and multi-omics-guided predictive and drug repurposing framework construction for colorectal cancer: evidence from succinylation–neutrophil signatures

Huimin Jie, Huaying Huo, Jiamei Wang

Background Succinylation-linked metabolic rewiring and neutrophil-driven inflammation are key drivers of colorectal carcinoma (COAD) progression; however, they have rarely been translated to an end-to-end artificial intelligence (AI) drug-design pipeline connecting target nomination, resistance-relevant tumor microenvironment states, and candidate evaluation. Methods We integrated bulk transcriptomes from The Cancer Genome Atlas colon adenocarcinoma (TCGA-COAD) and Gene Expression Omnibus databases to derive succin …

03.09.2026journal-article

Sage Sphere International Journal

Cirugía laparoscópica versus cirugía robótica en la resección de tumores hepáticos: resultados y beneficios clínicos

Joel Sebastian Chango Yosa, Kelvin Alejandro Torres Quezada, Mario Gabriel Salas Martínez, Dana Isabel Morales Figueroa, Alonso Patricio Espinoza Ayala

Introducción: La resección hepática constituye el tratamiento principal de diversos tumores hepáticos. Los abordajes laparoscópico y robótico han ampliado las posibilidades de cirugía mínimamente invasiva, especialmente en procedimientos técnicamente complejos. Objetivo: Sintetizar la evidencia científica sobre los resultados y beneficios clínicos de la cirugía laparoscópica versus robótica en la resección de tumores hepáticos. Metodología: Se realizó una revisión bibliográfica narrativa mediante búsquedas en PubMe …

03.09.2026journal-article

Frontiers in Oncology

Analysis of clinical features and outcomes in a Chinese cohort with ALK fusion across pan-cancer: a retrospective study

Meng Zhang, Yi Feng, Xue Du, Changda Qu, Meizhu Meng, Meiying Ye, Min Liang, Ziran Yang, Wenjuan Gong, Xingyu Ma, Jialiang Guo, Wenmei Li, Shuqin Jia

Background ALK fusions are validated oncogenic drivers, yet their molecular heterogeneity and therapeutic implications remain poorly characterized. This study defined the landscape of ALK fusion partners, EML4-ALK variants, and co-mutations and their impact on treatment responses in a large Chinese pan-cancer cohort. Methods We retrospectively analyzed 16,335 consecutive pan-cancer patients via next-generation sequencing to identify ALK fusions. Clinical characteristics, fusion partners, co-mutations, and treatment …

03.09.2026journal-article

Frontiers in Oncology

The learning curve of robotic esophagectomy: a systematic review with a proposed training and competency assessment framework

Konstantinos Kossenas, Adam Mylonakis, Dimitrios V. Avgerinos, Emmanouil I. Kapetanakis, Orestis Lyros, Ioannis Rouvelas, Ioannis Karavokyros, Dimitrios Schizas

Background Robotic-assisted minimally invasive esophagectomy (RAMIE) is a significant evolution in esophageal cancer surgery, providing improved visualization, dexterity and operative precision. However, RAMIE is technically demanding and has a steep learning curve. The goal of this systematic review was to assess the existing evidence on the learning curve of robotic esophagectomy and to develop a structured training and assessment framework for RAMIE. Methods We performed a systematic literature search in PubMed/ …

03.09.2026journal-article

Frontiers in Oncology

Oral selective estrogen receptor degraders in ER+/HER2− breast cancer: a systematic review with pooled analysis of metastatic randomized trials and narrative synthesis of adjuvant evidence

Bing Guan, Sijia Zhang, Rong Zhou, Yawen Chen, Lulu Li, Ping He

Background Oral selective estrogen receptor degraders (SERDs) have become a key therapeutic option for hormone receptor-positive, HER2−negative advanced breast cancer. The recent presentation of lidERA—the first positive adjuvant Phase III trial of any oral SERD—necessitates a comprehensive evidence synthesis spanning both early and advanced disease settings, beyond the scope of existing meta-analyses confined to metastatic disease. Methods This review was prospectively registered (PROSPERO CRD420261358420). We sea …

03.09.2026journal-article

BMC Cancer

Towards a universal ovarian cancer biomarker model: clinical validation of Trx1 and CA125 dual strategy

Mi A Park, Songhak Kim, Xiaoguang Yang, Jong Am Song, Geon Woo Lee, Heon Jong Yoo, Soyoung Kim, Kyoung Hoon Suh, Young Bok Ko

Abstract Background Ovarian cancer is the fifth leading cause of cancer-related mortality in women, with early detection being critical for improving patient outcomes. Current diagnostic biomarkers, including Cancer antigen 125 (CA125), human epididymis protein 4 (HE4), and their combined Risk of Ovarian Malignancy Algorithm (ROMA), exhibit limited sensitivity and specificity, particularly in early-stage disease and premenopausal women. Thioredoxin-1 (Trx1) has emerged as a potential complementary biomarker. This e …

03.09.2026journal-article

Frontiers in Oncology

Arginine is a protective factor for risk and prognosis of gastric cancer: an observational and Mendelian randomization study

Yuanyuan Wang, Yutong Xing, Zhitu Zhu

Background Previous research has indicated that certain amino acids possess anti-tumor properties. However, the impact of blood amino acid levels on the risk of gastric cancer remains uncertain, and a comprehensive analysis examining the association between blood amino acids and the prognosis of gastric cancer is lacking. Methods We performed a Mendelian randomization analysis to explore the link between 22 blood amino acids and gastric cancer risk. We also assessed how these amino acids affect gastric cancer progn …

03.09.2026journal-article

Frontiers in Human Neuroscience

The association between nonverbal fluency and anomia treatment outcomes in people with post-stroke aphasia

Deena Schwen Blackett, Victoria A. Diedrichs, Alexandra Zezinka Durfee, Courtney C. Jewell, Stacy M. Harnish

Introduction Many people with aphasia experience concomitant executive functioning deficits, and the literature supports a role of executive functioning in treatment response. However, the optimal executive functioning assessment for measuring this impact is unclear, as is the extent to which outcomes (e.g., acquisition, generalization) may be impacted differently. The present retrospective study aimed to determine the degree to which nonverbal fluency, one measure of executive functioning with minimal language dem …

03.09.2026journal-article

Frontiers in Medicine

PD-1/PD-L1 inhibitors combined with chemotherapy as first-line treatment for advanced biliary tract cancer: a systematic review and meta-analysis

Hongye Geng, Chengyuan Lu, Shuling Wang, Lijuan Tian

Objective To systematically evaluate the efficacy and safety of PD-1/PD-L1 inhibitors plus chemotherapy as first-line treatment for advanced biliary tract cancer (BTC). Methods PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases were searched for RCTs and retrospective studies. Meta-analysis was performed using R 4.6.1 software with the meta (v8.5–0) and metafor (v5.0–1) packages. The full R code and datasets are provided in the supplementary material to ensure reproducibility. Result …

03.09.2026journal-article

Frontiers in Oncology

Comparison of patient-reported outcomes and healthcare utilization between metastatic colorectal cancer patients receiving systemic therapy with or without concurrent palliative care support: a retrospective cohort study

Xiaoli Liu, Fangtuan Wu, Lunlan Li

Background Patients with metastatic colorectal cancer (mCRC) experience substantial symptom burden, yet evidence on the integration of specialist palliative care (PC) in real-world settings remains limited. We assessed the impact of concurrent PC on patient-reported outcomes and healthcare utilization. Objective To evaluate the impact of integrating professional palliative care (PC) with standard systemic therapy on patient-reported outcomes, medical resource utilization, and overall survival (OS) in metastatic col …

03.09.2026journal-article

Frontiers in Immunology

Traditional Chinese medicine remodels the immune microenvironment of colorectal cancer: mechanisms and therapeutic perspectives

Zeanbang Shi, Jie Mei, Qinchang Zhang, Liu Li, Haibo Cheng

Colorectal cancer (CRC) is a common malignancy of the digestive tract, and its initiation and progression are closely associated with dysregulation of the tumor immune microenvironment. The CRC immune microenvironment consists of effector immune cells, immunosuppressive cells, inflammatory mediators, immune checkpoint pathways, stromal cells, the extracellular matrix, the gut microbiota, and microbial metabolites. Its pathological features include impaired immune recognition and effector immunity, enhanced immunosu …

03.09.2026journal-article

Frontiers in Immunology

Immune evasion driven by lipid metabolic reprogramming in endocrine-resistant HR+ breast cancer: antigen presentation defects and T-cell dysfunction

Lutian Gong, Yujing Zhao, Minglu Che, Xiangyang Zhang, Dongni Zhang, Wenping Lu

Endocrine therapy has improved the prognosis of patients with hormone receptor-positive (HR + ) breast cancer. However, acquired resistance remains a major cause of recurrence and progression, and the limited response of this subtype to immunotherapy highlights the need to better understand the mechanisms underlying immune escape. Recent studies indicate that, in addition to an immunosuppressive microenvironment, alterations in antigen processing and presentation may also contribute to immune escape, although syste …

03.09.2026journal-article

Frontiers in Immunology

Complete and durable remission in a patient with brain metastasis from gastric cancer treated with SRS followed by RC48 plus camrelizumab after progression on chemo-immunotherapy: a case report and literature review

Xiao Liu, Baozhen Ma, Mengjiao Yang, Lingdi Zhao

Background Brain metastasis from gastric cancer carries a dismal prognosis, with median overall survival of only 3–6 months. Patients who progress on immune checkpoint inhibitor (ICI)-containing regimens have limited salvage options. HER2-low expression (IHC 1+ or IHC 2+/FISH-negative), historically excluded from anti-HER2 therapy, has now emerged as a novel therapeutic target for antibody-drug conjugates (ADCs) such as RC48 (disitamab vedotin). Case summary A 52-year-old male with HER2-low (IHC 2+/FISH-negative), …

03.09.2026journal-article

Frontiers in Surgery

Comparison of ACDF with stand-alone PEEK cage versus zero-p implant for the treatment of cervical degenerative disease: a systematic review and meta-analysis

Yiheng Zhao, Juan Xie, Ling Zhu, Jianna Zhang, Junhui Zhang

Introduction In recent years, stand-alone polyetheretherketone (PEEK) cages (SA) and Zero-P implants (ZP) have been widely adopted clinically in anterior cervical discectomy and fusion (ACDF) for cervical degenerative disease (CDD). However, which is superior between SA and ZP remains highly controversial. This meta-analysis was designed to conduct a head-to-head comparison of the safety, clinical efficacy, and radiological effectiveness of ACDF with ZP and SA. Methods This research was carried out in accordance wi …

03.09.2026journal-article

Journal of Palliative Medicine

Palliative Surgery to Restore Function and Dignity: A Case of Massive Breast Tumor Debulking in Rural Uganda

Simran Kripalani, Howard Eison, Goretti Nassali, Prossy Nafula, Benjamin Schwarz, Randi Diamond

Background: Palliative surgery plays a critical role in alleviating symptom burden and thus improving quality of life in patients with advanced disease. Case Presentation: This is a case of a 23-year-old female in rural Uganda with an untreated, massive right breast mass present since infancy and progressive abdominal distention of unclear etiology. Over time, the breast mass impaired her mobility, rendering her largely homebound and dependent on others for basic movement. Despite evidence of profound malnutrition, …

03.09.2026journal-article

Frontiers in Oncology

A collision tumor of buccal squamous cell carcinoma and diffuse large B-cell lymphoma: a case report and literature review

Xiao Pang, Ying Long, Hui Wang, Zhang Zhang

Background Collision tumors are rare entities in which two histologically distinct malignancies coexist in close proximity without histological admixture or transition. The coexistence of buccal squamous cell carcinoma (SCC) and diffuse large B-cell lymphoma (DLBCL) in the oral region is exceptionally uncommon. Because the clinical and radiological findings may overlap, such cases can pose substantial diagnostic and therapeutic challenges. Case presentation We report a case of a 66-year-old man with a long history …