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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Microbial Drug Resistance

Using an Online Registry of Carbapenemase-Producing Gram-Negative Organisms to Report the Clinical Profile, Outcomes, and Phenotypic and Genotypic Resistances in Two Tertiary Level Hospitals in the Philippines (ORiGiN Study)

Cybele Lara R. Abad, Adrian Ronald A. Espino, Veil Maria T. Castro, Andrei Dominique Montero, Mark B. Carascal, Shanaia Esthelle Joy Daguit, Eariel Francisco, Lawrence S. Macalalad, Kim L. Cochon, Danice Faith Alombro, Benjo P. Ato, Jayson Lumasag, Ralph Bryan B. Hernandez, Anna Flor G. Malundo, Christel V. Gutierrez, Justin Allister Ong, Heather Gutierrez, Karl Abalajon, Marc Agnew M. Cajucom

Background: This study describes the clinical profiles, phenotypic and genotypic resistance mechanisms, and outcomes of patients with carbapenem-resistant infections (CRIs) using a registry. Methods: Hospitalized adults with CRIs in two tertiary institutions were included in this prospective study from January 1, 2023, to December 31, 2025. Results: A total of 411 patients were included. Half were male (207/411, 50.4%), with median age 59 (range 19–98) years. Hypertension (251, 65.5%), diabetes mellitus (150, 39.2% …

03.09.2026journal-article

Plastic & Reconstructive Surgery

Balancing the Breast: Transsternal Cable Grafts as a Libra in Mastopexy for Long Term Symmetry and Projection

Ulaş Bali, Berrak Karatan, Aziz Parspanci

Recurrent ptosis, loss of upper pole fullness, and postoperative asymmetry remain persistent challenges in mastopexy surgery. Most conventional techniques primarily rely on a vertical support vector, which may be insufficient to resist long-term gravitational descent and asymmetric settling. To address these limitations, we describe a modified mastopexy technique using transsternal dermal cable grafts to provide additional horizontal vector support and improve breast stability. The technique was performed in 75 wom …

03.09.2026journal-article

BMC Medicine

Diagnostic accuracy of attended versus unattended automated blood pressure measurements compared to ambulatory blood pressure monitoring conducted by community health workers in rural sub-Saharan Africa

Ruth K. Lucinde, Modou Jobe, Alexander D. Perkins, Juliet O. Awori, Boniface Karia, Lamin Jobarteh, Robinson Oyando, Catherine Kalu, Sampa Sanneh, Clement Mwagwabi, Elminah Saru, Aurelia Brazeal, Samson Kinyanjui, Robert N. Peck, David A. Leon, Andrew M. Prentice, Benjamin Tsofa, Anoop S.V. Shah, Pablo Perel, Anthony O. Etyang, on behalf of the IHCoR-Africa Collaborators

Abstract Background Community Health Workers (CHWs) are increasingly being involved in screening for hypertension in rural sub-Saharan Africa. However the diagnostic accuracy of CHW-led attended (CHW present during procedure) and unattended (CHW absent) automated blood pressure (BP) in home settings has not been compared. Methods We conducted a cross-sectional, population-based diagnostic accuracy study in two health and demographic surveillance systems in Kenya and The Gambia. A random age-stratified sample of ind …

03.09.2026journal-article

Journal of Pharmaceutical Research and Integrated Medical Sciences

Multimodal AI and Machine Learning for Predictive Risk Stratification, Early Detection, And Clinical Management of Pica: Integrating Etiological and Pathophysiological Biomarkers

Yash Srivastav, Stuti Verma, Kamini Prajapati, Sandeep Prakash, Rajeev Kumar, Anubha Dhuriya, Anup Kumar Sirbaiya, Shivani Singh

Pica is a clinically significant and often overlooked feeding and eating disorder in which individuals have a persistent urge to eat or chew non-nutritious or non-food items and is linked to nutritional, hematological, behavioral, and environmental issues. Human studies have regularly found links between pica and iron deficiency and anemia, as well as between changes in hematological parameters, decreased ferritin, and decreased zinc concentrations; toxic-element exposure may also be a part of certain behaviors (li …

03.09.2026journal-article

Frontiers in Psychiatry

Anxiety- and depression-related somatic symptoms and atlantoaxial disorders: potential mechanistic links and clinical implications

Shuxian Yang, Qianru Li, Wanying Shi, Xiaoyun Liu

Background Anxiety and depressive disorders often include pain, dizziness, headache, fatigue, nausea, and sleep disturbance. These symptoms may also occur in atlantoaxial disorders, but overlap does not establish a shared cause. Objective To examine whether clinical or mechanistic evidence supports an association between objectively defined atlantoaxial disorders and somatic symptom burden in people with anxiety or depression, while distinguishing direct evidence from inferences based on general neck-pain research. …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of a nomogram prediction model for perioperative delirium in older patients with osteoporotic fractures based on LASSO regression and multiple parameters

Ni Hua, Hongmei Yuan, Yanhong Wei, Zhenqi Wei, Yanping Feng, Yong Liu, Tongguang Xu, Suliang Zhao, Li Zhang, Xiaohong He

Background Perioperative delirium (POD) is a severe postoperative complication in older patients with osteoporotic fractures. This study aimed to establish a nomogram prediction model incorporating multisystem stress, inflammation and frailty-related biomarkers for risk prediction. Methods This retrospective cohort study included 176 older patients (≥65 years) with osteoporotic fractures. Potential predictors, including the rate-pressure product (RPP), systemic inflammation response index (SIRI) and prognostic nutr …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Secondary syphilis with pulmonary involvement mimicking eosinophilic granulomatosis with polyangiitis — targeted next-generation sequencing as an adjunct in resolving an atypical non-exanthematous presentation

Shunjun Tang, Tiehan Zhang, Aiyi Hao, Bin Su, Bin Liu

Background The global resurgence of syphilis poses growing challenges for clinical diagnosis, particularly when atypical presentations without classic mucocutaneous lesions mimic systemic autoimmune diseases. Pulmonary involvement in secondary syphilis is rare and frequently misdiagnosed, leading to inappropriate immunosuppressive therapy. Case presentation A 24-year-old male presented with one month of inflammatory back pain and two weeks of cough, purulent sputum, and intermittent low-grade fever. He initially de …

03.09.2026journal-article

Frontiers in Psychiatry

Pre-treatment serum extracellular vesicle-enriched microbiome profiles and SSRI treatment response in obsessive-compulsive disorder: a prospective naturalistic cohort study

Jee In Kang, Chun Il Park, June-Ho Seo, Chil-sung Kang, Yoon-Keun Kim, Se Joo Kim

Objective The microbiome is emerging as an important component of brain–body communication and may influence treatment outcomes in psychiatric disorders. This naturalistic cohort study prospectively evaluated whether baseline microbiome abundance and composition of circulating bacterial extracellular vesicles (EVs) are associated with subsequent response to selective serotonin reuptake inhibitors (SSRIs) in patients with obsessive-compulsive disorder (OCD). Methods Thirty-two drug-naïve or medication-free patients …

03.09.2026journal-article

Frontiers in Immunology

Overall survival with immune checkpoint inhibitors across treatment settings and clinical and PD-L1-defined subgroups in advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis of randomized trials

Bing Wang, Xiaoyu Han, Zengli Shen

Introduction To quantify overall-survival effects of immune-checkpoint-inhibitor (ICI)-containing regimens by treatment line and to evaluate whether clinical characteristics or PD-L1 definitions modify relative treatment benefit in advanced esophageal squamous cell carcinoma (ESCC). Methods PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were searched from inception through 1 August 2026. Two reviewers independently screened records, assessed full texts, extracted data, and ev …

03.09.2026journal-article

Frontiers in Surgery

Paeoniflorin adjunct to scar release surgery for postoperative anorectal stenosis: a randomized controlled trial

Yuening Feng, Xi Wang, Dayong Feng, Chunhui Wang, Zhiyong Bai, Jingwen Wang, Yuhang Shen, Ayue An

Background Postoperative anorectal stenosis is a disabling complication of anorectal surgery, characterized by fibrotic narrowing that impairs defecation and quality of life. While scar-release surgery can restore lumen patency, long-term outcomes are undermined by recurrent fibrosis. Paeoniflorin, the active component of Shaobei Injection, is a promising botanical antifibrotic agent that may enhance perioperative efficacy. This study aims to evaluate whether combining Paeoniflorin with longitudinal scar-release su …

03.09.2026journal-article

Ege Tıp Dergisi

Evaluating GPT-4.1 Mini and GPT-5 in Postmastectomy Lymphedema Patient Education: A Comparative Study of Usefulness and Reliability

Benil Nesli Ata, Ece Cinar, Sibel Eyigör

Aim: To compare the reliability and usefulness of GPT-4.1 mini and GPT-5 in postmastectomy lymphedema patient education.Materials and Methods: Twenty patient-centered questions were developed from reputable sources. Responses from both models were independently rated by three blinded physiatrists using 7-point Likert scales for reliability and usefulness.Results: GPT-5 demonstrated higher usefulness and reliability scores compared to GPT-4.1 mini (p = 0.005 and p = 0.021, respectively).Conclusions: Both models prod …

03.09.2026journal-article

Frontiers in Medicine

Necroptosis–senescence crosstalk in tubulointerstitial fibrosis: the mtDNA–cGAS–STING–PFKFB3 axis as a metabolic bridge

Donghui Wang, Hongxiang Zheng, Xinyue Zhang, Chenghua Zhang, Dandan Zhao, Shuqi Min, Shenju Wang

Background Chronic kidney disease progresses irreversibly toward tubulointerstitial fibrosis. Although renin-angiotensin system inhibitors and sodium-glucose cotransporter 2 inhibitors slow progression, they cannot block or reverse fibrosis. Recent work shows that necroptosis and cellular senescence in tubular epithelial cells are not independent events; they form a dynamically evolving continuum through the mitochondrial DNA-cyclic GMP-AMP synthase-stimulator of interferon genes-interferon regulatory factor 3-6-ph …

03.09.2026journal-article

Livers

Early Versus Late Biliary Leakage After Hepatic Resection: Incidence, Risk Profiles, and Clinical Impact of Diagnostic Timing

Giacomo Paolini, Luca Tirloni, Ilenia Bartolini, Matteo Risaliti, Nicola Nocchi, Alessio Morandi, Maria Novella Ringressi, Antonio Taddei, Gian Luca Grazi

Background/Objectives: Post-hepatectomy biliary leakage (BL) remains a major source of postoperative morbidity. While traditional risk models treat BL as a single clinical entity, its chronological presentation follows distinct patterns that raise the hypothesis of distinct underlying pathophysiological mechanisms. This study aimed to stratify post-hepatectomy biliary fistulas into early and late onset to identify unique independent risk factors and clarify their separate risk profiles. Methods: This retrospective …

03.09.2026journal-article

Scientific Reports

A rolling bearing fault diagnosis method based on vibration sensor signals using adaptive VMD and correlation kurtosis feature enhancement

Jing Xing, Xiaohu Liu

Abstract In response to the serious noise interference in the fault signals obtained by the vibration sensors and the difficulty in effectively extracting the fault characteristics, a rolling bearing fault diagnosis method based on adaptive modal decomposition and correlation kurtosis feature enhancement is proposed. This method is based on the time-domain variation model of the vibration sensor output signal to obtain fault characterization features with enhanced impact and noise suppression capabilities. It uses …

03.09.2026journal-article

Saudi Journal of Medicine and Public Health

Abdominal Tuberculosis: An Interdisciplinary Approach to Diagnosis, Treatment, and Patient Care-An Updated Review

Majd Abdulrhman Almutiri, Eman Mohammad S. Al Dawood, Ashwag Saleem Almuzaini, Thekra Bandar Khalid Albahuoth, Hussam Hussain Abdullah Ashawi, Omar Muteb S. Alhammadi, Musaad Eid Saeed Aldosari, Abdullah Yahya H. Oagde, Awatef Rabah Almamoni

Background: Abdominal tuberculosis is an important extrapulmonary manifestation of Mycobacterium tuberculosis infection and remains a diagnostic challenge because of its variable, nonspecific, and often indolent presentation. Its clinical and pathological similarities with other gastrointestinal diseases may result in delayed or inappropriate diagnosis. Aim: To provide a comprehensive overview of the etiology, epidemiology, pathophysiology, histopathology, clinical presentation, diagnostic evaluation, differential …

03.09.2026journal-article

International Journal of Adolescent Medicine and Health

The dual impact of digital integration and peer influence on smartphone addiction and psychological distress among Indonesian adolescents

Marthoenis Marthoenis, Julianti Jauhari

Abstract Adolescents in higher health professional education experience heightened academic and clinical pressures, increasing their vulnerability to mental health problems. This study examined the prevalence of depression, anxiety, and stress, and identified key psychosocial predictors among Indonesian adolescents. A cross-sectional survey was conducted among 1,886 health polytechnic adolescents from multiple campuses of an Indonesian Health Polytechnic. Participants completed an online questionnaire including the …

03.09.2026journal-article

Frontiers in Pharmacology

Sustained improvement in dark-adapted sensitivity but not BCVA after voretigene neparvovec treatment in a mainland Chinese child with biallelic RPE65-associated LCA2: a case report

Yue Ren, Shu Liu, Yanbo Liu, Di Wang, Jia Rong, Wensheng Li, Chunhui Zheng, Ling Xu, Jun Li, Zhuoshi Wang, Jijing Pang

Inherited retinal dystrophies (IRDs) represent heterogeneous genetic eye disorders frequently linked to RPE65 mutations. Voretigene neparvovec (VN, Luxturna), an AAV2-mediated gene therapy, remains the sole approved drug for biallelic RPE65 -associated IRDs. This study presents 3-, 6- and 22-month follow-up findings of the first mainland Chinese patient with compound heterozygous RPE65 -related Leber congenital amaurosis type 2 (LCA2) receiving sequential bilateral subretinal Luxturna injections. Binocular full-fie …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Effects of a neo-functional psychotherapeutic approach on post-traumatic stress disorder following spontaneous coronary artery dissection: a case report

Emilia Solinas, Filippo Luca Gurgoglione, Andrea Denegri, Giorgio Benatti, Rossella Giacalone, Manjola Noni, Giulia Magnani, Luigi Vignali, Giampaolo Niccoli, Caterina Viaro, Enrica Pedrelli, Rita Pinetti, Roberta Rosin, Luciano Sabella, Giuseppe Rizzi, Luciano Rispoli

Background Post-traumatic stress disorder (PTSD) is increasingly recognized after acute coronary syndromes, including spontaneous coronary artery dissection (SCAD), a condition predominantly affecting women. PTSD symptoms may negatively influence autonomic regulation, adherence to therapy, and cardiovascular outcomes. Evidence regarding structured psychotherapeutic interventions targeting SCAD-related PTSD is limited. Case presentation A 58-year-old woman was admitted with non–ST-elevation myocardial infarction due …

03.09.2026journal-article

Frontiers in Medicine

Ab interno trabeculotomy with vs. without cataract surgery for POAG: a retrospective study

Lei Zhang, Junjie Bian

Purpose To compare the 12-month efficacy and safety of ab interno trabeculotomy combined with phacoemulsification vs. ab interno trabeculotomy alone in patients with primary open-angle glaucoma(POAG). Methods A retrospective analysis was performed on clinical data from patients diagnosed with POAG between January 2021 and January 2025 who underwent either combined surgery (combined group, 39 cases)or ab interno trabeculotomy alone (ab interno trabeculotomy-only group,44 cases). The primary outcome measures were pos …

03.09.2026journal-article

Frontiers in Synaptic Neuroscience

Activation of silent synapses driven by emerging technologies: mechanisms, disease associations, and prospects for clinical translation

Yongli Li, Yong Liao, Shouyao Zhang, Chenggui Xu, Ruhua Lan, Pengbin Zhao, Ruilu Liu, Yongli Song, Xinghe Zhang

Silent synapses represent a unique class of synaptic connections that are non-functional at rest but possess the potential to become functional, serving as a critical reservoir for neural plasticity. Their activation mechanisms not only challenge traditional models of synaptic maturation but also provide novel insights into brain function regulation and disease pathology. This article provides a systematic review of the regulatory mechanisms underlying silent synapse activation, encompassing pre-synaptic calcium si …

03.09.2026journal-article

Frontiers in Medicine

Epstein–Barr virus-associated inflammatory polyp of the proximal cervical trachea causing central airway obstruction: a case report

Ziran Lei, Ning Zheng, Linlin Wang, Ling Fang, Xiang Wu

Background Intraluminal lesions of the central airway can cause severe obstruction and are usually malignant. Epstein–Barr virus (EBV)-associated inflammatory tracheal polyps are extremely rare and may mimic airway tumors or EBV-associated lymphoproliferative disorders. Case presentation A 35-year-old woman presented with progressive dyspnea and wheezing for 1 month. Contrast-enhanced chest computed tomography and bronchoscopy revealed a solitary intraluminal polypoid lesion arising from the left anterior wall of t …

03.09.2026journal-article

Frontiers in Allergy

Clinical phenotypes, endotypes, and biomarker profiles of immediate rituximab hypersensitivity reactions: a prospective pharmacovigilance study

Narapong Yotinnoratham, Wannada Laisuan, Kumutnart Chanprapaph, Silada Kanokrungsee, Chavachol Setthaudom, Supornchai Onpun, Pungjai Mongkolpathumrat, Supranee Buranapraditkun, Apinya Chungcharoenpanich, Nichapha Dechapaphapitak, Supa Oncham, Nattakirana Tongdee, Sananya Khamkaew, Ratchaya Lertnawapan, Jettanong Klaewsongkram

Background Rituximab (RTX) has been associated with immediate hypersensitivity reactions (HSRs) involving multiple phenotypes and endotypes. Objective To characterize the clinical phenotypes and endotypes of immediate RTX HSRs. Methods A prospective study was conducted as part of a pharmacovigilance program from July 2020 to December 2021. Participants who experienced immediate RTX HSRs were enrolled. Skin testing, basophil activation testing (BAT), IFN- γ ELISpot assays, and IgG anti-drug antibody (ADA) ELISA assa …

03.09.2026journal-article

IPS Journal of Basic and Clinical Medicine

Kidney Function Responses to Ethanol Extracts of Chia Seed (Salvia hispanica L.) and Tiger Nut (Cyperus esculentus L.) in Alloxan-Induced Diabetic Rats

Chinyere S. Nwaka, Andrew C. Nwaka

Diabetic nephropathy is a common and progressive complication of poorly controlled diabetes mellitus, and there is growing interest in plant-derived agents that can slow or reverse this damage. This study evaluated the effect of ethanol extracts of chia seed (Salvia hispanica), tiger nut (Cyperus esculentus), and their combination on kidney function parameters in alloxan-induced diabetic rats. Sixty-three male Wistar rats were assigned to nine groups (n = 7): normal control (A), diabetic untreated (B), diabetic rat …

03.09.2026journal-article

Cosmetics

Effect of Topical HealFast Silver Ointment on Pain and Early Wound-Healing Parameters After Caesarean Section: A Randomized Placebo-Controlled Clinical Trial

Wafaa Uthman Ahmed, Bafreen hawez Hamadameen, Dastan Abdullah Salih, Shukur Wasman Smail, Abubakr Mohammed Amin, Mohammed Awat Ali

Background: Caesarean section is associated with postoperative pain and wound-related morbidity. Topical agents that promote early wound healing may enhance postoperative recovery. This randomized, placebo-controlled clinical trial evaluated the effect of HealFast Silver Ointment on pain and early wound-healing parameters after Caesarean section. Methods: Two hundred women who underwent Caesarean section were randomly allocated into two groups: a placebo group and a HealFast Silver Ointment group, each consisting o …