Medizin: neue Gesundheitspublikationen – Seite 148

07.09.2026journal-article

Transfusion

First molecularly characterized Para‐Bombay phenotype in Iraq: Clinical, serological and genetic insights with implications for transfusion safety

Dhargam Muhamed Aljebouri, Mohammed Aljadiri, Bassam Alshaikhli, Rawa Alattabi, Arwa Alkhamess, Sajjad Aldoori, Yousif Suleiman

Abstract Background H‐deficient states are important in ABO‐related transfusion practice. Patients may be misclassified as group O if testing stops at forward ABO typing. Anti‐IH may render group O units incompatible and increase hemolysis risk. Study Design and Methods A 70‐year‐old Iraqi man was referred for failure to obtain compatible blood before knee arthroplasty. ABO testing, crossmatching, antibody screening, anti‐H lectin testing, saliva inhibition and molecular analysis of fucosyltransferase 1 (FUT1) and …

07.09.2026journal-article

Journal of Occupational & Environmental Medicine

Beyond Ergonomics Training: Added Effects of a Supervised, Equipment-Free Workplace Exercise Program on Musculoskeletal Symptoms, Sleep, and Burnout in Artisanal Pastry Workers: A Randomized Controlled Trial

Ömer ŞEVGİN, Amin DANESHFAR

Objective: To determine whether adding a supervised exercise program to workplace ergonomics education adds benefit for musculoskeletal, sleep, and burnout outcomes in börek (Turkish pastry) workers. Methods: In this exploratory randomized controlled trial (NCT07447180), 60 male börek masters from 47 Istanbul shops were randomized to ergonomics education alone or education plus a 12-week supervised, equipment-free exercise program. The primary outcome was the number of symptomatic body regions (Nordic Musculoskelet …

07.09.2026journal-article

Thrombosis and Haemostasis

Clinical Characteristics and Early Outcomes of Acute Pulmonary Embolism Presenting with Syncope

Marina López-Rubio, Victor Manuel Martínez-Castilla, Andrea Cobo-Bustamante, Lorena Sanz-Tejeiro, Rubén Alonso-Beato, Lucía Ordieres-Ortega, Crhistian-Mario Oblitas, Luis Antonio Álvarez-Sala Walther, Francisco Galeano-Valle, Pablo Demelo-Rodriguez

Abstract The prognostic significance of syncope in patients with acute pulmonary embolism (PE) remains uncertain. We assessed its association with early outcomes and explored whether distinct clinical phenotypes could be identified within this group. We analyzed a prospectively collected single-center cohort of patients with confirmed symptomatic PE diagnosed between 2010 and 2025, grouped by syncope at presentation. The primary outcome was a 30-day composite of all-cause mortality, major bleeding, and recurrent ve …

07.09.2026journal-article

Sinusitis

Hyperbaric Oxygen Therapy in Sinonasal Disease: A Narrative Review of Mechanisms, Clinical Evidence, and Multidisciplinary Perspectives on Invasive Fungal Rhinosinusitis and Post-Radiotherapy Injury

Daniele Salvatore Paternò, Luigi La Via, Antonino Maniaci, Mario Lentini, Adriana Cordalonga, Caterina Maria Testa, Francesco Piccitto, Enrico Provinzano, Paolo Tummino, Emilia Concetta Lo Giudice, Massimiliano Sorbello

Background: Hyperbaric oxygen therapy (HBOT) is proposed as an adjunct in two sinonasal conditions of high morbidity: acute invasive fungal rhinosinusitis (AIFRS) and post-radiotherapy injury. Methods: We conducted a narrative review and reported it against SANRA; PubMed/MEDLINE was searched (1980–2026; 1414 records screened, 589 retained), with Cochrane, society guidance and reference screening. Results: No randomised trial has tested HBOT against sinonasal endpoints in either indication. In AIFRS the dedicated ev …

07.09.2026journal-article

Journal of Cardiovascular Development and Disease

Catheter-Based Renal Denervation in Uncontrolled and Resistant Hypertension: Evidence, Guidelines, Special Populations and Clinical Implementation

Ioannis Skalidis, Leonidas Koliastasis, Panayotis K. Vlachakis, Anastasios Apostolos, Maria Bozika, Kassiani-Maria Nastouli, Nicolas Amabile, Philippe Garot, Thomas Hovasse, Mariama Akodad, Livio D’Angelo, Antoinette Neylon, Thierry Unterseeh, Roswitha Schreier, Giacomo Maria Cioffi, Julius Jelisejevas, Peter Wenaweser, Pascal Meier, Mario Togni, Stephane Cook

Hypertension remains the leading modifiable cause of cardiovascular death, yet fewer than one in four treated adults achieves guideline-recommended blood pressure targets. Catheter-based renal denervation interrupts efferent and afferent renal sympathetic signalling and lowers blood pressure continuously and independently of medication adherence. After a decade of controversy following the neutral SYMPLICITY HTN-3 trial, a coherent body of second-generation sham-controlled randomised evidence, generated with radiof …

07.09.2026journal-article

Russian Journal of Transplantology and Artificial Organs

Kidney transplant program at the Chelyabinsk Regional Clinical Hospital

D. A. Altman, A. E. Poltorak, L. Yu. Zhuravleva, I. Ya. Bondarevsky, A. V. Gogolevskaya, B. H. Sarsenbaev, M. A. Poltorak, A. G. Istomin, A. S. Ryzhikh, P. A. Zasypkina

Objective: to evaluate the outcomes of kidney transplants performed at Chelyabinsk Regional Clinical Hospital between 2015 and 2025. Materials and methods . A retrospective analysis was conducted of 148 medical records of patients who underwent a kidney transplant (KT). The parameters assessed were recipient age and sex, duration of hemodialysis prior to transplantation, underlying cause of end-stage chronic kidney disease, duration of surgery and hospitalization, cold ischemia time, graft function, occurrence of a …

07.09.2026journal-article

Journal of Clinical Laboratory Analysis

MicroRNA ‐Mediated Autophagy and Cardiovascular Diseases: Exploring the Crossroads of Atherosclerosis and Beyond

Sepehr Ebrahimi‐Dehkordi, Amir Hossein Barjasteh, Aida Zarei, Sina Bazmi, Sarah Vaseghi, Sara Ashna, Amirreza Solati, Ali Yousefzadeh, Bita Safarzadeh Nasrabad, Zahra Mohammadi, Hamed Haddad Kashani, Mohammad Hossein Pourhanifeh

ABSTRACT Background Atherosclerosis (AS) is a complex cardiovascular disease characterized by the accumulation of lipids, inflammatory cells, and fibrous materials within arterial walls. Autophagy plays a critical role in maintaining cellular homeostasis and regulating lipid metabolism in vascular cells. MicroRNAs (miRNAs), small non‐coding RNA molecules involved in post‐transcriptional gene regulation, have emerged as key modulators of autophagy and contributors to AS progression. Methods This review synthesizes c …

07.09.2026journal-article

Journal of Clinical Psychopharmacology

The Antidepressant Effects of the mGlu2/3 Receptor Antagonist TS-161 in Treatment-Resistant Depression

Mark D. Kvarta, Mai Watanabe, Satoshi Ozaki, Dede Greenstein, Adam Fijtman, Gregory Jones, Hiroe I. Hu, Solaleh Azimipour, Peixiong Yuan, Jenessa N. Johnston, Jennifer W. Evans, Jessica R. Gilbert, Carlos A. Zarate

Background: Like ketamine, group II metabotropic glutamate receptor (mGluR2/3) antagonists increase glutamate release and monoaminergic signaling, promote synaptic plasticity, and show antidepressant-related activity in preclinical models. A recent phase I trial of the orthosteric mGluR2/3 antagonist prodrug TS-161 established its safety, tolerability, and pharmacokinetic profile. Methods: This phase IIa randomized, placebo-controlled, double-blind, crossover, proof-of-concept, single-site trial was designed to eva …

07.09.2026journal-article

Journal of Clinical Gastroenterology

Global Action in Addressing the Challenge of Environmental Change and Digestive Health

Anahita Sadeghi, Paria Boustani, Rui Morais, Desmond Leddin

Background: Environmental change is adversely affecting digestive health. Paradoxically, digestive health care contributes to the problem by generating emissions and waste. This study aimed to develop a set of metrics, a report card, to assess the response of the global digestive health community to this challenge. Methods: A survey was developed covering 26 actions that digestive health societies could take to reduce the environmental impact of digestive care. It was distributed to the leadership of national diges …

07.09.2026journal-article

Sensors

A Review of Fault Diagnosis and Intelligent Operations and Maintenance for Agricultural Machinery: Fault Mechanisms, Key Technologies, and Practical Recommendations

Yu Zhang, Xingzhu Qian, Ruifan Tang, Chenyu Xi, Tingrui Cui, Zhong Tang

Agricultural machinery operates under variable loads, impacts, dust, and changing soil–crop interactions, allowing faults to propagate through energy, material, information, and control pathways. This qualitative review synthesizes 195 research publications across fault formation, trustworthy diagnosis, prognostics and proactive risk control, maintenance and recovery, and case-based evidence assessment. Empirical findings are reported separately from review-derived recommendations, the authors’ conceptual requireme …

07.09.2026journal-article

Clinical Nuclear Medicine

Multiple Bone Metastases Exhibiting Exceptionally High 18F-MFBG Uptake Exceeding Physiological Bladder Activity in a Patient With Neuroblastoma

Mingyu Zhang, Jie Feng, Keyu Zhang, Xiaoya Wang, Jigang Yang

In neuroblastoma, 18 F-MFBG uptake in metastatic lesions is typically lower than physiological urinary bladder activity. We present a case of a 6-year-old boy with high-risk neuroblastoma who underwent multimodal therapy. A follow-up 18 F-MFBG PET/CT performed for treatment response assessment demonstrated markedly increased tracer accumulation in multiple skeletal metastases, with an SUVmax of 77.1, surpassing concurrent bladder activity. This case demonstrates that osseous metastases in patients with neuroblastom …

07.09.2026journal-article

Nano Research

CRISPR-Cas9 cleaves DNA microspheres to release drug for efficient thrombosis treatment

Shuai Yang, Ningning Wang, Yihang Huang, Xingang Wang, Qianyun Tang, Guoqing Tang, Jianggui Shan, Peifeng Liu

Abstract The drug delivery nanocarriers are widely employed in thrombolytic therapy. However, the off targeting and ineffective drug release of delivery vehicles make it difficult to targeted accumulation, effective diffusion, and penetration into thrombus tissue. Herein, we reported a biocompatible magnetic microsphere constructed via a programmable DNA rolling circle amplification (RCA) reaction integrated with iron oxide magnetic nanoparticles (Fe3O4 NPs). By combining ultrasound and photoacoustic imaging for di …

07.09.2026journal-article

Asian Journal of Pharmaceutical and Clinical Research

ANALYTICAL QUALITY BY DESIGN-ASSISTED DEVELOPMENT AND VALIDATION OF A RAPID STABILITY-INDICATING GRADIENT ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF EMPAGLIFLOZIN, SACUBITRIL, AND VALSARTAN IN PHARMACEUTICAL DOSAGE FORMS

BADRI SIREESHA, SARAVANAN RAVINDRAN

Objectives: Simultaneous estimation of empagliflozin, sacubitril, and valsartan in combined pharmaceutical formulations is analytically challenging due to their differing polarity, physicochemical properties, and chromatographic retention behavior. Conventional high-performance liquid chromatography methods often require longer analysis times and greater solvent consumption. To develop, optimize, and validate a rapid, robust, and stability-indicating gradient ultra-performance liquid chromatography (UPLC) method fo …

07.09.2026journal-article

Clinical Pharmacology & Therapeutics

Constructing an External Control Arm Using the French REALYSA Cohort to Replicate Outcomes of a Randomized Trial Arm in Advanced Hodgkin Lymphoma

Olivia Febvey‐Combes, Cédric Rossi, Behrouz Kassai, Tesla Murairi Mirimo, Loïc Chartier, Fanny Cherblanc, Emeline Cugnod, Hervé Ghesquières, Aurélien Belot

External control (EC) arms using routine data can be used as comparators in clinical trials under certain conditions. The objective of this study was to assess the ability of an EC arm to replicate outcomes of a randomized controlled trial (RCT) arm receiving the same treatment strategy in advanced stage classical Hodgkin lymphoma and serve as comparator in future trials. Using the prospective real‐world data in lymphoma and survival in adults (REALYSA) cohort, we constructed an EC arm by applying eligibility crite …

07.09.2026journal-article

Journal of Law, Medicine & Ethics

Industry Exposure in Medical Training: The Case for a Conflict-Free Learning Environment

Joshua D. Hauser, Aaron Seth Kesselheim, Rita Redberg

Abstract Conflicts of interest (COI) between physicians and for-profit companies have existed for centuries, but the last decade has dramatically increased their visibility through the Centers for Medicare and Medicaid Services’ Open Payments database. Despite growing documentation of COI in academic medical environments — where financial relationships are prevalent and industry payments to trainees exceed millions of dollars annually — formal COI policies and curriculum in US medical schools have stagnated or weak …

07.09.2026journal-article

Medicine, Science and the Law

Application of the pleural effusion ratio in diagnosing freshwater drowning: A comparative study

Nirmal Nagar, Binaya Kumar Bastia

Drowning is a leading cause of unintentional death globally, with diagnosis remaining challenging due to the non-specific nature of postmortem findings. This prospective study aimed to evaluate the diagnostic utility of the pleural effusion (PE) ratio in differentiating freshwater drowning from other causes of death. A total of 179 medico-legal autopsies conducted between July 2022 and April 2023 at a tertiary centre in Northern India were analysed, comprising 75 cases of freshwater drowning, 64 sudden cardiac deat …

07.09.2026journal-article

Journal of Pediatric Gastroenterology and Nutrition

Race and neighborhood factors influence clinical outcomes in children hospitalized with acute pancreatitis

Amy Fan, Elizabeth Baker, Chinenye R. Dike

Abstract Objectives Disparities impacting acute pancreatitis (AP) outcomes have been reported. Although racial/ethnic disparities are known in AP, geospatial disparities have been unexplored in pediatric AP. We aimed to investigate area level social determinant of health (SDOH) factors on pediatric AP outcomes. Methods This is a retrospective study of children hospitalized with AP over 5 years. Data including home addresses and zip codes were geocoded to determine area level factors for SDOH. Descriptive statistics …

07.09.2026journal-article

Revista Chilena de Reumatología

Paquidermodactilia: a raíz de un caso clínico con sospecha de artritis idiopática juvenil

Erasmo Benavente O., Martín Valderrama W., Antonia Morales M., Camila Rivera C., Luis Muse R., Alejandro Badilla P.

Se presenta un caso de paquidermodactilia (PDD). La PDD es una entidad rara y benigna, caracterizada por el engrasamiento de partes blandas periarticulares de predominio lateral en los dedos, con compromiso más frecuente de las articulaciones interfalángicas proximales (IFP), y que afecta principalmente a hombres adolescentes. En este paciente, el cuadro se desarrolló en el contexto de microtrauma periarticular repetitivo, tics persistentes de golpeteo digital y estiramiento de manos, conductas típicamente asociad …

07.09.2026journal-article

Journal of Internal Medicine

AA amyloidosis in the four historical monogenic autoinflammatory diseases: Clinical burden and insights from a retrospective referral‐centre study

Majdouline El Moussaoui, Léa Savey, Hassina Sofia Aloui‐Belhocine, Jean‐Jacques Boffa, Marion Delplanque, Catherine Grandpeix‐Guyodo, Irina Giurgea, Laurence Cuisset, Guilaine Boursier, Gilles Grateau, David Buob, Sophie Georgin‐Lavialle

Abstract Background AA amyloidosis (AAA) remains a life‐threatening yet largely preventable complication of monogenic autoinflammatory diseases (AIDs). Methods We retrospectively described patients with AAA secondary to one of the four historical monogenic AIDs (familial Mediterranean fever [FMF], cryopyrin‐associated periodic syndrome [CAPS], mevalonate kinase deficiency [MKD] and tumour necrosis factor receptor–associated periodic syndrome [TRAPS]) followed at the French National Referral Centre for Monogenic AID …

26.12.2026journal-article

Journal of Chemical Engineering Research Progress

Optimization Studies of The Treatment of Laundry Wastewater Using Activated Carbon Derived from HDPE Chars

David Emoefe Rockson-Itiveh, Cyril Oghenekome Anakpoha, Mabel Keke, Marcel Ajogri, Ulakpa Wisdom, Fabian Chidiebere Ozioko, Samson Onoriode Okpo

Growing plastic waste and industrial wastewater necessitate sustainable treatment solutions. This study optimized industrial wastewater treatment using activated carbon derived from high-density polyethylene (HDPE) pyrolysis char via thermal activation, eliminating the need for aggressive chemical agents. Characterization via FTIR, BET, and SEM-EDX revealed a micro-mesoporous structure with a BET surface area of 287.3 m²/g, a 90.05 atomic percent carbon content, and dominant pore sizes of 2.1 to 2.6 nm. The adsorbe …

07.09.2026journal-article

Frontiers in Endocrinology

Impaired bone health after pediatric acute lymphoblastic leukemia treatment despite normal DXA: insights from high-resolution peripheral quantitative computed tomography

Nina Dominique Stahel, Nicole Bodmer, Aziz Chaouch, Etienne Sochett, Flavia M. Wehrle, Marianne Rohrbach, Camilla Saladin, HansJörg Häuselmann, Daniel Konrad, Nina Lenherr-Taube

Introduction Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood. With improved survival rates, more attention has turned to long-term outcomes such as bone health. High-resolution peripheral quantitative computed tomography (HR-pQCT) allows a three-dimensional assessment of cortical and trabecular bone and may have advantages over standard dual-energy X-ray absorptiometry (DXA). The aim of this study was to evaluate whether HR-pQCT can detect early bone health impairment in children following …

07.09.2026journal-article

Frontiers in Public Health

The success-failure inversion in modern medicine

Madhur Mangalam, Jessica Fabianiak, Barry Cense

Twentieth-century medicine was most successful against diseases sharing a particular causal architecture: a discrete lesion standing in a relation of approximate necessity and sufficiency to a clinical syndrome, amenable to specific perturbation. Mortality from acute myocardial infarction has fallen by nearly 90 percent in the United States since 1970; pediatric leukemia has become survivable; HIV has become chronic. That success has shifted the residual burden toward conditions with a different architecture—late-l …

07.09.2026journal-article

Frontiers in Immunology

A truncating ELF4 variant in a pediatric patient with autoinflammatory disease and cell type-specific immune alterations

Qianlu Zhang, Yatang Lei, Lina Zhou, Zhiyong Zhang, Xuemei Tang, Yunfei An, Xiaodong Zhao, Hongqiang Du

Introduction ELF4 is an ETS family transcription factor involved in immune regulation, including antiviral responses and inflammatory signaling. Germline loss-of-function variants in ELF4 cause deficiency in ELF4, X-linked (DEX), a disorder characterized by recurrent mucocutaneous inflammation and variable immune abnormalities. To date, ELF4-related disease has been reported only in association with germline mutations. Here, we report a pediatric patient with autoinflammatory disease harboring a truncating ELF4 var …

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Aktuelle Forschung nach Fachgebiet

First molecularly characterized Para‐Bombay phenotype in Iraq: Clinical, serological and genetic insights with implications for transfusion safety

Beyond Ergonomics Training: Added Effects of a Supervised, Equipment-Free Workplace Exercise Program on Musculoskeletal Symptoms, Sleep, and Burnout in Artisanal Pastry Workers: A Randomized Controlled Trial

Clinical Characteristics and Early Outcomes of Acute Pulmonary Embolism Presenting with Syncope

Hyperbaric Oxygen Therapy in Sinonasal Disease: A Narrative Review of Mechanisms, Clinical Evidence, and Multidisciplinary Perspectives on Invasive Fungal Rhinosinusitis and Post-Radiotherapy Injury

Catheter-Based Renal Denervation in Uncontrolled and Resistant Hypertension: Evidence, Guidelines, Special Populations and Clinical Implementation

Kidney transplant program at the Chelyabinsk Regional Clinical Hospital

MicroRNA ‐Mediated Autophagy and Cardiovascular Diseases: Exploring the Crossroads of Atherosclerosis and Beyond

The Antidepressant Effects of the mGlu2/3 Receptor Antagonist TS-161 in Treatment-Resistant Depression

Global Action in Addressing the Challenge of Environmental Change and Digestive Health

A Review of Fault Diagnosis and Intelligent Operations and Maintenance for Agricultural Machinery: Fault Mechanisms, Key Technologies, and Practical Recommendations

Multiple Bone Metastases Exhibiting Exceptionally High 18F-MFBG Uptake Exceeding Physiological Bladder Activity in a Patient With Neuroblastoma

CRISPR-Cas9 cleaves DNA microspheres to release drug for efficient thrombosis treatment

ANALYTICAL QUALITY BY DESIGN-ASSISTED DEVELOPMENT AND VALIDATION OF A RAPID STABILITY-INDICATING GRADIENT ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF EMPAGLIFLOZIN, SACUBITRIL, AND VALSARTAN IN PHARMACEUTICAL DOSAGE FORMS

Constructing an External Control Arm Using the French REALYSA Cohort to Replicate Outcomes of a Randomized Trial Arm in Advanced Hodgkin Lymphoma

Industry Exposure in Medical Training: The Case for a Conflict-Free Learning Environment

Application of the pleural effusion ratio in diagnosing freshwater drowning: A comparative study

Race and neighborhood factors influence clinical outcomes in children hospitalized with acute pancreatitis

Paquidermodactilia: a raíz de un caso clínico con sospecha de artritis idiopática juvenil

AA amyloidosis in the four historical monogenic autoinflammatory diseases: Clinical burden and insights from a retrospective referral‐centre study

Optimization Studies of The Treatment of Laundry Wastewater Using Activated Carbon Derived from HDPE Chars

Impaired bone health after pediatric acute lymphoblastic leukemia treatment despite normal DXA: insights from high-resolution peripheral quantitative computed tomography

The success-failure inversion in modern medicine

A truncating ELF4 variant in a pediatric patient with autoinflammatory disease and cell type-specific immune alterations