Onkologie: neue Gesundheitspublikationen – Seite 140

30.08.2026journal-article

Iraqi Journal of Science

Classifying High-Dimensional Lung Cancer Data Using an Improved Deep Learning Model

Sarab M. Hameed, Dhuha Abdulhadi Abduljabbar

Anomalous cell growth, known as cancer, can cause tumors, weaken the immune system, and cause fatal complications. Early detection of cancer makes treatment easier and contributes to lower mortality rates. Gene expression data contributes crucially to the classification of cancer in its early stages. Accurately classifying cancer is a complex problem because gene expression data is high-dimensional compared to the limited number of samples. This research proposes an improved Deep Learning model that integrates both …

30.08.2026journal-article

Aggregate

Dual‐Acceptor Engineered Multimodal Phototheranostic NIR‐II AIEgens for Orthotopic Breast Cancer Treatment

Miaomiao Kang, Yu Pei, Zengming Yang, Yinzhen Pan, Zhijun Zhang, Xue Li, Dong Wang, Ben Zhong Tang

ABSTRACT “One‑for‑all” phototheranostics has emerged as a promising alternative to conventional cancer therapies. Aggregation‑induced emission luminogens (AIEgens) are exemplary templates for constructing such versatile systems. However, developing robust NIR‑II (1000–1700 nm)‐emitting “one‑for‑all” phototheranostic AIEgens remains challenging, due to the drastically lowered reactive oxygen species (ROS) generation capability and strong intermolecular π‐π stacking in the NIR‑II range. To address this, an ingenious …

30.08.2026journal-article

Jurnal Kejuruteraan

Influence of Bitumen Chemistry and Crumb Rubber Pre-Treatment on the Storage Stability and Rheological Performance of Modified Binders

Naeem Aziz Memon, Nur Izzi Md. Yusoff, Ahmed Suliman B. Ali, Warid Wazien, Aawag Mohsen Alawag, Zubair Ahmed Memon, Shabir Hussain Khahro

The incorporation of crumb rubber (CR) into bitumen offers significant performance and sustainability advantages, yet its widespread adoption is impeded by poor storage stability caused by thermodynamic incompatibility. To address this fundamental challenge, this study investigates the role of bitumen chemistry, specifically the balance of fractions determined via SARA analysis, and the efficacy of crumb rubber pre-treatment in creating a stable binder system. Two base bitumen with distinct chemical compositions (P …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Research Progress on the Use of Yue ju Pill in the Treatment of Functional Dyspepsia

Jianing Ma, Hui Ding

Yueju Pill are derived from *Danxi Xinfa*; the formula comprises Atractylodes lancea, Cyperus rotundus, Ligusticum chuanxiong, Shenqu and Gardenia jasminoides, and is primarily indicated for relieving various forms of stagnation. Later generations of medical practitioners have also extended its use to treat disorders of the digestive and nervous systems, amongst others. This article provides a systematic review of the progress made in clinical and basic research on Yueju pill in the treatment of functional dyspepsi …

30.08.2026journal-article

Cancer Science

Adding Intratumoral Antibody‐Photoabsorber Conjugate Improves Efficacy of Near‐Infrared Photoimmunotherapy ( NIR ‐ PIT )

Miyu Kano, Aki Furusawa, Seiichiro Takao, Makoto Kano, Motofumi Suzuki, Hiroshi Yamamoto, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi

ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near‐infrared light in an antibody‐photoabsorber conjugate (APC) bound to the cognate target antigen on the tumor cell surface. NIR‐PIT has already been clinically applied in Japan to head and neck cancer patients using an anti‐EGFR antibody‐IR700 dye conjugate, with very promising resul …

30.08.2026journal-article

International Journal of Human and Health Sciences (IJHHS)

The Submandibular Tumor: Unmasking a Rare Hypoglossal Schwannoma

Mohd Naqiuddin Mohd Najib, Norsyamira Aida Mohamad Umbaik, Nur Asyilla Che Jalil, Norhafiza Mat Lazim

Hypoglossal schwannoma(HS) is a rare benign tumor of the twelfth cranial nerve, and its extracranial presentation can closely resemble a submandibular gland mass. We report a patient with a painless, gradually enlarging left submandibular swelling initially thought to arise from the submandibular gland. Imaging revealed an enlarged left submandibular gland containing a well-defined, heterogeneous lesion and fine-needle aspiration(FNAC) suggested pleomorphic adenoma(PA). Surgical excision via a transcervical approac …

30.08.2026journal-article

The Laryngoscope

Beyond TNM : Tumor Volume as a Prognostic Marker in Laryngeal Cancer

Daniel Uralov, Chiara Iovine, Luciana Di Cristina, Alberto Paderno, Caterina Giannitto, Luca Canali, Federica Gullà, Elena Tosi, Marco Dassie, Marcello Rodari, Maria Ausilia Teriaca, Fabio Ferreli, Paolo Bossi, Ciro Franzese, Giuseppe Spriano, Francesca Gaino, Giuseppe Mercante

ABSTRACT Objectives The objective of this study is to determine whether radiologic tumor volume adds prognostic value for overall survival (OS) and disease‐free survival (DFS) in laryngeal squamous cell carcinoma (LSCC) and to evaluate associations with T stage, nodal status, histologic grade, subsite, and treatment modality. Methods Patients with cT2–T4 LSCC treated with curative intent between 2018 and 2024 were included. Tumor volumes derived from CT, MRI, or radiotherapy planning contours were analyzed as conti …

30.08.2026journal-article

Bipolar Disorders

Optimizing Ketamine Infusion Therapy for Treatment‐Resistant Bipolar Depression: Commentary on Zhou et al. (2023)

Chih‐Cheng Lin, Lien‐Chung Wei

ABSTRACT Objectives To contextualize the real‐world findings of repeated intravenous ketamine infusions for treatment‐resistant bipolar depression (TRBPD) and identify priorities for safer, more durable clinical implementation. Methods We provide a focused commentary on Zhou et al. (2023) and integrate selected evidence concerning inflammatory and metabolic correlates, neurocognitive outcomes, and continuation‐phase ketamine treatment. Results Repeated subanesthetic ketamine infusions may rapidly improve depressive …

30.08.2026journal-article

Ukrainian Heart Journal

Оцінка ефективності й безпечності використання аксилярної канюляції при хірургічному лікуванні патології грудної аорти

O. V. Zelenchuk

The aim – to evaluate the efficacy and safety of direct axillary artery cannulation during reconstructive surgery for thoracic aortic disease by comparing intraoperative parameters, early clinical outcomes, and the incidence of neurological and local complications with those of femoral artery cannulation.Materials and methods. The study included 110 patients who underwent reconstructive surgery for thoracic aortic disease between 2016 and 2025 using peripheral arterial cannulation. Femoral artery cannulation was pe …

30.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

A Novel 3D Hybrid Transformer-Dense Segmentation Network with Adaptive Capsule-LSTM Classification for Early-Stage Lung Cancer Detection on Kaggle CT Images

Shafiulla Shariff, Avinash K G

Background: Early lung cancer detection from CT scans is critical yet challenged by volumetric complexity and multi-site acquisition heterogeneity in benchmarks such as Kaggle Data Science Bowl 2017 (DSB 2017).Methods: We present HybridSeg-Net comprising: (1) 3D-HTDSeg with novel Attention-Modulated Dense Skip (AMDS) connections applying axial self-attention transformer blocks directly onto skip tensors; (2) ACaps-LSTM combining adaptive dynamic routing capsule encoding with bidirectional LSTM; (3) IQHO — Intensity …

30.08.2026journal-article

European Heart Journal – Cardio-Oncology

Coronary Plaque Burden and Plaque Composition in Long-Term Cancer Survivors: A Comparative CCTA Study

Cheng Hwee Soh, James Hua Wang, Shaun Khanna, Mark Nolan, Sean Tan, Joel Smith, Joshua Wong, Nitesh Nerlekar, Thomas H Marwick

Abstract Background The increased risk of atherosclerotic cardiovascular disease in cancer survivors is not fully elucidated. Understanding the coronary plaque burden and composition in survivors could address this gap. Objectives To determine whether cancer survivorship is associated with greater coronary plaque burden and more adverse plaque than non-cancer controls. Methods This analysis included asymptomatic cancer survivors ≥5 years after therapy and non-cancer controls from prospectively enrolled CT coronary …

30.08.2026journal-article

IPS Journal of Basic and Clinical Medicine

Navigating the Gap: A Review of Time to Treatment Intervals and Cervical Cancer Survival in Sub-Saharan Africa

Bright Odinaka Okorocha, Chigaemezu Remmy-Martin Akubuo, Abdulhafeez Opeyemi Busari, Lovelyn Chiamaka Nnanyereugo, John Perpetual Chimazuru, Confidence Chinaza Ogbomade, Victory Mmerichukwu Ogbatuo

Background: While cervical cancer is highly preventable through the HPV vaccine, early detection, and treatment, it continues to be a significant contributor to the morbidity and mortality of women in Sub-Saharan Africa (SSA). Poorer survival outcomes in SSA compared to high-income countries can, to a large extent, be attributed to patients being unable or unwilling to present to the health system to obtain curative treatment in a timely manner. Time-to-treatment interval (TTI) has gained traction as a key measure …

30.08.2026journal-article

JAMA Internal Medicine

Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer

Darryl P. Leong, Celestia Higano, Cristina Cano Garcia, Vincent Fradet, D. Robert Siemens, Tamim Niazi, Bobby Shayegan, Avirup Guha, Filipe Cirne, Joseph B. Selvanayagam, Philippe D. Violette, Felipe H. Valle, Luke T. Lavallée, Emmanuelle Duceppe, Patrick Anderson, Denis Xavier, Jose Patricio Lopez-Lopez, Nicolas Villareal Trujillo, Ariel Galapo Kann, Rafaela K. Piccoli, Marina Mourtzakis, David Sarid, Srivatsa Narasimha, Patrick P.W. Luke, Ludhmila A. Hajjar, Himu Lukka, Laurence Klotz, Kumar Balasubramanian, Rajibul Mian, Steven Agapay, Sumathy Rangarajan, Sarah Karampatos, Kelvin K. H. Ng, Alvaro Avezum, P. J. Devereaux, Jehonathan H. Pinthus, RADICAL PC Investigators, Alanna Hall, Meghan Cagnin, Maheen Farooqi

Importance Patients with prostate cancer have a high burden of cardiovascular risk factors, often suboptimally controlled, and adverse cardiovascular outcomes. Objective To determine whether the routine referral of patients with prostate cancer to a cardiovascular specialist to implement a systematic risk factor strategy is more likely to reduce adverse cardiovascular outcomes and improve risk factor control than usual care. Design, Settings, and Participants This randomized clinical trial included patients with pr …

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30.08.2026journal-article

Wilderness & Environmental Medicine

Epinephrine Autoinjectors as an Improvised Treatment for Severe Asthma in Austere Settings

Kenneth V. Iserson

Severe asthma exacerbations may rapidly become fatal when bronchodilator therapy is unavailable. In wilderness and disaster environments, inhaled β 2 -agonists—the standard treatment—may be lost, depleted, or otherwise inaccessible. Epinephrine has been used for more than a century as a bronchodilator and was historically administered subcutaneously or intramuscularly for acute asthma before selective β 2 -agonists became widely available. In emergency medicine, parenteral epinephrine remains an accepted rescue the …

30.08.2026journal-article

HEALTH RESEARCH IN AFRICA

Fardeau Psychosocial, Économique et Professionnel des Aidants de Patients Atteints de Cancer au Burkina Faso : Une Étude Transversale

Zerbo Nina Assanatou 2ème jumelle, Ilboudo Sylvain Romaric Tillius, Singbeogo Arzouma Jean Stanislas, Hien Youorsaon, Bambara Hierrhum Aboubacar

RÉSUMÉIntroduction. Le cancer représente un problème majeur de santé publique mondiale, dont les répercussions dépassent le patient pour atteindre ses proches aidants, en particulier dans les pays aux systèmes de santé fragiles. Au Burkina Faso, les données sur le fardeau des aidants de patients cancéreux demeurent rares. Cette étude avait pour but d’évaluer les impacts psychosociaux, économiques et professionnels des aidants principaux de patients suivis pour cancer au CHU de Bogodogo. Méthodes. Nous avons mené un …

30.08.2026journal-article

Arthroscopy

Editorial Commentary : Use of Glenoid Labral Augmentation as an Effective Treatment for Subcritical Glenoid Bone Loss

Anthony Zacharias

Abstract Restoration of joint function and mechanics is the goal of every shoulder stabilization surgery. Achieving this goal in the setting of altered anatomy and bone loss is easier said than done. In restoring a joint, it is important to understand what native tissue can be repaired, what can be augmented, or what needs to be reconstructed. For this, we rely on biomechanical research, patient outcomes, and long‐term follow‐up of patients. Bone augmentation procedures have provided a crucial role in shoulder inst …

30.08.2026journal-article

Journal of Surgical Oncology

When Explant Surprises: Management and Outcomes of Hepatocellular Carcinoma Beyond Milan Criteria Discovered Post‐Transplant‐ A Narrative Review of Literature

Serkan Sucu, Brian Longbottom, Hassan Aziz

ABSTRACT Liver transplantation (LT) is the definitive treatment for early hepatocellular carcinoma (HCC), based on established criteria. Pre‐transplant imaging occasionally underestimates the tumor burden or biological aggressiveness, leading to explant pathology that exceeds the projection criteria, such as Milan. This paper aims to review the incidence, prognostic implications, post‐transplant management, and outcomes of explant pathology in patients with HCC beyond Milan. We conducted a narrative review of the l …

30.08.2026journal-article

European Heart Journal – Cardio-Oncology

The use of natriuretic peptide to screen for stage B heart failure based on echocardiogram among cancer survivors

Cheng Hwee Soh, Joshua Wong, Guangli Zhu, Atro Azad, Kristyn Whitmore, Thomas H Marwick

Abstract Background and Aims Heart failure is a progressive disorder that can be identified at earlier stage, also known as stage B heart failure (SBHF). While N-terminal pro-B-type natriuretic peptide (NT-proBNP) was shown to be a key biomarker, its screening performance among cancer survivors remains uncertain. This study aimed to identify the performance of NT-proBNP in identifying SBHF, encompassing both structural and functional abnormalities, in survivors. Methods Survivors ≥5 years post cancer therapy and wi …

30.08.2026journal-article

Journal of Clinical Medicine

Comparison of the Effects of Sorafenib and Stem Cell Secretome on HepG2 Cancer Cells with Respect to the Ras/Raf/MEK/ERK Pathway

Aleksandra Gładyś, Aleksandra Skubis-Sikora, Bartosz Sikora, Kinga Pogoda-Mieszczak, Patrycja Wieczorek, Edyta Bogunia, Piotr Czekaj

Background/Objective: Liver cancer is a global health challenge due to its resistance to most systemic therapies. Human mesenchymal and epithelial stem cells exhibit anti-proliferative and pro-apoptotic effects on some cancer cell lines, which can be used to support standard therapy. The aim of this study was to investigate the effects of conditioned media (CM) derived from mesenchymal adipose tissue-derived stem cells (hADSCs) and amniotic membrane-derived cells expressing both mesenchymal and epithelial markers ( …

30.08.2026journal-article

Non-Coding RNA

Circulating Cell-Free miR-25-3p Is Upregulated in Brazilian Patients with Prostate Cancer and Contributes to Tumor Aggressiveness

Monyse Nobrega, Hellen Kuasne, Marilesia Ferreira de Souza, Mariana Bisarro dos Reis, Larissa Cristina Bastos de Oliveira, Paulo Emilio Fuganti, Morag Park, Ilce Mara de Syllos Cólus

Background/Objectives: Prostate cancer (PCa) has a high incidence worldwide, yet reliable prognostic biomarkers to distinguish indolent from aggressive forms are lacking. MicroRNAs (miRNAs), a class of small non-coding RNAs, are stable molecules that play an important role in cancer development and can be detected in circulation by non-invasive methods. This study aimed to examine the influence of the cell-free (cf) miRNAs levels on PCa risk and aggressiveness using plasma samples and cell models. Methods: Four ove …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Causes of pulmonary bleeding in cancer patients

Roman S. Kiselev, Evgeniy A. Tarabrin, Z. G. Berikkhanov, S. Yu. Muravev, M. Yu. Ivanova

Objective. To analyze the causes of pulmonary hemorrhage (PH) in cancer patients. Material and methods. During the period 2010–2022, pulmonary hemorrhage was treated in cancer patients. The causes of PH were analyzed based on the nosology of cancer diseases. The involvement of the great circle of circulation (GCC) was determined based on the presence of direct or indirect radiological signs of bronchial angiography, the clinical outcome of endovascular treatment for PH, and the results of autopsy. CT of the chest w …

30.08.2026journal-article

Journal of the American Heart Association

Sex Differences in Treatment Effect of Adjunctive Intra‐Arterial Urokinase After Successful Thrombectomy: A Post Hoc Secondary Analysis of the POST‐UK Randomized Clinical Trial

Xuanyu Chen, Linyu Li, Gaoming Li, Lingyu Zhang, Haoxuan Zhu, Xu Xu, Jinfu Ma, Lilan Wang, Zhixi Wang, Jiayu Li, Qiuyi Yang, Yian Chen, Mingyang Chen, Yihui Yang, Yuhan Fan, Kaiyuan Feng, Chunye Chen, Jiaxing Song, Wenjie Zi, Kunxin Lin

Background Whether adjunct intra‐arterial urokinase has differential effectiveness and safety by sex among patients with acute ischemic stroke who achieve near‐complete to complete reperfusion after endovascular thrombectomy (EVT) remains unknown. Methods This post hoc analysis of the POST‐UK (Adjunctive Intra‐Arterial Urokinase After Successful Endovascular Thrombectomy in Patients With Large‐Vessel Occlusion Stroke) multicenter randomized clinical trial included 534 patients with proximal intracranial large‐vesse …

30.08.2026journal-article

Libyan Journal of Medical Research

Study on Ginger as a Treatment for Stress and Anxiety Comparing With Diazepam

Ashraf Alzalitini, Naima El-Kakalli, Wafa Issadiq

Background: The psychological anxiety is considered one of the most significant animals of the modern era. The most common causes natural indictors that lead to tension, severe stress and un-desirable mental problems or disease are stress Anxiety problems or disease that considered as most frequently appearing as disorders. Anxiety disease is diagnosing as condition that showed or indicate to serious and severe or pathological case as the essential disturbance emotional tone. Aim: In this study, ginger was tested i …

30.08.2026journal-article

AI in Precision Oncology

Governing What We Cannot yet Verify: The Verification Paradox and Responsible AI Implementation in Precision Oncology

Yan Leyfman, Arturo Loaiza-Bonilla

Artificial intelligence (AI) is increasingly embedded in precision oncology, shaping molecular classification, biomarker interpretation, treatment selection, toxicity prediction, trial matching, and disease monitoring—yet institutional governance has not kept pace with clinical adoption. An original cross-sectional survey of U.S. oncology clinicians ( N = 52) reveals a structural governance gap: 83% use AI independently on personal platforms, 71% report no institutional governance policy, and 77% operate without in …

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Classifying High-Dimensional Lung Cancer Data Using an Improved Deep Learning Model

Dual‐Acceptor Engineered Multimodal Phototheranostic NIR‐II AIEgens for Orthotopic Breast Cancer Treatment

Influence of Bitumen Chemistry and Crumb Rubber Pre-Treatment on the Storage Stability and Rheological Performance of Modified Binders

Research Progress on the Use of Yue ju Pill in the Treatment of Functional Dyspepsia

Adding Intratumoral Antibody‐Photoabsorber Conjugate Improves Efficacy of Near‐Infrared Photoimmunotherapy ( NIR ‐ PIT )

The Submandibular Tumor: Unmasking a Rare Hypoglossal Schwannoma

Beyond TNM : Tumor Volume as a Prognostic Marker in Laryngeal Cancer

Optimizing Ketamine Infusion Therapy for Treatment‐Resistant Bipolar Depression: Commentary on Zhou et al. (2023)

Оцінка ефективності й безпечності використання аксилярної канюляції при хірургічному лікуванні патології грудної аорти

A Novel 3D Hybrid Transformer-Dense Segmentation Network with Adaptive Capsule-LSTM Classification for Early-Stage Lung Cancer Detection on Kaggle CT Images

Coronary Plaque Burden and Plaque Composition in Long-Term Cancer Survivors: A Comparative CCTA Study

Navigating the Gap: A Review of Time to Treatment Intervals and Cervical Cancer Survival in Sub-Saharan Africa

Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer

Epinephrine Autoinjectors as an Improvised Treatment for Severe Asthma in Austere Settings

Fardeau Psychosocial, Économique et Professionnel des Aidants de Patients Atteints de Cancer au Burkina Faso : Une Étude Transversale

Editorial Commentary : Use of Glenoid Labral Augmentation as an Effective Treatment for Subcritical Glenoid Bone Loss

When Explant Surprises: Management and Outcomes of Hepatocellular Carcinoma Beyond Milan Criteria Discovered Post‐Transplant‐ A Narrative Review of Literature

The use of natriuretic peptide to screen for stage B heart failure based on echocardiogram among cancer survivors

Comparison of the Effects of Sorafenib and Stem Cell Secretome on HepG2 Cancer Cells with Respect to the Ras/Raf/MEK/ERK Pathway

Circulating Cell-Free miR-25-3p Is Upregulated in Brazilian Patients with Prostate Cancer and Contributes to Tumor Aggressiveness

Causes of pulmonary bleeding in cancer patients

Sex Differences in Treatment Effect of Adjunctive Intra‐Arterial Urokinase After Successful Thrombectomy: A Post Hoc Secondary Analysis of the POST‐UK Randomized Clinical Trial

Study on Ginger as a Treatment for Stress and Anxiety Comparing With Diazepam

Governing What We Cannot yet Verify: The Verification Paradox and Responsible AI Implementation in Precision Oncology