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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Receptors

Differential Regulation of Soluble and Membrane 4-1BB and OX-40 Within the Peripheral Compartment of Cervical Cancer

Jose Manuel Rojas-Diaz, Fernando Galvan-Ledezma, Ksenia Klimov-Kravtchenko, Nadia Tatiana Garcia-Barrientos, Ana Delia Orozco-Jacobo, Alan Delgadillo-Gutierrez, Blanca Estela Bastidas-Ramirez, Jesse Haramati, Susana del Toro-Arreola

Background: Members of the tumor necrosis factor receptor superfamily (TNFRSF), including 4-1BB (CD137) and OX-40 (CD134), play central roles in regulating cytotoxic lymphocyte activation and anti-tumor immunity. In addition to their membrane-bound forms, soluble receptor isoforms may modulate signaling by influencing ligand availability and receptor engagement. However, the peripheral regulation of soluble and membrane 4-1BB and OX-40 in cervical cancer remains incompletely defined. Methods: Plasma concentrations …

02.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Implementing a Risk-Stratified National Breast Screening Programme in the United Kingdom: A Model-Based Cost-effectiveness Analysis

Stuart J. Wright, Joe Hilton, Gabriel Rogers, Ewan Gray, Anna Donten, Lorna McWilliams, D. Gareth R. Evans, David P. French, Katherine Payne

Abstract Background: Risk-stratified breast screening, in which women are offered different screening intervals based on their breast cancer risk, has been proposed as a way to improve the benefits of screening in the United Kingdom National Breast Screening Programme (UK-NBSP). The aim of this study was to explore the cost-effectiveness of potential risk-stratified breast screening strategies in the UK-NBSP. Methods: An existing validated discrete event simulation model (MANC-RISK-SCREEN) was used to evaluate the …

02.09.2026journal-article

Current Oncology

Real-World Outcomes of Second-Line Chemotherapy in Metastatic Urothelial Carcinoma

İlkay Çıtakkul, Hayati Arvas, Mert Karaoğlan, Bahadır Köylü, Nazan Demir, Gözde Balkaya Aykut, Elif Şahin, Mesut Yılmaz, Zuhat Urakçı, Duygu Bayır Garbioğlu, Fatih Selçukbiricik, Ece Baydar, Beşire Nurdan Tazebay, Melike Yazıcı, Yasemin Bakkal Temi, Devrim Çabuk, Kazım Uygun, Umut Kefeli

Second-line chemotherapy is widely used in metastatic urothelial carcinoma after progression on first-line platinum-based therapy, but its independent contribution to survival, as opposed to selection of healthier patients, remains unclear. In this multicenter retrospective cohort of 142 patients treated with first-line platinum-based chemotherapy across seven Turkish centers, overall survival (OS) from first-line progression was compared between patients who received second-line chemotherapy (n = 80) and those who …

02.09.2026journal-article

The Oncologist

Functional Brain Network Alterations Linked to Cancer-Related Cognitive Impairment in Breast Cancer Patients

Alberto Benelli, Julianne Reilly, Jorge Ortega-Márquez, Michael Parsons, Jorg Dietrich, Giulia Sprugnoli, Felipe Fregni, Emiliano Santarnecchi

Abstract Background Life expectancy for cancer patients has improved due to new therapies, but many survivors experience long-lasting side effects, including cancer-related cognitive impairment (CRCI). CRCI symptoms—such as difficulties with attention, memory, processing speed, fatigue, and concentration—can persist for years post-treatment. While clinical evidence of CRCI exists, its underlying mechanisms and neural correlates remain unclear. This study aimed to identify functional brain networks associated with C …

02.09.2026journal-article

Neuro-Oncology Advances

A multicenter analysis of prognostic factors for patients undergoing re-irradiation for recurrent glioblastoma

Niklas Benedikt Pepper, Maja Guberina, Christoph Pöttgen, Fabian Martin Troschel, Michael Oertel, Gerrit Fischedick, Lars Oliver Kiwitt, Cornelius Deuschl, Ramazan Jabbarli, Ulrich Sure, Philipp Dammann, Karsten Wrede, Sied Kebir, Andreas Junker, Michael Müther, Björn Scheffler, Oliver Grauer, Tanja Kuhlmann, Walter Stummer, Florian Padeberg, Hans Theodor Eich, Martin Stuschke, Nika Guberina

Abstract Background Re-irradiation (re-RT) has gained popularity in the treatment of recurrent or progressive glioblastoma (rGBM) after first-line treatment. However, uncertainties regarding optimal treatment dose, fraction size and target volume definition remain. In this multicenter analysis of the Western German Cancer Center (WTZ), we analyze prognostic factors for patients treated with re-RT for rGBM with different fraction regimens. Methods We analyzed patients with rGBM (CNS-WHO °4, IDH-wildtype) who receive …

02.09.2026journal-article

Frontiers in Pharmacology

The multifaceted functions of lactate and its translational potentials in cancer

Ping Wang, Xia Yang, Yunfei Yan, Qiang Fu, Jinxia Hu, Sen Xu, Xin Wang, Fei Jiao

As considered as a mere waste product historically, the biological functions of lactate have been overlooked for a long time. Over the past decades, accumulated data has implicated the multiple and substantial roles of lactate in physiological and pathological contexts, particularly in cancer. This review aims to provide a comprehensive overview about lactate biology in both health homeostasis and oncology. We first presented a systematic elaboration about lactate metabolism, including its property, production, tra …

02.09.2026journal-article

Journal of Chemical Technology and Metallurgy

EFFECT OF ULTRASONIC TREATMENT AND CALCINATION TEMPERATURE OF RICE HUSK ASH ON THE CHARACTERISTICS OF SILICA-CHITOSAN COMPOSITES

Ani Purwanti, Fajar Yulianto Prabowo

This study investigates the effect of calcination temperature and ultrasonic treatment during the extraction of silica from rice husk ash and its implications for the characteristics of silica-chitosan composites. Rice husk ash was calcined at temperatures of 500, 600, and 700°C, followed by extraction using 2M NaOH solution with and without ultrasonic treatment. The extracted silica was subsequently combined with chitosan to form silica-chitosan composites. Characterization was carried out using X-ray fluorescence …

02.09.2026journal-article

Applied Immunohistochemistry & Molecular Morphology

Profiling NFκB and VEGF Expression in Mouse Embryonic Stem Cells, Lung Cancer Cells, and Fibroblasts

Berrin Ozdil, Eda Acikgoz, Gulperi Oktem, Kubilay Dogan Kilic, Huseyin Aktug

Cancer is one of the leading causes of morbidity and mortality worldwide, with lung cancer ranked among the most lethal malignancies. A key hallmark of cancer progression is neovascularization, primarily mediated by vascular endothelial growth factor (VEGF), which stimulates vasculogenesis and angiogenesis. In parallel, the transcription factor nuclear factor of kappa B (NFκB) plays a critical role in inflammation, immune regulation, and tumor development by modifying numerous signaling pathways. In this study, we …

02.09.2026journal-article

Evidence-Based Dentistry

Does preoperative ibuprofen reduce pain during treatment of deep caries in children?

Marcin Baranowski, Greig D. Taylor

Abstract A Commentary on Bilmez Selen M, Kuru B. Effect of preoperative ibuprofen on pain perception and pulse rate in paediatric patients with deep caries: a randomised controlled trial. Eur J Paediatr Dent. 2026:1. https://doi.org/10.23804/ejpd.2026.2598 . Design A prospective, parallel single-blinded randomised controlled trial aimed to evaluate the effect of pre-operative ibuprofen administration on pain control during vital pulp therapy (VPT) procedures for a mandibular molar diagnosed with reversible pulpitis …

02.09.2026journal-article

Clinical and Translational Oncology

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Macarena Teja, Fernando López Campos, Álvaro Pinto, Israel J. Thuissard, María González, David Esteban, Abrahams Ocanto, Castalia Fernández, Daniela Gonsalves, Lisselott Torres, María Isabel Garrido, Escarlata López, Jaume Fernández, Loubna Aakki, Antonio Ristori, José Begara, Sigfredo Elias Romero Zoghbi, Jon Andreescu, Ana Belén Bezares, María Mateos, Miguel Ángel Berenguer, Daniel Rivas, Elisabet González del Portillo, Cristina Andreu, Esther Holgado, Shankar Siva, Constantinos Zamboglou, Felipe Couñago

Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study included oligometastatic patients with primary solid tumours treated with SBRT between 2020 and 2024 across 12 Spanish radiotherapy centres. The primary endpoint was 1-year progression-free survival (PFS). The secondary endpoints included ove …

02.09.2026journal-article

International Journal of Molecular Sciences

Nutritional Prevention of Oxidative Stress-Induced Cardiotoxicity in Pediatric Cardio-Oncology: Molecular Mechanisms and Translational Perspectives—A Narrative Review

Karmen Stankov, Bojan Stanimirov, Aleksandar Ninković, Maja Đanić, Slavica Lazarević, Dragana Zaklan, Nebojša Pavlović

Cancer therapy-related cardiotoxicity has emerged as a major challenge in contemporary oncology, particularly in long-term survivors of childhood malignancies. Oxidative stress (OS)-induced cardiotoxicity represents a key mechanistic pathway underlying myocardial injury caused by numerous anti-neoplastic drugs, most notably anthracycline-based chemotherapy, while OS also critically contributes to radiotherapy-induced cardiotoxicity. Excessive reactive oxygen and nitrogen species generation promotes mitochondrial dy …

02.09.2026journal-article

Journal of Clinical Medicine

Can Ultrasound Texture Analysis Differentiate Liver Metastases According to the Histopathological Origin of the Primary Tumor?

Seda Nida Karakucuk, Murat Baykara, Mehmet Demir, Ali İsler

Objective: We aimed to investigate whether ultrasound-based texture analysis can differentiate liver metastases according to the histopathological origin of the primary tumor and to evaluate the quantitative texture characteristics of metastases originating from colorectal, pancreatic, and breast cancer. Materials and Methods: This prospective study included 75 patients with biopsy-proven liver metastases, comprising 25 colorectal adenocarcinoma, 25 pancreatic ductal adenocarcinoma, and 25 invasive ductal breast ca …

02.09.2026journal-article

Current Oncology

Explainable Deep Learning Model for Predicting Overall Survival in Patients Receiving Palliative Radiotherapy for Bone Metastases

Yui Watanabe, Takuya Tomoda, Akiko Iwata, Hirokazu Matsuno, Hiroto Hayakawa, Takeshi Nagata

Purpose: Although machine learning-based prediction of overall survival (OS) in palliative radiotherapy for bone metastases has been investigated, explainable deep learning (DL) models remain underexplored. This study aimed to develop and validate an explainable DL model to predict OS in this setting, and to examine whether this flexible model provides predictive value beyond a standard Cox model based on routinely collected baseline variables. Methods and Materials: We analyzed all 472 eligible patients who receiv …

02.09.2026journal-article

Mycopathologia

Epidemiology and Species Distribution of Candida Bloodstream Infections in a Comprehensive Cancer Center, 2008–2023

Mohammad El-Atoum, George L. Chen, Brahm H. Segal, John P. Bonnewell, Nikolaos G. Almyroudis

Abstract Introduction Candida bloodstream infections remain a significant complication of malignancies and their therapies. Aim To investigate the epidemiology of Candida species causing bloodstream infections in patients with malignancies. Methods We retrospectively reviewed bloodstream infections due to Candida from July 2008 to June 2023 in patients admitted under hematological, solid tumor and surgical services. Common species included C. albicans, Nakaseomyces glabratus (formerly C. glabrata ), Pichia kudriavz …

02.09.2026journal-article

Laryngoscope Investigative Otolaryngology

Large Language Models Versus Multidisciplinary Tumor Board Decisions in Thyroid Cancer

Bayram Barış Büyük, Arzu Or Koca, Felat Toprak, Aslı Ayan, Tuncay Tunçcan, Ayça Arslan, ArzuBetül Duran, Elif Akyol Şen, Ömer Semih Budak, Alptekin Gürsoy, Caner Kılıç

ABSTRACT Objectives Large language models (LLMs) are increasingly proposed as clinical decision‐support tools; however, their agreement with real‐world multidisciplinary tumor board (MDT) decisions remains insufficiently investigated in thyroid oncology. To evaluate the concordance between treatment recommendations generated by ChatGPT 5.2 and Gemini 3.0 and decisions made by a tertiary multidisciplinary thyroid tumor board. Methods This study included 59 consecutive patients discussed at a tertiary MDT between Aug …

02.09.2026journal-article

Acta Odontologica Turcica

Evaluation of parents' knowledge and awareness of early orthodontic treatment for their children in Türkiye

Mehmed Taha Alpaydın, Merve Köklü, Tuğçe Alpaydin

ABSTRACT OBJECTIVE: The aim of this study is to evaluate the knowledge and awareness levels of parents in Turkish society regarding early orthodontic treatment and to explain how it is related to various factors. MATERIALS AND METHODS: The survey was distributed to voluntary participants across Türkiye via Google Forms. Sociodemographic data and data measuring the level of knowledge and awareness about early orthodontic treatment were obtained. Data analysis was performed using SPSS (Statistical Package for Social …

02.09.2026journal-article

British Journal of Healthcare and Medical Research

Associations of Musculoskeletal Pain with Sociodemographic, Health Related, Reproductive Related, Pain Related, Treatment Seeking Pattern and Outcome Among Postmenopausal Women From Dhaka City

Rojina Akter, Abu Sayed Mohammad Giasuddin, Jasim Uddin, Md. Raisul Hassan

Background: The associations (correlations) of Musculoskeletal pain (MSP) with the presenting characteristics in postmenopausal women from Dhaka City are not known; Objectives: To determine the statistical significance of the associations of MSP with the presenting characteristics in postmenopausal women from Dhaka City; Materials & Methods: Statistically further analyses were done for associations of MSP with the presenting features reported in our descriptive cross-sectional study. The SPSS version 22.0 was used …

02.09.2026journal-article

Acta Poloniae Pharmaceutica - Drug Research

Potential Mechanism of Ginsenoside Re in Tumor Progression of Colorectal Cancer Through Affecting MmiR-4516

Zeming Bai, Zhuoran Li, Lifen Mu, Juanjuan Yan, Xinfeng Wang, Limin Chai, Xiaoxia Wang, Zhiying Hao

This study aims to investigate whether G-Re exerts anti-tumor effects in CRC by modulating miR-4516. The anti-proliferative effect of G-Re was evaluated by CCK-8 (IC₅₀ calculation). MiR-4516 expression was detected via qRT-PCR. Functional assays (proliferation, migration, invasion) were performed after transfection with miR-4516 inhibitor/mimic and G-Re treatment. The miR-4516/ETV4 binding relationship was confirmed by dual-luciferase and RIP assays, with ETV4 expression examined. Rescue experiments were conducted …

02.09.2026journal-article

Mathematics

Optimal Chemotherapy Control and Dynamics of Tumor–Immune Interactions

Saira Batool, Muhammad Imran, Brett McKinney

This study develops and analyzes a nonlinear tumor–immune–chemotherapy model to investigate how chemotherapy influences tumor suppression in the presence of heterogeneous tumor subpopulations and immune responses. The model incorporates two tumor cell populations with different immunogenic characteristics, innate and adaptive immune responses, and a dynamic chemotherapy effect. We analytically identify the equilibrium points and assess the conditions for their stability in the presence of chemotherapy. A bifurcatio …

02.09.2026journal-article

INTERNATIONAL JOURNAL OF APPLIED SCIENCE AND MATHEMATICAL THEORY

Survival Times of Triple-Negative Breast Cancer Patients Based on Treatment Type: A Comparative Nonparametric Survival Analysis

Hindatu Saidu

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with poor prognosis and limited treatment options. Survival outcomes among TNBC patients are known to vary depending on the type of treatment received, making comparative survival evaluation essential for clinical decision-making. This study aimed to assess and compare the survival times of TNBC patients based on different treatment types, including chemotherapy, radiotherapy, surgery, and combination therapy. Survival data fr …

02.09.2026journal-article

Molecular Cancer Research

The PON1–NDUFA4 Axis Maintains Mitochondrial Respiratory Fitness and Drives Lenvatinib Tolerance in Hepatocellular Carcinoma

Shi-Lin Lin, Yue Wang, Yi-min Zheng, Ai-Wu Ke, A-ying Ma, Chao Gao

Abstract Metabolic plasticity driven by mitochondrial oxidative phosphorylation (OXPHOS) is increasingly recognized as a key determinant of therapeutic tolerance in hepatocellular carcinoma (HCC), but the upstream regulators that preserve electron transport chain stability during treatment remain poorly defined. In this study, we identified paraoxonase 1 (PON1) as a clinically relevant regulator of mitochondrial metabolism and lenvatinib response in HCC. PON1 was markedly upregulated in HCC and independently associ …

02.09.2026journal-article

Journal of Clinical Medicine

The Prognostic Value of the Advanced Lung Cancer Inflammation Index on Disease-Free Survival in Patients with Gastric Cancer Receiving Neoadjuvant Chemotherapy

Mahmut Kara, Muslih Ürün, Senar Ebinç, Yasin Sezgin, Yonca Yılmaz Ürün, Mehmet Naci Aldemir

Objectives: The present study investigated whether the pre-treatment Advanced Lung Cancer Inflammation Index (ALI) could serve as a prognostic indicator of disease-free survival (DFS) in patients with locally advanced gastric cancer treated with neoadjuvant chemotherapy followed by curative D2 gastrectomy. Methods: We retrospectively analyzed 157 patients with gastric adenocarcinoma who received treatment between 2016 and 2025. The pre-treatment ALI was derived from body mass index, serum albumin concentration, and …

02.09.2026journal-article

Frontiers in Microbiology

HIV-driven tumor ecosystem: from chronic immune dysfunction to cancer evolution

Guangchao Zhou, Juanyan Liao, Haolin Tang, Xingyu Hou, Qing Li, Xia Li

Although HIV-associated malignancies have been reviewed separately through the lens of individual oncogenic viruses (KSHV, EBV, HPV) or immune dysfunction in isolation, no prior synthesis has integrated these processes into a single, systemic “tumor ecosystem” framework spanning virology, immunology, the tumor microenvironment, and clinical treatment response. Human immunodeficiency virus (HIV) infection profoundly alters the immune landscape, establishing a distinctive tumor ecosystem characterized by chronic immu …

02.09.2026journal-article

Molecular Oncology

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane

Various environmental and endogenous stressors, including ultraviolet (UV) radiation, cytotoxins, and dysregulated translation, can induce ribosome stalling and collisions, disrupting protein homeostasis. The ribotoxic stress response (RSR) is a cellular surveillance mechanism that senses translational stress and activates stress signaling via the MAP3 kinase ZAKα and the stress‐activated protein kinases (SAPKs) p38 and JNK. This review outlines the molecular mechanisms behind RSR, distinguishes RSR from other tran …