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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Frontiers in Public Health

The role of voluntary health insurance in frailty onset and progression among older and aging European adults: a survival analysis, 2013–2022

Michele Sorrentino, Yamato Uejima, Giuseppina Affinito, Paolo Montuori, Raffaele Palladino

Background Frailty is a syndrome characterized by physiological decline and increased vulnerability to adverse health outcomes, including disability, hospitalization, and mortality In Europe, 5.8–27.3% of those aged ≥65 is frail, and up to 50.9% is pre-frail. With an aging population, and cuts to public health spending, erosion of universal health coverage is becoming more evident in European Health Systems. As a result, voluntary health insurance (VHI) is becoming more common, offering faster access and reduced ou …

01.09.2028journal-article

Nursing and Health Sciences Journal (NHSJ)

Culturally embedded resilience in the diabetes-COVID-19 syndemic: A phenomenological study of older adults in Bali, Indonesia

Putu Wira Kusuma Putra, Ni Komang Matalia Gandari, Ni Nyoman Suardani, Meriana Barreto Amaral

The COVID-19–diabetes mellitus (DM) syndemic disproportionately threatened older adults with Type 2 DM globally. This study investigates the culturally embedded resilience mechanisms enabling older Balinese adults with long-standing T2DM to maintain complication-free status during this crisis, directly challenging dominant deficit narratives. A descriptive phenomenological study grounded in Husserlian principles recruited ten older adults (aged 56–70; T2DM ≥20 years) in Badung Regency, Bali, utilizing purposive sam …

01.09.2026journal-article

Healthcare

Development and Preliminary Psychometric Evaluation of the Spiritual Needs Scale for Older Adults Receiving Palliative Care

Linan Cheng, Qian Chen

Background: Meeting the spiritual needs of older adults receiving palliative care requires culturally sensitive and psychometrically sound assessment instruments. This study aimed to develop and evaluate the psychometric properties of the Spiritual Needs Scale (SNS) for older adults receiving palliative care. Methods: The primary version of the SNS was developed through a scoping review, in-depth interviews, Rodgers’ concept analysis, and expert consultation. A consecutive sample of 395 older adults receiving palli …

01.09.2026journal-article

Autism in Adulthood

“A Delightful Embodiment of Dichotomies”: A Qualitative Exploration of Self-Concept and Identity Among Autistic and Non-Autistic People

Amy Pearson, Helen Knight, Ray Winter, Kieran Rose, Jon Rees

Background: There is a growing focus on a positive autistic identity; however, we know very little about self-defined autistic self-concept beyond what it means to be “autistic.” Methods: We conducted semistructured interviews (written or spoken) with 103 people; 51 were autistic, 10 were neurodivergent but not autistic, and 42 were neurotypical. We asked them questions about their identity and self-concept. We also invited them to submit an artifact (e.g., a photograph or a drawing) that they felt represented who …

01.09.2026journal-article

Frontiers in Aging Neuroscience

Structural and functional alterations of posterior cingulate cortex subregions in successful cognitive aging

Jie Wang, Yunfei Li, Tianyuyi Feng, Ruixia Xu, Jiaqi Li, Yanling Zheng, Yang Hu, Xiaohu Zhao

Successful cognitive aging (SCA) describes the preservation of cognitive abilities into advanced age, but its neural basis remains incompletely understood. Metabolic and pathological evidence implicates the posterior cingulate cortex (PCC) as a key region supporting cognitive resilience. However, functionally distinct PCC subregions have rarely been examined using complementary structural, microstructural, and functional imaging measures. In this cross-sectional secondary analysis of publicly available Human Connec …

01.09.2026journal-article

Economies

Aging Before Affluence: Welfare Regime Typologies and Social Protection Sustainability Across Asian Demographic Trajectories

Mana Luksamee-arunothai, Phubet Senbut

Population aging in Asia is arriving before the institutions to support it. Assessments of social protection usually treat sustainability, adequacy and fairness separately, obscuring how they trade off within one system. This study introduces NTA-SAFE, five indicators derived from the National Transfer Accounts lifecycle identity, applied to Japan, South Korea, Thailand, the Philippines and Indonesia. Base-year per capita profiles are combined with UN World Population Prospects 2024 populations through 2050, so all …

01.09.2026journal-article

Frontiers in Aging Neuroscience

Age-related variation in the association between intraoperative dynamic cerebral autoregulation impairment proportion and postoperative neutrophil-to-lymphocyte ratio: an exploratory observational study

Chengying Ji, Bokang Yang, Jiayi Xie, Jinxiang Xie, Xiaodong Su, Yatao Liu

Background Dynamic cerebral autoregulation (dCA) impairment during surgery has been associated with adverse neurologic outcomes. Whether the burden of impaired dCA is related to the postoperative peripheral inflammatory response, and whether this association varies with age, remains uncertain. Objective To examine whether age modifies the association between intraoperative dCA impairment proportion and the neutrophil-to-lymphocyte ratio on postoperative day 3 (NLR3). Methods This single-center exploratory observati …

01.09.2026journal-article

Journal of the American Heart Association

Associations of Cardiovascular–Kidney–Metabolic Syndrome With All‐Cause and Cardiovascular Death and the Progression of Cardiovascular–Kidney–Metabolic Syndrome Among Hong Kong Chinese People Over 2 Decades

Lanlan Li, David Tak‐Wai Lui, Carol Ho‐Yi Fong, Jimmy Ho‐Cheung Mak, Chloe Yu‐Yan Cheung, Aimin Xu, Kathryn Choon‐Beng Tan, Hung‐Fat Tse, Jean Woo, Tai‐Hing Lam, Yu‐Cho Woo, Bernard Man‐Yung Cheung, Karen Siu‐Ling Lam, Chi‐Ho Lee

Background In 2023, the American Heart Association established the cardiovascular–kidney–metabolic (CKM) syndrome and defined its different stages. Here, we analyzed the prospective associations of CKM stages with mortality outcomes and how CKM syndrome progresses over time. Methods This observational study used data from the Hong Kong CRISPS (Cardiovascular Risk Factor Prevalence Study) 2, a population‐based cohort involving community‐dwelling Chinese participants who underwent comprehensive health assessment betw …

01.09.2026journal-article

BMC Geriatrics

Food insecurity and gender inequalities in healthy ageing among older adults in India: Evidence from LASI Wave-I and Blinder-Oaxaca decomposition analysis

Anil Kumar Pal

Abstract Background Population ageing has become a major public health challenge in India, prompting increased attention to factors that promote healthy ageing. Food insecurity is an important social determinant of health that may adversely affect physical, cognitive, psychological, and social well-being in later life. However, evidence on the association between food insecurity and healthy ageing among older adults in India remains limited. This study examined the relationship between food insecurity and healthy a …

01.09.2026journal-article

Reviews in Medical Virology

An Appraisal of the Potential Downstream Benefits of RSV Vaccination in Older Adults

Piotr Rzymski

ABSTRACT Respiratory syncytial virus (RSV) has long been underrecognized as a significant pathogen in older adults, despite accumulating evidence of its substantial morbidity and mortality burden in this population. While RSV vaccination is now well established as an effective intervention for preventing lower respiratory tract disease, this narrative review examines whether its public health value may extend beyond these primary clinical endpoints. A targeted search of Scopus and Web of Science from database incep …

01.09.2026journal-article

Journal of Applied Physiology

Association between neural-drive variability and motor function in middle-aged and older adults

Roger M. Enoka, Jacques Duchateau

The purpose of this review was to examine the extent to which variability in the cumulative set of action potentials sent from the spinal cord (neural drive) to limb muscles can explain the variance in performance of middle-aged and older adults on the NIH Toolbox measures of motor function. Neural-drive variability is attributable to two spinal mechanisms: low-frequency oscillations in the shared synaptic input onto alpha motor neurons and synaptic noise in the generation and transmission of action potentials by i …

01.09.2026journal-article

GeroPsych

Predictors of Depression in Older Immigrants

N. Tuğba Bahar, Jasmin Tahmaseb-McConatha, V. K. Kumar, Frieder R. Lang

Abstract: Background: Depression has become a widespread mental health concern as millions of older immigrants are living and aging in host countries. This scoping review identified factors associated with depression among immigrants over 65 years old and provided evidence-based recommendations for future research, treatment, and policymaking. Method: We conducted a systematic search across four databases from 2005 to June 2025 and identified 21 studies for an in-depth review. Results: A thematic analysis helped id …

01.09.2026journal-article

Healthcare

Psychosocial Predictors of Healthcare Decision-Making Capacity in Older Adults: The Role of Cognitive Functioning and Affective Symptoms

Emília Santos, Ana S. Amaral, Rosa M. Afonso

Background/Objectives: The capacity for decision-making in healthcare is a critical component of autonomy in later life; however, its psychosocial determinants remain insufficiently understood. This study aimed to examine the relationship between decision-making capacity in healthcare, cognitive functioning, depressive and anxiety symptoms, and sociodemographic factors in cognitively healthy older adults, and to identify psychosocial predictors of capacity for decisions. Methods: A cross-sectional study was conduct …

03.09.2026journal-article

BMJ Open

Developing culturally appropriate physical activity promotion strategies for older Chinese adults in the UK: an evidence-based, theory-based and person-based intervention development study

Yang Yang, Kimberly Lazo Green, Nan Zhang, Lisa McGarrigle, Chris Todd

Background Older Chinese adults in the UK face unique needs when engaging in physical activity (PA), yet culturally appropriate strategies to promote PA remain limited. Objective To develop culturally appropriate PA promotion strategies for older Chinese adults living in the UK. Methods The intervention development comprised two stages: design and optimisation. It was informed by previous research findings and input from public and community involvement and engagement. Stage 1 combined the person-based approach (PB …

01.09.2026journal-article

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Seven days of warm water immersion modulate baseline fluid-regulatory hormones without altering acute multisystem physiological stress responses in older males

Ben J. Lee, James J. McCormick, Kelli E. McCormick, Kristina-Marie T. Janetos, Glen P. Kenny

This study demonstrates that short-term (7 days) passive heat acclimation via warm water immersion induces selective endocrine adaptation without uniform protection across physiological systems in older males aged 60–80. Although RAAS-mediated fluid regulation was modified following heat acclimation, gastrointestinal and renal stress responses to acute heat exposure persisted. These findings suggest that physiological adaptation to repeated heat exposure in aging may be compartmentalized across organ systems, with …

01.09.2026journal-article

Pharmaceuticals

Need for Medication Review and Deprescribing in People Living with HIV: A Longitudinal Observational Study

Emanuela De Bellis, Danilo Donnarumma, Annarita Pagano, Ines Mazza, Bruno Charlier, Simona Madonia, Alfonso Masullo, Mirella Onofrio, Valentina Fortunato, Anna Maria Spera, Federica Campana, Gianluigi Franci, Flora Salzano, Graziamaria Corbi, Amelia Filippelli, Pasquale Pagliano, Valeria Conti

Background/Objectives: People Living with HIV (PLWH) often have comorbidities require polypharmacy, increasing the risk of adverse events (AEs) associated with drug–drug/drug–supplement interactions (DDIs/DSIs). However, DDIs and DSIs, including those involving antiretrovirals (ARVs), and their related effects have not been exhaustively assessed. This study aimed to determine, in HIV patients on HAART who are taking multiple medications, the prevalence of DDIs and DSIs involving both ARVs and non-ARV co-medications …

01.09.2026journal-article

Journal of Iranian Medical Council

Changes in Lactobacillus and Bifidobacterium Load in a Population of Iranian People with Papillary Thyroid Cancer: The Effect of Radioactive Iodine therapy

Sakineh Moghadam Shiri, Nahid Hashemi-Madani, Sara Cheraghi, Babak Fallahi, Sara Minaeian, Maryam Honardoost, Fereshteh Shahrabi, Mohammad E. Khamseh

Background: To investigate the changes in Lactobacillus and Bifidobacterium load in a population of Iranian people with Papillary Thyroid Carcinoma (PTC) before and following Radioactive Iodine (RAI) therapy. Methods: This longitudinal cohort study included 28 healthy individuals and 30 PTC patients referred for RAI therapy. A total of 90 stool samples from the same 30 patients with PTC were collected one day before RAI therapy, two weeks and two months following RAI therapy. As a control group, 28 stool samples we …

01.09.2026journal-article

Frontiers in Medicine

Risk factors and prediction model for mortality risk in older adults septic patients

Shao-Zhen He, Lu-Zhen Qiu, Yong-Xiang Li, Zhao-Bin Yang, Xiao-Mei Cheng

Background The early identification of septic patients at high risk of mortality is essential for improving clinical outcomes. This study aimed to investigate the risk factors associated with 28-day mortality among older adults septic patients admitted to the intensive care unit (ICU) and to develop a predictive model based on these factors. Methods A total of 165 older adults septic patients admitted to the ICU of our hospital between April 2022 and March 2025 were included in this study. Multivariate logistic reg …

01.09.2026journal-article

Healthcare

The Number of Chronic Conditions and Domain-Specific Movement Behaviours Among People Aged ≥15 Years: Findings from the 2019 Serbian National Health Survey

Dragana Jovic, Jadranka Plavsic, Shihab Aldin Ahmad Al-Riyami, Maja Vukovic, Veroslava Stankovic, Jasmina Pluncevic Gligoroska

Background/Objectives: Previous studies have linked chronic conditions and multimorbidity to lower physical activity, but evidence across individual movement behaviours remains limited. We examined associations between the number of self-reported chronic diseases and conditions and transport-related walking, leisure time physical activity, muscle-strengthening activity and sedentary behaviour among people aged ≥15 years in Serbia. Methods: Nationally representative 2019 Serbian National Health Survey data were anal …

01.09.2026journal-article

Retos

Terapia ecuestre y riesgo de caída en adulto mayor post evento vascular cerebral: estudio de caso

Elia Veronica Benavides Pando, Britany Anahy Escárcega González, Fernando Israel Ponce Ramírez, César Delgado Valles

Introduction: Stroke is one of the leading causes of disability in older adults, resulting in impairments that compromise their autonomy. Among these impairments, deterioration of balance and gait stand out as factors that increase the risk of falls. In light of this scenario, equine-assisted therapy emerges as a rehabilitative intervention that uses the horse's movement to promote neuromuscular response together with postural control. Objective: To determine the impact of an equine-assisted therapy program on fall …

04.09.2026journal-article

Journal of Antimicrobial Chemotherapy

Switching from etravirine to doravirine in people with HIV harbouring NNRTI resistance-associated mutations: the DorSwitch pilot study

Abiu Sempere, Lorena de la Mora, Alexy Inciarte, Leire Berrocal, Ana Gonzalez-Cordón, María Mar Mosquera Cepeda, Elisa De Lazzari, María Martinez Rebollar, Montserrat Laguno, Berta Torres, Ivan Chivite, Pilar Callau, Julia Calvo, Juan Ambrosioni, Josep Mallolas, Alberto Foncillas, José María Miro, Raúl Rigo-Bonnin, Esteban Martínez, José Luis Blanco

Abstract Objectives The objective of this study is to evaluate the efficacy, resistance profile, pharmacokinetics (PK) and safety of switching from etravirine to doravirine in virologically suppressed, treatment-experienced individuals with prior non-nucleoside reverse transcriptase inhibitor (NNRTI)-associated resistance mutations (NNRTI-RAMs). Methods DorSwitch is a prospective pilot study including 13 adults with sustained virological suppression and documented historical NNRTI-RAMs. Etravirine was replaced by d …

01.09.2026journal-article

Journal of Gerontological Nursing

A Community-Based Health Literacy Intervention to Improve Health Literacy, Health Behavior Self-Efficacy, and Quality of Life Among Older Adults With Frailty: A Quasi-Experimental Study

Juan Fang, Lihui Li, Xinfang Xie, Jinlan Yao

Purpose: To investigate the effectiveness of a health education program on health literacy based on Wellness Motivation Theory (WMT) among frail older adults. Method: The current quasi-experimental study was conducted from September 2024 to January 2025 across two communities in Huzhou, Zhejiang Province, China. Participants aged 60 to 85 years with physical frailty were recruited, screened, and randomly assigned to an intervention ( n = 35) or control ( n = 35) group. The intervention included a 12-week program wi …

01.09.2026journal-article

Arteriosclerosis, Thrombosis, and Vascular Biology

Angiogenesis in Lung Regeneration and Aging

Priscilla Kyi, Mikaela Scheer, Tadanori Mammoto, Akiko Mammoto

Angiogenesis, the formation of new capillary blood vessels, plays a key role in organ development and regeneration, while its dysregulation contributes to disease pathogenesis. In addition to the passive roles of blood vessels in gas exchange and nutrient delivery, endothelial cells regulate tissue homeostasis by secreting angiocrine factors that dictate the behaviors of surrounding cells to build tissue architecture. In the lung, endothelial cells closely interact with alveolar epithelial cells and other resident …

01.09.2026journal-article

Archives of Hand and Microsurgery

Dual-linking free-flap reconstruction for above-knee amputation stump coverage in an older patient: a case report

Chang Hoon Jeong, Jeonghee Kim, Hyeokjae Kwon, Sunje Kim, Seung Han Song, Sang-Ha Oh, Yooseok Ha

Durable soft tissue coverage is essential for prosthetic rehabilitation after major lower-limb amputation. We report circumferential above-knee amputation (AKA) stump reconstruction using dual-linking free flaps in an 86-year-old man with bilateral lower-extremity crush injuries. The right AKA stump developed circumferential soft tissue loss with near-total femoral exposure. After debridement, reconstruction was performed using a muscle-sparing latissimus dorsi (msLD) flap and an anterolateral thigh (ALT) flap. The …