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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Medizin · Seite 137

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
04.09.2026journal-article

European Journal of Haematology

Treatment Patterns, Outcomes and Survival Trends in T‐Cell Prolymphocytic Leukemia: A Nationwide Population‐Based Study in the Netherlands

Mirian Brink, Arie C. van der Spek, Jeanette K. Doorduijn, Koen de Heer, Sabina Kersting, Lidwine W. Tick, Doreen G. te Raa, Hanneke M. van der Straaten, Gerrit Jan Veldhuis, Laurens Laterveer, Rogier Mous, Mark‐David Levin, Kees Meijer, Andre Mulder, M. Nijland, Gerwin Huls, Arnon P. Kater, Mar Bellido

ABSTRACT Background T‐cell prolymphocytic leukemia (T‐PLL) is a rare, aggressive mature T‐cell malignancy with limited therapeutic options. Alemtuzumab remains the backbone of therapy, and fit responders are consolidated with allogeneic stem cell transplantation (alloSCT). However, contemporary population‐level outcomes remain poorly defined. Methods All T‐PLL cases diagnosed between 2001 and 2023 were identified from the nationwide Netherlands Cancer Registry. Overall survival (OS) and survival after relapse (OS2) …

04.09.2026journal-article

Oral

Post-Treatment Aesthetic Perception and Facial Satisfaction After Mandibular Angle Volumization with Hyaluronic Acid: A Preliminary Prospective Clinical Study

Nicole Barbosa Bettiol, Selma Siéssere, Giovana Dornelas Azevedo Romero, Franciele Aparecida de Carvalho, Márcio de Menezes, Luana Cristina de Freitas, Jardel Francisco Mazzi-Chaves, Laís Valencise Magri, Simone Cecilio Hallak Regalo, Marcelo Palinkas

Background/Objectives: Mandibular angle volumization with hyaluronic acid is used to redefine facial contours and improve the aesthetics of the lower third of the face. However, beyond the aesthetic outcomes, it is important to understand the impact of this intervention on the aesthetic perception of subjects undergoing the procedure. This preliminary prospective, non-randomized, uncontrolled clinical trial aimed to evaluate post-treatment aesthetic satisfaction and facial appearance perception in subjects who unde …

04.09.2026journal-article

S.S. Korsakov Journal of Neurology and Psychiatry

Matrix metalloproteinases and vascular endothelial growth factor in the acute phase of ischemic stroke: correlation with pathogenetic subtypes and clinical outcomes

K.S. Kucherova, E.S. Koroleva, V.M. Alifirova, N.G. Brazovskaya, L.A. Levchuk, A.S. Boiko, S.A. Ivanova

Objective. To evaluate the changes in serum levels of matrix metalloproteinase (MMP)-2, MMP-9, and vascular endothelial growth factor (VEGF) during the acute phase of ischemic stroke (IS) to elucidate subtype-specific pathogenetic mechanisms and assess the predictive value of these biomarkers for clinical and functional recovery in patients. Material and methods. The study included 114 patients diagnosed with IS. Participants were categorized into the following groups: Group 1 (n=26) with atherothrombotic stroke, G …

04.09.2026journal-article

Frontiers in Public Health

Relapse prediction and individualized treatment-effect modeling in relapsing multiple sclerosis: a systematic review

Martin Budil, Martin Rožánek, Petra Petrová

Introduction Individualized prediction of relapse-related outcomes may support treatment selection and monitoring in relapsing multiple sclerosis. However, existing studies differ substantially in clinical purpose, target outcomes, modeling approaches, and validation strategies. Methods We conducted a systematic review in accordance with PRISMA 2020. PubMed, Web of Science, IEEE Xplore, and Scopus were searched for English-language records published from 1 January 2010 to 14 January 2026. Studies developing or eval …

04.09.2026journal-article

Journal of the American College of Surgeons

Lyon Consensus 2.0 vs Conventional Surgical Criteria for Predicting Favorable Outcomes After Antireflux Surgery

Sven E Eriksson, Vineeth Sadda, Ahmed Aly, Tasneem Ekhtiar, Inanc S Sarici, Ping Zheng, Shahin Ayazi

Background: Lyon Consensus 2.0 revised the criteria for conclusive GERD by including grade B esophagitis and requiring abnormal acid exposure on at least 2 monitoring days for physiologic confirmation. Whether these criteria improve selection of patients for antireflux surgery (ARS) remains uncertain. We compared Lyon 2.0 with conventional surgical criteria for their association with favorable postoperative outcomes. Study Design: Patients undergoing ARS after preoperative endoscopy and 48-hour wireless pH monitori …

04.09.2026journal-article

Journal of Clinical Medicine

Clazosentan Administration Was Not Associated with Intracranial Pressure Elevation in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study with Direct ICP Monitoring

Yo Nishimoto, Tadashi Miura, Ken Shinno, Yongran Yanase, Nao Kagimoto, Shota Nishimoto, Satoru Hayashi, Hitoshi Fukuda

Background/Objectives: Clazosentan reduces cerebral vasospasm and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage (aSAH). However, concerns that clazosentan may cause cerebral edema and increase intracranial pressure (ICP) have discouraged its use in patients with poor-grade aSAH. Methods: This single-center retrospective study included 59 patients with aSAH who underwent continuous direct ICP monitoring, of whom 23 received clazosentan and 24 received fasudil. Most clazosentan-treated patien …

04.09.2026journal-article

Journal of Translational Medicine

Decreased mechanosensitivity and metabolic reprogramming impair bone regeneration in type II diabetes: core mechanism and targeted scaffold design

Yongqiang Mo, Linqin Tang, Jingwei Zhang, Weitao He, Jingtao Chen, Songrui Zhang, Bo Chai, Xinli Tian, Zezheng Yang, Yiling Zhang, Peng Li, Xintao Wang

Abstract Background Bone regeneration in individuals with type 2 diabetes mellitus (T2DM) is significantly impaired, even when autologous bone grafts are used. However, previous studies have failed to elucidate the physiological mechanism, and effective treatments are lacking. This study investigated the underlying mechanisms and developed a targeted therapeutic strategy. Methods We established a femoral condyle defect model in diabetic rats and performed autologous bone grafting. Multiomics sequencing analyses rev …

04.09.2026journal-article

Frontiers in Pediatrics

AutoGluon-based interpretable machine learning for clinical risk stratification of retinopathy of prematurity in very preterm infants

Siyu Chen, Shuyue Deng, Xinyi Liu, Wanting Xu, Wenbin Dong, Linxiao Wan, Lan Kang

Introduction Retinopathy of prematurity (ROP) remains an important cause of preventable visual impairment in preterm infants. Current screening relies primarily on gestational age and birth weight, which may not fully capture the heterogeneous postnatal clinical course of very preterm infants. This study aimed to develop and internally validate an interpretable machine-learning framework using routinely collected clinical variables for clinical-course-based in-hospital ROP risk stratification. Methods A total of 23 …

04.09.2026journal-article

Journal of Eating Disorders

Exploring appetite-related biomarkers in anorexia nervosa during treatment: associations with diet and comparison with healthy controls

Ida Heir Hovland, Kathinka Larsen Otterdal, Lasse Bang, Hilde Vinje, Anne Mari Herfindal, Stine Sofie Strømland, Trude Elise Aspholm, Dunja Arsenovic, Hilde Tveit Reistad, Johan Dahl, Monica Linnea Ones, Siri Weider, Cynthia M. Bulik, Øyvind Rø, Siv Kjølsrud Bøhn

Abstract Background Nutritional treatment is a cornerstone in treatment of anorexia nervosa (AN). However, the interplay between diet and appetite hormones in the gut-brain axis remains poorly understood in AN, particularly during treatment. This study assessed the effects of 12-week inpatient treatment on appetite-related biomarker profiles in patients with AN, compared these profiles with healthy controls (HCs), and explored associations between appetite-related biomarkers, clinical characteristics and diet. Meth …

04.09.2026journal-article

Addiction Science & Clinical Practice

Extended Intervention for Tobacco Use (EXIT) for people experiencing homelessness: study protocol for a randomized controlled trial

Mark R. Hawes, Lillian Gelberg, William J. McCarthy, Tony P. George, David Strong, Jing Cheng, Deepalika Chakravarty, Jessica Alway, Jessica Escober, Jesica Giannola, Isaura Figueroa, Whitney Akabike, Maya Vijayaraghavan

Abstract Background Approximately 70% of people experiencing homelessness smoke cigarettes, compared to 9.9% in the US general population. Barriers to quitting and sustaining cessation include structural inequities (e.g., lack of housing; limited treatment access), and high rates of serious mental illness and substance use disorders. Existing cessation treatments are often brief, not integrated into community service settings, and lack ongoing behavioral support. Community pharmacies represent a promising strategy …

04.09.2026journal-article

The American Surgeon™

Proximity Is Not Access: Geographic Distance and Chemotherapy Receipt for Colon Cancer Requiring Surgery

Kathryn E. Ottaviano, Haoxuan Xu, Ashar Ata, Steven Wexner, Stephen P. Sharp

Background Access to health care facilities presents an obstacle to receiving appropriate cancer treatment. This retrospective cohort study analyzes how access to care by geographic distance and patient demographics affect receipt of chemotherapy in colon cancer patients requiring resection. Methods 342,779 patients with stages 2-4 colon cancer requiring surgery who were recommended to receive either neoadjuvant or adjuvant chemotherapy were analyzed using the NCDB from 2012 to 2021. Patients who refused chemothera …

04.09.2026journal-article

Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science

A digital twin-based approach for generalized fault diagnosis of high-speed train gearbox gears

Du Qinghua, Cui Wentao, Yang Xiaofei, Zheng Qing, Zhang Kai, Ding Guofu

Data-driven methods have been widely applied to fault diagnosis of high-speed train gearbox gears; however, their performance heavily depends on high-quality training data. Due to the inevitable degradation of gears during long-term service, significant distribution discrepancies arise between real-time operational data and historical data, which degrade the generalization capability and diagnostic accuracy of models. To address this issue, this paper proposes a digital twin-based generalized fault diagnosis method …

04.09.2026journal-article

Journal of Clinical Imaging Science

Clinical feasibility and image quality assessment of deep learning-based virtual contrast enhancement from photon-counting computed tomography

Julien G. Cohen, Joel Valentin Stadelmann, David Leite-Arada, Pierre-Alexandre Poletti

Objectives: The purpose of this study was to evaluate image quality and diagnostic performance of deep learning-based virtual contrast-enhanced (VCE) images generated from photon-counting CT (PCCT) datasets. Material and Methods: Forty consecutive patients who underwent contrast-enhanced PCCT were retrospectively included and divided into training ( n = 20) and testing ( n = 20) cohorts. A supervised U-Net-based convolutional neural network was trained to generate VCE images from virtual non-contrast inputs, using …

04.09.2026journal-article

Medicine

A systematic review and network meta-analysis of single nucleotide polymorphisms associated with oral submucous fibrosis risk

Chunxia Huang, Juan Liu, Bin Zeng, Lele Zhang, Zhihang Zhou, Xiaoshan Huang, Binsheng He, Meihua Bao

Background: Oral submucous fibrosis (OSF) is a chronic and insidious oral disease characterized by hyalinization of the subepithelial connective tissue and progressive fibrosis of the oral submucosa. It is a precancerous condition of oral squamous cell carcinoma. Studies have demonstrated that single nucleotide polymorphisms (SNPs) are closely associated with susceptibility to OSF. This study aims to comprehensively evaluate the association between SNPs and OSF risk and to rank the strength of the association betwe …

04.09.2026journal-article

Medicine

Potent bisphosphonate therapy for preventing fractures after denosumab discontinuation in osteoporosis

Asim Shah, Suleman Khan, Syeda Vilay Zehra Rizvi, Kanza Farhan, Misbah Uddin, Syeda Umme Abiha Rizvi, Sabika Fatima, Ang Raj Karan, Aizaz Anwar Khalid, Ahmad Ali, Somaiya Ahmed

Background: Denosumab cessation causes rebound bone turnover, fast bone loss, and an elevated risk of vertebral fractures. Pooled data about the fracture prevention efficacy of potent bisphosphonates (BPs) as sequential therapy have been lacking to counteract this risk. Methods: This systematic review and meta-analysis was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. PubMed, Scopus, the Cochrane Library, and ClinicalTrials.gov were searched from th …

04.09.2026journal-article

Medicine

The role of ferroptosis in juvenile idiopathic arthritis

Chun-Wu Yang, Xiu-Hua Pan, Ji-Gan Wang

This study employed a bidirectional 2-step, two-sample Mendelian randomization approach to investigate the causal relationships between ferroptosis-related genes and juvenile idiopathic arthritis (JIA) and to explore the mediating role of immune cells. Ferroptosis genes were identified from the deCODE database and matched with protein quantitative trait locus data as exposures to evaluate their causal effects on JIA, while immune cell traits were similarly assessed. For genes showing positive Mendelian randomizatio …

04.09.2026journal-article

Medicine

Electrolyte supplementation patterns and evaluation in perioperative parenteral nutrition for patients undergoing major thoracoabdominal surgery

Zhicheng Huang, Hua Jiang, Mingwei Zhu, Chun Gao, Zhenyi Jia, Wei Shen, He Huang, Wei Fan, Shiping Liu, Sheng Zhang, Lifu Zhu, Yang He, ZhiBing Hou, Linlin Fan, Caihong Hao, Jianghong Dai, Zijian Li, Ting Yuan, Lu Wang, Lianzhen Chen, Wei Chen

For patients undergoing major thoracoabdominal surgery, perioperative nutritional management is essential. Although enteral nutrition is preferred, parenteral nutrition (PN) is needed when oral or enteral intake is inadequate or contraindicated and serves as a key electrolyte source. Electrolytes are crucial for fluid balance, acid–base stability, and metabolic function, and inappropriate supplementation may cause serious disturbances. Real-world evidence on perioperative PN electrolyte use in China remains limited …

04.09.2026journal-article

Medicine

Relationship between cirrhosis patients’ social support and post-traumatic stress symptoms

Jintao Cheng, Huiqiong Gui, Suyun Guo, Yihua Yang, Yun Ran

Patients with cirrhosis frequently exhibit post-traumatic stress symptoms (PTSS), which may further aggravate serious psychological and psychiatric conditions. However, the underlying mediating mechanisms by which social support affects PTSS remain insufficiently elucidated. From November 2024 to July 2025, patients with cirrhosis were recruited via cluster sampling from a tertiary hospital in Shenzhen, Guangdong Province, China. A total of 380 participants completed the Perceived Social Support Scale, the civilian …

04.09.2026journal-article

Medicine

Incidental noninvasive diagnosis of isolated persistent left superior vena cava in asymptomatic adults

Dian Zhang, Meifang Pan

Rationale: Isolated persistent left superior vena cava (IPLSVC) is an extremely rare congenital malformation with a low overall prevalence in the general population. Most patients present without typical clinical manifestations, leading to a relatively high rate of missed diagnoses in clinical practice. Owing to abnormal venous drainage, IPLSVC is frequently complicated with lesions of the cardiac conduction system, which may further induce arrhythmias. Patient concerns: A 37-year-old asymptomatic male patient acci …

04.09.2026journal-article

Medicine

Causal associations of gastroesophageal reflux disease with sepsis and sepsis mortality within 28 days

Yangyang Tong, Jie Liu

Previous studies have demonstrated a potential correlation between gastroesophageal reflux disease (GERD) and sepsis. However, the causal association between GERD and sepsis remains unclear. We performed a bidirectional 2-sample Mendelian randomization (MR) analysis to investigate the causal associations of GERD with sepsis and sepsis mortality within 28 days. The inverse variance weighted method was used as a major method for the MR study, supplemented with multiple approaches, including MR-Egger, weighted median, …

04.09.2026journal-article

JAMA Network Open

Cognitive Behavioral Therapy vs Media Literacy for Prevention of Gaming Disorder and Unspecified Internet Use Disorder

Katajun Lindenberg, Sonja Kewitz, Ina Neumann, Sebastian Brand, Daniel Huth, Julia Lardinoix, Katharina Leo, Carolin Szász-Janocha, Daniel L. King, Lutz Wartberg

Importance Mitigating the harmful effects of digitalization on youth mental health is essential. Objectives To evaluate the effectiveness of cognitive behavioral therapy (CBT) compared with a media literacy–based intervention for gaming disorder and unspecified internet use disorder and to determine whether universal or indicated prevention yields stronger benefits. Design, Setting, and Participants PROTECTconfirm was a randomized clinical trial conducted from July 1, 2020, to August 31, 2024, across 44 secondary s …

04.09.2026journal-article

Applied Sciences

A Unified and Interpretable Benchmark of Classification Models for DGA-Based Power Transformer Fault Diagnosis

Kıvanç Doğan, Merve Ertarğın, Abuzer Çalışkan, Ayşenur Bakay

Power transformers are among the most critical components of electric power transmission and distribution systems, and unexpected failures can lead to substantial economic losses and prolonged power outages. Dissolved Gas Analysis (DGA) is the most widely used diagnostic technique for transformer fault diagnosis and involves interpreting gases dissolved in insulating oil. However, conventional interpretation methods, such as the Rogers ratio, the Doernenburg ratio, the IEC 60599 ratio method, and the Duval Triangle …

04.09.2026journal-article

International Journal of Innovative Technologies in Social Science

NITROUS OXIDE IN MEDICINE - ENHANCING PATIENT COMFORT AND HEALTH: A NARRATIVE REVIEW

Natalia Borek, Emilia Miśkiewicz, Julia Gałązka, Ewa Stopa, Hanna Krupa, Magdalena Kędrak, Zofia Wieczorek, Dominik Stanisławski, Wiktoria Jabłońska-Trzosek, Jakub Pochwalski

Introduction: Nitrous oxide (N2O) is a colorless inhalational agent widely used in medicine due to its analgesic, anxiolytic, and sedative properties. Owing to its effectiveness and safety, it has become an important tool for improving patient comfort during various medical and dental procedures. Aim: The aim of this narrative review was to summarize current evidence regarding the pharmacological properties, clinical applications and safety profile of nitrous oxide. Material and methods: A narrative review of the l …

04.09.2026journal-article

International Journal of Molecular Sciences

Multi-Target Antitumor Effects of Natural Products and Approved Drug Repurposing in Non-Small Cell Lung Cancer: Advances in Mechanisms, Combination Regimens, Delivery System Optimization, and Clinical Challenges

Yuli Xie, Dashuai Zhang, Pei Tang

Non-small cell lung cancer is one of the leading causes of cancer-related mortality. The effectiveness of treatment is limited by several factors, including significant tumoral heterogeneity, rapid development of drug resistance, high metastatic potential, and a complex tumor microenvironment. In recent years, natural products have emerged as valuable resources for the discovery of novel antitumor strategies against non-small cell lung cancer. These compounds possess diverse chemical properties, target multiple pat …