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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Medizin · Seite 127

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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
04.09.2026journal-article

Clinical Nuclear Medicine

Blood Pool and Late-phase 3D-ring CZT SPECT/CT in Painful Os Peroneum Syndrome

Yacine El Yaagoubi, Caroline Prunier-Aesch, Laurent Philippe, Thibaut Carsuzaa

A 52-year-old woman was referred for chronic left lateral foot pain, with suspicion of a stress fracture. 99m Tc-HDP bone scintigraphy using a new 3D-ring CZT system (StarGuide) was performed. Bloodpool and late-phase SPECT/CT demonstrated increased uptake in foci corresponding to the os peroneum, suggestive of painful os peroneum syndrome (POPS). Our case highlights the potential of this new generation of 3D-ring CZT SPECT/CT systems to identify POPS, as early diagnosis remains crucial for adequate management.

04.09.2026journal-article

Clinical Nuclear Medicine

Posttherapy [18F]FDOPA PET Findings in an Anaplastic Pleomorphic Xanthoastrocytoma With a BRAF V600E Mutation

Jacopo Passoni, Andrea Rossi, Claudia Milanaccio, Arnoldo Piccardo, Francesco Fiz

Anaplastic pleomorphic xanthoastrocytoma (APXA) is a rare pediatric high-grade glioma (pHGG). We report a 10-year-old boy with a left temporal APXA harboring a BRAF V600E mutation, who presented with generalized tonic–clonic seizures 3–4 times weekly, treated with combined BRAF and MEK inhibition. This case illustrates the utility of [ 18 F]FDOPA PET in monitoring targeted therapy, providing metabolic information that preceded and complemented conventional imaging.

04.09.2026journal-article

Angewandte Chemie International Edition

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros

ABSTRACT We introduce a solid‐phase synthesis platform for the rapid, modular, and scalable synthesis of the synthetic metallophore KO‐NH 2 , which is readily recognized by bacterial siderophore transporters, but has optimized affinity for Ga 3+ over Fe 3+ . Four synthetic protochelin (PC) analogues, KK‐COOH, KO‐NH 2 , KO‐COOH, and OK‐COOH were constructed. Growth recovery, radioactive uptake, and covalent photocrosslinker studies in Escherichia coli identified CirA and Fiu as the dominant outer membrane transport …

04.09.2026journal-article

Clinical Pharmacology & Therapeutics

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Alice Ke, Ernesto Callegari, Manthena V.S. Varma, Mayur K Ladumor, Chieko Muto, Richard J. Bertz, Hannah M. Jones, Vaishali Sahasrabudhe, Jing Liu

Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na + /taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4). In clinical drug–drug interaction (DDI) studies, oral zavegepant exposure increased in the presence of multiple‐dose (MD) rifampin or itraconazole; however, no interaction was observed …

04.09.2026journal-article

Medicine

Comparative evaluation of large language models for text-based diagnostic reasoning in fetal central nervous system MRI

Runze Yu, Miao Peng, Huiying Li, Simeng Liu, Tong Su, Hanjie Guan, Yufeng Shen, Yuhui Deng, Deli Zhao

Fetal magnetic resonance imaging (MRI) plays an important role in evaluating prenatal central nervous system (CNS) abnormalities, but expert interpretation and counseling remain challenging. Large language models (LLMs) may support text-based diagnostic reasoning, yet their performance in fetal CNS MRI has not been well characterized. The study aimed to compare ChatGPT, Gemini, and DeepSeek in text-based diagnostic reasoning for fetal CNS MRI cases. This retrospective single-center study included 85 fetal MRI cases …

04.09.2026journal-article

Medicine

Clinical and CT features of patients with pneumatosis intestinalis

Weiheng He, Yihui Yin, Yongqi Zhu, Huimin Rao, Lin Lu

This study investigates the clinical and abdominal computed tomography (CT) characteristics of pneumatosis intestinalis (PI). This retrospective single-center study included 58 patients with PI. Clinical data and CT images were reviewed. CT findings included location, extent, and associated features, and PI was classified into 3 morphological patterns: bandlike, grapelike, and beadlike. Inter-observer agreement was evaluated, and subgroup analysis was performed using analysis of variance and chi-square tests. The m …

04.09.2026journal-article

Medicine

Association between alpha-1-acid glycoprotein and serum uric acid in young and middle-aged US women

Jiangtao Zhu, Mengge Feng, Wenqi Wu, Jianhua Zhang, Guoliang Xu, Yujie Ma

Evidence on the association between alpha-1-acid glycoprotein (AGP), a systemic inflammatory marker, and serum uric acid (SUA) remains limited, particularly among young and middle-aged women. Using cross-sectional data from 614 US women aged 20 to 49 years from the 2015 to 2018 National Health and Nutrition Examination Survey, we assessed the AGP-SUA relationship and the mediating role of the triglyceride-glucose index using multiple linear regression, smooth curve fitting, and mediation analysis. After full adjust …

04.09.2026journal-article

Medicine

Tobacco and alcohol use, fruit and vegetable consumption, physical activity habits, and participation in routine checkups and cancer screenings among adults aged 40 and older with and without chronic diseases

Elif Nur Yildirim-Ozturk, Mehmet Uyar

The study aimed to investigate tobacco and alcohol use, fruit and vegetable consumption, physical activity habits, and participation in routine checkups and cancer screenings in adults aged 40 years and older with and without a diagnosis of chronic disease. It also aimed to compare the frequentist and Bayesian statistical methods used for comparisons and to evaluate the practical significance of these associations using effect sizes. The study was cross-sectional. The data used in the study came from the Turkey Hea …

04.09.2026journal-article

Medicine

A novel hemostatic suture technique for uterine rupture complicated by placenta accreta spectrum

Ruiyan Shang, Jing Yang, Li Li, Yiyi Zhuge

Rationale: Uterine rupture secondary to the placenta accreta spectrum (PAS) is a life-threatening obstetric emergency. Intractable massive hemorrhage in this setting often necessitates emergent hysterectomy, while effective fertility-sparing surgical options for such critical bleeding remain limited. This report highlights the utility of a novel suturing technique for achieving effective hemostasis and fertility preservation in patients with PAS-related uterine rupture. Patient concerns: A 36-year-old Asian woman d …

04.09.2026journal-article

Journal of Community Hospital Internal Medicine Perspectives

Survival outcome of Gallbladder cancer in the US: An updated surveillance, epidemiology, and end results-based analysis of age and gender disparities

Ayrton Bangolo, Behzad Amoozgar, Budoor Alqinai, Ravleen Chowdhary, Rishabh Goyal

Introduction: Gallbladder cancer (GBC) is a rare but highly lethal malignancy with significant variability in mortality based on demographic and clinical factors. This study aims to analyze the impact of gender, age, tumor stage, and treatment modalities on mortality in GBC patients, providing a comprehensive overview of the factors influencing survival outcomes. Methods: We conducted a retrospective analysis of 1,527 patients diagnosed with GBC between 2005 and 2021. Data were collected on demographic variables, t …

04.09.2026journal-article

Journal of Community Hospital Internal Medicine Perspectives

Recurrent Ischemic Colitis Associated with Chronic Low-Flow Physiology: Diagnostic and Therapeutic Implications

Mustafa Sadek, Alaa Almallouhi

Ischemic colitis is the most common form of intestinal ischemia and is typically associated with acute hypoperfusion states such as shock or dehydration.1 Chronic low-flow states related to persistently low baseline blood pressure may represent an underrecognized contributor to recurrent disease in the absence of classic acute triggers.2 We present a case of a 54-year-old woman with recurrent, biopsy-proven ischemic colitis occurring in the setting of persistently low blood pressure documented across multiple clini …

04.09.2026journal-article

Egyptian Journal of Radiology and Nuclear Medicine

Deep learning-based segmentation of abdominal aortic aneurysm: a systematic review and meta-analysis of performance and clinical applicability

Negin Letafatkar, Saisree Reddy Adla Jala, Kavya Priya Somu, Mohammad Amouzadeh-Lichahi, Gokhan Anil, Hariprasad Reddy Korsapati, Casra Saeedi, Behrad Eftekhari, Abinash Mahapatro, Maryam Jafari, Amirhossein Pourebrahimi, Arman Habibi, Faezeh Pourshakoori, Ali Fatehi Hassanabad, Ehsan Amini-Salehi

Abstract Background Abdominal aortic aneurysm (AAA) management relies heavily on imaging for surveillance, treatment planning, and follow-up. Deep learning (DL)-based segmentation may improve the efficiency and reproducibility of AAA image analysis; however, reported performance varies across studies. This study aimed to systematically review and quantitatively summarize the performance of DL models for AAA-related segmentation. Methods PubMed, Embase, Scopus, and Web of Science were searched for studies applying D …

04.09.2026journal-article

Innovative Medicine of Kuban

Morphological and Functional Diagnosis of Precancerous Cervical Lesions in Premenopausal Women Using Advanced Diagnostic Methods

G. D. Reymnazarova, A. F. Asatulaev, B. A. Magrupov

Background : Cervical cancer remains a major public health challenge in Uzbekistan, with 2,654 new cases diagnosed in 2022. The premenopausal period (40–55 years) represents a particularly difficult stage for cervical cancer detection, as epithelial atrophy and migration of the transformation zone into the endocervical canal reduce the sensitivity of conventional cytology. Objective: To characterize morphometric, ultrastructural, nanotopographic, and immunohistochemical features of precancerous cervical lesions in …

04.09.2026journal-article

Frontiers in Microbiology

CSF peptidomics reveals an IGF2-derived peptide as a candidate biomarker for neurosyphilis diagnosis

Yue Yin, Xinru Li, Jiayin Han, Jiatong Li, Lijiao Zeng, Jianfeng Lan, Weizhen Weng, Yanhua Liang, Ying Zhang, Rongrong Zou, Shuai Wu, Guoyu Tan, Shenghong Tang, Jing Yuan

Background Neurosyphilis (NS) diagnosis is challenging due to the cerebrospinal fluid-Venereal Disease Research Laboratory (CSF-VDRL) assay has limited sensitivity, whereas CSF abnormalities lack sufficient specificity. Methods To identify novel CSF peptide biomarkers for NS, we performed comparative peptidomic analysis of CSF samples from 51 individuals across four groups: NS, syphilis/non-NS (NNS), infectious brain diseases without syphilis (IBD), and non-infectious brain disorders without syphilis (NIBD). Peptid …

04.09.2026journal-article

Frontiers in Chemical Biology

Second-generation N,N′-disubstituted aliphatic diamines: discovery of potent hits for multi-species leishmaniasis treatment

Alejandro I. Recio-Balsells, Esteban A. Panozzo-Zenere, Elizabeth M. Coser, Bianca A. Ferreira, Adriano Cappellazzo Coelho, Shane R. Wilkinson, Babu L. Tekwani, Guillermo R. Labadie

Kinetoplastid diseases remain a major global health challenge, highlighting the need for new antiparasitic chemotypes. N,N′ -disubstituted aliphatic diamines have emerged as a promising scaffold against trypanosomatid parasites. Building on our previous studies, we expanded the structure–activity relationship (SAR) of this chemotype through the synthesis of fifty-two analogues obtained by one-pot reductive amination of aliphatic diamine linkers with structurally diverse aromatic and heteroaromatic aldehydes. The co …

04.09.2026journal-article

Frontiers in Digital Health

Engaging veterans in the development of mobile health interventions to support medication treatment for opioid use disorder

Noah R. Wolkowicz, Christie W. Musket, Erin D. Reilly, Eric Kuhn, Mehmet Sofuoglu, R. Ross MacLean, Galina A. Portnoy

Introduction Opioid Use Disorder (OUD) is an ongoing and pervasive public health problem. Despite the availability of efficacious Medication treatments for OUD (MOUD), many patients require additional support to address OUD's wide-ranging consequences. Mobile Health Interventions (MHIs), or smartphone-based software applications (“apps”), could serve as a scalable and flexible medium to increase adjunctive care access within MOUD. Method As an initial step in potential MHI creation, we conducted semi-structured int …

04.09.2026journal-article

Journal of Clinical Medicine

Comparative Prognostic Performance of Platelet-Containing and Platelet-Free Inflammatory Indices After Percutaneous Coronary Intervention

Donghyeon Joo, Sungho Jo, Jeong Tae Byoun, Jae Young Cho, Kyeong Ho Yun

Background/Objectives: Systemic inflammatory indices derived from the complete blood count differ in whether they incorporate platelet count. Whether platelet-containing indices outperform platelet-free indices and whether platelet count adds independent prognostic information remain insufficiently tested. Methods: We retrospectively analyzed 2244 consecutive patients undergoing percutaneous coronary intervention (PCI) at a single center. The neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response inde …

04.09.2026journal-article

Clinical Pharmacology & Therapeutics

Special Populations in Pivotal Clinical Trials: Eligibility and Supporting Evidence for Exclusion in EMA ‐Authorised Medicines

Maja J. Jørgensen, Débora D. Gräf, Christine E. Hallgreen

Evidence on the efficacy and safety of medicines supporting marketing authorization is largely derived from randomized controlled trials, yet these trials often exclude populations likely to use the medications in clinical practice. This study assessed eligibility of special populations, defined as pregnant and breast‐feeding individuals, elderly individuals, and individuals with comorbidities, in pivotal clinical trials supporting centrally authorized products in the European Union between 2022 and 2024. It also e …

04.09.2026journal-article

Medicine

Umbilical vein recanalization with a diameter greater than 6.48mm may promote deterioration of liver reserve function

Feng Ding, Yuan Yang, Jing Wang, Liping Chen

This study aimed to investigate the clinical characteristics of cirrhotic patients with umbilical vein recanalization (UVR) and explore the effects of UVR on portal hypertension and liver reserve function (LRF). A total of 122 cirrhotic patients were enrolled and stratified into UVR and non-UVR groups based on the presence or absence of UVR. Clinical and laboratory indices, including hepatic biochemical parameters, portal venous system diameters, portal vein thrombosis, portal pressure gradient (PPG), Child-Pugh cl …

04.09.2026journal-article

Medicine

Renal outcomes associated with sodium–glucose cotransporter 2 inhibitor use in kidney transplant recipients with type 2 or posttransplant diabetes

Guillermo Edinson Guzmán, Fabio Figueroa, Santiago Granados, Oriana Arias-Valderrama, Juan Lukas Ordóñez, Carlos Eduardo Durán

Posttransplant diabetes mellitus (PTDM) increases the risk of graft failure and mortality. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve cardiovascular and renal outcomes in type 2 diabetes mellitus (T2DM), but evidence in kidney transplant recipients (KTRs) with T2DM or PTDM remains limited. We conducted a retrospective cohort study including adult KTRs with pretransplant T2DM or PTDM. Exposure was defined as continuous SGLT2i use for ≥90 days. The primary outcome was a composite of graft loss, all-ca …

04.09.2026journal-article

Medicine

Primary mediastinal ectopic thyroid in a 43-year-old woman

Zheng Wang, Shuo Liang, Kunpeng Li, Xike Lu, Xin Li, Daqiang Sun

Rationale: Primary mediastinal ectopic thyroid (PMET) is exceedingly rare, and its imaging features often overlap with those of thymic epithelial tumors, lymphoma, Castleman disease, and paraganglioma. The absence of anatomical continuity with the cervical thyroid and the presence of an independent intrathoracic blood supply are important considerations in differential diagnosis and surgical planning. This report aims to highlight the diagnostic value of thyroid-like enhancement and the absence of cervical continui …

04.09.2026journal-article

American Journal of Hospice and Palliative Medicine®

Unmet Needs of Transgender and Gender-Diverse Adults With Serious Illness Receiving Hospice and Palliative Care: A Thematic Scoping Review

Emma Max, Steven Meanley, Nancy A. Hodgson

Background Transgender and gender-diverse individuals experience higher mortality rates and elevated incidence of serious illness compared to cisgender populations. Despite these disparities, discrimination and stigma continue to create barriers to high-quality hospice and palliative care. Aims This scoping review identified the unmet needs of gender-diverse adults receiving hospice and palliative care in the United States. Methods Following PRISMA-ScR guidelines, we systematically searched seven databases between …

04.09.2026journal-article

Critical Care Medicine

Feasibility and Operator-Reported Utility of Transesophageal Lung Ultrasound As an Adjunct to Resuscitative Transesophageal Echocardiography in the Evaluation of Shock: A Multicenter Observational Study

Vladyslav Dieiev, Pedro D. Salinas, Felipe Teran, Clark G. Owyang, Dylan Rupska, Aniruddh Kapoor, Zubair Siddiqui, Daniel Strama, Cindy Ndiaye, Nathaniel A. Sands, Aarthi Kaviyarasu, Katharine M. Burns, on behalf of the Resuscitative Transesophageal Echocardiography Collaborative Registry (rTEECoRe) Investigators

Objectives: To describe the utilization, feasibility, and operator-reported diagnostic and management impact of transesophageal lung ultrasound (TELUS) integrated into resuscitative transesophageal echocardiography (TEE) for the assessment of mechanically ventilated adults with shock. Design: Multicenter observational cohort study using prospectively collected data. Setting: Twenty-three hospitals from the Resuscitative Transesophageal Echocardiography Collaborative Registry (rTEECoRe) network. Patients: From 1213 …

04.09.2026journal-article

Cancers

Real-World Treatment Patterns and Clinical Outcomes After First-Line Therapy in Patients with KRAS G12C-Mutant Advanced Non-Small-Cell Lung Cancer in the United States

Kristin M. Sheffield, Tarun Puri, Kelli Thoele, Himanshu Karu, Arti Mansharamani, Dipesh Uprety

Background: Approximately 13% of NSCLC cases have KRAS G12C mutations. As therapeutic strategies targeting KRAS G12C-mutant NSCLC evolve, it is important to understand clinical presentation and current outcomes for these patients. Methods: This retrospective study used data from two US nationwide databases, an electronic health records (EHR) database and a clinico-genomic database (CGDB) of EHR data linked to data from comprehensive genomic profiling tests. Eligible patients had advanced NSCLC, initiated first-line …