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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

International Journal of Biology and Life Sciences

Research Progress on TACE Combined with Targeted and Immunotherapy in the Comprehensive Treatment of Massive Hepatocellular Carcinoma

Kewei Fang, Hongwei Lei

Massive hepatocellular carcinoma (HCC) is characterized by large tumor volume, strong invasiveness, high propensity for vascular invasion and intrahepatic dissemination. Consequently, most patients lose the opportunity of radical surgical resection at initial diagnosis. Monotherapy with conventional transarterial chemoembolization (TACE) is associated with low remission rate, high risk of recurrence and metastasis, and poor long-term survival. In recent years, the rapid development of targeted therapy and immunothe …

28.08.2026journal-article

Cancer Medicine

Preoperative RDW –Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery

Xinhang Cao, Weiwei Shang, Dandan Xiao, Wei Wang, Ziyu Wang, Yangbai Sun, Yan Zhang, Mingzhe Ma

ABSTRACT Background The ratio of red blood cell distribution width (RDW) to serum albumin (RAR) combines hematologic and nutritional information from routine blood tests and has shown potential value for prognostication in several diseases. This study aimed to evaluate the prognostic significance of preoperative RAR in patients with gastric cancer undergoing curative gastrectomy and to explore whether RAR could provide additional prognostic information beyond conventional indicators such as TNM stage. Aims This stu …

28.08.2026journal-article

Advanced Materials

A Receptor‐Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF‐α Degradation for Sustained Treatment of Mucosal Inflammation

Wenxue Xie, Yuqing Wu, Xichen Wan, Yuanyuan Chen, Yuanyuan Wu, Xiaowei Huang, Yujian Wen, Yiteng Lu, Yirou Zhang, Bo Gong, Xujiao Zhou, Hang Xing, Jiaxu Hong

ABSTRACT Mucosal inflammatory disorders such as dry eye disease (DED) and inflammatory bowel disease (IBD), driven by TNF‐α‐mediated immune‐epithelial crosstalk, remain therapeutically challenging. Conventional inhibitors often suffer from poor mucosal permeability and transient efficacy with 1:1 binding. Although extracellular protein degradation (eTPD) technologies can eliminate pathogenic proteins, most of them operate stoichiometrically, limiting dosage efficiency and durability. Here, we report a receptor‐medi …

28.08.2026journal-article

JAMA Network Open

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Cora Schefft, Heiner Stuke, Selin Demir, Maximilian Preiß, Lukas Pezawas, Jakob Kaminski, Björn Meyer, Steffen Moritz, Thomas Berger, Johanne Schröder, Jan Philipp Klein, Stephan Köhler

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develop a model predicting individual treatment benefit from iCBT for depression across programs and to externally validate it in independent samples. Design, Setting, and Participants This prognostic study used individual participant data from 5 …

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28.08.2026journal-article

Head & Neck

Head and Neck Lymph Node Metastases From Cancer of Unknown Primary: Outcomes From p16‐Guided Mucosal Radiotherapy

Philippe Harris, Dhiya‐Eddine Mabrouki, Felix‐Phuc Nguyen‐Tan, Edith Filion, Olivier Ballivy, Brian O'Sullivan, Apostolos Christopoulos, Tareck Ayad, Louis Guertin, Eric Bissada, Paul Tabet, Denis Soulières, Antoine Desilets, Alexandre Pellan Cheng, Robert Doucet, Laurent Létourneau‐Guillon, Houda Bahig

ABSTRACT Background The AJCC 8th edition distinguishes p16‐positive oropharyngeal head and neck carcinoma of unknown primary (HNCUP) due to its superior prognosis. However, standardized radiation volume guidelines are lacking. This study evaluates the safety of p16‐guided mucosal volume reduction. Methods A retrospective review of 126 HNCUP patients (2009–2023) was conducted. p16‐negative patients received comprehensive mucosal and laryngeal irradiation; p16‐positive patients received risk‐adapted, reduced‐volume r …

28.08.2026journal-article

Malignant tumours

Resolution on the results of the expert council on the topic “Diagnosis and treatment of advanced non-small cell lung cancer with BRAF mutation: from the search for molecular targets to therapeutic strategies in real-world clinical practice”

K. K. Laktionov, V. V. Breder, I. A. Demidova, V. V. Karaseva, F. V. Moiseenko, S. V. Orlov, E. V. Reutova, D. L. Stroyakovsky

On January 27, 2026, an Advisory Board was held to discuss issues of molecular genetic diagnosis of the BRAF V600E mutation in patients with advanced non-small cell lung cancer (NSCLC), as well as current treatment options for NSCLC patients with the BRAF V600E mutation. Next generation sequencing (NGS) is the most sensitive and specific method for molecular genetic testing. Its implementation in routine clinical practice will improve the detection rate of BRAF positive NSCLC patients. The accepted standard of care …

28.08.2026journal-article

The American Surgeon™

Influence of Anatomical Variations due to Horseshoe Kidney on Colorectal Cancer Surgery

Tetsuhiro Urashima, Yasuhiro Ishiyama, Sohei Akuta, Akihito Nakanishi, Yume Minagawa, Hisashi Hayashi, Yusuke Nishi, Takatsugu Fujii, Toshimasa Ishii, Shintaro Ishikawa, Hirofumi Sugita, Chikashi Hiranuma, Yasumitsu Hirano

Background Horseshoe kidney is a rare renal fusion anomaly often associated with vascular and ureteral variations. Previous case reports have described technical considerations during colectomy in patients with horseshoe kidney. However, studies systematically evaluating the impact of anatomical anomalies associated with horseshoe kidney on surgical procedures remain limited. Methods We retrospectively analyzed 13 patients with horseshoe kidney who underwent colectomy for primary colorectal adenocarcinoma at a sing …

28.08.2026journal-article

Frontiers in Immunology

Intratumoral Bacillus regulating colorectal cancer liver metastasis: links to lipid metabolism and APOE+ macrophages

Juhang Chu, Haitao Huang, Yuheng Hu, Qiaoer Wang, Tao Yuan, Shengyu Huang, Jianbo Lin, Chenxiang He, Haoyu Li, Hao Shen, Jun Li

Introduction Colorectal cancer liver metastasis (CRLM) develops in a hepatic niche where tumor cells encounter organ‑specific microbial, metabolic, and immune constraints. The role of intratumoral bacteria in this metastatic ecosystem remains incompletely defined. Methods We analyzed tumor and peritumoral tissues from 20 patients with non‑metastatic colorectal cancer (CRC) and 20 patients with CRLM by 5R 16S rDNA sequencing, untargeted metabolomics, and functional assays. Public datasets were used for single‑cell a …

28.08.2026journal-article

Cancers

C-Reactive Protein-Based Composite Indices for Predicting Tumor Overgrowth Restenosis After Partially Covered Duodenal Stenting in Gastric Cancer: A Cohort Study

Hyuk Lee, Young Eun Oh, Tae-Se Kim, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee

Background/Objectives: Partially covered duodenal stents rapidly relieve malignant gastric outlet obstruction, but tumor overgrowth restenosis limits durability. We compared six preprocedural inflammatory, nutritional, and immune indices for predicting this outcome in patients with gastric cancer. Methods: We retrospectively analyzed 68 consecutive patients from a prospectively maintained cohort. The primary endpoint was endoscopically or radiologically confirmed tumor overgrowth restenosis. Discrimination was asse …

28.08.2026journal-article

Academia Drug Development and Pharmacotherapy

Micelles in cancer nanomedicine: targeted delivery, imaging, and therapy

Amirhossein Rashnoodi, Zaynab Seraj, Niyoosha Zamani, Bahareh Khalili Najafabad

Despite advancements in oncology, conventional cancer therapies remain limited by poor specificity, systemic toxicity, and suboptimal therapeutic indices. Micellar nanostructures have emerged as a transformative platform to overcome these hurdles, leveraging their amphiphilic nature to encapsulate hydrophobic agents within aqueous biological environments. This review evaluates the current landscape of micelle-based technologies in cancer management, focusing on their integration into medical physics through diagnos …

28.08.2026journal-article

Substance Use & Addiction Journal

Evaluation of an Online, Asynchronous Tobacco Treatment Specialist Training: A Mixed-Methods Analysis of Reach, Perceived Trainee Competency, and Training Quality

Tresza D. Hutcheson, Sharon Fitzgerald Wolff, MeLinda Lair, Kimber P. Richter, Babalola Faseru

Background: Although tobacco use disorder is the most prevalent substance use disorder in the United States and remains the world’s leading cause of preventable mortality, health care and social service providers receive little training in how to treat it during their formal education. To enhance access to Tobacco Treatment Specialist (TTS) training, we developed an online, self-paced, asynchronous training paired with a 1-day virtual workshop for skills building and demonstration. Methods: We calculated the reach …

28.08.2026journal-article

Journal of Pediatric Hematology/Oncology

Implementation of a Digital Clinical Management Platform in a Tertiary Pediatric Hemato-Oncology Center: Impact on Clinical Outcomes and Patient Safety

Michal Singer, Uri Ilan, Guy Dolinski, Nitsan Halabi, Yuliana Edri, Nisim Rahman, Sigal Sina, Maor Sagi, Sivan Tam, Moshe Ashkenazi

Introduction: Healthcare delivery is increasingly challenged by rising demand, escalating costs, and the need for efficiency. Contributing factors such as the nursing workforce crisis, fragmented and excessive clinical data, outdated IT infrastructures, and the growing complexity of care exacerbate the risk of medical errors, treatment delays, and staff burnout. To address these challenges, we evaluated AMIT, a novel digital platform designed to support nursing practice in pediatric oncology. Methods: AMIT is a web …

28.08.2026journal-article

Journal of Testing and Evaluation

Comparative Performance Analysis of AdaBoost-Assisted Deep Learning Models for Lung Cancer Nodule Detection

Ghousia Usman, Usman Ahmad, Huma Tauseef, Muhammad Murad Khan, Ayesha Adnan

ABSTRACT Lung cancer (LC) is among the leading causes of cancer-related deaths, and early identification of pulmonary nodules plays a crucial role in reducing mortality. This work proposes a novel hybrid framework that combines preprocessing, segmentation, feature extraction, and classification for accurate nodule detection from computed tomography scans. Digital imaging and communications in medicine images are first preprocessed using median filtering to remove noise and contrast limited adaptive histogram equali …

28.08.2026journal-article

CA: A Cancer Journal for Clinicians

The new (version 9) American Joint Committee on Cancer (AJCC) tumor‐node‐metastasis (TNM) staging protocol for carcinoma of the vulva

Alexander B. Olawaiye, Elliot A. Asare, Ian S. Hagemann, Priya R. Bhosale, Stephanie Gaillard, Brian Rous, Bunja Rungruang, Shitanshu Uppal, Gulisa Turashvili, Kaled M. Alektiar, Jonathan A. Cosin, Uma Krishnamurti, Lee‐may Chen, Keiichi Fujiwara, Matthew A. Powell, Mauricio A. Cuello, David G. Mutch

Abstract The American Joint Committee on Cancer (AJCC) tumor‐node‐metastasis (TNM) staging for all cancer sites has been updated periodically as a published manual for many years. The last update of the manual version, the eighth edition AJCC Cancer Staging Manual , went into use on January 1, 2018. The AJCC has since restructured and updated its processes for curating, analyzing, and publishing updates to the TNM staging system. All AJCC staging‐related data are now housed on its new application programming interf …

28.08.2026journal-article

Journal of Environmental Quality

Pesticide occurrence, transformation, and transport from wastewater treatment plants into stream networks with diverse land uses

Kyra Sigler, Matthew V. Russell, William Ford, Wayne Sanderson, Tiffany L. Messer

Abstract Neonicotinoid insecticides and strobilurin fungicides are detected in many environmental compartments and have been associated with negative environmental and human health implications. Wastewater treatment plants (WWTPs) are often hotspots for introducing such contaminants into the environment. Therefore, the occurrence of strobilurin fungicides, neonicotinoids, and their metabolites at two WWTPs with varying land uses and population sizes was investigated. Polar organic chemical integrative samplers were …

28.08.2026journal-article

Cancers

From Pixels to Stroma: AI-Driven Spatial Profiling of Cancer-Associated Fibroblasts on H&E and Its Implications for Immunotherapy

Dalani Tarun, Wong Kwun Hin Jerry, Jialin Wu, Xin Fang, Tiejun Feng, Fuda Xie, Muyang Huang, Yuanke Liang, Ka Fai To, Wei Kang, Haoyu Lin, Bonan Chen

Immune checkpoint blockade (ICB) has transformed cancer therapy, but clinical responses remain heterogeneous across tumor types and patient populations. Cancer-associated fibroblasts (CAFs) are key stromal components of the tumor microenvironment and can contribute to immunotherapy resistance through immune exclusion, extracellular matrix remodeling, chemokine signaling, and interactions with suppressive immune cells. Although CAF-directed strategies are under active investigation, their clinical translation is lim …

28.08.2026journal-article

ACS Sensors

Reprogramming RNA Degraders as Intracellular Molecule Sensors for Tumor Cell Sensing and Manipulation

Pin-Ru Chen, Ying Han, Pei-Pei Qin, Ying-Yue Xu, Qian Tao, Bang-Ce Ye, Bin-Cheng Yin

Abstract Engineering transgene expression to respond specifically to intracellular cues holds transformative potential for monitoring cell states and modulating cellular functions. Here we introduce TRADER (Target-induced Transgene Activators via Reprogramming of dCas6-barnase Degrader), a versatile and modular platform that enables transgene activation in response to intracellular molecules at the post-transcriptional level. TRADER leverages a proximity-dependent RNA degrader system, in which a catalytically inact …

28.08.2026journal-article

Journal of The Society of Obstetricians and Gynaecologists of Pakistan

Diagnostic accuracy of visual inspection with acetic acid in diagnosing cervical cancer, taking histopathology as gold standard

Moiz Hassan, Hajira Masood, Tehreem Azhar, Seerat Tayyaba, Amara Malik

Objective: To compare the diagnostic accuracy of visual inspection with acetic acid (VIA) in screening cervical cancer, taking histopathology as the gold standard. Methodology: This analytical, cross-sectional study was performed at the Obstetrics and Gynecology Department of Nishtar Hospital, Multan, Pakistan, during June 2025 to November 2025. A total of 120 women, aged 45–70 years, with symptoms suggestive of cervical malignancy were analyzed through consecutive sampling. VIA was performed using 5% acetic acid u …

28.08.2026journal-article

International Journal of Molecular Sciences

Dual Targeting of FGFR4 and PI3K–mTOR Suppresses Tumor-Associated Phenotypes in Pancreatic Ductal Adenocarcinoma

Joseph A. Goode, Savannah A. Harris, Deborah A. Altomare

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive adaptive signaling plasticity and metabolic reprogramming that contribute to therapeutic resistance. While the PI3K–mTOR pathway is a central regulator of these processes, the role of the FGF19–FGFR4 axis and its interaction with PI3K-mTOR signaling remains incompletely defined in PDAC. This study investigated whether co-targeting FGFR4 and PI3K-mTOR signaling could overcome adaptive pathway reactivation and suppress tumor-promoting phenotypes. P …

28.08.2026journal-article

Micromachines

Artificial Versus Magneto-Aerotactic Bacterial Robots for Cancer Therapy

Sylvain Martel

The use of magnetotactic bacteria (MTB), proposed by the author about 25 years ago, allowed the implementation of embedded capabilities allowing the execution of specific complex tasks such as the target delivery of therapeutics in tumoral hypoxic zones that could not be implemented in artificial micro/nanorobots due to technological limitations at such a small scale. Since then, technology has evolved but the question remains about how long such superior advantage of using only certain types of live microorganisms …

28.08.2026journal-article

Frontiers in Medicine

Metachronous multifocal early gastric cancer after partial gastrectomy for synchronous multifocal early gastric cancer: a case report and literature review

Qiang Geng, Qing Yang, Shubei Chen, Wei Qiu, Xiaoling Liu, Changfeng Sun, Cunliang Deng, Ou Jiang

With the rapid advancement of digestive endoscopy techniques, an increasing number of early gastric cancers (EGCs) have been diagnosed and treated, substantially improving the 5-year survival rate of patients with EGC. Multifocal gastric cancer is a relatively uncommon subtype, and repeated occurrences of multifocal gastric cancer are even less frequently observed. The pathogenesis may involve persistent field cancerization of the background gastric mucosa and, in some patients, an inherited predisposition; evaluat …

28.08.2026journal-article

VNU Journal of Science: Medical and Pharmaceutical Sciences

Small Bowel Obstruction Caused by a Jackfruit Seed in a Patient With a History of Miles’ Operation for Rectal Cancer: The First Case Report in Vietnam

Tran Que Son, Trinh Ke Diep, Nong Ngoc Quang, Nguyen Chi Trung, Pham Anh Tuan, Vu Thi Thu, Tran Hoang Phuong Thao, Luong Thi Ngoc

Background: Small bowel obstruction secondary to fruit seed phytobezoars is a rare clinical entity, particularly in patients with a history of major abdominal surgery. Case Report: We report the case of an 83-year-old man who presented with abdominal pain, vomiting, and a non-functioning colostomy four days after accidentally ingesting a jackfruit seed. He had a history of Miles’ operation 15 years prior for rectal cancer. Abdominal computed tomography confirmed small bowel obstruction caused by a foreign body meas …

28.08.2026journal-article

Diagnostics

Veil-Based Collector Device Enabling Self-Collected Cervicovaginal Sampling for Site-of-Care Primary HPV-Based Cervical Cancer and Sexually Transmitted Infections Screening: A Pilot Feasibility Study in Romania

Madalina Ciuhodaru, Alina-Mihaela Calin, Bogdan-Florentin Nițu, Claudia Simona Cambrea, Ioana Denisa Popa, Cristian Bucsineanu, Ralph-Sydney Mboumba Bouassa, Juval Avala Ntsigouaye, Vincent Vernet, David Sebaoun, Franck Chaubron, Laurent Bélec

Background/Objectives: High-risk human papillomavirus (HR-HPV) causes cervical cancer, but other sexually transmitted infections (STIs) act as possible cofactors. We herein evaluated the feasibility, logistics, and epidemiology of a community-based screening program in Romania using an innovative veil-based self-sampling device and a digital platform. Methods: Adult women self-collected genital secretions using the Vaginal Veil Collector V-Veil UP2™ device (V-Veil-Up Production SRL, Pitesti, Romania). A digital pla …