Vollständiger Abstract
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ABSTRACT Background The AJCC 8th edition distinguishes p16‐positive oropharyngeal head and neck carcinoma of unknown primary (HNCUP) due to its superior prognosis. However, standardized radiation volume guidelines are lacking. This study evaluates the safety of p16‐guided mucosal volume reduction. Methods A retrospective review of 126 HNCUP patients (2009–2023) was conducted. p16‐negative patients received comprehensive mucosal and laryngeal irradiation; p16‐positive patients received risk‐adapted, reduced‐volume radiation limited to the ipsilateral naso‐ and oropharyngeal mucosa and elective nodal regions. Acute and late toxicities were reviewed. Results The cohort included 97 p16‐positive and 29 p16‐negative patients (median follow‐up 38 months). Five‐year overall survival was 90.0% versus 69.2% for p16‐positive and p16‐negative patients. All mucosal emergences and neck recurrences occurred within the radiation fields. Acute grade 3 toxicities were comparable between groups. Conclusions p16‐guided mucosal volume reduction in HNCUP appears oncologically safe, without compromising disease control or survival, supporting radiotherapy volume de‐intensification for p16‐positive disease.
Bibliografischer Nachweis
Publikationsdaten
- Autor:innen
- Philippe Harris, Dhiya‐Eddine Mabrouki, Felix‐Phuc Nguyen‐Tan, Edith Filion, Olivier Ballivy, Brian O'Sullivan, Apostolos Christopoulos, Tareck Ayad, Louis Guertin, Eric Bissada, Paul Tabet, Denis Soulières, Antoine Desilets, Alexandre Pellan Cheng, Robert Doucet, Laurent Létourneau‐Guillon, Houda Bahig
- Quelle
- Head & Neck
- Publikation
- 2026-01-01
- Band / Ausgabe
- Nicht angegeben
- Seiten
- Nicht angegeben
- ISSN / ISBN
- 1043-3074, 1097-0347
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Zitierfähiger Nachweis
Philippe Harris, Dhiya‐Eddine Mabrouki, Felix‐Phuc Nguyen‐Tan, Edith Filion, Olivier Ballivy, Brian O'Sullivan, Apostolos Christopoulos, Tareck Ayad, Louis Guertin, Eric Bissada, Paul Tabet, Denis Soulières, Antoine Desilets, Alexandre Pellan Cheng, Robert Doucet, Laurent Létourneau‐Guillon, Houda Bahig (2026). Head and Neck Lymph Node Metastases From Cancer of Unknown Primary: Outcomes From p16‐Guided Mucosal Radiotherapy. Head & Neck. https://doi.org/10.1002/hed.70431
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